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1.
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12 p, 1.5 MB |
Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy : international individual patient data pooled analysis
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Hostettler, Isabel Charlotte (University College London) ;
Wilson, Duncan (University College London) ;
Fiebelkorn, Catherine Arnold (Mayo Clinic) ;
Aum, Diane (Washington University School of Medicine) ;
Ameriso, Sebastián Francisco (Institute for Neurological Research) ;
Eberbach, Federico (Institute for Neurological Research) ;
Beitzke, Markus (Medical University of Graz) ;
Kleinig, Timothy (Royal Adelaide Hospital) ;
Phan, Thanh (Monash University) ;
Marchina, Sarah (Beth Israel Deaconess Medical Center) ;
Schneckenburger, Romain (CHU Caen Normandie) ;
Carmona Iragui, María (Institut d'Investigació Biomèdica Sant Pau) ;
Charidimou, Andreas (Massachusetts General Hospital) ;
Mourand, Isabelle (Hôpital Gui-de-Chauliac) ;
Parreira, Sara (University of Lisbon) ;
Ambler, Gareth (UCL. Department of Statistical Science) ;
Jäger, Hans Rolf (University College London) ;
Singhal, Shaloo (Monash University) ;
Ly, John (Monash University) ;
Ma, Henry (Monash University) ;
Touzé, Emmanuel (Normandy University) ;
Geraldes, Ruth (Frimley Health Foundation Trust) ;
Fonseca, Ana Catarina (University of Lisbon) ;
Melo, Teresa (Hospital de Santa Maria, University of Lisbon) ;
Labauge, Pierre (Hôpital Gui-de-Chauliac) ;
Lefèvre, Pierre-Henry (Hôpital Gui-de-Chauliac) ;
Viswanathan, Anand (Harvard Medical School) ;
Greenberg, Steven Mark (Massachusetts General Hospital) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Apoil, Marion (CHU Caen Normandie) ;
Boulanger, Marion (Normandy University) ;
Viader, Fausto (CHU Caen Normandie) ;
Kumar, Sandeep (Beth Israel Deaconess Medical Center) ;
Srikanth, Velandai (Monash University) ;
Khurram, Ashan (Royal Adelaide Hospital) ;
Fazekas, Franz (Medical University of Graz) ;
Bruno, Veronica (Institute for Neurological Research) ;
Zipfel, Gregory Joseph (Washington University School of Medicine) ;
Refai, Daniel (Emory University) ;
Rabinstein, Alejandro (Mayo Clinic) ;
Graff-Radford, Jonathan (Mayo Clinic) ;
Werring, David John (University College London) ;
Universitat Autònoma de Barcelona
To investigate the frequency, time-course and predictors of intracerebral haemorrhage (ICH), recurrent convexity subarachnoid haemorrhage (cSAH), and ischemic stroke after cSAH associated with cerebral amyloid angiopathy (CAA). [...]
2021 -  10.1007/s00415-021-10706-3
Journal of Neurology, Vol. 269 (july 2021) , p. 1427-1438
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2.
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13 p, 1.6 MB |
Cognitive and brain cytokine profile of non-demented individuals with cerebral amyloid-beta deposition
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Flores-Aguilar, Lisi (McGill University) ;
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau) ;
Orciani, Chiara (McGill University) ;
Tanna, Neil (McGill University) ;
Yang, Jingyun (Rush University Medical Center) ;
Bennett, David A. (Rush University Medical Center) ;
Cuello, A.C. (Oxford University) ;
Universitat Autònoma de Barcelona
Brain inflammation has been increasingly associated with early amyloid accumulation in Alzheimer's disease models; however, evidence of its occurrence in humans remains scarce. To elucidate whether amyloid deposition is associated with neuroinflammation and cognitive deficits, we studied brain inflammatory cytokine expression and cognitive decline in non-demented elderly individuals with and without cerebral amyloid-beta deposition. [...]
2021 - 10.1186/s12974-021-02169-0
Journal of neuroinflammation, Vol. 18 (july 2021)
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3.
