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11 p, 1.4 MB |
Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly
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Marques-Pamies, Montserrat (Hospital Municipal de Badalona) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hernández García, Marta (Hospital Universitari Arnau de Vilanova) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Giménez-Palop, Olga (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Martínez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pons, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Villar-Taibo, Rocío (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Araujo-Castro, Marta (Hospital Ramón y Cajal) ;
Blanco, Concepción (Hospital Universitario Príncipe de Asturias) ;
Simón, Inmaculada (Hospital Universitari Joan XXIII de Tarragona) ;
Simó-Servat, Andreu (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Xifra, Gemma (Hospital Universitari de Girona Doctor Josep Trueta) ;
Vázquez, Federico (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pavón, Isabel (Hospital Universitario de Getafe) ;
García-Centeno, Rogelio (Hospital General Universitari Gregorio Marañón) ;
Zavala, Roxana (Hospital Universitari Joan XXIII de Tarragona) ;
Hanzu, Felicia A (Hospital Clínic i Provincial de Barcelona) ;
Mora, Mireia (Hospital Clínic i Provincial de Barcelona) ;
Aulinas, Anna (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vilarrasa, Nuria (Instituto de Salud Carlos III) ;
Librizzi, Soledad (Hospital Universitario 12 de Octubre) ;
Calatayud, María (Hospital Universitario 12 de Octubre) ;
de Miguel, Paz (Hospital Clínico San Carlos (Madrid)) ;
Alvarez-Escola, Cristina (Hospital Universitario La Paz) ;
Picó Alfonso, Antonio M (Instituto de Investigación Sanitaria y Biomédica de Alicante) ;
Sampedro, Miguel (Hospital Universitario de La Princesa) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Bernabeu Morón, Ignacio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Webb, S. M 1952- (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
We previously described that a short version of the acute octreotide test (sAOT) can predict the response to first-generation somatostatin receptor ligands (SRLs) in patients with acromegaly. We have prospectively reassessed the sAOT in patients from the ACROFAST study using current ultra-sensitive GH assays. [...]
2023 -  10.3389/fendo.2023.1269787
Frontiers in Endocrinology, Vol. 14 (october 2023)
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10 p, 988.4 KB |
Development of ACRODAT®, a new software medical device to assess disease activity in patients with acromegaly
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van der Lely, Aart J. (Erasmus University Medical Center) ;
Gomez, Roy (Pfizer Medical Affairs) ;
Pleil, Andreas (Pfizer Inc) ;
Badia, Xavier (University of Barcelona and Omakase Consulting) ;
Brue, Thierry (Centre de Référence des Maladies Rares de l'hypophyse HYPO) ;
Buchfelder, Michael (Universitatsklinikum Erlangen) ;
Burman, Pia (University of Lund) ;
Clemmons, David (UNC Hospitals Diabetes and Endocrinology Clinic) ;
Ghigo, Ezio (University Hospital Città Salute e Scienza) ;
Jorgensen, Jens Otto Lunde (Aarhus University) ;
Luger, Anton (Medizinische Universität und Allgemeines Krankenhaus Wien) ;
van der Lans-Bussemaker, Joli (Pfizer Medical Affairs) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Strasburger, Christian J. (Charitė Universitätsmedizin Berlin) ;
Universitat Autònoma de Barcelona
Despite availability of multimodal treatment options for acromegaly, achievement of long-term disease control is suboptimal in a significant number of patients. Furthermore, disease control as defined by biochemical normalization may not always show concordance with disease-related symptoms or patient's perceived quality of life. [...]
