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1.
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17 p, 2.6 MB |
β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia
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García-Hernández, Violeta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Arambilet Mobilla, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Lobo-Jarne, Teresa (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Maqueda, Maria (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gekas, Christos (Institut Hospital del Mar d'Investigacions Mèdiques) ;
González Miranda, Jessica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Iglesias, Arnau (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Vega-García, Nerea (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Sentís, Inés (Centre de Regulació Genòmica) ;
Trincado Alonso, Juan Luis, 1987- (Centre de Regulació Genòmica) ;
Márquez-López, Ian (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Camós, Mireia (Hospital Sant Joan de Déu (Barcelona, Catalunya)) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the evolution of T-cell Acute Lymphoblastic Leukemia (T-ALL) patients and its involvement in therapy resistance. [...]
2023 -  10.15252/emmm.202216554
EMBO Molecular Medicine, Vol. 15 Núm. 2 (february 2023)
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2.
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26 p, 1.1 MB |
Structural and kinetic features of aldehyde dehydrogenase 1A (ALDH1A) subfamily members, cancer stem cell markers active in retinoic acid biosynthesis
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Pequerul Pavon, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Vera Lillo, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Giménez Dejoz, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Crespo, Isidro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Coines, Joan (Universitat de Barcelona) ;
Porté, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Rovira, Carme (Universitat de Barcelona) ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases catalyze the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. The three-dimensional structures of the human ALDH1A enzymes were recently obtained, while a complete kinetic characterization of them, under the same experimental conditions, is lacking. [...]
2020 - 10.1016/j.abb.2020.108256
Archives of biochemistry and biophysics, Vol. 681 (2020) , p. 108256
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3.
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11 p, 547.4 KB |
Pretransplant Consolidation Is Not Beneficial for Adults with ALL Undergoing Myeloablative Allogeneic Transplantation
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Bejanyan, Nelli (University of Minnesota) ;
Zhang, Mei-Jie (Medical College of Wisconsin) ;
Wang, Hai-Lin (Medical College of Wisconsin) ;
Lazaryan, Aleksandr (University of Minnesota) ;
de Lima, Marcos (University Hospitals Case Medical Center) ;
Marks, David I. (University Hospitals Bristol NHS Trust) ;
Sandmaier, Brenda M. (Fred Hutchinson Cancer Research Center) ;
Bachanova, Veronika (University of Minnesota) ;
Rowe, Jacob (Shaare Zedek Medical Center) ;
Tallman, Martin (Memorial Sloan Kettering Cancer Center) ;
Kebriaei, Partow (The University of Texas MD Anderson Cancer Center) ;
Kharfan-Dabaja, Mohamed (H. Lee Moffitt Cancer Center and Research Institute) ;
Peter Gale, Robert (Imperial College London) ;
Lazarus, Hillard M. (University Hospitals Cleveland Medical Center) ;
Ustun, Celalettin (University of Minnesota) ;
Copelan, Edward (Carolinas HealthCare System) ;
Ky Hamilton, Betty (Cleveland Clinic Taussig Cancer Institute) ;
Schiller, Gary (David Geffen School of Medicine at UCLA) ;
Hogan, Willian (Mayo Clinic Rochester) ;
Hashmi, Shahrukh (King Faisal Specialist Hospital and Research Centre (Aràbia Saudita)) ;
Seftel, Matthew (CancerCare Manitoba) ;
Kanakry, Christopher G. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Olsson, Richard F. (Uppsala University) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Saber, Wael (Medical College of Wisconsin) ;
Khoury, H.Jean (Emory University Hospital) ;
Weisdorf, Daniel J. (University of Minnesota) ;
Universitat Autònoma de Barcelona
Allogeneic hematopoietic cell transplantation (alloHCT) is curative for patients with acute lymphoblastic leukemia (ALL) who achieve complete remission (CR1) with chemotherapy. However, the benefit of consolidation chemotherapy remains uncertain in patients undergoing alloHCT. [...]
2018 - 10.1016/j.bbmt.2017.12.784
Biology of blood and marrow transplantation, Vol. 24 Núm. 5 (may 2018) , p. 945-955
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4.
