Resultats globals: 36 registres trobats en 0.02 segons.
Articles, 30 registres trobats
Contribucions a jornades i congressos, 1 registres trobats
Documents de recerca, 5 registres trobats
Articles 30 registres trobats  1 - 10següentfinal  anar al registre:
1.
Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles / Carratalá, José Vicente (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cano Garrido, Olivia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez, Julieta María (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Membrado, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pérez, Eudald (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Conchillo-Solé, Oscar (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Arís i Giralt, Anna (Institut de Recerca i Tecnologia Agroalimentàries) ; García Fruitós, Elena (Institut de Recerca i Tecnologia Agroalimentàries) ; Ferrer Miralles, Neus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Efficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein aggregates is detrimental to biopharmaceutical development. [...]
2020 - 10.1016/j.nbt.2020.02.001
New Biotechnolgy, Vol. 57 (July 2020) , p. 11-19
2 documents
2.
20 p, 6.2 MB Computational assessment of bacterial protein structures indicates a selection against aggregation / Carija, Anita (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pinheiro, Francisca (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
The aggregation of proteins compromises cell fitness, either because it titrates functional proteins into non-productive inclusions or because it results in the formation of toxic assemblies. Accordingly, computational proteome-wide analyses suggest that prevention of aggregation upon misfolding plays a key role in sequence evolution. [...]
2019 - 10.3390/cells8080856
Cells, Vol. 8 (2019) , p. 1-20  
3.
14 p, 2.0 MB PH-dependent aggregation in intrinsically disordered proteins is determined by charge and lipophilicity / Santos Suárez, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Iglesias, Valentin (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mangiagalli, Marco (Department of Biotechnology and Biosciences, University of Milano-Bicocca) ; Santos-Suárez, Juan (Galicia Supercomputing Center (CESGA)) ; Brocca, Stefania (Department of Biotechnology and Biosciences, University of Milano-Bicocca) ; Pallarès,Irantzu (Institut de Biotecnologia i Biomedicina and Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Protein aggregation is associated with an increasing number of human disorders and premature aging. Moreover, it is a central concern in the manufacturing of recombinant proteins for biotechnological and therapeutic applications. [...]
2020 - 10.3390/cells9010145
Cells, Vol. 9 (2020)  
4.
9 p, 1.5 MB Gold nanoparticles and microwave irradiation inhibit beta-amyloid amyloidogenesis / Araya, Eyleen (Universitat de Barcelona) ; Olmedo, Ivonne (Universidad de Chile) ; Gómez Bastús, Neus (Institut Català de Nanociència i Nanotecnologia) ; Guerrero, Simón (Universidad de Santiago de Chile) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ; Giralt, Ernest (Universitat de Barcelona) ; Kogan, Marcelo J. (Centro para la Investigación Interdisciplinaria Avanzada en Ciencias de Materiales)
Peptide-Gold nanoparticles selectively attached to β-amyloid protein (Aβ) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the Aβ aggregates, inhibiting both the amyloidogenesis and the restoration of the amyloidogenic potential. [...]
2008 - 10.1007/s11671-008-9178-5
Nanoscale research letters, Vol. 3 (October 2008) , art. 435  
5.
17 p, 3.4 MB Protein environment : A crucial triggering factor in josephin domain aggregation: The role of 2,2,2-trifluoroethanol / Visentin, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Grasso, Gianvito (Università della Svizzera italiana. Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA)) ; Regonesi, Maria Elena (Università di Milano-Bicocca. Dipartimento di Biotecnologie e Bioscienze) ; Deriu, Marco Agostino (Università della Svizzera italiana. Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA)) ; Tortora, Paolo (Università di Milano-Bicocca. Dipartimento di Biotecnologie e Bioscienze) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. [...]
2018 - 10.3390/ijms19082151
International journal of molecular sciences, Vol. 19, Núm. 8 (August 2018) , art. 2151  
6.
13 p, 1.4 MB An improved secretion signal enhances the secretion of model proteins from Pichia pastoris / Barrero, Juan J. (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Casler, Jason C. (University of Chicago. Department of Molecular Genetics and Cell Biology) ; Valero Barranco, Francisco (Universitat Autònoma de Barcelona. Departament d'Enginyeria Quimica, Biològica i Ambiental) ; Ferrer, Pau (Universitat Autònoma de Barcelona. Departament d'Enginyeria Química, Biològica i Ambiental) ; Glick, Benjamin S. (University of Chicago. Department of Molecular Genetics and Cell Biology)
Background: proteins can be secreted from a host organism with the aid of N-terminal secretion signals. The budding yeast Pichia pastoris (Komagataella sp. ) is widely employed to secrete proteins of academic and industrial interest. [...]
