Resultats globals: 9 registres trobats en 0.03 segons.
Articles, 8 registres trobats
Documents de recerca, 1 registres trobats
Articles 8 registres trobats  
1.
14 p, 4.5 MB Effects of Sigma-1 Receptor Ligands on Peripheral Nerve Regeneration / Cottilli, Patrick (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gaja Capdevila, Núria (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Peripheral nerve injuries lead to the loss of motor, sensory and autonomic functions in the territories supplied by the injured nerve. Currently, nerve injuries are managed by surgical repair procedures, and there are no effective drugs in the clinic for improving the capacity of axonal regeneration. [...]
2022 - 10.3390/cells11071083
Cells, Vol. 11 Núm. 7 (2022) , art. 1083  
2.
26 p, 9.8 MB Presenilin/γ-secretase-dependent epha3 processing mediates axon elongation through non-muscle myosin IIA / Javier, Miriam (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Marco, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Rocandio, Daniel (Institut de Recerca Biomèdica de Lleida) ; Pons Vizcarra, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Janes, Peter W. (Tumour Targeting Program. Olivia Newton-John Cancer Research Institute) ; Lackmann, Martin (Department of Biochemistry and Molecular Biology. Monash University) ; Egea, Joaquim (Institut de Recerca Biomèdica de Lleida) ; Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain. [...]
2019 - 10.7554/eLife.43646
eLife, Vol. 8 (october 2019) , p. e43646  
3.
36 p, 10.5 MB Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism / Malone, Samuel Andrew (Jean-Pierre Aubert Research Center) ; Papadakis, Georgios E. (Lausanne University Hospital) ; Messina, Andrea (Lausanne University Hospital) ; Mimouni, Nour El Houda (Jean-Pierre Aubert Research Center) ; Trova, Sara (Jean-Pierre Aubert Research Center) ; Imbernon, Monica (Jean-Pierre Aubert Research Center) ; Allet, Cecile (Jean-Pierre Aubert Research Center) ; Cimino, Irene (Jean-Pierre Aubert Research Center) ; Acierno, James (Lausanne University Hospital) ; Cassatella, Daniele (Lausanne University Hospital) ; Xu, Cheng (Lausanne University Hospital) ; Quinton, Richard (University of Newcastle-upon-Tyne. Institute of Genetic Medicine) ; Szinnai, Gabor (University Children's Hospital Basel (Basilea, Suïssa)) ; Pigny, Pascal (Centre de Biologie Pathologie Génétique. Service Hormonologie Métabolisme Nutrition Oncologie) ; Alonso-Cotchico, Lur (Universitat Autònoma de Barcelona. Departament de Química) ; Masgrau, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ; Prevot, V. (Jean-Pierre Aubert Research Center) ; Pitteloud, Nelly (Lausanne University Hospital) ; Giacobini, Polo (Jean-Pierre Aubert Research Center)
Congenital hypogonadotropic hypogonadism (CHH) is a condition characterized by absent puberty and infertility due to gonadotropin releasing hormone (GnRH) deficiency, which is often associated with anosmia (Kallmann syndrome, KS). [...]
2019 - 10.7554/eLife.47198
eLife, Vol. 8 (2019) , art. e47198  
4.
26 p, 1.2 MB Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors / Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia) ; Santos, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Delgado Martínez, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències) ; de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giudetti, Guido (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Micera, Silvestro (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Segregation of regenerating motor and sensory axons may be a good strategy to improve selective functionality of regenerative interfaces to provide closed-loop commands. Provided that extracellular matrix components and neurotrophic factors exert guidance effects on different neuronal populations, we assessed in vivo the potential of separating sensory and motor axons regenerating in a bicompartmental Y-type tube, with each branch prefilled with an adequate combination of extracellular matrix and neurotrophic factors. [...]
2018 - 10.1002/term.2629
Journal of tissue engineering and regenerative medicine, Vol. 12, Issue 4 (April 2018) , p. e1991-e2000  
5.
