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1.
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18 p, 3.4 MB |
Single-cell multi-omics analysis of COVID-19 patients with pre-existing autoimmune diseases shows aberrant immune responses to infection
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Barmada, Anis (Department of Medical Genetics. University of Cambridge) ;
Handfield, Louis-François (Wellcome Sanger Institute (Regne Unit)) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Arutyunyan, Anna (Wellcome Sanger Institute (Regne Unit)) ;
Andrés-León, Eduardo (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Hoo, Regina (Wellcome Sanger Institute (Regne Unit)) ;
Porter, Tarryn (Wellcome Sanger Institute (Regne Unit)) ;
Oszlanczi, Agnes (Wellcome Sanger Institute (Regne Unit)) ;
Richardson, Laura (Wellcome Sanger Institute (Regne Unit)) ;
Calero-Nieto, Fernando (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Wilson, Nicola K. (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Marchese, Domenica (Centre de Regulació Genòmica) ;
Sancho-Serra, Carmen (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Presas-Rodríguez, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ramo-Tello, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ruiz-Sanmartin, Adolfo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ferrer, Ricard (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ruiz-Rodriguez, Juan Carlos (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez Gallo, Mónica (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Munera-Campos, Mónica (Institut Germans Trias i Pujol) ;
Carrascosa, José Manuel (Institut Germans Trias i Pujol) ;
Göttgens, Berthold (Department of Haematology and Wellcome & MRC Cambridge Stem Cell Institute. University of Cambridge) ;
Heyn, Holger (Universitat Pompeu Fabra) ;
Prigmore, Elena (Wellcome Sanger Institute (Regne Unit)) ;
Casafont-Solé, Ivette (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Solanich, Xavier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez-Cerrillo, Idelfonso (Department of Immunology. Hospital Universitario La Princesa) ;
González-Álvaro, Isidoro (Rheumatology Service. Hospital Universitario La Princesa) ;
Raimondo, Maria Gabriella (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ;
Ramming, Andreas (Deutsches Zentrum Immuntherapie. Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen) ;
Martin, Javier (Instituto de Parasitología y Biomedicina "López-Neyra") ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vento-Tormo1, Roser (Wellcome Sanger Institute. Wellcome Genome Campus) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. [...]
2024 -  10.1002/eji.202350633
European Journal of Immunology, Vol. 54 Núm. 1 (january 2024) , p. 2350633
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2.
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12 p, 506.2 KB |
IgG anti-high density lipoprotein antibodies are elevated in abdominal aortic aneurysm and associated with lipid profile and clinical features
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Rodríguez-Carrio, J. (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Lindholt, J.S. (Odense University Hospital (Dinamarca)) ;
Canyelles, Marina (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-López, D. (IIS-Fundación Jiménez Díaz) ;
Tondo, Mireia (Institut d'Investigació Biomèdica Sant Pau) ;
Blanco-Colio, Luis Miguel (IIS-Fundación Jiménez Díaz) ;
Michel, J.B. (Hospital Bichat Claude Bernard) ;
Escolà-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ;
Suárez, A. (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Martín-Ventura, J.L. (IIS-Fundación Jiménez Díaz) ;
Universitat Autònoma de Barcelona
High-density lipoproteins cholesterol (HDLc) levels are decreased in abdominal aortic aneurysm (AAA), which is hallmarked by autoimmunity and lipid aortic deposits. To investigate whether IgG anti-HDL antibodies were present in AAA and their potential association with clinical features, IgG anti-HDL and total IgG along with HDLc plasma levels were measured in 488 AAA patients and 184 controls from the Viborg Vascular (VIVA) study, and in tissue-conditioned media from AAA intraluminal thrombus and media layer samples compared to control aortas. [...]
2020 - 10.3390/jcm9010067
Journal of clinical medicine, Vol. 9 Núm. 1 (january 2020) , p. 67
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3.
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27 p, 6.2 MB |
Immunoregulatory Biomarkers of the Remission Phase in Type 1 Diabetes : miR-30d-5p Modulates PD-1 Expression and Regulatory T Cell Expansion
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Gómez Muñoz, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Murillo-Vallés, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Armengol, Maria Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alcalde, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Català, Martí (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sunye, Sergi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Valls, Aina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez Sánchez, Jacobo (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Corripio, Raquel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Vives Pi, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The partial remission (PR) phase of type 1 diabetes (T1D) is an underexplored period characterized by endogenous insulin production and downmodulated autoimmunity. To comprehend the mechanisms behind this transitory phase and develop precision medicine strategies, biomarker discovery and patient stratification are unmet needs. [...]
