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17 p, 839.2 KB Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus / de la Higuera, Ignacio (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Ferrer-Orta, Cristina (Institut de Biologia Molecular de Barcelona (CSIC)) ; de Ávila, Ana I. (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Perales, Celia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sierra, Macarena (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Singh, Kamalendra (Christopher S. Bond Life Sciences Center, University of Missouri) ; Sarafianos, Stefan G. (Christopher S. Bond Life Sciences Center, University of Missouri) ; Dehouck, Yves (Machine Learning Group, Université Libre de Bruxelles (ULB)) ; Bastolla, Ugo (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Verdaguer, Nuria (Institut de Biologia Molecular de Barcelona (CSIC)) ; Domingo, Esteban (Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM)) ; Universitat Autònoma de Barcelona
The selective pressures acting on viruses that replicate under enhanced mutation rates are largely unknown. Here, we describe resistance of foot-and-mouth disease virus to the mutagen 5-fluorouracil (FU) through a single polymerase substitution that prevents an excess of A to G and U to C transitions evoked by FU on the wild-type foot-and-mouth disease virus, while maintaining the same level of mutant spectrum complexity. [...]
2017 - 10.1093/gbe/evx075
Genome biology and evolution, Vol. 9 (may 2017) , p. 1212-1228  

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