Resultados globales: 62 registros encontrados en 0.02 segundos.
Artículos, Encontrados 34 registros
Documentos de investigación, Encontrados 28 registros
Artículos Encontrados 34 registros  1 - 10siguientefinal  ir al registro:
1.
Modeling Cu2+-Aβ complexes from computational approaches / Alí Torres, Jorge (Universidad Nacional de Colombia. Departamento de Química) ; Mirats Arce, Andrea (Universitat Autònoma de Barcelona. Departament de Química) ; Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ; Rodríguez Santiago, Luis (Universitat Autònoma de Barcelona. Departament de Química) ; Sodupe Roure, Mariona (Universitat Autònoma de Barcelona. Departament de Química)
Amyloid plaques formation and oxidative stress are two key events in the pathology of the Alzheimer disease (AD), in which metal cations have been shown to play an important role. In particular, the interaction of the redox active Cu metal cation with Aβ has been found to interfere in amyloid aggregation and to lead to reactive oxygen species (ROS). [...]
2015 - 10.1063/1.4921072
AIP advances, Vol. 5, Issue 9 (September 2015) , art. 92402  
2.
21 p, 965.2 KB CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline / Suárez‐Calvet, Marc (Ludwig Maximilians Universität München) ; Capell, Anja (Ludwig Maximilians Universität München) ; Araque Caballero, Miguel Ángel (Ludwig Maximilians Universität München) ; Morenas‐Rodríguez, Estrella (Universitat Autònoma de Barcelona) ; Fellerer, Katrin (Ludwig Maximilians Universität München) ; Franzmeier, Nicolai (Ludwig Maximilians Universität München) ; Kleinberger, Gernot (Munich Cluster for Systems Neurology (SyNergy)) ; Eren, Erden (Dokuz Eylul University, Turkey) ; Deming, Yuetiva (Washington University School of Medicine) ; Piccio, Laura (Washington University School of Medicine) ; Karch, Celeste M (Washington University School of Medicine) ; Cruchaga, Carlos (Washington University School of Medicine) ; Paumier, Katrina (Washington University School of Medicine) ; Bateman, Randall J (Washington University School of Medicine) ; Fagan, Anne M (Washington University School of Medicine) ; Morris, John C (Washington University School of Medicine) ; Levin, Johannes (Ludwig Maximilians Universität München) ; Danek, Adrian (Ludwig Maximilians Universität München) ; Jucker, Mathias (University of Tübingen) ; Masters, Colin L (University of Melbourne) ; Rossor, Martin N (UCL Institute of Neurology) ; Ringman, John M (University of Southern California) ; Shaw, Leslie M (University of Pennsylvania) ; Trojanowski, John Q (University of Pennsylvania) ; Weiner, Michael (University of California at San Francisco) ; Ewers, Michael (Ludwig Maximilians Universität München) ; Haass, Christian (Munich Cluster for Systems Neurology (SyNergy))
Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked whether expression is changed in a disease severity‐specific manner in . [...]
2018 - 10.15252/emmm.201809712
EMBO Molecular Medicine, Vol. 10 (november 2018)  
3.
9 p, 1.5 MB Gold nanoparticles and microwave irradiation inhibit beta-amyloid amyloidogenesis / Araya, Eyleen (Universitat de Barcelona) ; Olmedo, Ivonne (Universidad de Chile) ; Gómez Bastús, Neus (Institut Català de Nanociència i Nanotecnologia) ; Guerrero, Simón (Universidad de Santiago de Chile) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ; Giralt, Ernest (Universitat de Barcelona) ; Kogan, Marcelo J. (Centro para la Investigación Interdisciplinaria Avanzada en Ciencias de Materiales)
Peptide-Gold nanoparticles selectively attached to β-amyloid protein (Aβ) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the Aβ aggregates, inhibiting both the amyloidogenesis and the restoration of the amyloidogenic potential. [...]
