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Articles, 3 registres trobats
Articles 3 registres trobats  
1.
15 p, 1007.8 KB An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers / Blein, Sophie (Université Lyon 1) ; Bardel, Claire (Université Claude Bernard Lyon 1) ; Danjean, Vincent (INRIA Rhône-Alpes (França)) ; McGuffog, Lesley (University of Cambridge) ; Healey, Sue (QIMR Berghofer (Australia)) ; Barrowdale, Daniel (University of Cambridge) ; Lee, Andrew (University of Cambridge) ; Dennis, Joe (University of Cambridge) ; Kuchenbaecker, Karoline B (University of Cambridge) ; Soucy, Penny (Laval University (Canadà)) ; Terry, Mary Beth (Columbia University) ; Chung, Wendy K (Columbia University College of Physicians and Surgeons) ; Goldgar, David E (University of Utah School of Medicine) ; Buys, Saundra S (University of Utah School of Medicine) ; Janavicius, Ramunas (State Research Institute (Lituania)) ; Tihomirova, Laima (Latvian Biomedical Research and Study Centre) ; Tung, Nadine (Beth Israel Deaconess Medical Center (Estats Units d'Amèrica)) ; Dorfling, Cecilia M (University of Pretoria) ; van Rensburg, Elizabeth J (University of Pretoria (Estats Units d'Amèrica)) ; Neuhausen, Susan L (Beckman Research Institute (Estats Units d'Amèrica)) ; Ding, Yuan Chun (Beckman Research Institute (Estats Units d'Amèrica)) ; Gerdes, Anne-Marie (Copenhagen University Hospital) ; Ejlertsen, Bent (Copenhagen University Hospital) ; Nielsen, Finn C (Copenhagen University Hospital) ; Hansen, Thomas VO (Copenhagen University Hospital) ; Osorio, Ana (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Benitez, Javier (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Conejero, Raquel Andrés (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ; Segota, Ena (Clinical Cancer Genetics Community Research Network(Estats Units d'Amèrica)) ; Weitzel, Jeffrey N (Division of Clinical Cancer Genetics(Estats Units d'Amèrica)) ; Thelander, Margo (Walnut Creek (Estats Units d'Amèrica)) ; Peterlongo, Paolo (Istituto FIRC di Oncologia Molecolare) ; Radice, Paolo (Istituto di Ricovero e Cura a Carattere Scientifico) ; Pensotti, Valeria (Cogentech Cancer Genetic Test Laboratory (Itàlia)) ; Dolcetti, Riccardo (Centro di Riferimento Oncologico (Itàlia)) ; Bonanni, Bernardo (Istituto Europeo di Oncologia (Itàlia)) ; Peissel, Bernard (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Zaffaroni, Daniela (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Scuvera, Giulietta (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Manoukian, Siranoush (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Varesco, Liliana (Istituto di Ricovero e Cura a Carattere Scientifico (Itàlia)) ; Capone, Gabriele L (University of Florence, Florence) ; Papi, Laura (University of Florence, Florence) ; Ottini, Laura (Sapienza University) ; Yannoukakos, Drakoulis (Aristotle University of Thessaloniki School of Medicine) ; Konstantopoulou, Irene (Aghia Paraskevi Attikis) ; Garber, Judy (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ; Hamann, Ute (Deutsches Krebsforschungszentrum) ; Donaldson, Alan (St Michael's Hospital) ; Brady, Angela (Kennedy-Galton Centre) ; Brewer, Carole (Royal Devon & Exeter Hospital (Exeter, Regne Unit)) ; Foo, Claire (Liverpool Women's NHS Foundation Trust) ; Evans, D Gareth (Central Manchester University Hospitals NHS Foundation Trust) ; Frost, Debra (University of Cambridge, Worts Causeway) ; Eccles, Diana (Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Mailpoint 801, South Academic Block, PAH/G/MP105, Tremona Road, Southampton, SO16 6YD UK) ; Douglas, Fiona (Institute of Human Genetics, Northern Genetic Service (Regne Unit)) ; Cook, Jackie (Sheffield Children's Hospital (Sheffield, Regne Unit)) ; Adlard, Julian (Yorkshire Regional Genetics Service) ; Barwell, Julian (Leicestershire Clinical Genetics Service) ; Walker, Lisa (Churchill Hospital) ; Izatt, Louise (St Thomas' NHS Foundation Trust) ; Side, Lucy E (Great Ormond Street Hospital for Children (Londres)) ; Kennedy, M John (St. James's Hospital ( Dublín, Irlanda)) ; Tischkowitz, Marc (Addenbrookes Hospital (Cambridge, Regne Unit)) ; Rogers, Mark T (University Hospital of Wales) ; Porteous, Mary E (Western General Hospital) ; Morrison, Patrick J (Belfast City Hospital, Lisburn Road) ; Platte, Radka (University of Cambridge) ; Eeles, Ros (The Institute of Cancer Research and Royal Marsden NHS Foundation Trust) ; Davidson, Rosemarie (Yorkhill Hospitals) ; Hodgson, Shirley (St George's University of London) ; Cole, Trevor (Birmingham Women's Hospital Healthcare NHS