13 p, 3.4 MB Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage / Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Isus, Laura (Institut de Recerca Biomèdica de Lleida) ; Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Mancuso, Francesco M. (Vall d'Hebron Institut d'Oncologia) ; Borràs, Eva (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ; Sabidó, Eduard (Universitat Pompeu Fabra. Centre de Regulació Genòmica (CRG-UPF)) ; Forés Vineta, Joaquim (Hospital Clínic i Provincial de Barcelona) ; Aloy, Patrick (Institució Catalana de Recerca i Estudis Avançats)
Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a regenerative reaction, depending injury proximity among other factors. [...]
2015 - 10.1038/srep09185
Scientific reports, Vol. 5 (2015) , art. 9185  
6.
16 p, 7.1 MB Preferential enhancement of sensory and motor axon regeneration by combining extracellular matrix components with neurotrophic factors / Santos, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ; González Pérez, Francisco J. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Giudetti, Guido (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Micera, Silvestro (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ; Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
After peripheral nerve injury, motor and sensory axons are able to regenerate but inaccuracy of target reinnervation leads to poor functional recovery. Extracellular matrix (ECM) components and neurotrophic factors (NTFs) exert their effect on different neuronal populations creating a suitable environment to promote axonal growth. [...]
2017 - 10.3390/ijms18010065
International journal of molecular sciences, Vol. 18 Núm. 1 (January 2017)  
7.
43 p, 2.0 MB Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo / Santos, Daniel (Universitat Autònoma de Barcelona) ; Giudetti, Guido (Scuola Superiore Sant׳Anna (Pontedera, Itàlia)) ; Micera, Silvestro (Scuola Superiore Sant׳Anna (Pontedera, Itàlia)) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Del Valle, Jaume (Universitat Autònoma de Barcelona. Institut de Neurociències)
Neurotrophic factors (NTFs) promote nerve regeneration and neuronal survival after peripheral nerve injury. However, drawbacks related with administration and bioactivity during long periods limit their therapeutic application. [...]
2016 - 10.1016/j.brainres.2016.01.051
Brain research, Vol. 1636 (2016) , p. 93-106  
8.
13 p, 844.6 KB A TrkB/EphrinA interaction controls retinal axon branching and synaptogenesis / Marler, Katharine J. M. (MRC Centre for Developmental Neurobiology) ; Becker-Barroso, Elena (MRC Centre for Developmental Neurobiology) ; Martínez, Albert (Institut de Recerca Biomèdica de Lleida) ; Llovera, Marta (Institut de Recerca Biomèdica de Lleida) ; Wentzel, Corinna (MRC Centre for Developmental Neurobiology) ; Poopalasundaram, Subathra (MRC Centre for Developmental Neurobiology) ; Hindges, Robert (MRC Centre for Developmental Neurobiology) ; Soriano García, Eduardo (Institut de Recerca Biomèdica de Lleida) ; Comella i Carnicé, Joan Xavier, 1963- (Institut de Recerca Biomèdica de Lleida) ; Drescher, Uwe (MRC Centre for Developmental Neurobiology)
Toward understanding topographically specific branching of retinal axons in their target area, we have studied the interaction between neurotrophin receptors and members of the Eph family. TrkB and its ligand BDNF are uniformly expressed in the retina and tectum, respectively, and exert a branch-promoting activity, whereas EphAs and ephrinAs are expressed in gradients in retina and tectum and can mediate a suppression of axonal branching. [...]
2008 - 10.1523/JNEUROSCI.1915-08.2008
The Journal of neuroscience, Vol. 28, No. 48 (Nov. 2008) , p. 12700-12712  

Documents de recerca 1 registres trobats  
1.
209 p, 3.9 MB Role of PS/γ-secretase-mediated signaling during neuronal development and degeneration / Javier, Miriam ; Saura Antolín, Carlos, dir. ; Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular
Presenilina-1 (PS1), el component catalític de γ-secretasa que regula el processament de múltiples proteïnes transmembrana, es troba mutada en la majoria de casos d'Alzheimer familiar (FAD). Evidències recents indiquen que mutacions en PS1 lligades a FAD redueixen el processament de múltiples proteïnes transmembrana, suggerint un mecanisme de pèrdua de funció. [...]
Presenilin-1 (PS1), the catalytic component of γ-secretase that regulates the processing of multiple transmembrane proteins is mutated in the majority of cases of familial Alzheimer's disease (FAD). [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2019.  

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