Resultats globals: 11 registres trobats en 0.03 segons.
Articles, 11 registres trobats
Articles 11 registres trobats  1 - 10següent  anar al registre:
1.
17 p, 5.7 MB An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells / Colli, M.L. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ; Ramos-Rodríguez, M. (Endocrine Regulatory Genomics Laboratory. Germans Trias i Pujol University Hospital and Research Institute) ; Nakayasu, E.S. (Biological Sciences Division. Pacific Northwest National Laboratory) ; Alvelos, M.I. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ; Lopes, M. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ; Hill, J.L.E. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ; Turatsinze, J.V. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ; Coomans de Brachène, A. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ; Russell, M.A. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ; Raurell-Vila, H. (Endocrine Regulatory Genomics Laboratory. Germans Trias i Pujol University Hospital and Research Institute) ; Castela, A. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ; Juan-Mateu, J. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ; Webb-Robertson, B.J.M. (Biological Sciences Division. Pacific Northwest National Laboratory) ; Krogvold, L. (Division of Pediatric and Adolescent Medicine. Faculty of Medicine. Oslo University Hospital) ; Dahl-Jorgensen, K. (Division of Pediatric and Adolescent Medicine. Faculty of Medicine. Oslo University Hospital) ; Marselli, L. (Department of Clinical and Experimental Medicine. Islet Cell Laboratory. University of Pisa) ; Marchetti, P. (Department of Clinical and Experimental Medicine. Islet Cell Laboratory. University of Pisa) ; Richardson, S.J. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ; Morgan, N.G. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ; Metz, T.O. (Biological Sciences Division. Pacific Northwest National Laboratory) ; Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Eizirik, D.L. (Indiana Biosciences Research Institute) ; Universitat Autònoma de Barcelona
Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. [...]
2020 - 10.1038/s41467-020-16327-0
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2584  
2.
28 p, 6.3 MB PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells / Georgilis, Athena (Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK) ; Klotz, Sabrina (Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen) ; Hanley, Christopher J. (Cancer Sciences Unit, Cancer Research UK Centre, University of Southampton) ; Herranz, Nicolas (Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London) ; Weirich, Benedikt (Division of Chronic Inflammation and Cancer, German Cancer Research Centre (DKFZ)) ; Morancho, Beatriz (Vall d'Hebron Institut d'Oncologia) ; Leote, Ana Carolina (Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal) ; D'Artista, Luana (Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Tübingen 72076, Germany) ; Gallage, Suchira (Division of Chronic Inflammation and Cancer, German Cancer Research Centre (DKFZ), Heidelberg 69121, Germany) ; Seehawer, Marco (Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, Tübingen 72076, Germany) ; Carroll, Thomas (Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK) ; Dharmalingam, Gopuraja (Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK) ; Wee, Keng Boon (Bioinformatics Institute, A ∗ STAR, 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Singapore) ; Mellone, Marco (Cancer Sciences Unit, Cancer Research UK Centre, University of Southampton, Somers Building, Southampton SO16 6YD, UK) ; Pombo, Joaquim (Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK) ; Heide, Danijela (Division of Chronic Inflammation and Cancer, German Cancer Research Centre (DKFZ), Heidelberg 69121, Germany) ; Guccione, Ernesto (Methyltransferases in Development and Disease Group, Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A ∗ STAR), Singapore, Singapore) ; Arribas, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Barbosa-Morais, Nuno L. (Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa) ; Heikenwalder, Mathias (Division of Chronic Inflammation and Cancer, German Cancer Research Centre (DKFZ)) ; Thomas, Gareth J. (Cancer Sciences Unit, Cancer Research UK Centre, University of Southampton) ; Zender, Lars (Translational Gastrointestinal Oncology Group, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ)) ; Gil, Jesús (Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London)
Oncogene-induced senescence is a potent tumor-suppressive response. Paradoxically, senescence also induces an inflammatory secretome that promotes carcinogenesis and age-related pathologies. Consequently, the senescence-associated secretory phenotype (SASP) is a potential therapeutic target. [...]
2018 - 10.1016/j.ccell.2018.06.007
Cancer Cell, Vol. 34 (july 2018) , p. 85-102.e9  
3.
18 p, 3.6 MB hnRNPDL phase separation is regulated by alternative splicing and disease-causing mutations accelerate its aggregation / Batlle Carreras, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yang, Peiguo (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Coughlin, Maura (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Messing, James (Howard Hughes Medical Institute) ; Pesarrodona Roches, Mireia (Institut de Recerca Biomèdica) ; Szulc, Elzbieta (Institut de Recerca Biomèdica) ; Salvatella, Xavier (Institut de Recerca Biomèdica) ; Kim, Hong Joo (St. Jude Children's Research Hospital. Department of Cell and Molecular Biology) ; Taylor, J. Paul (Howard Hughes Medical Institute) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Prion-like proteins form multivalent assemblies and phase separate into membraneless organelles. Heterogeneous ribonucleoprotein D-like (hnRNPDL) is a RNA-processing prion-like protein with three alternative splicing (AS) isoforms, which lack none, one, or both of its two disordered domains. [...]
2020 - 10.1016/j.celrep.2019.12.080
Cell reports, Vol. 30, issue 4 (Jan. 2020) , p. 1117-1128  
4.
12 p, 1.0 MB Site-Specific mRNA Cleavage for Selective and Quantitative Profiling of Alternative Splicing with Label-Free Optical Biosensors / Huertas, César S (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ; Escuela, Alfonso M. (Universidad de Las Palmas de Gran Canaria) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors is a key process in gene regulation, contributing to the diversity of proteomes by the alternative selection of exonic sequences. Alterations in this mechanism are associated with most cancers, enhancing their proliferation and survival, and can be employed as cancer biomarkers. [...]