Trust) ; Godwin, Andrew K (DUniversity of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160 USA) ; Isaacs, Claudine (Lombardi Comprehensive Cancer Center, MedStar Georgetown University Hospital, 3800 Reservoir Road NW, Washington, DC 20057 USA) ; Claes, Kathleen (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ; De Leeneer, Kim (Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium) ; Meindl, Alfons (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ; Gehrig, Andrea (Center of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institut für Humangenetik, Biozentrum, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany) ; Wappenschmidt, Barbara (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ; Sutter, Christian (Heidelberg University Hospital (Alemanya)) ; Engel, Christoph (Institute for Medical Informatics, Statistics and Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany) ; Niederacher, Dieter (University Hospital of Düsseldorf (Alemanya)) ; Steinemann, Doris (Institute of Cell and Molecular Pathology, Centre for Pathology and Forensic and Genetic Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany) ; Plendl, Hansjoerg (Institute of Human Genetics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ; Kast, Karin (Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus of Dresden, Technical University Dresden, Dresden, Germany) ; Rhiem, Kerstin (Center for Molecular Medicine Cologne (CMMC), University of Cologne, Robert-Koch-Strasse 21, 50931 Cologne, Germany) ; Ditsch, Nina (Division of Tumor Genetics, Department of Gynaecology and Obstetrics, University Hospital Klinikum Rechts der Isar, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany) ; Arnold, Norbert (Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Campus Kiel, Arnold-Heller-Strasse 3, D-24105 Kiel, Germany) ; Varon-Mateeva, Raymonda (Institute of Medical Genetics and Human Genetics, Campus Virchow-Klinikum, Charité Berlin - Universtitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany) ; Schmutzler, Rita K (German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC), Cologne, Germany) ; Preisler-Adams, Sabine (University Hospital of Münster (Alemanya)) ; Markov, Nadja Bogdanova (University Hospital of Münster (Alemanya)) ; Wang-Gohrke, Shan (University Hospital of Ulm (Alemanya)) ; o (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Lefol, Cédrick (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Lasset, Christine (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ; Leroux, Dominique (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ; Rouleau, Etienne (Laboratoire d'Oncogénétique, Hôpital René Huguenin, Institut Curie, 35 rue Dailly, 92210 Saint-Cloud, France) ; Damiola, Francesca (Centre National de la Recherche Scientifique (França)) ; Dreyfus, Hélène (Institut Albert Bonniot - Inserm U823, Université Joseph Fourier, Rond-point de la Chantourne, 38706 La Tronche, France) ; Barjhoux, Laure (Centre National de la Recherche Scientifique (França)) ; Golmard, Lisa (Department of Tumour Biology, Institut Curie, 26 rue d'Ulm 75248, Paris, cedex 05 France) ; Uhrhammer, Nancy (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ; Bonadona, Valérie (Unité de Prévention et d'Épidémiologie Génétique, Centre Léon Bérard, 28 rue Laenned, 69008 Lyon, France) ; Sornin, Valérie (Centre National de la Recherche Scientifique (França)) ; Bignon, Yves-Jean (Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, 58 rue Montalembert, BP 392, 63011 Clermont-Ferrand, France) ; Carter, Jonathan (Gynaecological Oncology, Sydney Cancer Centre, Royal Prince Alfred Hospital and University of Sydney, Missenden Road, Camperdown, NSW 2050 Australia) ; Van Le, Linda (Gynecologic Oncology Group, Department of OB-GYN, University of North Carolina at Chapel Hill, 103B Physicians' Office Building, CB# 7572, Chapel Hill, NC 27599-7572 USA) ; Piedmonte, Marion (Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263-0001 USA) ; DiSilvestro, Paul A (Women & Infants Hospital, 1 Blackstone Place, Providence, RI 02905 USA) ; de la Hoya, Miguel (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Caldes, Trinidad (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ; Nevanlinna, Heli (Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Biomedicum Helsinki, PO Box 700, 00029 Helsinki, Finland) ; Aittomäki, Kristiina (Department of Clinical Genetics, Helsinki University Central Hospital, Biomedicum Helsinki 1, Haartmaninkatu 8, 00290 Helsinki, Finland) ; Jager, Agnes (Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands) ; van den