2008 - 10.1007/s11671-008-9178-5
Nanoscale research letters, Vol. 3 (October 2008) , art. 435  
4.
17 p, 9.8 MB Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice / Fernández de Retana Alda, Sofía (Hospital Universitari Vall d'Hebron) ; Marazuela, Paula (Hospital Universitari Vall d'Hebron) ; Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron) ; Colell, Guillem (Hospital Universitari Vall d'Hebron) ; Bonaterra, Anna (Hospital Universitari Vall d'Hebron) ; Sánchez Quesada, José Luis (Hospital de la Santa Creu i Sant Pau) ; Montaner, Joan (Vall d'Hebron Institut de Recerca) ; Maspoch Comamala, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Cano Sarabia, Antonia María (Institut Català de Nanociència i Nanotecnologia) ; Hernández Guillamón, María del Mar (Vall d'Hebron Institut de Recerca)
Background: ApoJ/clusterin is a multifunctional protein highly expressed in the brain. The implication of ApoJ in β-amyloid (Aβ) fibrillization and clearance in the context of Alzheimer's disease has been widely studied, although the source and concentration of ApoJ that promotes or inhibits Aβ cerebral accumulation is not clear yet. [...]
2019 - 10.1186/s13195-019-0498-8
Alzheimer's research and therapy, Vol. 11 (May 2019) , art. 42  
5.
11 p, 1.2 MB Alzheimer's disease in Down syndrome : An overlooked population for prevention trials / Strydom, André (South London and Maudsley NHS Foundation Trust) ; Coppus, Antonia (Department of Primary and Community Care, Radboud University Medical Center, Nijmegen) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Danek, Adrian (Department of Neurology, Ludwig-Maximilians-Universität München) ; Fortea, Juan (Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down) ; Hardy, John (Reta Lila Weston Institute, Institute of Neurology, University College London) ; Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) site Munich) ; Nuebling, Georg (Department of Neurology, Ludwig-Maximilians-Universität München) ; Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ; Ritchie, Craig (Centre for Clinical Brain Sciences. University of Edinburgh) ; van Duijn, Cornelia (Department of Epidemiology, Erasmus Medical Centre, Rotterdam) ; Zaman, Shahid (Cambridgeshire & Peterborough NHS Foundation Trust (CBFT), Fulbourn Hospital) ; Zetterberg, Henrik (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital) ; Universitat Autònoma de Barcelona
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. [...]
2018 - 10.1016/j.trci.2018.10.006
Alzheimer's & Dementia : Translational Research & Clinical Interventions, Vol. 4 (december 2018) , p. 703-713  
6.
11 p, 334.7 KB Survival curves and behavioral profiles of female 3xTg-AD mice surviving to 18-months of age as compared to mice with normal aging / Torres-Lista, Virginia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; De la Fuente, Mónica (Universidad Complutense de Madrid. Departamento de Fisiología Animal II) ; Giménez Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències)
New evidence reveals a high degree of heterogeneity in Alzheimer's disease (AD) clinical and temporal patterns, supporting the existence of several subgroups of patients. Prognosticators of end-of-life dementia specific to elderly patients are necessary to address this heterogeneity. [...]
2017 - 10.3233/ADR-170011
Journal of Alzheimer's disease reports, Vol. 1, issue 1 (2017) , p. 47-57  
7.
32 p, 913.8 KB Alzheimer's disease biomarkers detection in human samples by efficient capturing through porous magnetic microspheres and labelling with electrocatalytic gold nanoparticles / De la Escosura Muñiz, Alfredo (Institut Català de Nanociència i Nanotecnologia) ; Plichta, Zdeněk (Akademie věd České republiky) ; Horák, Daniel (Akademie věd České republiky) ; Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)
A nanobiosensor based on the use of porous magnetic microspheres (PMM) as efficient capturing/pre-concentrating platform is presented for detection of Alzheimer's disease (AD) biomarkers. These PMMs prepared by a multistep swelling polymerization combined with iron oxide precipitation afford carboxyl functional groups suitable for immobilization of antibodies on the particle surface allowing an enhanced efficiency in the capturing of AD biomarkers from human serum samples. [...]
