|
1.
|
|
20 p, 2.3 MB |
Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA
/
Quintana-Bustamante, O. (Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
Fañanas-Baquero, S. (Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
Orman, I. (Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Duchateau, P. (CELLECTIS) ;
Poirot, L. (CELLECTIS) ;
Gouble, A. (CELLECTIS) ;
Bueren, J.A. (Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
Segovia, J.C. (Instituto de Investigación Sanitaria Fundación Jiménez Díaz) ;
Universitat Autònoma de Barcelona
Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme. Erythrocytes from PKD patients show an energetic imbalance and are susceptible to hemolysis. [...]
2019 -  10.1371/journal.pone.0223775
PloS one, Vol. 14 Núm. 10 (january 2019) , p. e0223775
|
|
|
2.
|
|
15 p, 4.1 MB |
Donkey genomes provide new insights into domestication and selection for coat color
/
Wang, Changfa (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding) ;
Li, Haijing (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Guo, Yu (BGI-Shenzhen) ;
Huang, Jinming (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Sun, Yan (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Min, Jiumeng (BGI-Shenzhen) ;
Wang, Jinpeng (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Fang, Xiaodong (BGI-Shenzhen) ;
Zhao, Zicheng (City University of Hong Kong. Department of Computer Science) ;
Wang, Shuai (City University of Hong Kong. Department of Computer Science) ;
Zhang, Yanlin (City University of Hong Kong. Department of Computer Science) ;
Liu, Qingfeng (BGI-Shenzhen) ;
Jiang, Qiang (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Wang, Xiuge (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Guo, Yijun (BGI-Shenzhen) ;
Yang, Chunhong (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Wang, Yinchao (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Tian, Fang (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Zhuang, Guilong (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Fan, Yanna (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Gao, Qican (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Li, Yuhua (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding) ;
Ju, Zhihua (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Li, Jianbin (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Li, Rongling (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Hou, Minghai (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Yang, Guiwen (Shandong Normal University. College of Life Science) ;
Liu, Guiqin (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding) ;
Liu, Wenqiang (Liaocheng University Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding.) ;
Guo, Jiao (BGI-Shenzhen) ;
Pan, Shanshan (BGI-Shenzhen) ;
Fan, Guangyi (BGI-Shenzhen) ;
Zhang, Wei (Shandong Academy of Agricultural Sciences. Dairy Cattle Research Center) ;
Zhang, Ruitao (Liaocheng University. Liaocheng Research Institute of Donkey High-Efficiency Breeding and Ecological Feeding) ;
Yu, Jie (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Zhang, Xinhao (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Yin, Qi (BGI-Shenzhen) ;
Ji, Chuanliang (National Engineering Research Center for Gelatin-based Traditional Chinese Medicine) ;
Jin, Yuanchun (BGI-Shenzhen) ;
Yue, Guidong (BGI-Shenzhen) ;
Liu, Mei (Nanjing Normal University. Jiangsu Key Laboratory for Molecular and Medical Biotechnology) ;
Xu, Jiake (The University of Western Australia . School of Biomedical Sciences) ;
Liu, Shimin (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Jordana i Vidal, Jordi (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments) ;
Noce, Antonia (Centre de Recerca en Agrigenòmica) ;
Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica) ;
Wu, Dong-Dong (Chinese Academy of Sciences. Center for Excellence in Animal Evolution and Genetics) ;
Li, Shuaicheng (City University of Hong Kong. Department of Computer Science) ;
Zhou, Xiangshan (East China University of Science and Technology. State Key Laboratory of Bioreactor Engineering) ;
Zhong, Jifeng (Jiangsu Academy of Agricultural Sciences. Institute of Animal Science)
Current knowledge about the evolutionary history of donkeys is still incomplete due to the lack of archeological and whole-genome diversity data. To fill this gap, we have de novo assembled a chromosome-level reference genome of one male Dezhou donkey and analyzed the genomes of 126 domestic donkeys and seven wild asses. [...]