2017 - 10.1007/s11102-017-0835-5
Pituitary, Vol. 20 Núm. 6 (january 2017) , p. 692-701
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14 p, 1.9 MB |
Data mining analyses for precision medicine in acromegaly : a proof of concept
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Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol) ;
Sampedro, Miguel (Hospital Universitario de la Princesa (Madrid)) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Blanco, Alberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Picó Alfonso, Antonio M (Universidad Miguel Hernández de Elche. Departamento de Medicina Clínica) ;
García-Martínez, Araceli (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Martel-Duguech, Luciana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sardon, Teresa (Anaxomics Biotech S.L.) ;
Simó-Servat, Andreu (Hospital Universitari Mútua Terrassa. Servei d'Endocrinologia) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Villabona, Carles (Hospital Universitari de Bellvitge) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Fajardo-Montañana, Carmen (Hospital de La Ribera (Alzira). Servicio de Endocrinología) ;
Álvarez-Escolá, Cristina (Hospital Universitario La Paz (Madrid)) ;
Lamas, Cristina (Hospital General Universitario de Albacete. Servicio de Endocrinología) ;
Alvarez, Clara V. (Universidade de Santiago de Compostela) ;
Bernabeu Morón, Ignacio (Complejo Hospitalario Universitario de Santiago de Compostela) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Puig-Domingo, Manel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Universitat Autònoma de Barcelona
Predicting which acromegaly patients could benefit from somatostatin receptor ligands (SRL) is a must for personalized medicine. Although many biomarkers linked to SRL response have been identified, there is no consensus criterion on how to assign this pharmacologic treatment according to biomarker levels. [...]
2022 - 10.1038/s41598-022-12955-2
Scientific reports, Vol. 12 Núm. 1 (december 2022) , p. 8979
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10 p, 635.4 KB |
Factors associated with therapeutic response in acromegaly diagnosed in the elderly in Spain
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Biagetti, Betina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Iglesias, Pedro (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Villar-Taibo, Rocío (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Moure, Maria-Dolores (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Paja, Miguel (Hospital de Basurto (Bilbao, Biscaia)) ;
Araujo-Castro, Marta (Hospital Universitario Ramón y Cajal (Madrid)) ;
Ares, Jessica (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Álvarez-Escolá, Cristina (Hospital Universitario La Paz (Madrid)) ;
Vicente, Almudena (Hospital Universitario de Toledo) ;
Álvarez Guivernau, Èlia (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Novoa-Testa, Iria (Complejo Hospitalario Universitario de A Coruña) ;
Guerrero Perez, Fernando (Hospital Universitari de Bellvitge) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Lecumberri, Beatriz (Hospital Universitario La Paz (Madrid)) ;
García Gómez, Carlos (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Bernabeu Morón, Ignacio (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Manjón, Laura (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Gaztambide, Sonia (Universidad del País Vasco) ;
Cordido, Fernando (Complejo Hospitalario Universitario de A Coruña) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Menéndez Torre, E. (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Díez, Juan J. (Instituto de Investigación Sanitaria Puerta de Hierro - Segovia de Arana) ;
Simó, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Puig-Domingo, Manel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Context: Some reports suggest that acromegaly in elderly patients has a more benign clinical behavior and could have a better response to first-generation long-acting somatostatin receptor ligands (SRL). [...]
2022 - 10.3389/fendo.2022.984877
Frontiers in Endocrinology, Vol. 13 (September 2022) , p. 984877
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9 p, 466.6 KB |
Patient journey experiences may contribute to improve healthcare for patients with rare endocrine diseases
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Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Kristensen, Jette (ePAG & Chair of Danish Addison Patient Association) ;
Nordenström, Anna (Pediatric Endocrinology) ;
Vitali, Diana (ePAG & Chair SOD ITALIA - Italian Patients Organization for Septo Optic Dysplasia and other Neuroendocrine Conditions) ;
Amodru, Vincent (Aix-Marseille Université) ;
Wiehe, Lenja Katharina (EURORDIS - Rare Diseases Europe) ;
Bolz-Johnson, Matt (EURORDIS - Rare Diseases Europe) ;
Universitat Autònoma de Barcelona
Patient journeys are instruments developed by EURORDIS, The Voice of Rare Disease Patients in Europe, to collect patients' experiences; they may identify gaps and areas deserving improvement, as well as elements positively considered by affected persons. [...]
