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12 p, 772.4 KB |
Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3
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Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Santana-Santana, Mikel (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Ratia, Míriam (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Camps García, Pelayo (Universitat de Barcelona. Laboratori de Química Farmacèutica) ;
Muñoz-Torrero López-Ibarra, Diego (Universitat de Barcelona. Laboratori de Química Farmacèutica) ;
Badia Sancho, Albert (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Clos, Victòria (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
A new hypothesis highlights sleep-dependent learning/memory consolidation and regards the sleep-wake cycle as a modulator of β-amyloid and tau Alzheimer's disease (AD) pathologies. Sundowning behavior is a common neuropsychiatric symptom (NPS) associated with dementia. [...]
2021 -  10.3390/brainsci11040426
Brain sciences, Vol. 11 Núm. 4 (2021) , p. 426
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13 p, 1.2 MB |
Peripheral inflammation preceeding ischemia impairs neuronal survival through mechanisms involving miR-127 in aged animals
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Loppi, Sanna (University of Arizona) ;
Korhonen, Paula (University of Eastern Finland) ;
Bouvy-Liivrand, Maria (University of Eastern Finland) ;
Caligola, Simone (University of Verona) ;
Turunen, Tiia A. (University of Eastern Finland) ;
Turunen, Mikko P. (University of Eastern Finland) ;
Hernandez de Sande, Ana (University of Eastern Finland) ;
Kołosowska, Natalia (University of Eastern Finland) ;
Scoyni, Flavia (University of Eastern Finland) ;
Rosell Novel, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García-Berrocoso, Teresa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lemarchant, Sighild (University of Eastern Finland) ;
Dhungana, Hiramani (University of Helsinki) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Koistinaho, Jari (University of Helsinki) ;
Kanninen, Katja M. (University of Eastern Finland) ;
Kaikkonen, Minna U. (University of Eastern Finland) ;
Giugno, Rosalba (University of Verona) ;
Heinäniemi, Merja (University of Eastern Finland) ;
Malm, Tarja (University of Eastern Finland) ;
Universitat Autònoma de Barcelona
Ischemic stroke, the third leading cause of death in the Western world, affects mainly the elderly and is strongly associated with comorbid conditions such as atherosclerosis or diabetes, which are pathologically characterized by increased inflammation and are known to influence the outcome of stroke. [...]
2020 - 10.1111/acel.13287
Aging Cell, Vol. 20 (december 2020)
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13 p, 534.4 KB |
Depressive symptoms, fatigue and social relationships influenced physical activity in frail older community-dwellers during the Spanish lockdown due to the COVID-19 pandemic
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Pérez, Laura Mónica (Parc Sanitari Pere Virgili (Barcelona)) ;
Castellano Tejedor, Carmina (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació) ;
Cesari, Matteo (Università di Milano) ;
Soto-Bagaria, Luis (Parc Sanitari Pere Virgili (Barcelona)) ;
Ars, Joan (Parc Sanitari Pere Virgili (Barcelona)) ;
Zambom-Ferraresi, Fabricio (Universidad Pública de Navarra) ;
Baró, Sonia (Parc Sanitari Pere Virgili (Barcelona)) ;
Díaz-Gallego, Francisco (Institut Català de la Salut. Centre d'Atenció Primària Bordeta-Magòria) ;
Vilaró, Jordi (Universitat Ramon Llull. Departament de Ciències de la Salut) ;
Enfedaque, María B. (Institut Català de la Salut. Gerència de Barcelona) ;
Espí-Valbé, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Inzitari, Marco (Universitat Autònoma de Barcelona. Departament de Medicina)
Due to the dramatic impact of the COVID-19 pandemic, Spain underwent a strict lockdown (March-May 2020). How the lockdown modified older adults' physical activity (PA) has been poorly described. This research assesses the effect of the lockdown on PA levels and identifies predictors of sufficient/insufficient PA in frail older community-dwellers. [...]