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8 p, 1.4 MB |
Effect of the recent economic crisis on socioeconomic inequalities in mortality in nine urban areas in Europe
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Palència, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Gotsens, Mercè (Institut d'Investigació Biomèdica Sant Pau) ;
Marí-Dell'Olmo, Marc 1978- (Institut d'Investigació Biomèdica Sant Pau) ;
Bosakova, L. (Palacky University in Olomouc) ;
Burstrom, Bo (Karolinska Institutet (Estocolm, Suècia)) ;
Costa, C. (University of Coimbra) ;
Deboosere, P. (Vrije Universiteit Brussels) ;
Dzurova, D. (Charles University) ;
Lustigova, M. (Charles University) ;
Morrison, J. (University College London) ;
Santana, Paula (University of Coimbra) ;
Borrell i Thió, Carme (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
To analyse socioeconomic inequalities in all-cause mortality among men and women in nine European urban areas during the recent economic crisis, and to compare the results to those from two periods before the crisis. [...]
2020 - 10.1016/j.gaceta.2019.11.001
Gaceta sanitaria, Vol. 34 Núm. 3 (mayo 2020) , p. 253-260
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5.
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16 p, 2.0 MB |
Vitamin D Supplementation and Its Impact on Mortality and Cardiovascular Outcomes : Systematic Review and Meta-Analysis of 80 Randomized Clinical Trials
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Ruiz-García, Antonio (Centro de Salud Universitario Pinto) ;
Pallares-Carratala, Vicente (Universitat Jaume I) ;
Turégano-Yedro, Miguel (Centro de Salud Aldea Moret) ;
Torres, Ferran (Universitat Autònoma de Barcelona) ;
Sapena, Victor (Universitat Autònoma de Barcelona) ;
Martin-Gorgojo, Alejandro (Ayuntamiento de Madrid) ;
Martin-Moreno, Jose M. (Hospital Clínic Universitàri de València)
The impact of vitamin D supplementation on cardiovascular outcomes and mortality risk reduction remains unclear due to conflicting study findings. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs), published between 1983 and 2022, that reported the effect of vitamin D supplementation in adults versus placebo or no treatment on all-cause mortality (ACM), cardiovascular mortality (CVM), non-cardiovascular mortality (non-CVM), and cardiovascular morbidities. [...]
2023 - 10.3390/nu15081810
Nutrients, Vol. 15 (april 2023)
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13 p, 983.7 KB |
Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus
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Rodríguez-Calvo, Ricardo (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Granado-Casas, Minerva (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Pérez-Montes de Oca, Alejandra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domingo, Mar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Codina, Pau (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Santiago Vacas, Evelyn (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Cediel, Germán (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Rossell, Joana (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Masana, Lluís (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Mauricio Puente, Dídac (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Lupón, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Alonso Pedrol, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)
Subjects with type 2 diabetes mellitus (T2D) are at increased risk for heart failure (HF). The cardiac-specific (FABP3) and adipose-tissue-specific (FABP4) types of the fatty acid binding proteins have been associated with both all-cause and cardiovascular (CV) mortality. [...]
2023 - 10.3390/antiox12030645
Antioxidants, Vol. 12 (march 2023)
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23 p, 936.9 KB |
Long-term outcomes among a nationwide cohort of patients using an implantable cardioverter-defibrillator : UMBRELLA study final results
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Briongos-Figuero, S. (Universidad Complutense de Madrid) ;
García-Alberola, A. (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Rubio, J. (Hospital Clínico Universitario de Valladolid) ;
Segura, J. M. (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Rodríguez, A. (Hospital Universitario de Canarias (La Laguna)) ;
Peinado, R. (Hospital Universitario La Paz (Madrid)) ;
Alzueta, J. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Martínez-Ferrer, J.B. (Arabako Unibertsitate Ospitalea (Vitoria, País Basc)) ;
Viñolas, Xavier (Institut d'Investigació Biomèdica Sant Pau) ;
De La Concha, J.F. (Hospital Infanta Cristina) ;
Anguera, Ignasi (Hospital Universitari de Bellvitge) ;
Martín, M. (Medtronic Ibérica) ;
Cerdá, L. (Medtronic Ibérica) ;
Pérez, L. (Complejo Hospitalario Universitario de A Coruña)
BACKGROUND: Large-scale studies describing modern populations using an implantable cardioverter-defibrillator (ICD) are lacking. We aimed to analyze the incidence of arrhythmia, device interventions, and mortality in a broad spectrum of real-world ICD patients with different heart disorders. [...]
