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27 p, 1.2 MB |
Apoptosis mediated by phosphatidylserine externalization in the elimination of aneuploid germ cells during human spermatogenesis
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Garcia-Quevedo, Lydia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Blanco, Joan (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sarrate Navas, Zaida (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Vidal, Francesca (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
It has been described that aneuploidies trigger cell cycle checkpoints leading to apoptosis. The aim of this study was to assess the relationship between the presence of chromosomal abnormalities and apoptosis in germ cells and in Sertoli cells. [...]
2014 -  10.1111/j.2047-2927.2014.00272.x
Andrology, Vol. 2 Núm. 6 (november 2014) , p. 892-898
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3.
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21 p, 2.8 MB |
Involvement of the PI3K/AKT Intracellular Signaling Pathway in the AntiCancer Activity of Hydroxytyrosol, a Polyphenol from Olea europaea, in Hematological Cells and Implication of HSP60 Levels in Its Anti-Inflammatory Activity
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Parra-Perez, Alberto M. (GENYO. Centre for Genomics and Oncological Research: Pfizer. Universidad de Granada) ;
Pérez-Jiménez, Amalia (Universidad de Granada. Departamento de Zoología. Facultad de Ciencias) ;
Gris-Cárdenas, Isabel (CIC bioGUNE. Centre for Cooperative Research in Biosciences) ;
Bonel-Pérez, Gloria C. (Centro Nacional de Investigaciones Oncológicas Carlos III (Espanya)) ;
Carrasco-Díaz, Luis Miguel (Institut d'Investigació Biomèdica Sant Pau) ;
Mokhtari, khalida (Mohammed I University. Laboratory of Bioresources. Biotechnologies. Ethnopharmacology and Health. Department of Biology. Faculty of Sciences) ;
García-Salguero, Encarnacion Leticia (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ;
Lupiáñez, José Antonio (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ;
Rufino-Palomares, Eva E. (Universidad de Granada. Departamento de Bioquímica y Biología Molecular I) ;
Universitat Autònoma de Barcelona
Hydroxytyrosol (HT), the main representative of polyphenols of olive oil, has been described as one of the most powerful natural antioxidants, also showing anti-inflammatory, antimicrobial, cardioprotective and anticancer activity in different type of cancers, but has been little studied in hematological neoplasms. [...]
2022 - 10.3390/ijms23137053
International journal of molecular sciences, Vol. 23 Núm. 13 (july 2022) , p. 7053
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4.
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19 p, 2.6 MB |
A Novel Family of Lysosomotropic Tetracyclic Compounds for Treating Leukemia
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Carbó, José María (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cornet-Masana, Josep Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Cuesta-Casanovas, Laia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Delgado-Martínez, Jennifer (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Banús, Antònia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Clément-Demange, Lise (Leukos Biotech (Barcelona)) ;
Serra, Carme (Institut de Química Avançada de Catalunya) ;
Catena, Juanlo (Institut de Química Avançada de Catalunya) ;
Llebaria, Amadeu (Institut de Química Avançada de Catalunya) ;
Esteve Reyner, Jordi (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Risueño, Ruth M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
In spite of the recent expansion of the therapeutic landscape for acute myeloid leukemia (AML), resistance mechanisms and relapsed disease still pose a serious barrier to achieve curation for most patients. [...]
2023 - 10.3390/cancers15061912
Cancers, Vol. 15 (march 2023)
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5.
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16 p, 2.1 MB |
Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice
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Coral-Pérez, Santiago (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Martel, Ignacio (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-Serrat, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Batallé Melgarejo, Gerard (Institut d'Investigació Biomèdica Sant Pau) ;
Bai, Xue (Institut d'Investigació Biomèdica Sant Pau) ;
Leite-Panissi, C.R.A. (Department of Psychology. Faculty of Philosophy Science and Letters of Ribeirão Preto. University of São Paulo) ;
Pol, Olga (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H) as a new therapy for neurological disorders has been demonstrated. Recent studies prove its analgesic properties in animals with neuropathic pain, but the possible antinociceptive, antidepressant, and/or anxiolytic actions of H during persistent inflammatory pain have not been investigated. [...]
2022 - 10.3390/antiox11112153
Antioxidants, Vol. 11 Núm. 11 (november 2022) , p. 2153
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6.
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10 p, 7.6 MB |
Cell Senescence-Related Pathways Are Enriched in Breast Cancer Patients With Late Toxicity After Radiotherapy and Low Radiation-Induced Lymphocyte Apoptosis
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Aguado-Flor, Ester (Vall d'Hebron Institut d'Oncologia) ;
Fuentes-Raspall, María J. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gonzalo, Ricardo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Alonso, Carmen (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Ramon y Cajal, Teresa (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Fisas, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Seoane, A. (Hospital Universitari Vall d'Hebron) ;
Sánchez, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Giralt López de Sagredo, Jordi (Vall d'Hebron Institut d'Oncologia) ;
Diez, Orland (Hospital Universitari Vall d'Hebron) ;
Gutiérrez-Enríquez, Sara (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
Background: Radiation-induced late effects are a common cause of morbidity among cancer survivors. The biomarker with the best evidence as a predictive test of late reactions is the radiation-induced lymphocyte apoptosis (RILA) assay. [...]