Ouweland, Ans MW (Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands) ; Kets, Carolien M (Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands) ; Aalfs, Cora M (Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands) ; van Leeuwen, Flora E (Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Hogervorst, Frans BL (Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Meijers-Heijboer, Hanne EJ (Department of Clinical Genetics, VU University Medical Center Amsterdam, De Boelelaan 1118, 1081 HV Amsterdam, the Netherlands) ; Oosterwijk, Jan C (Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands) ; van Roozendaal, Kees EP (Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands) ; Rookus, Matti A (Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands) ; Devilee, Peter (Department of Pathology, Leiden University Medical Center, PO Box 9600, 2300 RC L1Q Leiden, the Netherlands) ; van der Luijt, Rob B (Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands) ; Olah, Edith (Department of Molecular Genetics, National Institute of Oncology, Ráth György u 7-9, PO Box 1525 Budapest PF 21, 1122 Budapest, Hungary) ; Diez, Orland (Vall d'Hebron Institut d'Oncologia) ; Teulé, Alex (Institut d'Investigació Biomèdica de Bellvitge) ; Lazaro, Conxi (Institut d'Investigació Biomèdica de Bellvitge) ; Blanco, Ignacio (Institut d'Investigació Biomèdica de Bellvitge) ; Del Valle, Jesús (Institut d'Investigació Biomèdica de Bellvitge) ; Jakubowska, Anna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Sukiennicki, Grzegorz (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Gronwald, Jacek (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Lubinski, Jan (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Durda, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Jaworska-Bieniek, Katarzyna (Department of Genetics and Pathomorphology, Faculty of Medicine and Dentistry, Pomeranian Medical University, al Powstancow Wlkp 72, 70-111 Szczecin, Poland) ; Agnarsson, Bjarni A (Landspítali National University Hospital of Iceland and Faculty of Medicine, School of Health Sciences, University of Iceland School of Medicine, Sæmundargötu 2, 101 Reykjavik, Iceland) ; Maugard, Christine (Laboratoire de diagnostic génétique et Service d'Onco-hématologie, Les Hopitaux Universitaire de Strasbourg, Nouvel Hôpital Civil, 1 place de l'Hôpital, BP 426, 67091 Strasbourg, France) ; Amadori, Alberto (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ; Montagna, Marco (Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), via Gattamelata 64, 35128 Padua, Italy) ; Teixeira, Manuel R (Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal) ; Spurdle, Amanda B (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ; Foulkes, William (Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, 546 Pine Avenue West, Montreal, QC J2W 1S6 Canada) ; Olswold, Curtis (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Lindor, Noralane M (Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259 USA) ; Pankratz, Vernon S (Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Szabo, Csilla I (National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 31 Center Drive, MSC 2152, 9000 Rockville Pike, Bethesda, MD 20892-2152 USA) ; Lincoln, Anne (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Jacobs, Lauren (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Corines, Marina (Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Robson, Mark (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Vijai, Joseph (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Berger, Andreas (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Fink-Retter, Anneliese (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Singer, Christian F (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Rappaport, Christine (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Kaulich, Daphne Geschwantler (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Pfeiler, Georg (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Tea, Muy-Kheng (Department of Obstetrics and Gynecology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Universitätsklinik für Frauenheilkunde, AKH - Wien, Währinger Gürtel 18-20, 1090 Vienna, Austria) ; Greene, Mark H (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ; Mai, Phuong L (Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ; Rennert, Gad (Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, 2 Horev Street, 34362 Haifa, Israel) ; Imyanitov, Evgeny N (NN Petrov Institute of Oncology, 68 Leningradskaya Street, Pesochny, 197758 