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30 p, 1.1 MB |
Molecular characterization of OXA-48 carbapenemase-producing Klebsiella pneumoniae strains after a carbapenem resistance increase in Catalonia
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Argente Viñals, Marc (Institut d'Investigació Biomèdica Sant Pau) ;
Miró, Elisenda (Institut d'Investigació Biomèdica Sant Pau) ;
Martí, Carmina (Hospital General de Granollers) ;
Vilamala, Ana (Consorci Hospitalari de Vic) ;
Alonso-Tarrés, Carles (Fundació Puigvert) ;
Ballester, Frederic (Universitat Rovira i Virgili) ;
Calderón, Ana (Hospital Municipal de Badalona) ;
Gallés, Carmen (Corporació de Salut del Maresme i la Selva) ;
Gasós, Asunción (SJD Barcelona Children's Hospital) ;
Mirelis, Beatriz (Institut d'Investigació Biomèdica Sant Pau) ;
Morta, Montserrat (Hospital Sant Joan de Déu (Manresa)) ;
Olsina, Montserrat (Hospital Quirón Salud) ;
Sauca, Goretti (Hospital de Mataró. Consorci Sanitari del Maresme) ;
Sierra, Montserrat (Universitat de Barcelona) ;
Rivera, Alba (Institut d'Investigació Biomèdica Sant Pau) ;
Navarro Risueño, Ferran (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Introduction: To characterize OXA-48 carbapenemase-producing Klebsiella pneumoniae strains isolated after an increase in carbapenem resistance in Catalonia. Methodology: K. pneumoniae identification, antimicrobial susceptibility studies, the Modified Hodge Test method, amplification of antimicrobial resistance genes (against β-lactamases, quinolones and aminoglycosides), molecular typing (by PFGE and MLST), conjugation assays, plasmid characterization (PBRT-PCR and Southern blot), a description of mobile genetic elements and statistical analysis were done. [...]
Introducción: El objetivo de este estudio fue caracterizar las cepas de Klebsiella pneumoniae productoras de carbapenemasa OXA-48 aisladas tras observar un aumento de estos aislados resistentes a los carbapenémicos en Cataluña. [...]
2019 -  10.1016/j.eimc.2018.02.003
Enfermedades infecciosas y microbiología clínica, Vol. 37, Issue 2 (February 2019) , p. 82-88
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2.
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26 p, 358.3 KB |
Antibiotic resistance genes in phage particles isolated from human faeces and induced from clinical bacterial isolates
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Brown-Jaque, Maryury (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Calero-Cáceres, William (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Espinal, Paula (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Rodríguez-Navarro, Judith (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Miró, Elisenda (Institut d'Investigació Biomèdica Sant Pau) ;
González-López, Juanjo 1975- (Hospital Universitari Vall d'Hebron) ;
Cornejo-Sánchez, Thais (Hospital Universitari Vall d'Hebron) ;
Hurtado, Juan Carlos (Barcelona Institute for Global Health (ISGlobal)) ;
Navarro Risueño, Ferran (Institut d'Investigació Biomèdica Sant Pau) ;
Muniesa, Maite (Institut d'Investigació Biomèdica Sant Pau)
Phage particles have emerged as elements with the potential to mobilise antibiotic resistance genes (ARGs) in different environments, including the intestinal habitat. This study aimed to determine the occurrence of ARGs in phage particles present in faecal matter and induced from strains isolated from faeces. [...]
2018 - 10.1016/j.ijantimicag.2017.11.014
International Journal of Antimicrobial Agents, Vol. 51, Issue 3 (March 2018) , p. 434-442
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3.
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0 p, 2.2 MB |
The identification of intrinsic chloramphenicol and tetracycline resistance genes in members of the bacillus cereus group (sensu lato)
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Glenwright, Helen (Newcastle University. Institute for Cell and Molecular Biology) ;
Pohl, Susanne (Newcastle University. Institute for Cell and Molecular Biology) ;
Navarro Risueño, Ferran (Institut d'Investigació Biomèdica Sant Pau) ;
Miró, Elisenda (Institut d'Investigació Biomèdica Sant Pau) ;
Jiménez, Guillermo (Rubinum, S.A. Research and Development Department) ;
Blanch Gisbert, Anicet Ramon (Universitat de Barcelona. Departament de Microbiologia) ;
Harwood, Colin R. (Newcastle University. Institute for Cell and Molecular Biology)
Bacillus toyonensis strain BCT-7112T (NCIMB 14858T) has been widely used as an additive in animal nutrition for more than 30 years without reports of adverse toxigenic effects. However, this strain is resistant to chloramphenicol and tetracycline and it is generally considered inadvisable to introduce into the food chain resistance determinants capable of being transferred to other bacterial strains, thereby adding to the pool of such determinants in the gastro-enteric systems of livestock species. [...]
2017 - 10.3389/fmicb.2016.02122
Frontiers in microbiology, Vol. 7 (January 2017) , art. 2122
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4.
