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16 p, 8.0 MB |
The Inhibition of Neuropathic Pain Incited by Nerve Injury and Accompanying Mood Disorders by New Heme Oxygenase-1 Inducers : Mechanisms Implicated
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Suárez-Rojas, Irene (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Pérez-Fernández, Montse (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Bai, Xue (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Martel, Ignacio (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Intagliata, Sebastiano (University of Catania) ;
Pittalà, Valeria (Arabian Gulf University) ;
Salerno, Loredana (University of Catania) ;
Pol, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Neuropathic pain is a type of pain that persists for a long time and becomes pathological. Additionally, the anxiodepressive disorders derived from neuropathic pain are difficult to palliate with the current treatments and need to be resolved. [...]
2023 - 10.3390/antiox12101859
Antioxidants, Vol. 12 (october 2023)
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16 p, 2.4 MB |
Novel Heme Oxygenase-1 Inducers Palliate Inflammatory Pain and Emotional Disorders by Regulating NLRP3 Inflammasome and Activating the Antioxidant Pathway
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Pérez-Fernández, Montse (Institut d'Investigació Biomèdica Sant Pau) ;
Suárez-Rojas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Bai, Xue (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Martel, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Ciaffaglione, Valeria (Istituto di Cristallografia-CNR) ;
Pittalà, Valeria (Università di Catania. Dipartimento di Scienze del Farmaco e della Salute) ;
Salerno, Loredana (Università di Catania. Dipartimento di Scienze del Farmaco e della Salute) ;
Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Chronic pain caused by persistent inflammation is current in multiple diseases and has a strong negative impact on society. It is commonly associated with several mental illnesses, which can exert a negative influence on pain perception, and needs to be eradicated. [...]
2023 - 10.3390/antiox12101794
Antioxidants, Vol. 12 Núm. 10 (2023) , p. 1794
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19 p, 3.9 MB |
Hydrogen Sulfide Interacting with Cannabinoid 2 Receptors during Sciatic Nerve Injury-Induced Neuropathic Pain
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Bai, Xue (Institut d'Investigació Biomèdica Sant Pau) ;
Batallé Melgarejo, Gerard (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Martel, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Pol, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Hydrogen sulfide (HS) donors make opioids more effective in inhibiting nociception during inflammatory and neuropathic pain. We examined whether the analgesic, anxiolytic and/or antidepressant actions of the cannabinoid 2 receptor (CB2R) agonist, JWH-133, might be improved by pretreatment with HS donors, DADS and GYY4137 in mice with sciatic nerve injury-provoked neuropathy (CCI). [...]
2023 - 10.3390/antiox12061179
Antioxidants, Vol. 12 (may 2023)
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19 p, 4.6 MB |
Hydrogen-rich water as a novel therapeutic strategy for the affective disorders linked with chronic neuropathic pain in mice
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Martínez-Serrat, Maria (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Martínez-Martel, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Coral-Pérez, Santiago (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Bai, Xue (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Batallé Melgarejo, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Institut d'Investigació Biomèdica Sant Pau
Neuropathic pain manifested with allodynia and hyperalgesia usually becomes a chronic condition accompanied with mood disorders. Clinical therapies for neuropathic pain are still unsatisfactory with notable side effects. [...]
2022 - 10.3390/antiox11091826
Antioxidants, Vol. 11, Issue 9 (September 2022) , art. 1826
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21 p, 3.3 MB |
Hydrogen sulfide inhibits inflammatory pain and enhances the analgesic properties of delta opioid receptors
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Porta, Aina (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Rodríguez, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Bai, Xue (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Batallé Melgarejo, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Roch, Gerard (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Pouso-Vázquez, Enric (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Balboni, Gianfranco (University of Cagliari. Department of Life and Environmental Sciences) ;
Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Chronic inflammatory pain is present in many pathologies and diminishes the patient's quality of life. Moreover, most current treatments have a low efficacy and significant side effects. Recent studies demonstrate the analgesic properties of slow-releasing hydrogen sulfide (HS) donors in animals with osteoarthritis or neuropathic pain, but their effects in inflammatory pain and related pathways are not completely understood. [...]
2021 - 10.3390/antiox10121977
Antioxidants, Vol. 10 Núm. 12 (december 2021) , p. 1977
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