2018 - 10.1186/s12934-018-1009-5
Microbial cell factories, Vol. 17 (2018) , art. 161  
7.
13 p, 2.6 MB The disordered C-terminus of yeast hsf1 contains a cryptic low-complexity amyloidogenic region / Pujols, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Santos Suárez, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Response mechanisms to external stress rely on networks of proteins able to activate specific signaling pathways to ensure the maintenance of cell proteostasis. Many of the proteins mediating this kind of response contain intrinsically disordered regions, which lack a defined structure, but still are able to interact with a wide range of clients that modulate the protein function. [...]
2018 - 10.3390/ijms19051384
International journal of molecular sciences, Vol. 19, Núm. 5 (May 2018) , p. 1384  
8.
10 p, 559.2 KB Genetic etiology for alcohol-induced cardiac toxicity / Ware, James S. (Imperial College London. National Heart and Lung Institute) ; Amor-Salamanca, Almudena (Hospital Universitario Puerta de Hierro. Departamento de Cardiología) ; Tayal, Upasana (Imperial College London. National Heart and Lung Institute) ; Govind, Risha (Imperial College London. National Heart and Lung Institute) ; Serrano, Isabel (Hospital Universitari de Tarragona Joan XXIII. Departament de Cardiología) ; Salazar-Mendiguchía, Joel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; García-Pinilla, Jose Manuel (Hospital Universitario Virgen de la Victoria. Departamento de Cardiología) ; Pascual-Figal, Domingo A. (Hospital Universitario Virgen de la Arrixaca. Departamento de Cardiología) ; Nuñez, Julio (INCLIVA (Valencia, Spain). Departamento de Cardiología) ; Guzzo-Merello, Gonzalo (Hospital Universitario Puerta de Hierro. Departamento de Cardiología) ; Gonzalez-Vioque, Emiliano (Hospital Universitario Puerta de Hierro. Departamento de Bioquímica) ; Bardají, Alfredo (Hospital Universitari de Tarragona Joan XXIII. Departament de Cardiología) ; Manito, Nicolas (Hospital Universitari de Bellvitge. Departament de Cardiología) ; López-Garrido, Miguel A. (Hospital Universitario Virgen de la Victoria. Departamento de Cardiología) ; Padron-Barthe, Laura (Hospital Universitario Puerta de Hierro. Departamento de Cardiología) ; Edwards, Elizabeth (Imperial College London. National Heart and Lung Institute) ; Whiffin, Nicola (Imperial College London. National Heart and Lung Institute) ; Walsh, Roddy (Imperial College London. National Heart and Lung Institute) ; Buchan, Rachel J. (Imperial College London. National Heart and Lung Institute) ; Midwinter, William (Imperial College London. National Heart and Lung Institute) ; Wilk, Alicja (Imperial College London. National Heart and Lung Institute) ; Prasad, Sanjay (Imperial College London. National Heart and Lung Institute) ; Pantazis, Antonis (Royal Brompton and Harefield. Cardiovascular Research Centre) ; Baski, John (Royal Brompton and Harefield. Cardiovascular Research Centre) ; O'Regan, Declan P. (Imperial College London. MRC London Institute of Medical Sciences) ; Alonso-Pulpón, Luis (Hospital Universitario Puerta de Hierro. Departamento de Cardiología) ; Cook, Stuart A. (Imperial College London. National Heart and Lung Institute) ; Lara-Pezzi, Enrique (Centro Nacional de Investigaciones Cardiovasculares (Madrid, Spain)) ; Barton, Paul J. (Imperial College London. National Heart and Lung Institute) ; Garcia-Pavia, Pablo (Universidad Francisco de Vitoria)
Alcoholic cardiomyopathy (ACM) is defined by a dilated and impaired left ventricle due to chronic excess alcohol consumption. It is largely unknown which factors determine cardiac toxicity on exposure to alcohol. [...]
2018 - 10.1016/j.jacc.2018.03.462
Journal of the American College of Cardiology, Vol. 71, issue 20 (May 2018) , p. 2293-2302  
9.
