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Resultats globals: 8 registres trobats en 0.02 segons.
Articles, 6 registres trobats
Documents de recerca, 2 registres trobats
Articles 6 registres trobats  
1.
52 p, 705.6 KB Role of Amyloid-β and Tau Proteins in Alzheimer's Disease : Confuting the Amyloid Cascade / Gulisano, W. (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ; Maugeri, Daniele (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ; Baltrons Soler, Ma. Antonia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Fà, Mauro (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Medicine. Columbia University) ; Amato, Arianna (Department of Anaesthesiology. Università Cattolica Del Sacro Cuore) ; Palmeri, Agostino (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ; D'Adamio, Luciano (Department of Pharmacology. Physiology and Neuroscience. Rutgers University) ; Grassi, Claudio (Institute of Human Physiology. Università Cattolica Del Sacro Cuore) ; Devanand, D.P. (Department of Psychiatry. Columbia University. College of Phys. and Surg.) ; Honig, Lawrence S. (Department of Neurology. Columbia University. College of Phys. and Surg.) ; Puzzo, Daniela (Department of Biomedical and Biotechnological Sciences. Section of Physiology. University of Catania) ; Arancio, Ottavio (Taub Institute for Research on Alzheimer's Disease and the Aging Brain. Department of Medicine. Columbia University)
The "Amyloid Cascade Hypothesis" has dominated the Alzheimer's disease (AD) field in the last 25 years. It posits that the increase of amyloid-β (Aβ) is the key event in AD that triggers tau pathology followed by neuronal death and eventually, the disease. [...]
2018 - 10.3233/JAD-179935
Journal of Alzheimer's disease, Vol. 64 Núm. s1 (2018) , p. S611-S631  
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2.
27 p, 369.7 KB Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden / Esquerda-Canals, Gisela (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Roda, Alejandro Ramos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Martí-Clúa, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Montoliu-Gaya, Laia (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Rivera-Hernández, Geovanny (Universitat Autònoma de Barcelona. Disseny de Proteïnes i Immunoteràpia) ; Villegas Hernández, Sandra (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The intracellular deposition of amyloid-beta (A beta) peptides has been described in the brains of both Alzheimer's disease (AD) patients and animal models. A correlation between the intracellular amyloid burden and neurodegeneration has recently been reported in a triple-transgenic AD (3xTg-AD) murine model. [...]
2019 - 10.3233/JAD-190484
Journal of Alzheimer's disease, Vol. 70 Núm. 4 (2019) , p. 1069-1091  
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3.
13 p, 162.5 KB Validation of plasma proteomic biomarkers relating to brain amyloid burden in the EMIF-Alzheimer's disease multimodal biomarker discovery cohort / Westwood, Sarah (University of Oxford) ; Baird, Alison L (University of Oxford) ; Anand, Sneha N. (University of Oxford) ; Nevado-Holgado, Alejo (University of Oxford) ; Kormilitzin, Andrey (University of Oxford) ; Shi, Liu (University of Oxford) ; Hye, Abdul (King's College London) ; Ashton, Nicholas J (University of Gothenburg) ; Morgan, Angharad R. (Cardiff University) ; Bos, Isabelle (Maastricht University) ; Vos, Stephanie J.B. (Maastricht University) ; Baker, Susan (Janssen R and D) ; Buckley, Noel J (University of Oxford) ; Ten Kate, Mara (Vrije Universiteit University Medical Center) ; Scheltens, Philip (Vrije Universiteit University Medical Center) ; Teunissen, Charlotte E. (Vrije Universiteit University Medical Center) ; Vandenberghe, Rik (University Hospitals Leuven (Bèlgica)) ; Gabel, Silvy (Ku Leuven) ; Meersmans, Karen (Ku Leuven) ; Engelborghs, Sebastiaan (Vrije Universiteit Brussel (VUB)) ; De Roeck, Ellen E. (Vrije Universiteit Brussel (VUB)) ; Sleegers, Kristel (Center for Molecular Neurology) ; Frisoni, Giovanni B. (Irccs Istituto Centro San Giovanni di Dio Fatebenefratelli) ; Blin, Olivier (Aix-Marseille Université) ; Richardson, Jill C. (GlaxoSmithKline R and D) ; Bordet, Régis (University of Lille) ; Molinuevo, José Luis (Hospital Clínic i Provincial de Barcelona) ; Rami, Lorena (Universitat Pompeu Fabra) ; Wallin, Anders (Sahlgrenska Academy at University of Gothenburg) ; Kettunen, Petronella (Sahlgrenska Academy at University of Gothenburg) ; Tsolaki, Magda (AHEPA University Hospital (Grècia)) ; Verhey, Frans (Maastricht University) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Sala, Isabel (Institut d'Investigació Biomèdica Sant Pau) ; Popp, Julius (Geneva University Hospitals) ; Peyratout, Gwendoline (Lausanne University Hospital) ; Martinez-Lage, Pablo (Geneva University Hospitals) ; Tainta, Mikel (CITA-Alzheimer Foundation) ; Johannsen, Peter (Copenhagen University Hospital) ; Freund-Levi, Yvonne (Karolinska Institutet (Estocolm, Suècia)) ; Frölich, Lutz (University of Heidelberg) ; Dobricic, Valerija (University of Lübeck) ; Legido-Quigley, Cristina (Steno Diabetes Center) ; Bertram, Lars (University of Oslo) ; Barkhof, Frederik (Ucl Institutes of Neurology and Healthcare Engineering) ; Zetterberg, Henrik (Ucl Institute of Neurology) ; Morgan, B.Paul (Cardiff University) ; Streffer, Johannes (Janssen R and D. Llc) ; Visser, Pieter Jelle (Vu University Medical Center) ; Lovestone, Simon (Janssen R and D) ; Universitat Autònoma de Barcelona
We have previously investigated, discovered, and replicated plasma protein biomarkers for use to triage potential trials participants for PET or cerebrospinal fluid measures of Alzheimer's disease (AD) pathology. [...]