2021 - 10.1161/JAHA.120.018108
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol. 10 Núm. 1 (may 2021) , p. 1-23
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16 p, 4.6 MB |
Miyoshi myopathy and limb girdle muscular dystrophy R2 are the same disease
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Moore, Ursula (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Gordish-Dressman, Heather (George Washington University) ;
Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
James, Meredith K. (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Mayhew, Anna G. (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Guglieri, Michela (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Fernandez-Torron, Roberto (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Rufibach, Laura E. (The Jain Foundation) ;
Feng, Jia (Center for Translational Science. Division of Biostatistics and Study Methodology. Children's National Health System) ;
Blamire, Andrew (Magnetic Resonance Centre. Translational and Clinical Research Institute. Newcastle University) ;
Carlier, Pierre G. (AIM & CEA NMR Laboratory. Institute of Myology. Pitié-Salpêtrière University Hospital) ;
Spuler, Simone (Charite Muscle Research Unit. Experimental and Clinical Research Center. a Joint Cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine) ;
Day, John W (Stanford University School of Medicine) ;
Jones, Kristi J. (The Children's Hospital at Westmead. and The University of Sydney) ;
Bharucha-Goebel, Diana (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Salort-Campana, Emmanuelle (Service des maladies neuromusculaire et de la SLA. Hôpital de La Timone) ;
Pestronk, Alan (Washington University School of Medicine) ;
Walter, Maggie C. (Friedrich-Baur-Institute. Department of Neurology. Ludwig-Maximilians-University of Munich) ;
Paradas, Carmen (Instituto de Biomedicina de Sevilla) ;
Stojkovic, Tanya (Sorbonne Université) ;
Mori-Yoshimura, Madoka (Department of Neurology. National Center Hospital. National Center of Neurology and Psychiatry) ;
Bravver, Elena (Neuroscience Institute. Carolinas Neuromuscular/ALS-MDA Center. Carolinas HealthCare System) ;
Pegoraro, Elena (University of Padova) ;
Lowes, Linda P (The Abigail Wexner Research Institute at Nationwide Children's Hospital) ;
Mendell, Jerry R. (The Abigail Wexner Research Institute at Nationwide Children's Hospital) ;
Bushby, Kate (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust) ;
Straub, Volker (The John Walton Muscular Dystrophy Research Centre. Translational and Clinical Research Institute. Newcastle University and Newcastle Hospitals NHS Foundation Trust)
This study aims to determine clinically relevant phenotypic differences between the two most common phenotypic classifications in dysferlinopathy, limb girdle muscular dystrophy R2 (LGMDR2) and Miyoshi myopathy (MMD1). [...]
2021 - 10.1016/j.nmd.2021.01.009
Neuromuscular Disorders, Vol. 31 Núm. 4 (april 2021) , p. 265-280
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7 p, 1.3 MB |
Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL)
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Genescà, Eulàlia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morgades, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
González-Gil, Celia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fuster-Tormo, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Haferlach, Claudia (MLL Munich Leukemia Laboratory) ;
Meggendorfer, Manja (MLL Munich Leukemia Laboratory) ;
Montesinos, Pau (Hospital Universitari i Politècnic La Fe (València)) ;
Barba, Pere (Hospital Universitari Vall d'Hebron) ;
Gil, Cristina (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Coll, Rosa (Hospital Universitari de Girona Doctor Josep Trueta) ;
Moreno, María-José (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia)) ;
Martínez-Carballeira, Daniel (Hospital Universitario Central de Asturias) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Vives Polo, Susana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ribera, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Campos, José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Díaz-Beyá, Marina (Hospital Clínic i Provincial de Barcelona) ;
Mercadal, Santiago (Hospital Duran i Reynals (Hospitalet del Llobregat)) ;
Artola, Maria Teresa (Hospital de Donostia (Sant Sebastià, País Basc)) ;
Cladera, Antonia (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Tormo, Mar (Hospital Clínic Universitari (València)) ;
Bermúdez, Arancha (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria)) ;
Vall-Llovera, Ferran (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Martínez-Sánchez, Pilar (Hospital Universitario 12 de Octubre (Madrid)) ;
Amigo, María-Luz (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Monsalvo, Silvia (Hospital General Universitario Gregorio Marañón) ;
Novo, Andrés (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Cervera, Marta (Hospital Universitari Joan XXIII de Tarragona) ;
García-Guiñon, Antonio (Hospital Arnau de Vilanova (València)) ;
Ciudad Pizarro, Juana (Instituto de Investigación Biomédica de Salamanca) ;
Cervera, José (Hospital Universitari i Politècnic La Fe (València)) ;
Hernández Rivas, Jesús María (Hospital Clínico Universitario (Salamanca)) ;
Granada, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Haferlach, Torsten (MLL Munich Leukemia Laboratory) ;
Orfao, Alberto (Instituto de Investigación Biomédica de Salamanca) ;
Sole, F (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ribera, Jose-Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. [...]
2021 - 10.1016/j.leukres.2021.106612
Leukemia Research, Vol. 109 (october 2021) , p. 106612
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