2022 - 10.3389/fonc.2022.825703
Frontiers in Oncology, Vol. 12 (24 2022) , p. 825703
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13 p, 2.1 MB |
Follicular Atresia, Cell Proliferation, and Anti-Mullerian Hormone in Two Neotropical Primates (Aotus nancymae and Sapajus macrocephalus)
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Cardoso, Deise de Lima (Universidade Federal Rural da Amazônia. Programa de Pós-Graduação em Saúde e Produção Animal na Amazônia) ;
Guimarães, Diva Anélie de Araújo (Universidade Federal do Pará. Programa de pós-graduação em Ciência Animal) ;
Mayor Aparicio, Pedro Ginés (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Ferreira, Maria Auxiliadora Pantoja (Universidade Federal do Pará. Programa de pós-graduação em Ciência Animal) ;
Coutinho, Leandro Nassar (Universidade Federal do Pará. Programa de pós-graduação em Ciência Animal) ;
Monteiro, F.O.B (Universidade Federal Rural da Amazônia. Programa de Pós-Graduação em Saúde e Produção Animal na Amazônia)
Reproductive processes in Neotropical primates are still poorly understood. Complications arising in these processes may result in a compromised reproductive condition for a significant portion of these species. [...]
2023 - 10.3390/ani13061051
Animals, Vol. 13 (march 2023)
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8.
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15 p, 3.3 MB |
Methuosis Contributes to Jaspine-B-Induced Cell Death
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Bielsa, Núria (Institut de Química Avançada de Catalunya) ;
Casasampere, Mireia (Institut de Química Avançada de Catalunya) ;
Abad, José Luis (Institut de Química Avançada de Catalunya) ;
Enrich, Carlos (Universitat de Barcelona. Departament de Biomedicina) ;
Delgado, Antonio (Institut de Química Avançada de Catalunya) ;
Fabriàs, Gemma (Institut de Química Avançada de Catalunya) ;
Lizcano de Vega, José Miguel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Casas, Josefina (Institut de Química Avançada de Catalunya)
Methuosis is a type of programmed cell death in which the cytoplasm is occupied by fluid-filled vacuoles that originate from macropinosomes (cytoplasmic vacuolation). A few molecules have been reported to behave as methuosis inducers in cancer cell lines. [...]
2022 - 10.3390/ijms23137257
International journal of molecular sciences, Vol. 23 Núm. 13 (2022) , p. 7257
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9.
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20 p, 24.8 MB |
Constitutive Activation of p62/Sequestosome-1-Mediated Proteaphagy Regulates Proteolysis and Impairs Cell Death in Bortezomib-Resistant Mantle Cell Lymphoma
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Quinet, Grégoire (Laboratoire de Chimie de Coordination (LCC) CNRS-UPR8241) ;
Xolalpa, Wendy (CIC bioGUNE) ;
Reyes Garau, Diana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Profitós-Pelejà, Núria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Azkargorta, Mikel (CICbioGUNE) ;
Ceccato, Laurie (Laboratoire de Chimie de Coordination (LCC) CNRS-UPR8241) ;
Gonzalez-Santamarta, María (Laboratoire de Chimie de Coordination (LCC) CNRS-UPR8241) ;
Marsal, Maria (Institut de Ciències Fotòniques) ;
Andilla, Jordi (Institut de Ciències Fotòniques) ;
Aillet, Fabienne (CIC bioGUNE) ;
Bosch, Francesc (Vall d'Hebron Institut d'Oncologia) ;
Elortza, Felix (CICbioGUNE) ;
Loza-Alvarez, Pablo (Institut de Ciències Fotòniques) ;
Sola, Brigitte (INSERM UMR1245. Unicaen) ;
Coux, Olivier (Centre de Recherche de Biologie Cellulaire de Montpellier (CRBM) CNRS-UMR 5237. Université de Montpellier) ;
Matthiesen, Rune (Computational and Experimental Biology Group. CEDOC-Chronic Diseases Research Center. Universidade Nova de Lisboa) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodriguez, Manuel S. (Laboratoire de Chimie de Coordination (LCC) CNRS-UPR8241)
Protein ubiquitylation coordinates crucial cellular events in physiological and pathological conditions. A comparative analysis of the ubiquitin proteome from bortezomib (BTZ)-sensitive and BTZ-resistant mantle cell lymphoma (MCL) revealed an enrichment of the autophagy-lysosome system (ALS) in BTZ-resistant cells. [...]
2022 - 10.3390/cancers14040923
Cancers, Vol. 14 Núm. 4 (Feb. 2022) , art. 923
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10.
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15 p, 2.1 MB |
MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia
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Manzano-Muñoz, A. (Institut de Bioenginyeria de Catalunya) ;
Alcon, Clara (Institut de Bioenginyeria de Catalunya) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ramírez, Manuel (Department of Pediatric Hematology and Oncology. Niño Jesús University Children's Hospital) ;
Seyfried, F. (Department of Pediatrics and Adolescent Medicine. Ulm University Medical Center) ;
Debatin, K.M. (Department of Pediatrics and Adolescent Medicine. Ulm University Medical Center) ;
Meyer, L.H. (Department of Pediatrics and Adolescent Medicine. Ulm University Medical Center) ;
Samitier, J. (Networking Biomedical Research Center in Bioengineering. Biomaterials and Nanomedicine (CIBER-BBN)) ;
Montero, J. (Institut de Bioenginyeria de Catalunya)
Multiple targeted therapies are currently explored for pediatric and young adult B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment. However, this new armamentarium of therapies faces an old problem: choosing the right treatment for each patient. [...]
2021 - 10.3389/fcell.2021.695225
Frontiers in Cell and Developmental Biology, Vol. 9 (september 2021) , art. 695225
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