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15 p, 1.0 MB |
Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage
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Marazuela, Paula (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bonaterra-Pastra, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Faura, Júlia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Penalba, Anna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pizarro Gonzálvez, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pancorbo, Olalla (Hospital Universitari Vall d'Hebron) ;
Rodríguez-Luna, David (Hospital Universitari Vall d'Hebron) ;
Vert, Carla (Hospital Universitari Vall d'Hebron) ;
Rovira, Alex (Hospital Universitari Vall d'Hebron) ;
Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ;
Freijo, M. Mar (Instituto de Investigación Sanitaria Biocruces Bizkaia) ;
Tur, Silvia (Hospital Universitari Son Espases (Palma de Mallorca, Balears)) ;
Martínez-Zabaleta, Maite (Hospital Universitario de Donostia (País Basc)) ;
Cardona Portela, Pere (Hospital Universitari de Bellvitge) ;
Vera, Rocío (Hospital Universitario Ramón y Cajal (Madrid)) ;
Lebrato-Hernández, Lucia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Arenillas, Juan F. (Universidad de Valladolid) ;
Pérez-Sánchez, Soledad (Hospital Universitario Virgen Macarena) ;
Montaner, Joan (Universidad de Sevilla) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernandez Guillamon, Maria Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage (ICH) in elderly patients. Growing evidence suggests a potential role of aquaporin 4 (AQP4) in amyloid-beta-associated diseases, including CAA pathology. [...]
2021 - 10.3390/jcm10050989
Journal of clinical medicine, Vol. 10 (march 2021)
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4.
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10 p, 1.8 MB |
AMYQ : An index to standardize quantitative amyloid load across PET tracers
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Pegueroles, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Montal, Victor (Institut d'Investigació Biomèdica Sant Pau) ;
Bejanin, Alexandre (Institut d'Investigació Biomèdica Sant Pau) ;
Vilaplana, Eduard (Institut d'Investigació Biomèdica Sant Pau) ;
Aranha, Mateus (Institut d'Investigació Biomèdica Sant Pau) ;
Santos-Santos, Miguel Angel (Institut d'Investigació Biomèdica Sant Pau) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Carrió, Ignasi (Institut d'Investigació Biomèdica Sant Pau) ;
Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Positron emission tomography (PET) amyloid quantification methods require magnetic resonance imaging (MRI) for spatial registration and a priori reference region to scale the images. Furthermore, different tracers have distinct thresholds for positivity. [...]
2021 - 10.1002/alz.12317
Alzheimer's & Dementia, Vol. 17 (april 2021) , p. 1499-1508
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5.
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12 p, 1.7 MB |
Cerebrospinal fluid A beta 1-40 peptides increase in Alzheimer's disease and are highly correlated with phospho-tau in control individuals
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Lehmann, Sylvain (Univ Montpellier) ;
Dumurgier, Julien (Université Paris Diderot) ;
Ayrignac, Xavier (Univ Montpellier) ;
Marelli, Cecilia (Univ Montpellier) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Thouvenot, Eric (Univ Montpellier) ;
Delaby, Constance (Univ Montpellier) ;
Hirtz, Christophe (Univ Montpellier) ;
Vialaret, Jérôme (Univ Montpellier) ;
Ginestet, Nelly (Univ Montpellier) ;
Bouaziz-Amar, Elodie (Université Paris Diderot) ;
Laplanche, Jean-Louis (Université Paris Diderot) ;
Labauge, Pierre (Univ Montpellier) ;
Paquet, Claire (Université Paris Diderot) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Gabelle, Audrey (Univ Montpellier) ;
Universitat Autònoma de Barcelona
Amyloid pathology, which is one of the characteristics of Alzheimer's disease (AD), results from altered metabolism of the beta-amyloid (Aβ) peptide in terms of synthesis, clearance, or aggregation. [...]
2020 - 10.1186/s13195-020-00696-1
Alzheimer's research & therapy, Vol. 12 (october 2020)
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6.