2023 - 10.3390/ncrna9020017
Non-Coding RNA, Vol. 9 (february 2023)
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4.
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6 p, 453.4 KB |
Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
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Gimenez-Perez, Gabriel (Hospital General de Granollers) ;
Vlacho, Bogdan (Institut d'Investigació Biomèdica Sant Pau) ;
Navas, Elena (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Mata-Cases, Manel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Real, Jordi (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Cos, Xavier (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Franch-Nadal, Josep (Institut Català de la Salut. Centre d'Atenció Primària Raval Sud (Barcelona, Catalunya)) ;
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
AIM: To assess the prevalence of autoimmune diseases (AID) in patients with type 1 diabetes (T1D) and to evaluate whether the rate of diabetes-related complications differs depending on the presence of AID. [...]
2022 - 10.1016/j.diabres.2022.110031
Diabetes research and clinical practice, Vol. 191 (january 2022) , p. 110031
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5.
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6.
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10 p, 2.2 MB |
Role of B Cell Profile for Predicting Secondary Autoimmunity in Patients Treated With Alemtuzumab
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Walo-Delgado, Paulette Esperanza (Hospital Universitario Ramón y Cajal (Madrid)) ;
Monreal, Enric (Hospital Universitario Ramón y Cajal (Madrid)) ;
Medina, Silvia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Quintana, Ester (Institut d'Investigació Biomèdica de Girona) ;
Sainz de la Maza, Susana (Hospital Universitario Ramón y Cajal (Madrid)) ;
Fernández-Velasco, José Ignacio (Hospital Universitario Ramón y Cajal (Madrid)) ;
Lapuente, Paloma (Hospital Universitario Ramón y Cajal (Madrid)) ;
Comabella, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramió-Torrentà, Lluís (Institut d'Investigació Biomèdica de Girona) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Midaglia, Luciana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Villarrubia, Noelia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Carrasco-Sayalero, Angela (Hospital Universitario Ramón y Cajal (Madrid)) ;
Rodríguez-Martín, Eulalia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Roldán, Ernesto (Hospital Universitario Ramón y Cajal (Madrid)) ;
Meca-Lallana, José (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Alvarez-Lafuente, Roberto (Hospital Clínico San Carlos (Madrid)) ;
Masjuan, Jaime (Hospital Universitario Ramón y Cajal (Madrid)) ;
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid)) ;
Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ;
Universitat Autònoma de Barcelona
UDHEBRON.
To explore if baseline blood lymphocyte profile could identify relapsing remitting multiple sclerosis (RRMS) patients at higher risk of developing secondary autoimmune adverse events (AIAEs) after alemtuzumab treatment. [...]
2021 - 10.3389/fimmu.2021.760546
Frontiers in immunology, Vol. 12 (october 2021)
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7.
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8 p, 1.1 MB |
Autoimmunity and long-term safety and efficacy of alemtuzumab for multiple sclerosis : Benefit/risk following review of trial and post-marketing data
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Coles, Alasdair J. (University of Cambridge) ;
Jones, Joanne L. (University of Cambridge) ;
Vermersch, Patrick (Université de Lille) ;
Traboulsee, Anthony (University of British Columbia) ;
Bass, Ann D. (Neurology Center of San Antonio) ;
Boster, Aaron (Boster Center for Multiple Sclerosis) ;
Chan, Andrew (University of Bern) ;
Comi, Giancarlo (Vita-Salute San Raffaele University) ;
Fernández, Óscar (Hospital Regional Universitario Carlos Haya (Málaga)) ;
Giovannoni, Gavin (Queen Mary University of London) ;
Kubala Havrdova, Eva (Charles University) ;
LaGanke, Christopher (North Central Neurology Associates) ;
Montalban, Xavier (Hospital Universitari Vall d'Hebron) ;
Oreja-Guevara, Celia (Universidad Complutense de Madrid) ;
Piehl, Fredrik (Karolinska Institutet (Estocolm, Suècia)) ;
Wiendl, Heinz (University of Münster) ;
Ziemssen, Tjalf (Dresden University of Technology) ;
Universitat Autònoma de Barcelona
Does preexisting or treatment-emergent autoimmunity increase the risk of subsequent autoimmune disease in individuals with relapsing-remitting multiple sclerosis (MS) after alemtuzumab? In the extended phase 2/3 trials, 34/96 (35. [...]
2022 - 10.1177/13524585211061335
Multiple sclerosis, Vol. 28 Núm. 5 (2022) , p. 842-846
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8.
