Results overview: Found 2 records in 0.02 seconds.
Articles, 2 records found
Articles 2 records found  
11 p, 1.2 MB Alzheimer's disease in Down syndrome : An overlooked population for prevention trials / Strydom, André (South London and Maudsley NHS Foundation Trust) ; Coppus, Antonia (Department of Primary and Community Care, Radboud University Medical Center, Nijmegen) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Danek, Adrian (Department of Neurology, Ludwig-Maximilians-Universität München) ; Fortea, Juan (Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down) ; Hardy, John (Reta Lila Weston Institute, Institute of Neurology, University College London) ; Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) site Munich) ; Nuebling, Georg (Department of Neurology, Ludwig-Maximilians-Universität München) ; Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ; Ritchie, Craig (Centre for Clinical Brain Sciences. University of Edinburgh) ; van Duijn, Cornelia (Department of Epidemiology, Erasmus Medical Centre, Rotterdam) ; Zaman, Shahid (Cambridgeshire & Peterborough NHS Foundation Trust (CBFT), Fulbourn Hospital) ; Zetterberg, Henrik (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital) ; Universitat Autònoma de Barcelona
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. [...]
2018 - 10.1016/j.trci.2018.10.006
Alzheimer's & Dementia : Translational Research & Clinical Interventions, Vol. 4 (december 2018) , p. 703-713  
6 p, 420.8 KB ATP5H/KCTD2 locus is associated with Alzheimer's disease risk / Boada Rovira, Mercè (Hospital Universitari Vall d'Hebron) ; Antúnez, C. (University Hospital Virgen de la Arrixaca) ; Ramírez Lorca, Repo (Neocodex) ; DeStefano, Anita L. (Boston University School of Medicine) ; González Pérez, A. (Neocodex) ; Gayán, Javier (Neocodex) ; López Arrieta, Jesús (University Hospital La Paz-Cantoblanco) ; Ikram, M. Arfan (Erasmus MC University Medical Center) ; Hernández, Isabel (Institut Català de Neurociències Aplicades) ; Marín, J. (University Hospital Virgen de la Arrixaca) ; Galán, José Jorge (Neocodex) ; Bis, Joshua C. (University of Washington) ; Mauleón, Ana (Institut Català de Neurociènces Aplicades) ; Rosende-Roca, Maitée (Institut Català de Neurociènces Aplicades) ; Moreno Rey, Concha (Neocodex) ; Gudnasson, Vilmundur (Kopavogur University of Iceland) ; Morón, Francisco Jesús (Neocodex) ; Velasco, Juan (Neocodex) ; Carrasco, José Miguel (Neocodex) ; Alegret, Montserrat (Institut Català de Neurociències Aplicades) ; Espinosa, Ana (Institut Català de Neurociències Aplicades) ; Vinyes, Georgina (Institut Català de Neurociències Aplicades) ; Lafuente, Asunción (Institut Català de Neurociències Aplicades) ; Vargas, Liliana (Institut Català de Neurociències Aplicades) ; Fitzpatrick, Annette L. (University of Washington) ; Launer, Lenore Joy (National Institute on Aging) ; Sáez, María Eugenia (Neocodex) ; Vázquez, Enrique (Neocodex) ; Becker, James T. (University of Pittsburgh) ; López, Oscar L. (University of Pittsburgh School of Medicine) ; Serrano Ríos, Manuel (Hospital Clínico San Carlos) ; Tárraga, Lluís (Institut Català de Neurociènces Aplicades) ; van Duijn, Cornelia M. (Erasmus MC University Medical Center) ; Real, Luis Miguel (Neocodex) ; Seshadri, Sudha (National Heart, Lung and Blood Institute's Framingham Heart Study) ; Ruiz, Agustín (Department of Structural Genomics, Neocodex) ; Universitat Autònoma de Barcelona
To identify loci associated with Alzheimer disease, we conducted a three-stage analysis using existing genome-wide association studies (GWAS) and genotyping in a new sample. In Stage I, all suggestive single-nucleotide polymorphisms (at P <0. [...]
2014 - 10.1038/mp.2013.86
Molecular Psychiatry, Vol. 19, Issue 6 (June 2014) , p. 682-687  

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