2020 - 10.1038/s41467-020-19813-7
Nature communications, Vol. 11 (December 2020) , art. 6014
|
|
|
3.
|
|
17 p, 2.7 MB |
Identification of strong candidate genes for backfat and intramuscular fatty acid composition in three crosses based on the Iberian pig
/
Crespo-Piazuelo, Daniel (Centre de Recerca en Agrigenòmica) ;
Criado Mesas, Lourdes (Centre de Recerca en Agrigenòmica) ;
Revilla Sánchez, Manuel (Centre de Recerca en Agrigenòmica) ;
Castelló, Anna (Centre de Recerca en Agrigenòmica) ;
Noguera, José L. (Institut de Recerca i Tecnologia Agroalimentàries. Genètica i Millora Animal) ;
Fernández, Ana I. (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria. Departamento de Mejora Genética Animal) ;
Ballester Devis, Maria (Institut de Recerca i Tecnologia Agroalimentàries. Departament de Genètica i Millora Animal) ;
Folch, Josep M. (Centre de Recerca en Agrigenòmica) ;
Universitat Autònoma de Barcelona.
Departament de Ciència Animal i dels Aliments
Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition and the amount of fat contained in adipose tissue and muscle. The present study aimed to find genomic regions associated with the FA composition in backfat and muscle (longissimus dorsi) in 439 pigs with three different genetic backgrounds but having the Iberian breed in common. [...]
2020 - 10.1038/s41598-020-70894-2
Scientific reports (Nature Publishing Group), Vol. 10 (August 2020) , art. 13962
|
|
|
4.
|
|
11 p, 2.4 MB |
Amino acid substitutions at sugar-recognizing codons confer ABO blood group system-related α1,3 Gal(NAc) transferases with differential enzymatic activity
/
Cid, Emili (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Yamamoto, Miyako (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Yamamoto, Fumiichiro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Functional paralogous ABO, GBGT1, A3GALT2, and GGTA1 genes encode blood group A and B transferases (AT and BT), Forssman glycolipid synthase (FS), isoglobotriaosylceramide synthase (iGb3S), and α1,3-galactosyltransferase (GT), respectively. [...]
2019 - 10.1038/s41598-018-37515-5
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 846
|
|
|
5.
|
|
16 p, 2.3 MB |
SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina
/
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Thackray, J.K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Simonet, N.G. (Chromatin Biology Laboratory. Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL)) ;
Chahar, S. (Montpellier Institute of Molecular Genetics (IGMM). CNRS. University of Montpellier) ;
Kane-Goldsmith, N. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Newkirk, S.J. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Lee, S. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Xing, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Verzi, M.P. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
An, W. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tischfield, J.A. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Serrano, L. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Universitat Autònoma de Barcelona
Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process becomes dysfunctional during aging and in cancer cells is poorly understood. [...]
2019 - 10.1093/nar/gkz519
Nucleic acids research, Vol. 47 Núm. 15 (january 2019) , p. 7870-7885
|
|
|
6.
|
|
13 p, 3.9 MB |
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions
/
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Calero-Nieto, F.J. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Wang, X. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Valdes-Mas, R. (Dreamgenics S.L. Oviedo) ;
Gutiérrez-Agüera, Francisco (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Roca Ho, Heleia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ayllon, V. (GENyO. Centre for Genomics and Oncological Research. Pfizer/University of Granada/Andalusian Regional Government and University of Granada. Department of Biochemistry and Molecular Biology) ;
Real, P.J. (GENyO. Centre for Genomics and Oncological Research. Pfizer/University of Granada/Andalusian Regional Government and University of Granada. Department of Biochemistry and Molecular Biology) ;
Arambilet Mobilla, David (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Varela, I. (Instituto de Biomedicina y Biotecnologia de Cantabria (CSIC-UC-Sodercan). Departamento de Biologia Molecular. Universidad de Cantabria) ;
De Boer, J. (Cancer Section. UCL Great Ormond Street Institute of Child Health) ;
Bigas, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gottgens, B. (Department of Hematology. Cambridge Institute for Medical Research and Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute. University of Cambridge) ;
Marschalek, R. (Institute of Pharmaceutical Biology. Goethe-University) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis. The developmental/pathogenic contribution of the t(4;11)-resulting MLL-AF4 (MA4) and AF4-MLL (A4M) fusions remains unclear; MA4 is always expressed in patients with t(4;11)+ B-cell acute lymphoblastic leukemia, but the reciprocal fusion A4M is expressed in only half of the patients. [...]