10 p, 1.2 MB A single cysteine post-translational oxidation suffices to compromise globular proteins kinetic stability and promote amyloid formation / Marinelli, Patrizia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Graña Montes, Ricardo (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bañó-Polo, Manuel (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fernández Gallegos, Ma. Rosario (María Rosario) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Papaleo, Elena (Kræftens Bekæmpelse) ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Oxidatively modified forms of proteins accumulate during aging. Oxidized protein conformers might act as intermediates in the formation of amyloids in age-related disorders. However, it is not known whether this amyloidogenic conversion requires an extensive protein oxidative damage or it can be promoted just by a discrete, localized post-translational modification of certain residues. [...]
2017 - 10.1016/j.redox.2017.10.022
Redox biology, Vol. 14 (April 2018) , p. 566-575  
10.
13 p, 1.1 MB Protein aggregation into insoluble deposits protects from oxidative stress / Carija, Anita (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biomedicina Molecular) ; Sánchez de Groot, Natalia (Centre de Regulació Genòmica) ; Ventura, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Protein misfolding and aggregation have been associated with the onset of neurodegenerative disorders. Recent studies demonstrate that the aggregation process can result in a high diversity of protein conformational states, however the identity of the specific species responsible for the cellular damage is still unclear. [...]
2017 - 10.1016/j.redox.2017.03.027
Redox biology, Vol. 12 (Aug. 2017) , p. 699-711  

Articles : 30 registres trobats   1 - 10següentfinal  anar al registre:
Contribucions a jornades i congressos 1 registres trobats  
1.
51 p, 394.4 KB On the measurement of multidimensional poverty in multiple domain contexts / Permanyer, Iñaki
We develop the measurement of multidimensional poverty for the case in which the different dimensions taken into account are partitioned in several domains-an issue with crucial implications for the identification and aggregation of the poor which has been neglected in the literature. [...]
2016
Meeting of the Society for Social Choice and Welfare. Lund (Suècia), 13è : 2016  

Documents de recerca 5 registres trobats  
1.
1 p, 10.8 MB Deciphering hIAPP : a novel way to cure diabetes / Ruiz López, Iñigo ; Pallarés Goitiz, Irantzu, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Human islet amyloid polypeptide (hIAPP) is produced by pancreatic β-cells and is involved in type-II diabetes mellitus (T2DM) pathogenesis. In T2DM, the loss of pancreatic β-cell mass is accompanied by the accumulation of amyloid deposits of hIAPP. [...]
2019-05-29
Graduat o Graduada en Biotecnologia [815]  
2.
1 p, 410.9 KB DJ-1, a possible therapeutic target against Parkinson's disease / Oliva Vilarnau, Núria ; Yuste Mateos, Víctor J., (Víctor José), dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Biotecnologia [815]  
3.
171 p, 3.7 MB Analysis of different evolutionary strategies to prevent protein aggregation / Graña Montes, Ricardo ; Ventura, Salvador, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
En els darrers 15 anys, l'estudi de l'agregació de proteïnes ha evolucionat de ser una part de la química de proteïnes que tradicionalment generava poc interès, a convertir-se en una àrea d'investigació dinàmica que ha ampliat el seu abast a diferents camps de recerca incloenthi la bioquímica, la biotecnologia, la nanotecnologia y la biomedicina. [...]
In the last 15 years, the study of protein aggregation has evolved from a mostly neglected topic of protein chemistry to a highly dynamic research area which has expanded its implications through different fields including biochemistry, biotechnology, nanotechnology and biomedicine. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  
4.
199 p, 6.0 MB Characterization of intracellular protein aggregates / Villar i Piqué, Anna ; Ventura, Salvador, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular
Durant les últimes dècades, l'agregació de proteïnes ha esdevingut un tema d'investigació molt dinàmic que s'estén transversalment per diferents camps de recerca, incloent la bioquímica, la biotecnologia, la biomedicina i la nanotecnologia. [...]
During the last decades, protein aggregation has become a dynamic research topic extending across distinct investigation fields, including biochemistry, biotechnology, biomedicine and nanotechnology. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2013  
5.
39 p, 341.1 KB Heterogeneous dynamics, aggregation and the persistence of economic shocks / Mayoral, Laura ; Universitat Autònoma de Barcelona. Unitat de Fonaments de l'Anàlisi Econòmica ; Universitat Autònoma de Barcelona. Institut d'Anàlisi Econòmica
It has been recently emphasized that, if individuals have heterogeneous dynamics, estimates of shock persistence based on aggregate data are significatively higher than those derived from its disaggregate counterpart. [...]
2009 (Working papers ; 786.09)  

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