St Petersburg Russia) ; Mulligan, Anna Marie (Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, 209 Victoria Street, Toronto, ON M5B 1T8 Canada) ; Glendon, Gord (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ; Andrulis, Irene L (Department of Molecular Genetics, University of Toronto, Medical Science Building, Room 4386, 1 King's College Circle, Toronto, ON M5S 1A8 Canada) ; Tchatchou, Sandrine (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G 1X5 Canada) ; Toland, Amanda Ewart (The Ohio State University Comprehensive Cancer Center - Arthur G James Cancer Hospital and Richard J Solove Research Institute (OSUCCC - James), 460 West 10th Avenue, Columbus, OH 43210 USA) ; Pedersen, Inge Sokilde (Aalborg University Hospital (Dinamarca)) ; Thomassen, Mads (Odense University Hospital (Dinamarca)) ; Kruse, Torben A (Odense University Hospital (Dinamarca)) ; Jensen, Uffe Birk (Aarhus University Hospital (Aarhus, Dinamarca)) ; Caligo, Maria A (Laboratorio di Genetica Oncologica, Divisione di Anatomia Patologica e di Diagnostica Molecolare ed Ultrastrutturale, Azienda Ospedaliero Universitaria Pisana - Ospedale S Chiara, via Roma 67, 56126 Pisa, Italy) ; Friedman, Eitan (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ; Zidan, Jamal (Institute of Oncology, Rivka Ziv Medical Center, Maimonides, 13100 Safed, Israel) ; Laitman, Yael (Sheba Laboratory of Molecular Genetics, The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Ramat Gan, 52621 Tel Aviv, Israel) ; Lindblom, Annika (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Melin, Beatrice (Oncology, Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden) ; Arver, Brita (Karolinska University Hospital and Karolinska Institutet (Suècia)) ; Loman, Niklas (Division of Oncology and Pathology, Department of Clinical Sciences, Lund University Hospital, Barngatan 2B, SE-221 85 Lund, Sweden) ; Rosenquist, Richard (Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, 751 85 Uppsala, Sweden) ; Olopade, Olufunmilayo I (Center for Clinical Cancer Genetics and Global Health, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637 USA) ; Nussbaum, Robert L (Department of Medicine and Genetics, University of California, San Francisco, CA USA) ; Ramus, Susan J (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Norris Comprehensive Cancer Center, NOR-4435, Los Angeles, CA 90089-9175 USA) ; Nathanson, Katherine L (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Domchek, Susan M (Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Rebbeck, Timothy R (Department of Epidemiology and Biostatistics, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, 3535 Market Street, Suite 750, Philadelphia, PA 19104-3309 USA) ; Arun, Banu K (Division of Cancer Medicine, Department of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Unit 1354, PO Box 301439, Houston, TX 77230-1439 USA) ; Mitchell, Gillian (Sir Peter MacCallum Department of Oncology, The University of Melbourne, Level 5, 161 Barry Street, Parkville, 3010 VIC Australia) ; Karlan, Beth Y (Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 USA) ; Lester, Jenny (Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 USA) ; Orsulic, Sandra (Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048 USA) ; Stoppa-Lyonnet, Dominique (Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, 15 rue de l'école de médecine, 75006 Paris, France) ; Thomas, Gilles (Institut National du Cancer (INCa), La Fondation Synergie Lyon Cancer, Centre Léon Bérard, 28 rue Laënnec, 69008 Lyon, Cedex 08 France) ; Simard, Jacques (Centre de recherche du Centre hospitalier universitaire de Québec, Laval University, Charlesbourg, PQ Canada) ; Couch, Fergus J (Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905 USA) ; Offit, Kenneth (Clinical Genetics Research Laboratory, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 USA) ; Easton, Douglas F (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ; Chenevix-Trench, Georgia (Department of Genetics and Computational Biology, QIMR Berghofer, Brisbane, Australia) ; Antoniou, Antonis C (Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK) ; Mazoyer, Sylvie (Université Lyon 1, 69100 Villeurbanne, France) ; Phelan, Catherine M (Department of Cancer Epidemiology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612 USA) ; Sinilnikova, Olga M (Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, 69373 Lyon, Cedex 08 France) ; Cox, David G (Université Lyon 1, 69100 Villeurbanne, France) ; Universitat Autònoma de Barcelona
Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. [...]