2019 - 10.1021/acs.analchem.9b03898
Analytical chemistry, Vol. 91, Issue 23 (December 2019) , p. 15138-15146  
5.
32 p, 1.1 MB Quantitative evaluation of alternatively spliced mRNA isoforms by label-free real-time plasmonic sensing / Huertas, César S (Institut Català de Nanociència i Nanotecnologia) ; Carrascosa, Laura G. (Institut Català de Nanociència i Nanotecnologia) ; Bonnal, Sophie (Universitat Pompeu Fabra) ; Valcárcel, Juan (Universitat Pompeu Fabra) ; Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
Alternative splicing of mRNA precursors enables cells to generate different protein outputs from the same gene depending on their developmental or homeostatic status. Its deregulation is strongly linked to disease onset and progression. [...]
2016 - 10.1016/j.bios.2015.11.023
Biosensors and bioelectronics, Vol. 78 (April 2016) , p. 118-125  
6.
8 p, 985.7 KB Analysis of alternative splicing events for cancer diagnosis using a multiplexing nanophotonic biosensor / Huertas, César S (Institut Català de Nanociència i Nanotecnologia) ; Domínguez Zotes, Santos (Institut Català de Nanociència i Nanotecnologia) ; Lechuga, Laura (Institut Català de Nanociència i Nanotecnologia)
Personalized medicine is a promising tool not only for prevention, screening and development of more efficient treatment strategies, but also for diminishing the side effects caused by current therapies. [...]
2017 - 10.1038/srep41368
Scientific reports (Nature Publishing Group), Vol. 7 (January 2017) , art. 41368  
7.
21 p, 6.7 MB Identification and characterization of new isoforms of human fas apoptotic inhibitory molecule (FAIM) / Coccia, Elena (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Calleja Yagüe, Isabel (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Planells Ferrer, Laura (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sanuy, Blanca (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Sanz, Belen (Cell Division and Cancer Group. Spanish National Cancer Research Centre (CNIO)) ; López Soriano, Joaquin (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Moubarak, Rana S. (Department of Pathology. NYU Langone Medical Center) ; Munell Casadesus, Francina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Barneda Zahonero, Bruna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Comella i Carnicé, Joan Xavier 1963- (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Pérez García, María José (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
Fas Apoptosis Inhibitory Molecule (FAIM) is an evolutionarily highly conserved death receptor antagonist, widely expressed and known to participate in physiological and pathological processes. Two FAIM transcript variants have been characterized to date, namely FAIM short (FAIM-S) and FAIM long (FAIM-L). [...]
2017 - 10.1371/journal.pone.0185327
PloS one, Vol. 12 Núm. 10 (october 2017) , p. e0185327  
8.
12 p, 786.7 KB Differential expression of mRNA isoforms in the skeletal muscle of pigs with distinct growth and fatness profiles / Cardoso, Tainã Figueiredo (Centre de Recerca en Agrigenòmica) ; Quintanilla, Raquel (Institut de Recerca i Tecnologia Agroalimentàries) ; Castelló Farré, Anna (Centre de Recerca en Agrigenòmica) ; González Prendes, Rayner (Centre de Recerca en Agrigenòmica) ; Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ; Cánovas Tienda, Ángela (University of Guelph. Department of Animal Biosciences)
Background: the identification of genes differentially expressed in the skeletal muscle of pigs displaying distinct growth and fatness profiles might contribute to identify the genetic factors that influence the phenotypic variation of such traits. [...]
2018 - 10.1186/s12864-018-4515-2
BMC genomics, Vol. 19 (2018) , art. 145  
9.
13 p, 2.4 MB Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461 / Li, Guihong (Zhengzhou, 450000 China) ; Shen, Jing (Department of Cardiology, Shengze Hospital of Jiangsu Province, Suzhou, 215200 China) ; Cao, Junguo (Changchun, 130021 China) ; Zhou, Guangtong (Zhengzhou, 450000 China) ; Lei, Ting (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sun, Yuxue (Changchun, 130021 China) ; Gao, Haijun (Changchun, 130021 China) ; Ding, Yaonan (Changchun, 130021 China) ; Xu, Weidong (Changchun, 130021 China) ; Zhan, Zhixin (Changchun, 130021 China) ; Chen, Yong (Changchun, 130021 China) ; Huang, Haiyan (Changchun, 130021 China) ; Universitat Autònoma de Barcelona
Glioma is a heterogeneous, invasive primary brain tumor with a wide range of patient survival and a lack of reliable prognostic biomarkers. Human telomerase reverse transcriptase (hTERT) has been reported in the presence of multiple transcripts in various tumor systems. [...]
2018 - 10.1186/s13046-018-0749-8
Journal of Experimental & Clinical Cancer Research : CR, Vol. 37 (april 2018)  
10.
15 p, 1.8 MB Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression / Massó Chacón, Anna (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Sánchez, Angela (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Cañete Ríos, Manuel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; García, Belen (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Torres-Lista, Virginia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Puig, Meritxell (Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG)) ; Bosch i Merino, Assumpció (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Chillón Rodríguez, Miguel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The Klotho protein is a β-glucuronidase, and its overexpression is associated with life extension. Its mechanism of action is not fully understood, although it has been recently reported that αKlotho improves synaptic and cognitive functions, and it may also influence a variety of structures and functions during CNS maturation and aging. [...]
2015 - 10.1371/journal.pone.0143623
PloS one, Vol. 10, Num. 11 (November 2015) , p. 1-15  

Articles : 11 registres trobats   1 - 10següent  anar al registre:
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