2019 - 10.3324/haematol.2018.202044
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1189-1201
|
|
|
7.
|
|
8 p, 1.4 MB |
Antitumoral effect of maintained neutrophilia induced by rhG-CSF in a murine model of pancreatic cancer
/
Brú, A. (Faculty of Mathematics. Universidad Complutense de Madrid) ;
Bosch, R. (Institut d'Investigació Biomèdica Sant Pau) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Pascual, E. (Institut d'Investigació Biomèdica Sant Pau) ;
Brú, I. (Centro de Salud La Estación) ;
Souto, J.C. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Although the protumoral functions of polymorphonuclear neutrophils are well known, some now-forgotten studies report antitumoral roles for these cells. The present work examines the antitumoral effect of maintained neutrophilia induced via the injection of recombinant human granulocyte colony stimulating factor (rhG-CSF, 100 μg/kg/day) in a Panc-1 subcutaneous xenograft murine model of pancreatic cancer. [...]
2019 - 10.1038/s41598-019-39805-y
Scientific reports (Nature Publishing Group), Vol. 9 Núm. 1 (january 2019) , p. 2879
|
|
|
8.
|
|
22 p, 5.2 MB |
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment
/
Urdinguio, R.G. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Lopez, V. (Nanomaterials and Nanotechnology Research Center (CINN-CSIC). Universidad de Oviedo-Principado de Asturias) ;
Bayón, G.F. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Díaz de la Guardia, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sierra, M.I. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
García-Toraño, E. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Perez, R.F. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
García, M.G. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Carella, A. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Pruneda, P.C. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Prieto, C. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Dmitrijeva, M. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Santamarina, P. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Belmonte, T. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Mangas, C. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Diaconu, E. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Ferrero, C. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Tejedor, J.R. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Fernandez-Morera, J.L. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Bravo, C. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sanjuan-Pla, A. (Hematology Research Group. Instituto de Investigación Sanitaria la Fe (IIS la Fe)) ;
Rodriguez, R.M. (Translational Immunology Laboratory. Instituto de Investigación Sanitarias Del Principado de Asturias (ISPA). Immunology Department. Hospital Universitario Central de Asturias (HUCA)) ;
Suarez-Alvarez, B. (Translational Immunology Laboratory. Instituto de Investigación Sanitarias Del Principado de Asturias (ISPA). Immunology Department. Hospital Universitario Central de Asturias (HUCA)) ;
López-Larrea, C. (Translational Immunology Laboratory. Instituto de Investigación Sanitarias Del Principado de Asturias (ISPA). Immunology Department. Hospital Universitario Central de Asturias (HUCA)) ;
Bernal, T. (Servicio de Hematología. Hospital Universitario Central de Asturias (HUCA)) ;
Colado, E. (Servicio de Hematología. Hospital Universitario Central de Asturias (HUCA)) ;
Balbín, M. (Service of Molecular Oncology. Hospital Universitario Central de Asturias. Instituto Universitario de Oncología Del Principado de Asturias. Universidad de Oviedo) ;