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10 p, 1.3 MB |
Coordinated local RNA overexpression of complement induced by interferon gamma in myositis
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Casal-Dominguez, Maria (Johns Hopkins University School of Medicine) ;
Pinal-Fernandez, Iago (Johns Hopkins University School of Medicine) ;
Pak, Katherine (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Muñoz-Braceras, Sandra (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Milisenda, Jose C. (Hospital Clínic i Provincial de Barcelona) ;
Torres-Ruiz, Jiram (Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán) ;
Dell'Orso, Stefania (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Naz, Faiza (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Gutierrez-Cruz, Gustavo (National Institute of Arthritis and Musculoskeletal and Skin Diseases) ;
Duque-Jaimez, Yaiza (Hospital Clínic i Provincial de Barcelona) ;
Matas-Garcia, Ana (Hospital Clínic i Provincial de Barcelona) ;
Valls-Roca, Laura (Hospital Clínic i Provincial de Barcelona) ;
Garrabou, Glòria (Hospital Clínic i Provincial de Barcelona) ;
Trallero-Araguas, Ernesto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Walitt, Brian (National Institute of Neurological Disorders and Stroke) ;
Christopher-Stine, Lisa (Johns Hopkins University School of Medicine) ;
Lloyd, Thomas E. (Johns Hopkins University School of Medicine) ;
Paik, Julie J. (Johns Hopkins University School of Medicine) ;
Albayda, Jemima (Johns Hopkins University School of Medicine) ;
Corse, Andrea (Johns Hopkins University School of Medicine) ;
Grau, Josep Maria (Hospital Clínic i Provincial de Barcelona) ;
Selva O'Callaghan, Albert (Universitat Autònoma de Barcelona) ;
Mammen, Andrew L. (Johns Hopkins University School of Medicine)
Complement proteins are deposited in the muscles of patients with myositis. However, the local expression and regulation of complement genes within myositis muscle have not been well characterized. In this study, bulk RNA sequencing (RNAseq) analyses of muscle biopsy specimens revealed that complement genes are locally overexpressed and correlate with markers of myositis disease activity, including the expression of interferon-gamma (IFN γ)-induced genes. [...]
2023 - 10.1038/s41598-023-28838-z
Scientific reports, Vol. 13 (february 2023)
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9.
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18 p, 2.5 MB |
Transfection of Vitamin D3-Induced Tolerogenic Dendritic Cells for the Silencing of Potential Tolerogenic Genes. Identification of CSF1R-CSF1 Signaling as a Glycolytic Regulator
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Mansilla Lopez, Maria Jose (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
González-Larreategui, Íñigo (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Figa-Martín, Neus (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barallat, Jaume (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fondelli, Federico (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Sellés-Rius, Ares (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Quirant, Bibiana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Teniente Serra, Aina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Martínez Cáceres, Eva María (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The use of autologous tolerogenic dendritic cells (tolDC) has become a promising strategy to re-establish immune tolerance in autoimmune diseases. Among the different strategies available, the use of vitamin D3 for the generation of tolDC (VitD3-tolDC) has been widely tested because of their immune regulatory properties. [...]
2021 - 10.3390/ijms22147363
International journal of molecular sciences, Vol. 22, Num. 14 (July 2021) , art. 7363
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10.
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16 p, 5.7 MB |
The synovial and blood monocyte DNA methylomes mirror prognosis, evolution, and treatment in early arthritis
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de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ramírez, Julio (Hospital Clínic i Provincial de Barcelona) ;
Celis, Raquel (Hospital Clínic i Provincial de Barcelona) ;
Azuaga, Ana Belén (Hospital Clínic i Provincial de Barcelona) ;
Cuervo, Andrea (Hospital Clínic i Provincial de Barcelona) ;
Graell, Eduard (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pérez-García, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Díaz Torne, César (Institut d'Investigació Biomèdica Sant Pau) ;
Salvador, Georgina (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya)) ;
Gómez-Puerta, Jose A. (Hospital Clínic i Provincial de Barcelona) ;
Haro, Isabel (Institut de Química Avançada de Catalunya) ;
Sanmartí, Raimon (Hospital Clínic i Provincial de Barcelona) ;
Cañete, Juan D (Hospital Clínic i Provincial de Barcelona) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Identifying predictive biomarkers at early stages of inflammatory arthritis is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes (MOs) and macrophages, largely associated with arthritis, are contributors and sensors of inflammation through epigenetic modifications. [...]
2022 - 10.1172/jci.insight.158783
JCI Insight, Vol. 7 Núm. 9 (september 2022) , p. e158783
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