Allosteric modulation - Search Results - UAB Digital Repository of Documents

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Articles, 3 records found

Articles	3 records found

16 p, 4.5 MB

Mapping the Interface of a GPCR Dimer : A Structural Model of the A Adenosine and D Dopamine Receptor Heteromer / Borroto-Escuela, Dasiel O. (Karolinska Institutet (Estocolm, Suècia) ; Rodriguez, David (Science for Life Laboratory, Stockholm University) ; Romero-Fernandez, Wilber (Uppsala University) ; Kapla, Jon (Uppsala University) ; Jaiteh, Mariama (Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University) ; Ranganathan, Anirudh (Stockholm University) ; Lazarova, Tzvetana (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Fuxe, Kjell (Karolinska Institutet (Estocolm, Suècia)) ; Carlsson, Jens (Uppsala University)
The A adenosine (AR) and D dopamine (DR) receptors form oligomers in the cell membrane and allosteric interactions across the AR-DR heteromer represent a target for development of drugs against central nervous system disorders. [...]
2018 - DOI (Digital Object Identifier)

10.3389/fphar.2018.00829
Frontiers in Pharmacology, Vol. 9 (august 2018)

Detailed record -

20 p, 2.1 MB

Optical control of pain in vivo with a photoactive mGlu receptor negative allosteric modulator / Font Inglès, Joan (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López-Cano, Marc (Institut d'Investigació Biomèdica de Bellvitge) ; Notartomaso, Serena (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Scarselli, Pamela (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Di Pietro, Paola (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Bresolí-Obach, Roger (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Battaglia, Giuseppe (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Malhaire, Fanny (Université de Montpellier) ; Rovira, Xavier (Université de Montpellier) ; Catena, Juanlo (Institut de Química Avançada de Catalunya) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pin, Jean-Philippe (Université de Montpellier) ; Fernández-Dueñas, Víctor (Institut d'Investigació Biomèdica de Bellvitge) ; Goudet, Cyril (Université de Montpellier) ; Nonell, Santi (Universitat Ramon Llull. Institut Químic de Sarrià-IQS) ; Nicoletti, Ferdinando (I.R.C.C.S. Neuromed, Pozzilli, Italy) ; Llebaria, Amadeu (Institut de Química Avançada de Catalunya) ; Ciruela, Francisco (Institut d'Investigació Biomèdica de Bellvitge)
Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i. e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate type 5 (mGlu) receptor negative allosteric modulator raseglurant. [...]
2017 - DOI (Digital Object Identifier)

10.7554/eLife.23545
eLife, Vol. 6 (april 2017)

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24 p, 1.3 MB

Shining Light On An mGlu5 Photoswitchable NAM : A Theoretical Perspective / Dalton, James A. R.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lans, Isaias (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rovira Algans, Xavier (Institut de Génomique Fonctionnelle) ; Malhaire, Fanny (Institut de Génomique Fonctionnelle) ; Gómez-Santacana, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pittolo, Silvia (Institut de Bioenginyeria de Catalunya) ; Gorostiza, Pau (Institut de Bioenginyeria de Catalunya) ; Llebaria, Amadeu (Institut de Química Avançada de Catalunya) ; Goudet, Cyril (Institut de Génomique Fonctionnelle) ; Pin, Jean-Philippe (Institut de Génomique Fonctionnelle) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Metabotropic glutamate receptors (mGluRs) are important drug targets because of their involvement in several neurological diseases. Among mGluRs, mGlu5 is a particularly high-profile target because its positive or negative allosteric modulation can potentially treat schizophrenia or anxiety and chronic pain, respectively. [...]
2016 - DOI (Digital Object Identifier)

10.2174/1570159X13666150407231417
Current neuropharmacology, Vol. 14, Num. 5 (July 2016) , p. 441-454

2 documents

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