García-Suarez, O. (Department of Morphology and Cellular Biology. Faculty of Medicine. University of Oviedo) ;
Chiara, M.D. (Otorhinolaryngology Service. Hospital Universitario Central de Asturias. Instituto Universitario de Oncología Del Principado de Asturias. Universidad de Oviedo. CIBERONC) ;
Sáenz-De-Santa-María, I. (Otorhinolaryngology Service. Hospital Universitario Central de Asturias. Instituto Universitario de Oncología Del Principado de Asturias. Universidad de Oviedo. CIBERONC) ;
Rodríguez, F. (Departamento de Bioquímica y Biología Molecular. Facultad de Medicina. Instituto Universitario de Oncología (IUOPA). Universidad de Oviedo) ;
Pando-Sandoval, A. (Hospital Universitario Central de Asturias (HUCA). Instituto Nacional de Silicosis (INS). Área Del Pulmón. Facultad de Medicina. Universidad de Oviedo) ;
Rodrigo, L. (Hospital Universitario Central de Asturias (HUCA). Gastroenterology Service. Facultad de Medicina. Universidad de Oviedo) ;
Santos, L. (Fundación para la Investigación Biosanitaria de Asturias (FINBA). Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA)) ;
Salas, A. (Cytometry Service. Servicios Científico-Técnicos (SCTs). Universidad de Oviedo) ;
Vallejo-Díaz, J. (Department of Immunology and Oncology. National Center for Biotechnology. CNB-CSIC) ;
C Carrera, A. (Department of Immunology and Oncology. National Center for Biotechnology. CNB-CSIC) ;
Rico, D. (Institute of Cellular Medicine. Newcastle University) ;
Hernández-López, I. (Institute of Cellular Medicine. Newcastle University) ;
Vayá, A. (Hemorheology and Haemostasis Unit. Service of Clinical Pathology. La Fe University Hospital) ;
Ricart, J.M. (Dermatology Service. Quirón Clinic) ;
Seto, E. (George Washington University Cancer Center. Department of Biochemistry and Molecular Medicine. George Washington University) ;
Sima-Teruel, N. (Chromatin Biology Laboratory. Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL)) ;
Vaquero, Alejandro (Chromatin Biology Laboratory. Cancer Epigenetics and Biology Program (PEBC). Bellvitge Biomedical Research Institute (IDIBELL)) ;
Valledor, L. (Plant Physiology Lab. Department of Organisms and Systems Biology. Faculty of Biology. University of Oviedo) ;
Cañal, M.J. (Plant Physiology Lab. Department of Organisms and Systems Biology. Faculty of Biology. University of Oviedo) ;
Pisano, D. (Bioinformatics Unit. Structural Biology and Biocomputing Program. Spanish National Cancer Research Center (CNIO)) ;
Graña-Castro, O. (Bioinformatics Unit. Structural Biology and Biocomputing Program. Spanish National Cancer Research Center (CNIO)) ;
Thomas, T. (Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology. University of Melbourne) ;
Voss, A.K. (Walter and Eliza Hall Institute of Medical Research. Department of Medical Biology. University of Melbourne) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villar-Garea, A. (R and D. Sanofi-Aventis Deutschland GmbH. Industriepark Höchst Building G878) ;
Deutzmann, R. (Institute of Biochemistry. Genetics and Microbiology. University of Regensburg) ;
Fernandez, A.F. (Cancer Epigenetics Laboratory. Institute of Oncology of Asturias (IUOPA). ISPA-Hospital Universitario Central de Asturias HUCA. Universidad de Oviedo) ;
Fraga, M.F. (Nanomaterials and Nanotechnology Research Center (CINN-CSIC). Universidad de Oviedo-Principado de Asturias) ;
Universitat Autònoma de Barcelona
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. [...]
2019 - 10.1093/nar/gkz195
Nucleic acids research, Vol. 47 Núm. 10 (april 2019) , p. 5016-5037
|
|
|
9.