2015 - 10.1186/s13058-015-0567-2
Breast cancer research, Vol. 17 (april 2015)  
2.
12 p, 2.3 MB A comprehensive custom panel design for routine hereditary cancer testing: preserving control, improving diagnostics and revealing a complex variation landscape / Castellanos, Elisabeth (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Gel, Bernat (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Rosas, Inma (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Tornero, Eva (Institut Català d'Oncologia) ; Santín, Sheila (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Pluvinet, Raquel (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Velasco, Juan (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Sumoy, Lauro (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Del Valle, Jesús (Institut Català d'Oncologia) ; Perucho, Manuel (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Blanco Guillermo, Ignacio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Navarro, Matilde (Institut Català d'Oncologia) ; Brunet, Joan (Institut Català d'Oncologia) ; Pineda, Marta (Institut Català d'Oncologia) ; Feliubadaló, Lidia (Institut Català d'Oncologia) ; Capellá, Gabriel (Institut Català d'Oncologia) ; Lázaro, Conxi (Institut Català d'Oncologia) ; Serra, Eduard (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
We wanted to implement an NGS strategy to globally analyze hereditary cancer with diagnostic quality while retaining the same degree of understanding and control we had in pre-NGS strategies. To do this, we developed the I2HCP panel, a custom bait library covering 122 hereditary cancer genes. [...]
2017 - 10.1038/srep39348
Scientific reports (Nature Publishing Group), 2017, p. 1-12  
3.
11 p, 1.3 MB Benchmarking of Whole Exome Sequencing and Ad Hoc Designed Panels for Genetic Testing of Hereditary Cancer / Feliubadaló, Lidia (Institut Català d'Oncologia) ; Tonda, Raúl (Centro Nacional de Análisis Genómico (CNAG-CRG)) ; Gausachs, Mireia (Institut Català d'Oncologia) ; Trotta, Jean-Rémi (Centro Nacional de Análisis Genómico (CNAG-CRG)) ; Castellanos, Elisabeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; López-Doriga, Adriana (Institut Català d'Oncologia) ; Teulé, Àlex (Institut Català d'Oncologia) ; Tornero, Eva (Institut Català d'Oncologia) ; Del Valle, Jesús (Institut Català d'Oncologia) ; Gel, Bernat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Gut,Marta (Centro Nacional de Análisis Genómico (CNAG-CRG)) ; Pineda,Marta (Institut Català d'Oncologia) ; González,Sara (Institut Català d'Oncologia) ; Menéndez,Mireia (Institut Català d'Oncologia) ; Navarro, Matilde (Institut Català d'Oncologia) ; Capellá, Gabriel (Institut Català d'Oncologia) ; Gut, Ivo (Centro Nacional de Análisis Genómico (CNAG-CRG)) ; Serra, Eduard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Brunet, Joan (Institut Català d'Oncologia) ; Beltran i Agulló, Sergi (Centro Nacional de Análisis Genómico (CNAG-CRG)) ; Lázaro, Conxi (Institut Català d'Oncologia)
Next generation sequencing panels have been developed for hereditary cancer, although there is some debate about their cost-effectiveness compared to exome sequencing. The performance of two panels is compared to exome sequencing. [...]
2017 - 10.1038/srep37984
Scientific reports (Nature Publishing Group), 2017-11  

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