2022 - 10.1530/EC-22-0385
Endocrine Connections, Vol. 11 (october 2022)
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17 p, 24.9 MB |
Implications of Heterogeneity of Epithelial-Mesenchymal States in Acromegaly Therapeutic Pharmacologic Response
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Gil, Joan (Institut d'Investigació Biomèdica Sant Pau) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valassi, Elena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
García-Martínez, Araceli (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Serra, Guillermo (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Hostalot, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fajardo-Montañana, Carmen (Hospital Universitari de la Ribera (València)) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernabeu Morón, Ignacio (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Rodríguez-Lloveras, Helena (Institut Germans Trias i Pujol) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Salinas, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lamas, Cristina (Complejo Hospitalario Universitario de Albacete) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Simó-Servat, Andreu (Mútua de Terrassa) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Picó Alfonso, Antonio M (Universidad de Miguel Hernández de Elche) ;
Jordà, Mireia (Institut Germans Trias i Pujol) ;
Puig Domingo, Manuel (Universitat Autònoma de Barcelona. Departament de Medicina)
Acromegaly is caused by excess growth hormone (GH) produced by a pituitary tumor. First-generation somatostatin receptor ligands (SRLs) are the first-line treatment. Several studies have linked E-cadherin loss and epithelial-mesenchymal transition (EMT) with resistance to SRLs. [...]
2022 - 10.3390/biomedicines10020460
Biomedicines, Vol. 10 (february 2022)
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9 p, 714.0 KB |
Pasireotide in the Personalized Treatment of Acromegaly
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Puig Domingo, Manuel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bernabeu Morón, Ignacio (Endocrinology & Nutrition Service, Complejo Universitario de Santiago de Compostela) ;
Picó Alfonso, Antonio M (Hospital General Universitario de Alicante (Alacant, País Valencià)) ;
Biagetti, Betina (Hospital Universitari Vall d'Hebron) ;
Gil, Joan (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Álvarez-Escolá, Cristina (Hospital Universitario La Paz (Madrid)) ;
Jordà, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marques-Pamies, Montserrat (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soldevila i Madorell, Berta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gálvez, María-Angeles (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Cámara, Rosa (Hospital Universitari i Politècnic La Fe (València)) ;
Aller, Javier (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Lamas, Cristina (Complejo Hospitalario Universitario de Albacete) ;
Marazuela, Mónica (Hospital Universitario de la Princesa (Madrid)) ;
Universitat Autònoma de Barcelona
The delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some months to be fully evaluated. [...]
2021 - 10.3389/fendo.2021.648411
Frontiers in Endocrinology, Vol. 12 (march 2021)
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14 p, 1.4 MB |
Metabolic Fingerprint of Acromegaly and Its Potential Usefulness in Clinical Practice
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Biagetti, Betina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Herance, José Raul (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer-Costa, Roser (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aulinas, Anna (Hospital Universitari de Vic) ;
Palomino-Schätzlein, Martina (Centro de Investigación Príncipe Felipe (València)) ;
Mesa Manteca, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Castaño, Justo P.. (Department of Cell Biology, Physiology, and Immunology, CIBERobn, 14004 Cordoba, Spain) ;
Luque, Raul M. (CIBERobn (Córdoba)) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) levels are the main targets for monitoring acromegaly activity, but they are not in close relationship with the clinical course of the disease and the associated comorbidities. [...]
2019 - 10.3390/jcm8101549
Journal of clinical medicine, Vol. 8 (september 2019)
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8 p, 984.9 KB |
Hypertension in Acromegaly in Relationship to Biochemical Control and Mortality : Global ACROSTUDY Outcomes
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Vila, Greisa (Medical University of Vienna) ;
Luger, Anton (Medical University of Vienna) ;
van der Lely, Aart Jan (Erasmus University Medical Centre) ;
Neggers, Sebastian J. C. M. M. (Erasmus University Medical Centre) ;
Webb, S. M 1952- (Institut d'Investigació Biomèdica Sant Pau) ;
Biller, Beverly M. K. (Massachusetts General Hospital (Boston)) ;
Valluri, Srinivas (Global Biometrics & Data Management, Pfizer Inc) ;
Hey-Hadavi, Judith (Endocrine Care, Pfizer Inc) ;
Universitat Autònoma de Barcelona
Hypertension is a major cardiovascular risk factor related to increased mortality in acromegaly. Surgical cure of acromegaly is associated with improvement in blood pressure levels, however little is known about the effect of pegvisomant (PEGV) treatment in patients with hypertension. [...]
2020 - 10.3389/fendo.2020.577173
Frontiers in Endocrinology, Vol. 11 (november 2020)
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