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Metagenomic analysis of antibiotic-resistance genes and viruses released from glaciers into downstream habitats
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Wang, Yan (Zhejiang University of Technology. College of Environment) ;
Xu, Nuohan (Zhejiang University of Technology. College of Environment) ;
Chen, Bingfeng (Zhejiang University of Technology. College of Environment) ;
Zhang, Zhenyan (Zhejiang University of Technology. College of Environment) ;
Lei, Chaotang (Zhejiang University of Technology. College of Environment) ;
Zhang, Qi (Zhejiang University of Technology. College of Environment) ;
Gu, Yanpeng (Zhejiang University of Technology. College of Environment) ;
Wang, Tingzhang (Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province) ;
Wang, Meixia (Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Qian, Haifeng (Zhejiang University of Technology. College of Environment)
Glaciers serve as effective reservoirs of antibiotic resistance genes (ARGs) and viruses for millions of years. Climate change and anthropogenic activity have accelerated the melting of glaciers, but the patterns of release of ARGs and viruses from melting glaciers into downstream habitats remain unknown. [...]
2024 - 10.1016/j.scitotenv.2023.168310
Science of the total environment, Vol. 908 (Jan. 2024) , art. 168310
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5.
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Antimicrobial peptides in the global microbiome : biosynthetic genes and resistance determinants
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Chen, Bingfeng (Zhejiang University of Technology. College of Environment) ;
Zhang, Zhenyan (Zhejiang University of Technology. College of Environment) ;
Zhang, Qi (Zhejiang University of Technology. College of Environment) ;
Xu, Nuohan Xu (Zhejiang University of Technology. College of Environment) ;
Lu, Tao (Zhejiang University of Technology. College of Environment) ;
Wang, Tingzhang (Key Laboratory of Microbial Technology and Bioinformatics (Zhejiang, Xina)) ;
Hong, Wenjie (Key Laboratory of Microbial Technology and Bioinformatics (Zhejiang, Xina)) ;
Fu, Zhengwei (Zhejiang University of Technology. College of Biotechnology and Bioengineering) ;
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Antimicrobial peptides are a promising new class of antimicrobials that could address the antibiotic resistance crisis, which poses a major threat to human health. These peptides are present in all kingdoms of life, but especially in microorganisms, having multiple origins in diverse taxa. [...]
2023 - 10.1021/acs.est.3c01664
Environmental Science & Technology, Vol. 57, issue 20 (2023) , p.7698-7708
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6.
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17 p, 4.5 MB |
Genomic Characterization of Staphylococcus aureus in Wildlife
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Martínez-Seijas, Carmen (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Mascarós, Patricia (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Lizana, Victor (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Martí-Marco, Alba (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Arnau-Bonachera, Alberto (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Chillida-Martínez, Eva (Universidad CEU Cardenal Herrera. Servicio de Análisis, Investigación, Gestión de Animales Silvestres) ;
Cardells-Peris, Jesús (Universitat Autònoma de Barcelona. Grup de Recerca Wildlife Ecology & Health) ;
Selva, Laura (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Viana, David (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico) ;
Corpa Arenas, Juan Manuel (Universidad CEU Cardenal Herrera. Instituto de Investigación Biomedico)
Staphylococcus aureus is both a commensal and opportunistic pathogen that colonizes human and animal skin and mucosal membranes. It is widely acknowledged that livestock can act as a reservoir for human strains and genetic traits, but less is known about the epidemiological significance of wild animals. [...]
2023 - 10.3390/ani13061064
Animals, Vol. 13 (march 2023)
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14 p, 12.6 MB |
Rational Design of Hydrogels for Cationic Antimicrobial Peptide Delivery : A Molecular Modeling Approach
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Pereira, Alfredo (Universidad de Chile) ;
Valdés-Muñoz, Elizabeth (Universidad Católica del Maule) ;
Marican, Adolfo (Universidad de Talca) ;
Cabrera-Barjas, Gustavo (Universidad de Concepción) ;
Vijayakumar, Sekar (Shandong University) ;
Valdés, Oscar (Universidad Católica del Maule) ;
Rafael, Diana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Universitat de Barcelona. Departament de Farmàcia i Tecnologia Farmacèutica, i Fisicoquímica) ;
Abaca, Paulina (Universidad de Talca. Instituto Ciencias Biologicas) ;
Bustos, Daniel (Universidad Católica del Maule) ;
Durán-Lara, Esteban F. (Universidad de Talca) ;
Universitat Autònoma de Barcelona
In light of the growing bacterial resistance to antibiotics and in the absence of the development of new antimicrobial agents, numerous antimicrobial delivery systems over the past decades have been developed with the aim to provide new alternatives to the antimicrobial treatment of infections. [...]