2015 - 10.1016/j.bios.2014.07.086
Biosensors and bioelectronics, Vol. 67 (May 2015) , p. 162-169  
8.
13 p, 787.1 KB Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease / Dekker, Alain D. (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Vermeiren, Yannick (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Carmona-Iragui, Maria (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; Benejam, Bessy (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; Videla, Laura (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; Gelpi, Ellen (Neurological Tissue Bank—Biobanc, Hospital Clinic Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain) ; Aerts, Tony (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Van Dam, Debby (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Fernández, Susana (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; Lleó Bisa, Alberto (Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain) ; Videla, Sebastian (Faculty of Health and Life Sciences, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain) ; Sieben, Anne (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Martin, Jean-Jacques (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; Fortea, Juan (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ; De Deyn, Peter P. (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium)
People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS. [...]
2017 - 10.1016/j.dadm.2017.11.001
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 10 (november 2017) , p. 99-111  
9.
23 p, 1.3 MB The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale : comprehensive assessment of psychopathology in Down syndrome / Dekker, Alain D. (Universitair Medisch Centrum Groningen) ; Sacco, Silvia (Institut Jérôme Lejeune) ; Carfi, Angelo (Universitá Cattolica del Sacro Cuore) ; Benejam, Bessy (Fundació Catalana Síndrome de Down) ; Vermeiren, Yannick (Universitair Medisch Centrum Groningen) ; Beugelsdijk, Gonny (Ipse de Bruggen) ; Schippers, Mieke (Ipse de Bruggen) ; Hassefras, Lyanne (Ipse de Bruggen) ; Eleveld, José (Cosis (Groningen)) ; Grefelman, Sharina (Cosis (Groningen)) ; Fopma, Roelie (Talant (Heerenveen)) ; Bomer-Veenboer, Monique (Pameijer (Rotterdam)) ; Boti, Mariángeles (Fundació Catalana Síndrome de Down) ; Oosterling, G. Danielle E. (Aveleijn (Borne)) ; Scholten, Esther (Elver (Nieuw-Wehl)) ; Tollenaere, Marleen (Institute Born-Bunge) ; Checkley, Laura (University College London. Division of Psychiatry) ; Strydom, André (University College London. Division of Psychiatry) ; Van Goethem, Gert (Het GielsBos (Gierle)) ; Onder, Graziano (Universitá Cattolica del Sacro Cuore) ; Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ; zu Eulenburg, Christine (Universitair Medisch Centrum Groningen) ; Coppus, Antonia M.W. (Dichterbij (Gennep)) ; Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ; Fortea, Juan (Fundació Catalana Síndrome de Down) ; De Deyn, Peter P. (Universitair Medisch Centrum Groningen) ; Universitat Autònoma de Barcelona
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. [...]
2018 - 10.3233/JAD-170920
Journal of Alzheimer's disease, Vol. 63, issue 2 (2018) , p. 797-819  
10.
