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11 p, 1.2 MB |
Alzheimer's disease in Down syndrome : An overlooked population for prevention trials
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Strydom, André (South London and Maudsley NHS Foundation Trust) ;
Coppus, Antonia (Department of Primary and Community Care, Radboud University Medical Center, Nijmegen) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Danek, Adrian (Department of Neurology, Ludwig-Maximilians-Universität München) ;
Fortea, Juan (Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down) ;
Hardy, John (Reta Lila Weston Institute, Institute of Neurology, University College London) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) site Munich) ;
Nuebling, Georg (Department of Neurology, Ludwig-Maximilians-Universität München) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Ritchie, Craig (Centre for Clinical Brain Sciences. University of Edinburgh) ;
van Duijn, Cornelia (Department of Epidemiology, Erasmus Medical Centre, Rotterdam) ;
Zaman, Shahid (Cambridgeshire & Peterborough NHS Foundation Trust (CBFT), Fulbourn Hospital) ;
Zetterberg, Henrik (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital) ;
Universitat Autònoma de Barcelona
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. [...]
2018 -  10.1016/j.trci.2018.10.006
Alzheimer's & Dementia : Translational Research & Clinical Interventions, Vol. 4 (december 2018) , p. 703-713
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17 p, 3.4 MB |
Protein environment : A crucial triggering factor in josephin domain aggregation: The role of 2,2,2-trifluoroethanol
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Visentin, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Grasso, Gianvito (Università della Svizzera italiana. Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA)) ;
Regonesi, Maria Elena (Università di Milano-Bicocca. Dipartimento di Biotecnologie e Bioscienze) ;
Deriu, Marco Agostino (Università della Svizzera italiana. Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA)) ;
Tortora, Paolo (Università di Milano-Bicocca. Dipartimento di Biotecnologie e Bioscienze) ;
Ventura i Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
The protein ataxin-3 contains a polyglutamine stretch that triggers amyloid aggregation when it is expanded beyond a critical threshold. This results in the onset of the spinocerebellar ataxia type 3. [...]
2018 - 10.3390/ijms19082151
International Journal of Molecular Sciences, Vol. 19, Núm. 8 (August 2018) , art. 2151
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3.
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13 p, 2.6 MB |
The disordered C-terminus of yeast hsf1 contains a cryptic low-complexity amyloidogenic region
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Pujols, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Santos Suárez, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Ventura i Zamora, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Response mechanisms to external stress rely on networks of proteins able to activate specific signaling pathways to ensure the maintenance of cell proteostasis. Many of the proteins mediating this kind of response contain intrinsically disordered regions, which lack a defined structure, but still are able to interact with a wide range of clients that modulate the protein function. [...]
2018 - 10.3390/ijms19051384
International Journal of Molecular Sciences, Vol. 19, Núm. 5 (May 2018) , p. 1384
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4.
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12 p, 2.4 MB |
The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
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Valls-Comamala, Victòria (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Guivernau, Biuse (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Bonet, Jaume (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB)) ;
Puig, Marta (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Perálvarez Marín, Àlex (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Palomer, Ernest (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Fernàndez-Busquets, Xavier (Institut de Bioenginyeria de Catalunya (IBEC)) ;
Altafaj, Xavier (Universitat de Barcelona. Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)) ;
Tajes, Marta (Institut d'Investigació Mèdica Hospital del Mar (IMIM)) ;
Puig-Pijoan, Albert (Parc de Salut Mar. Hospital del Mar (IMI) ;
Vicente, Rubén (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular) ;
Oliva, Baldomero (Universitat Pompeu Fabra. Unitat de Recerca en Informàtica Biomèdica (GRIB)) ;
Muñoz, Francisco J. (Universitat Pompeu Fabra. Laboratori de Fisiologia Molecular)
The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both neurotoxic. [...]
2017 - 10.18632/oncotarget.17074
Oncotarget, Vol. 8, Num. 25 (June 2017) , p. 41154-41165
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4 p, 393.4 KB |
Copper(II) and the pathological H50Q α-synuclein mutant : environment meets genetics
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Villar-Piqué, Anna (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research) ;
Rossetti, Giulia (Jülich Forschungszentrum. Institut für Neurowissenschaften und Medizin) ;
Ventura i Zamora, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Carloni, Paolo (Jülich Forschungszentrum. Institut für Neurowissenschaften und Medizin) ;
Fernández, Claudio O. (Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario) ;
Outeiro, Tiago Fleming (University Medical Centre Göottingen. Department of Neurodegeneration and Restorative Research) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i Biologia Molecular
Copper is one of the metals described to bind the Parkinson disease-related protein α-synuclein (aSyn), and to promote its aggregation. Although histidine at position 50 in the aSyn sequence is one of the most studied copper-anchoring sites, its precise role in copper binding and aSyn aggregation is still unclear. [...]