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11 p, 10.9 MB |
The Aβ1-42/Aβ1-40 ratio in CSF is more strongly associated to tau markers and clinical progression than Aβ1-42 alone
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Estellés, Teresa (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Zhu, Nuole (Institut d'Investigació Biomèdica Sant Pau) ;
Arranz, Javier (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Barroeta, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona Iragui, María (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Illán-Gala, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Santos-Santos, Miguel Ángel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Altuna-Azkargorta, Miren (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Sánchez-Saudinós, María Belén (Institut d'Investigació Biomèdica Sant Pau) ;
Videla Toro, Laura (Fundació Catalana Síndrome de Down) ;
Valldeneu, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Subirana, Andrea (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Tondo, Mireia (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco Vaca, Francisco (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Lehmann, Sylvain (Université de Montpellier) ;
Belbin, Olivia (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Lleó, Alberto (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alcolea, Daniel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
Cerebrospinal fluid (CSF) Aβ1-42 levels and the Aβ1-42/Aβ1-40 ratio are markers of amyloid pathology, but previous studies suggest that their levels might be influenced by additional pathophysiological processes. [...]
2022 - 10.1186/s13195-022-00967-z
Alzheimer's research & therapy, Vol. 14 (february 2022)
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7.
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8.
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14 p, 2.5 MB |
Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation
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Esperante, Sebastián A. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Varejāo, Nathalia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sant'Anna, Ricardo (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Luque-Ortega, Juan Román (Centro de Investigaciones Biológicas Margarita Salas) ;
Alfonso, Carlos (Centro de Investigaciones Biológicas Margarita Salas) ;
Sora, Valentina (Technical University of Denmark. Cancer Systems Biology, Health and Technology Department) ;
Papaleo, Elena (Technical University of Denmark. Cancer Systems Biology, Health and Technology Department) ;
Rivas, Germán (Centro de Investigaciones Biológicas Margarita Salas) ;
Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Hereditary transthyretin amyloidosis (ATTR) is an autosomal dominant disease characterized by the extracellular deposition of the transport protein transthyretin (TTR) as amyloid fibrils. Despite the progress achieved in recent years, understanding why different TTR residue substitutions lead to different clinical manifestations remains elusive. [...]
2021 - 10.1016/j.jbc.2021.101039
Journal of biological chemistry, Vol. 297, Issue 3 (September 2021) , art. 101039
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9.
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15 p, 1.5 MB |
CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals
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Tijms, Betty Marije (Amsterdam UMC) ;
Gobom, Johan (Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 413 45 Mölndal) ;
Teunissen, Charlotte (Amsterdam UMC. University Medical Center) ;
Dobricic, Valerija (University of Lübeck) ;
Tsolaki, Magda (AHEPA University Hospital (Grècia)) ;
Verhey, Frans (Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University, 6211 LK Maastricht, The Netherlands; (F.V.); (S.V.)) ;
Popp, Julius (University of Zürich) ;
Martinez-Lage, Pablo (Fundación CITA-Alzhéimer Fundazioa, 20009 San Sebastian, Spain) ;
Vandenberghe, Rik (Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, 3000 Leuven) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Molinuévo, José Luis (Hospital Clínic i Provincial de Barcelona) ;
Engelborghs, Sebastiaan (Department of Neurology, Universitair Ziekenhuis Brussel and Center for Neurosciences, Vrije Universiteit Brussel, 1090 Brussels) ;
Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia). Department of Neurobiology, Care Sciences and Society) ;
Froelich, Lutz (University of Heidelberg. Department of Geriatric Psychiatry) ;
Bertram, Lars (Center for Lifespan Changes in Brain and Cognition, Department of Psychology, University of Oslo) ;
Lovestone, Simon (University of Oxford, Oxford OX1 2JD) ;
Streffer, Johannes (AC Immune SA, 1024 Lausanne) ;
Vos, Stephanie (Alzheimer Center Limburg, School for Mental Health and Neuroscience, Maastricht University) ;
, ADNI ;
Blennow, Kaj (Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, 413 45 Mölndal) ;
Scheltens, Philip (Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, 1007 MB Amsterdam) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit). UK Dementia Research Institute) ;
Visser, Pieter Jelle (Karolinska Institutet (Estocolm, Suècia). Department of Neurobiology, Care Sciences and Society) ;
Universitat Autònoma de Barcelona
We recently discovered three distinct pathophysiological subtypes in Alzheimer's disease (AD) using cerebrospinal fluid (CSF) proteomics: one with neuronal hyperplasticity, a second with innate immune system activation, and a third subtype with blood-brain barrier dysfunction. [...]
2021 - 10.3390/proteomes9030036
Proteomes, Vol. 9 (august 2021)
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