10 p, 92.4 KB Social Representation of Dementia : An Analysis of 5,792 Consecutive Cases Evaluated in a Memory Clinic / Cañabate, Pilar (Institut Català de Neurociènces Aplicades) ; Martínez, Gabriel (University of Antofagasta) ; Rosende-Roca, Maitée (Institut Català de Neurociènces Aplicades) ; Moreno, Mariola (Institut Català de Neurociènces Aplicades) ; Preckler, Silvia (Institut Català de Neurociènces Aplicades) ; Valero Ventura, Sergi (Hospital Universitari Vall d'Hebron) ; Sotolongo Grau, Oscar (Institut Català de Neurociènces Aplicades) ; Hernández, Isabel (Institut Català de Neurociènces Aplicades) ; Alegret, Montserrat (Institut Català de Neurociènces Aplicades) ; Ortega Linares, Gemma (Institut Català de Neurociènces Aplicades) ; Espinosa, Ana (Institut Català de Neurociènces Aplicades) ; Mauleón, Ana (Institut Català de Neurociènces Aplicades) ; Vargas, Liliana (Institut Català de Neurociènces Aplicades) ; Rodríguez, Octavio (Institut Català de Neurociènces Aplicades) ; Abdelnour, Carla (Institut Català de Neurociènces Aplicades) ; Sánchez, Domingo (Institut Català de Neurociènces Aplicades) ; Martín, Elvira (Institut Català de Neurociènces Aplicades) ; Ruiz, Agustín (Institut Català de Neurociènces Aplicades) ; Tárraga, Lluís (Institut Català de Neurociènces Aplicades) ; Boada Rovira, Mercè (Institut Català de Neurociènces Aplicades) ; Universitat Autònoma de Barcelona
Background: Different interpretations of cognitive impairment and dementia due to differences in health structures, such as cultural differences could affect the diagnosis and treatment of the condition. [...]
2017 - 10.3233/JAD-161119
Journal of Alzheimer's Disease, Vol. 58, Núm. 4 (June 2017) , p. 1099-1108  

Artículos : Encontrados 34 registros   1 - 10siguientefinal  ir al registro:
Documentos de investigación Encontrados 28 registros  1 - 10siguientefinal  ir al registro:
1.
1 p, 943.6 KB Astrocytes and Alzheimer's disease : the amyloid-β clearance / Compte Sancerni, Sara ; Masgrau Juanola, Roser, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Graduat o Graduada en Bioquímica [814]  
2.
1 p, 356.7 KB Alterations of astrocytic glutamate regulation in Alzheimer disease / Burgaya Julià, Mar ; Masgrau Juanola, Roser, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Graduat o Graduada en Bioquímica [814]  
3.
1 p, 516.2 KB Protective and pathological role of microglia in Alzheimer's disease / Ramos-Roda, Alejandro ; Villegas Hernández, Sandra, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Graduat o Graduada en Biologia [812]  
4.
1 p, 1.2 MB IL-6 and neuroinflammation : a cause and a consequence of Alzheimer's disease / Mogas Barcons, Aina ; Molinero Egea, María Amalia, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Biologia [812]  
5.
1 p, 1.0 MB Interleukin-1β in neuroinflammation associated to Alzheimer disease / López Zambrana, Patricia ; Molinero Egea, María Amalia, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Biologia [812]  
6.
1 p, 593.0 KB Adult neurogenesis and alzheimer's disease : what can we learn? / Adame Castillo, Cristina ; Martí Clua, Joaquín, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Biologia [812]  
7.
1 p, 642.9 KB Gene therapy strategies for Alzheimer disease / Heras Vila, Francesc d'Assís de las ; Villaverde Corrales, Antonio, dir. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Bioquímica [814]  
8.
1 p, 627.5 KB Alzheimer's biomarkers and its use in drug development / Valeros Cejas, David ; Barquinero, J. F., (Joan Francesc), dir. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
• Alzheimer's disease (AD) is a common, irreversible subtype of dementia in industrialized countries and characterized by the progressive appearance of abnormalities in biomarkers before its symptoms. [...]
2015
Graduat o Graduada en Bioquímica [814]  
9.
1 p, 776.4 KB The Alzheimer's disease : the unsolved puzzle / Jolis Orriols, Núria ; Molinero Egea, María Amalia, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Biologia [812]  
10.
1 p, 1.1 MB Biomarkers of Alzheimer's disease : in search of a non-invasive diagnosis / Barlabé Ginesta, Paula ; Barquinero, J. F., (Joan Francesc), dir. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Ciències Biomèdiques [832]  

Documentos de investigación : Encontrados 28 registros   1 - 10siguientefinal  ir al registro:
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