|
|
11 p, 1.9 MB |
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma
/
Recasens-Zorzo, C. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Cardesa-Salzmann, T. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Petazzi, Paolo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ros-Blanco, L. (Grup d'Enginyeria Molecular. IQS School of Engineering. Universitat Ramon Llull) ;
Esteve-Arenys, A. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Clot, G. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Guerrero-Hernández, M. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Rodríguez, V. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Soldini, D. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Valera, A. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Moros, A. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Climent, F. (Pathology Department. Hospital Universitari de Bellvitge) ;
González-Barca, E. (Institut Català d'Oncologia) ;
Mercadal, S. (Institut Català d'Oncologia) ;
Arenillas, Leonor (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Calvo, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mate, J.L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gutiérrez-García, G. (Department of Hematology. Hospital Clinic) ;
Casanova Rigat, Isolda (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Mangues, Ramon (Institut d'Investigació Biomèdica Sant Pau) ;
Sanjuan-Pla, A. (Hematology Research Group. Health Research Institute La Fe) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez, A. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Colomer, D. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
Tejedor, R.E. (Grup d'Enginyeria Molecular. IQS School of Engineering. Universitat Ramon Llull) ;
Teixidó, J. (Grup d'Enginyeria Molecular. IQS School of Engineering. Universitat Ramon Llull) ;
Campo, E. (Hematopathology Unit. Department of Pathology. Hospital Clinic) ;
López-Guillermo, A. (Department of Hematology. Hospital Clinic) ;
Borrell, J.I. (Grup d'Enginyeria Molecular. IQS School of Engineering. Universitat Ramon Llull) ;
Colomo, Luís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-Galán, P. (Division of Hemato-Oncology. Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS). CIBERONC) ;
Roué, Gaël (VHIO) ;
Universitat Autònoma de Barcelona
Constitutive activation of the chemokine receptor CXCR4 has been associated with tumor progression, invasion, and chemotherapy resistance in different cancer subtypes. Although the CXCR4 pathway has recently been suggested as an adverse prognostic marker in diffuse large B-cell lymphoma, its biological relevance in this disease remains underexplored. [...]
2019 - 10.3324/haematol.2017.180505
Haematologica, Vol. 104 Núm. 4 (31 2019) , p. 778-788
|
|
|
10.
|
|
18 p, 4.0 MB |
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
/
Visnes, T. (Department of Biotechnology and Nanomedicine. Sintef Industry) ;
Benítez-Buelga, C. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Cázares-Körner, A. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Sanjiv, K. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Hanna, B.M.F. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Mortusewicz, O. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Rajagopal, V. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Albers, J.J. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Hagey, D.W. (Department of Laboratory Medicine. Karolinska Institutet) ;
Bekkhus, T. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Eshtad, S. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Baquero, J.M. (Human Genetics Group. Spanish National Cancer Research Centre (CNIO)) ;
Masuyer, G. (Department of Pharmacy and Pharmacology. Centre for Therapeutic Innovation. University of Bath) ;
Wallner, O. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Müller, S. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Pham, T. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Göktürk, C. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Rasti, A. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Suman, S. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sarno, A. (Department of Environment and New Resources. Sintef Ocean) ;
Wiita, E. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Homan, E.J. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Karsten, S. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Marimuthu, K. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Michel, M. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Koolmeister, T. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Scobie, M. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Loseva, O. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Almlöf, I. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Unterlass, J.E. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Pettke, A. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Boström, J. (Science for Life Laboratory. Division of Clinical Physiology. Department of Laboratory Medicine. Karolinska Institutet) ;
Pandey, M. (Weston Park Cancer Centre. Department of Oncology and Metabolism. University of Sheffield) ;
Gad, H. (Weston Park Cancer Centre. Department of Oncology and Metabolism. University of Sheffield) ;
Herr, P. (Weston Park Cancer Centre. Department of Oncology and Metabolism. University of Sheffield) ;
Jemth, A.S. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
El Andaloussi, S. (Department of Laboratory Medicine. Karolinska Institutet) ;
Kalderén, C. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Rodriguez-Perales, S. (Molecular Cytogenetics Group. Human Cancer Genetics Program. Spanish National Cancer Research Centre (CNIO)) ;
Benítez, J. (Spanish Network on Rare Diseases (CIBERER)) ;
Krokan, H.E. (The Liaison Committee for Education. Research and Innovation in Central Norway) ;
Altun, M. (Science for Life Laboratory. Division of Clinical Physiology. Department of Laboratory Medicine. Karolinska Institutet) ;
Stenmark, P. (Department of Experimental Medical Science. Lund University) ;
Berglund, U.W. (Science for Life Laboratory. Department of Oncology and Pathology. Karolinska Institutet) ;
Helleday, T. (Weston Park Cancer Centre. Department of Oncology and Metabolism. University of Sheffield) ;
Universitat Autònoma de Barcelona
Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e. g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG. [...]
2021 - 10.1093/nar/gkaa1048
Nucleic acids research, Vol. 48 Núm. 21 (february 2021) , p. 12234-12251
|
|
guest ::
email alert
or subscribe to the 
RSS feed.
