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Articles 2 registres trobats  
1.
12 p, 2.0 MB A multicentre validation study of the diagnostic value of plasma neurofilament light / Ashton, Nicholas J. (NIHR Biomedical Research Centre for Mental Health (Londres, Regne Unit)) ; Janelidze, Shorena (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ; Al Khleifat, Ahmad (Department of Basic and Clinical Neuroscience. Maurice Wohl Clinical Neuroscience Institute. King's College London) ; Leuzy, Antoine (Clinical Memory Research Unit. Department of Clinical Sciences Malmö. Lund University) ; van der Ende, Emma L. (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ; Karikari, Thomas K (Department of Psychiatry and Neurochemistry. Institute of Neuroscience & Physiology. The Sahlgrenska Academy at the University of Gothenburg) ; Benedet, AndreaL. (Montreal Neurological Institute) ; Pascoal, Tharick A. (Montreal Neurological Institute) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Parnetti, Lucilla (Laboratory of Clinical Neurochemistry. Neurology Clinic. University of Perugia) ; Galimberti, Daniela (University of Milan) ; Bonanni, Laura (Department of Neuroscience. Imaging and Clinical Sciences. University G.d'Annunzio of Chieti-Pescara) ; Pilotto, Andrea (Parkinson's Disease Rehabilitation Centre. FERB ONLUS) ; Padovani, Alessandro (Neurology Unit. Department of Clinical and Experimental Sciences. University of Brescia) ; Lycke, Jan (Sahlgrenska University Hospital (Suècia)) ; Novakova, Lenka (Sahlgrenska University Hospital (Suècia)) ; Axelsson, Markus (Sahlgrenska University Hospital (Suècia)) ; Velayudhan, Latha (Department of Health Sciences. University of Leicester) ; Rabinovici, Gil D. (Department of Radiology & Biomedical Imaging. University of California) ; Miller, Bruce L. (University of California San Francisco. Memory and Aging Center) ; Pariante, Carmine M (Stress. Psychiatry and Immunology Lab & Perinatal Psychiatry. Maurice Wohl Clinical Neuroscience Institute. King's College London) ; Nikkheslat, Naghmeh (King's College London (Regne Unit)) ; Resnick, Susan M. (Brain Aging and Behavior Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ; Thambisetty, Madhav (Clinical and Translational Neuroscience Section. Laboratory of Behavioral Neuroscience. National Institute on Aging. National Institutes of Health) ; Schöll, Michael (Department of Neurodegenerative Disease. Queen Square Institute of Neurology. University College London) ; Fernández-Eulate, Gorka (Department of Neurology. Donostia University Hospital. Osakidetza) ; Gil-Bea, Francisco J. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; López de Munain, Adolfo (Universidad del País Vasco. Departamento de Neurociencias) ; Al-Chalabi, Ammar (King's College Hospital NHS Foundation Trust) ; Rosa-Neto, Pedro (Montreal Neurological Institute) ; Strydom, Andre (London Down Syndrome Consortium (LonDowns)) ; Svenningsson, Per (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ; Stomrud, Erik (Skåne University Hospital (Suècia)) ; Santillo, Alexander (Lund University. Department of Clinical Sciences Malmö) ; Aarsland, Dag (Stavanger University Hospital) ; van Swieten, John C. (Erasmus University Medical Center) ; Palmqvist, Sebastian (Lund University. Skåne University Hospital) ; Zetterberg, Henrik (University College London. UK Dementia Research Institute) ; Blennow, Kaj (Sahlgrenska University Hospital (Suècia)) ; Hye, Abdul (Stavanger University Hospital) ; Hansson, Oskar (Skåne University Hospital (Suècia))
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n = 805) and the Swedish BioFINDER study (n = 1,464). [...]
2021 - 10.1038/s41467-021-23620-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 3400  
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2.
5 p, 501.6 KB CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia / van der Ende, Emma L (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ; Morenas-Rodriguez, Estrella (Ludwig-Maximilians-Universität München) ; McMillan, Corey T. (Penn Frontotemporal Degeneration Center. University of Pennsylvania Perelman School of Medicine) ; Grossman, Murray (Penn Frontotemporal Degeneration Center. University of Pennsylvania Perelman School of Medicine) ; Irwin, David J. (Penn Frontotemporal Degeneration Center. University of Pennsylvania Perelman School of Medicine) ; Sanchez-Valle, Raquel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Graff, Caroline (Unit of Hereditary Dementia. Theme Aging. Karolinska University Hospital-Solna) ; Vandenberghe, Rik (Laboratory for Cognitive Neurology. Department of Neurosciences. Leuven Brain Institute) ; Pijnenburg, Yolande (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Vrije Universiteit Amsterdam) ; Laforce, Robert Jr (Clinique Interdisciplinaire de Mémoire du CHU de Québec. département des Sciences Neurologiques. Université Laval) ; Le Ber, Isabelle (Sorbonne Université. Paris Brain Institute. Institut du Cerveau. ICM. Inserm U1127. CNRS UMR 7225. APHP. Hôpital Pitié-Salpêtrière) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Haass, Christian (Munich Cluster for Systems Neurology (SyNergy)) ; Suárez-Calvet, Marc (German Center for Neurodegenerative Diseases (DZNE) Munich) ; van Swieten, John Cornelis (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center) ; Seelaar, Harro (Alzheimer Center Rotterdam and Dept. of Neurology. Erasmus University Medical Center)
Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation carriers and 67 healthy noncarriers by ELISA. [...]
2021 - 10.1016/j.neurobiolaging.2021.02.024
Neurobiology of Aging, Vol. 103 (july 2021) , p. 158.e1-158.e5  
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