2020 - 10.3233/JAD-190434
Journal of Alzheimer's disease, Vol. 74 Núm. 1 (2020) , p. 213-225  
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4.
15 p, 1.2 MB Kynurenic acid levels are increased in the CSF of Alzheimer's disease patients / González-Sánchez, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Jiménez, Javier (Universidad de Alcalá) ; Narváez García, Arantzazu (Universidad de Alcalá) ; Antequera, Desiree (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Llamas-Velasco, Sara (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Herrero San-Martín, Alejandro (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Molina Arjona, Jose Antonio (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Lopez de Munain, Adolfo (Biodonostia Osasun Ikerketako Institutura (País Basc)) ; Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ; Marco, María Pilar (Centro de Investigación Biomédica en Red (CIBER) de Bioingeniería. Biomateriales y Nanomedicina (CIBER-BBN)) ; Rodríguez-Núñez, Montserrat (Centro de Investigación Biomédica en Red (CIBER) de Bioingeniería. Biomateriales y Nanomedicina (CIBER-BBN)) ; Pérez-Martínez, David Andrés (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Villarejo-Galende, Alberto (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Bartolome, Fernando (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Domínguez, Elena (Universidad de Alcalá) ; Carro, Eva M. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Universitat Autònoma de Barcelona
Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer's disease (AD). KYNA is primarily produced by astrocytes and is considered neuroprotective. [...]
2020 - 10.3390/biom10040571
Biomolecules, Vol. 10 Núm. 4 (april 2020) , p. 571  
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5.
10 p, 2.1 MB Structure-Based Virtual Screening and in vitro and in vivo Analyses Revealed Potent Methyltransferase G9a Inhibitors as Prospective Anti-Alzheimer's Agents / Bellver-Sanchis, Aina (Universitat de Barcelona) ; Singh Choudhary, Bhanwar (Ganpat University) ; Companys-Alemany, Júlia (Universitat de Barcelona) ; Sukanya, None (Central University of Rajasthan) ; Ávila-López, Pedro A. (Northwestern University) ; Martínez Rodríguez, Antón Leandro (Universidade de Santiago de Compostela) ; Brea Floriani, Jose Manuel (Universidade de Santiago de Compostela) ; Malik, Ruchi (Central University of Rajasthan) ; Pallàs, Mercè (Universitat de Barcelona) ; Pérez, Belén (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ; Griñán-Ferré, Christian (Universitat de Barcelona)
G9a is a lysine methyltransferase able to di-methylate lysine 9 of histone H3, promoting the repression of genes involved in learning and memory. Novel strategies based on synthesizing epigenetic drugs could regulate gene expression through histone post-translational modifications and effectively treat neurodegenerative diseases, like Alzheimer's disease (AD). [...]
2022 - 10.1002/cmdc.202200002
ChemMedChem, Vol. 17 (may 2022)  
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6.
10 p, 1.8 MB Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer's disease / González-Marrero, Ibrahim (Universidad de La Laguna. Departamento de Anatomía Humana) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Johanson, Conrad E. (Alpert Medical School at Brown University. Department of Neurosurgery) ; Carmona-Calero, Emilia María (Universidad de La Laguna. Departamento de Anatomía Humana) ; Castañeyra-Ruiz, Leandro (Universidad de La Laguna. Departamento de Anatomía Humana) ; Brito-Armas, José Miguel (Universidad de La Laguna. Departamento de Psicología) ; Castañeyra-Perdomo, Agustín (Universidad de La Laguna. Departamento de Anatomía Humana) ; Castro-Fuentes, Rafael (Universidad de La Laguna. Departamento de Psicología) ; Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal
Compromised secretory function of choroid plexus (CP) and defective cerebrospinal fluid (CSF) production, along with accumulation of beta-amyloid (Aβ) peptides at the blood-CSF barrier (BCSFB), contribute to complications of Alzheimer's disease (AD). [...]
2015 - 10.3389/fncel.2015.00017
Frontiers in cellular neuroscience, Vol. 9 (February 2015) , art. 17  
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Documents de recerca 2 registres trobats  
1.
1 p, 943.6 KB Astrocytes and Alzheimer's disease : the amyloid-β clearance / Compte Sancerni, Sara ; Masgrau Juanola, Roser, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Grau en Bioquímica [814]  
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2.
1 p, 15.1 MB Alzheimer's disease : β-amyloid peptide aggregation and endogenous elimination / Podadera Aliseda, Elena ; Villegas Hernández, Sandra, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2013
Grau en Bioquímica [814]  
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