2021 - 10.3390/ijerph18020808
International journal of environmental research and public health, Vol. 18, núm. 2 (2021) , p. 808
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21 p, 2.7 MB |
Epigenome-wide gene-age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients
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Chen, C. (China International Cooperation Center for Environment and Human Health. Nanjing Medical University) ;
Wei, Y. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Wei, Liangmin (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Chen, X. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Dong, X. (Department of Epidemiology and Biostatistics. School of Public Health. Southeast University) ;
He, J. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Lin, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Zhu, Y. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Huang, H. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
You, D. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Lai, L. (Department of Biostatistics. Center for Global Health. School of Public Health. Nanjing Medical University) ;
Shen, S. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Duan, W. (Department of Bioinformatics. School of Biomedical Engineering and Informatics. Nanjing Medical University) ;
Su, L. (Department of Environmental Health. Harvard T.H. Chan School of Public Health) ;
Shafer, A. (Pulmonary and Critical Care Division. Department of Medicine. Massachusetts General Hospital and Harvard Medical School) ;
Fleischer, T. (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Bjaanæs, M.M. (Department of Cancer Genetics. Institute for Cancer Research. Oslo University Hospital) ;
Karlsson, A. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Planck, M. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Wang, R. (Department of Medical Oncology. Jinling Hospital. School of Medicine. Nanjing University) ;
Staaf, J. (Division of Oncology and Pathology. Department of Clinical Sciences Lund and CREATE Health Strategic Center for Translational Cancer Research. Lund University) ;
Helland, Å. (Institute of Clinical Medicine. University of Oslo) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zhang, R. (Department of Medical Oncology. Jinling Hospital. School of Medicine. Nanjing University) ;
Chen, F. (Jiangsu Key Lab of Cancer Biomarkers. Prevention and Treatment. Cancer Center. Collaborative Innovation Center for Cancer Personalized Medicine. Nanjing Medical University) ;
Christiani, D.C. (Pulmonary and Critical Care Division. Department of Medicine. Massachusetts General Hospital and Harvard Medical School) ;
Universitat Autònoma de Barcelona
DNA methylation changes during aging, but it remains unclear whether the effect of DNA methylation on lung cancer survival varies with age. Such an effect could decrease prediction accuracy and treatment efficacy. [...]
2020 - 10.18632/aging.103284
Aging (Albany NY), Vol. 12 Núm. 11 (15 2020) , p. 10642-10662
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14 p, 2.3 MB |
Delayed γH2AX foci disappearance in mammary epithelial cells from aged women reveals an age-associated DNA repair defect
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Anglada, Teresa (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Repullés, Joan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Espinal, Anna (Universitat Autònoma de Barcelona. Servei d'Estadística Aplicada) ;
LaBarge, Mark A (Lawrence Berkeley National Laboratory) ;
Stampfer, Martha R (Lawrence Berkeley National Laboratory) ;
Genescà, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martín, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Institut d'Investigació Biomèdica Sant Pau
Aging is a degenerative process in which genome instability plays a crucial role. To gain insight into the link between organismal aging and DNA repair capacity, we analyzed DNA double-strand break (DSB) resolution efficiency in human mammary epithelial cells from 12 healthy donors of young and old ages. [...]
2019 - 10.18632/aging.101848
Aging (Albany NY), Vol. 11, Num. 5 (March 2019) , p. 1510-1523
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9 p, 1.0 MB |
Effect of Cd(II) on the ripening of ferrihydrite in alkaline media
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Alvarez, Mariana (Universidad Nacional del Sur. Departamento de Química) ;
Horst, María Fernanda (Universidad Nacional del Sur. Departamento de Química) ;
Sileo, Elsa E. (Universidad de Buenos Aires. Departamento de Química Inorgánica) ;
Rueda, Elsa H. (Universidad Nacional del Sur. Departamento de Química)
To acquire a better understanding of the influence exerted by the presence of Cd during the process of transforming ferrihydrite to goethite, the morphological and structural changes of several samples obtained by the addition of Cd to a suspension of nascent goethite were explored, and their chemical reactivity in acid media assessed. [...]
2012 - 10.1346/CCMN.2012.0600201
Clays and Clay Minerals, Vol. 60, Núm. 2 (2012) , p. 99-107
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27 p, 3.0 MB |
A multiscale model of epigenetic heterogeneity-driven cell fate decision-making
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Folguera Blasco, Núria (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Pérez Carrasco, Rubén (University College London. Department of Mathematics) ;
Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
Menendez, Javier A. (Institut d'Investigació Biomèdica de Girona) ;
Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ;
Universitat Autònoma de Barcelona.
Centre de Recerca Matemàtica
The inherent capacity of somatic cells to switch their phenotypic status in response to damage stimuli in vivo might have a pivotal role in ageing and cancer. However, how the entryexit mechanisms of phenotype reprogramming are established remains poorly understood. [...]
2019 - 10.1371/journal.pcbi.1006592
PLoS computational biology, Vol. 15, Issue 4 (April 2019) , art. e1006592
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