2023 - 10.3390/pharmaceutics15020474
Pharmaceutics, Vol. 15 (january 2023)
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14 p, 1.7 MB |
A New Variant of the aadE-sat4-aphA-3 Gene Cluster Found in a Conjugative Plasmid from a MDR Campylobacter jejuni Isolate
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Guirado, Pedro (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Miró, Elisenda (Institut d'Investigació Biomèdica Sant Pau) ;
Iglesias Torrens, Yaidelys (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Navarro Risueño, Ferran (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Campoy Sánchez, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Alioto, Tyler Scott (Universitat Pompeu Fabra) ;
Gómez-Garrido, Jessica (Centre de Regulació Genòmica) ;
Madrid Xufré, Cristina (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística) ;
Balsalobre Parra, Carlos (Universitat de Barcelona. Departament de Genètica, Microbiologia i Estadística)
Campylobacter jejuni is a foodborne pathogen causing bacterial gastroenteritis, with the highest incidence reported in Europe. The prevalence of antibiotic resistance in C. jejuni, as well as in many other bacterial pathogens, has increased over the last few years. [...]
2022 - 10.3390/antibiotics11040466
Antibiotics, Vol. 11, Issue 4 (March 2022) , art. 466
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22 p, 5.2 MB |
Comparative Genomics of Clinical and Environmental Isolates of Vibrio spp. of Colombia : Implications of Traits Associated with Virulence and Resistance
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Pérez-Duque, Alejandra (Centro de Bioinformática y Biología Computacional BIOS) ;
Gonzalez-Muñoz, Andrea (Centro de Bioinformática y Biología Computacional BIOS) ;
Arboleda-Valencia, Jorge (Centro de Bioinformática y Biología Computacional BIOS) ;
Vivas-Aguas, Lizbeth Janet (Instituto de Investigaciones Marinas y Costeras José Benito Vives De Andreis INVEMAR) ;
Córdoba-Meza, Tania (Instituto de Investigaciones Marinas y Costeras José Benito Vives De Andreis INVEMAR) ;
Rodriguez-Rey, Ghennie Tatiana (Universidad de Caldas. BIONAT: Grupo de Investigaciones en Biodiversidad y Recursos Naturales) ;
Díaz-Guevara, Paula (Instituto Nacional de Salud. Grupo de Microbiología (Bogotá)) ;
Martinez-Urtaza, Jaime (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Wiesner-Reyes, Magdalena (Instituto Nacional de Salud. Grupo de Microbiología (Bogotá))
There is widespread concern about the increase in cases of human and animal infections caused by pathogenic Vibrio species due to the emergence of epidemic lineages. In Colombia, active surveillance by the National Institute of Health (INS) has confirmed the presence of Vibrio; however, in routine surveillance, these isolates are not genomically characterized. [...]
2021 - 10.3390/pathogens10121605
Pathogens, Vol. 10, Num. 12 (December 2021) , art. 1605
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10.
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11 p, 1.8 MB |
Clonal Spread and Intra- and Inter-Species Plasmid Dissemination Associated With Klebsiella pneumoniae Carbapenemase-Producing Enterobacterales During a Hospital Outbreak in Barcelona, Spain
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Marí-Almirall, Marta (Hospital Clínic i Provincial de Barcelona) ;
Ferrando, Núria (Hospital Clínic i Provincial de Barcelona) ;
Fernández, Mariana José (Hospital Clínic i Provincial de Barcelona) ;
Cosgaya, Clara (Hospital Clínic i Provincial de Barcelona) ;
Viñes, Joaquim (Universitat Autònoma de Barcelona. Servei Veterinari de Genètica Molecular (SVGM)) ;
Rubio, Elisa (Hospital Clínic i Provincial de Barcelona) ;
Cuscó, Anna (Universitat Autònoma de Barcelona. Vetgenomics) ;
Muñoz, Laura (Hospital Clínic i Provincial de Barcelona) ;
Pellice, Martina (Hospital Clínic i Provincial de Barcelona) ;
Vergara, Andrea (Hospital Clínic i Provincial de Barcelona) ;
Campo, Irene (Hospital Clínic i Provincial de Barcelona) ;
Rodríguez-Serna, Laura (Hospital Clínic i Provincial de Barcelona) ;
Santana, Gemina (Hospital Clínic i Provincial de Barcelona) ;
Del Río, Ana (Hospital Clínic i Provincial de Barcelona) ;
Francino, Olga (Universitat Autònoma de Barcelona. Servei Veterinari de Genètica Molecular (SVGM)) ;
Ciruela, Pilar (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Ballester, Frederic (Hospital Universitari Sant Joan de Reus (Tarragona)) ;
Marco, Francesc (Hospital Clínic i Provincial de Barcelona) ;
Martínez, José Antonio (Hospital Clínic i Provincial de Barcelona) ;
Soriano, Álex (Hospital Clínic i Provincial de Barcelona) ;
Pitart, Cristina (Hospital Clínic i Provincial de Barcelona) ;
Vila Estapé, Jordi (Hospital Clínic i Provincial de Barcelona) ;
Roca, Ignasi (Hospital Clínic i Provincial de Barcelona)
Objectives: The study aimed to characterize the clonal spread of resistant bacteria and dissemination of resistance plasmids among carbapenem-resistant Enterobacterales at a tertiary hospital in Catalonia, Spain. [...]
2021 - 10.3389/fmicb.2021.781127
Frontiers in microbiology, Vol. 12 (november 2021)
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