2017 - 10.1080/19420889.2016.1270484
Communicative & integrative Biology, Vol. 10, no. 1 (2017) , e127048
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13 p, 129.1 KB |
Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype
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Espinosa, Ana (Institut Català de Neurociències Aplicades) ;
Alegret, Montserrat (Institut Català de Neurociències Aplicades) ;
Pesini, Pedro (Araclon Biotech S.L.) ;
Valero Ventura, Sergi (Hospital Universitari Vall d'Hebron) ;
Lafuente, Asunción (Institut Català de Neurociències Aplicades) ;
Buendía, Mar (Institut Català de Neurociències Aplicades) ;
San José, Itziar (Araclon Biotech S.L.) ;
Ibarria, Marta (Institut Català de Neurociències Aplicades) ;
Tejero, Miguel A. (Clínica Corachán) ;
Giménez Ruiz, Joan (Clínica Corachán) ;
Ruiz, Susana (Institut Català de Neurociències Aplicades) ;
Hernández, Isabel (Institut Català de Neurociències Aplicades) ;
Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ;
Martínez Lage, Pablo (Fundación CITA) ;
Munuera del Cerro, Josep (Hospital Universitari Germans Trias i Pujol) ;
Arbizu, Javier (Clínica Universitaria de Pamplona) ;
Tárraga, Lluís (Institut Català de Neurociències Aplicades) ;
Hendrix, Suzanne B. (Pentara Corporation) ;
Ruiz, Agustín (Institut Català de Neurociències Aplicades) ;
Becker, James T. (University of Pittsburgh) ;
Landau, Susan M. (University of California) ;
Sotolongo Grau, Oscar (Institut Català de Neurociències Aplicades) ;
Sarasa, Manuel (Araclon Biotech S.L.) ;
Boada Rovira, Mercè (Institut Català de Neurociències Aplicades) ;
Universitat Autònoma de Barcelona
The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8. 5 times more risk of conversion to dementia, mainly Alzheimer's disease (AD), than the possible non-amnestic (Pss-na) MCI. [...]
2017 - 10.3233/JAD-161223
Journal of Alzheimer's Disease, Vol. 57, Núm. 2 (March 2017) , p. 447-459
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12 p, 12.3 MB |
High-throughput screening methodology to identify alpha-synuclein aggregation inhibitors
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Pujols, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Peña Díaz, Samuel (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Conde-Giménez, María (Universidad de Zaragoza. Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos) ;
Pinheiro, Francisca (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Sancho, Javier (Universidad de Zaragoza. Instituto Universitario de Investigación de Biocomputación y Física de Sistemas Complejos) ;
Ventura i Zamora, Salvador (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
An increasing number of neurodegenerative diseases are being found to be associated with the abnormal accumulation of aggregated proteins in the brain. In Parkinson's disease, this process involves the aggregation of alpha-synuclein (α-syn) into intraneuronal inclusions. [...]
2017 - 10.3390/ijms18030478
International journal of molecular sciences, Vol. 18 (March 2017) , art. 478
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9.
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24 p, 5.9 MB |
Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease
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Unzeta López, Mercedes (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Esteban, Gerard (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ;
Bolea Tomás, Irene (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Fogel, Wieslawa A. (Medical University of Lodz. Department of Hormone Biochemistry) ;
Ramsay, Rona R. (University of St Andrews. Biomedical Sciences Research Complex) ;
Youdim, Moussa B. H. (Ruth and Bruce Rappaport Faculty of Medicine. Department of Pharmacology) ;
Tipton, Keith F. (Trinity College Dublin. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute) ;
Marco-Contelles, José (Spanish National Research Council. Institute of General Organic Chemistry) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i Biologia Molecular
HIGHLIGHTS Alzheimer's disease (AD), the most common form of adult onset dementia, is an age-related neurodegenerative disorder characterized by progressive memory loss, decline in language skills, and other cognitive impairments. [...]
2016 - 10.3389/fnins.2016.00205
Frontiers in Neuroscience, Vol. 10 (May 2016) , art. 205
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