Resultados globales: 7 registros encontrados en 0.02 segundos.
Artículos, Encontrados 6 registros
Documentos de investigación, Encontrados 1 registros
Artículos Encontrados 6 registros  
1.
9 p, 821.2 KB Biallelic germline BRCA1 mutations in a patient with early onset breast cancer, mild Fanconi anemia-like phenotype, and no chromosome fragility / Keupp, Katharina (Center for Familial Breast and Ovarian Cancer. Center for Integrated Oncology (CIO). University of Cologne) ; Hampp, Stephanie (Department of Obstetrics and Gynecology. Ulm University) ; Hübbel, Annette (Center for Familial Breast and Ovarian Cancer. Center for Integrated Oncology (CIO). University of Cologne) ; Maringa, Monika (Center for Familial Breast and Ovarian Cancer. Center for Integrated Oncology (CIO). University of Cologne) ; Kostezka, Sarah (Department of Obstetrics and Gynecology. Ulm University) ; Rhiem, Kerstin (Center for Familial Breast and Ovarian Cancer. Center for Integrated Oncology (CIO). University of Cologne) ; Waha, Anke (Center for Familial Breast and Ovarian Cancer. Center for Integrated Oncology (CIO). University of Cologne) ; Wappenschmidt, Barbara (Center for Familial Breast and Ovarian Cancer. Center for Integrated Oncology (CIO). University of Cologne) ; Pujol, Roser. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Surrallés i Calonge, Jordi (Instistut d'Investigació Biomèdica Sant Pau) ; Schmutzler, Rita K. (Center for Familial Breast and Ovarian Cancer. Center for Integrated Oncology (CIO). University of Cologne) ; Wiesmüller, Lisa (Department of Obstetrics and Gynecology. Ulm University) ; Hahnen, Eric (Center for Familial Breast and Ovarian Cancer. Center for Integrated Oncology (CIO). University of Cologne)
Background: Biallelic BRCA1 mutations are regarded either embryonically lethal or to cause Fanconi anemia (FA), a genomic instability syndrome characterized by bone marrow failure, developmental abnormalities, and cancer predisposition. [...]
2019 - 10.1002/mgg3.863
Molecular genetics & genomic medicine, Vol. 7 Núm. 9 (january 2019) , p. e863  
2.
7 p, 306.9 KB Genetic counselling and testing of susceptibility genes for therapeutic decision-making in breast cancer-an European consensus statement and expert recommendations / Singer, C.F. (Medical University of Vienna. Department of Obstetrics and Gynecology) ; Balmaña, J. (Hospital Universitari Vall d'Hebron) ; Bürki, N. (University Hospital Basel (UHB)) ; Delaloge, S. (Gustave Roussy) ; Filieri, M.E. (University Hospital of Modena) ; Gerdes, A.M. (Rigshospitalet) ; Grindedal, E.M. (Oslo University Hospital) ; Han, S. (UZ Leuven) ; Johansson, O. (Landspitali-the National University Hospital of Iceland) ; Kaufman, B. (Breast Oncology Institute. Sheba Medical Center) ; Krajc, M. (Institute of Oncology Ljubljana) ; Loman, N. (Lund University Hospital) ; Olah, E. (National Institute of Oncology) ; Paluch-Shimon, S. (Shaare Zedek Medical Centre) ; Plavetic, N.D. (University of Zagreb) ; Pohlodek, K. (Comenius University of Bratislava) ; Rhiem, K. (University Hospital of Cologne) ; Teixeira, M. (Portuguese Oncology Institute) ; Evans, D.G. (University of Manchester) ; Universitat Autònoma de Barcelona ; VHIO
An international panel of experts representing 17 European countries and Israel convened to discuss current needs and future developments in BRCA testing and counselling and to issue consensus recommendations. [...]
2019 - 10.1016/j.ejca.2018.10.007
European journal of cancer, Vol. 106 (january 2019) , p. 54-60  
3.
18 p, 288.5 KB Translational research opportunities regarding homologous recombination in ovarian cancer / Romeo Marín, Margarita (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Pardo, J.C. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Cardús, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Quiroga, Vanesa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Martínez Román, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Solé, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Margelí, Mireia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Universitat Autònoma de Barcelona
Homologous recombination (HR) is a DNA repair pathway that is deficient in 50% of high-grade serous ovarian carcinomas (HGSOC). Deficient HR (DHR) constitutes a therapeutic opportunity for these patients, thanks to poly (ADP-ribose) polymerases (PARP) inhibitors (PARPi; olaparib, niraparib, and rucaparib are already commercialized). [...]
2018 - 10.3390/ijms19103249
International journal of molecular sciences, Vol. 19 Núm. 10 (19 2018) , p. 3249  
4.
19 p, 13.4 MB Germline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis : evidence for metformin-based "starvation" strategies in BRCA1 carriers / Cuyàs, Elisabet (Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain) ; Fernández-Arroyo, Salvador (Hospital Universitari Sant Joan de Reus) ; Alarcón, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques) ; Joven, Jorge (Hospital Universitari Sant Joan de Reus) ; Menendez, Javier A. (Molecular Oncology Group, Girona Biomedical Research Institute (IDIBGI), Girona, Catalonia, Spain)
We hypothesized that women inheriting one germline mutation of the BRCA1 gene ("one-hit") undergo cell-type-specific metabolic reprogramming that supports the high biosynthetic requirements of breast epithelial cells to progress to a fully malignant phenotype. [...]
2016 - 10.18632/oncotarget.9732
Oncotarget, Vol. 7 (may 2016) , p. 52974-52992  
5.
6 p, 538.4 KB Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer / Bonanno, Laura (Medical Oncology 2 Unit, Istituto Oncologico Veneto I.R.C.C.S, Via Gattamelata 64, 35128 Padova, Italy) ; Costa, Carlota (Laboratory of translational Oncology, Pangaea Biotech, Sabino de Arana, 5-9, Barcelona, Spain) ; Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ; Sanchez, Jose-Javier (Universidad Autónoma de Madrid) ; Rodriguez, Ignacio (Universitat Autònoma de Barcelona. Institut Universitari Dexeus) ; Gimenez-Capitan, Ana (Laboratory of translational Oncology, Pangaea Biotech, Sabino de Arana, 5-9, Barcelona, Spain) ; Molina-Vila, Miquel Angel (Laboratory of translational Oncology, Pangaea Biotech, Sabino de Arana, 5-9, Barcelona, Spain) ; Vergnenegre, Alain (Hospital du Cluzeau, 23, rue Larey, Limoges, France) ; Massuti, Bartomeu (Medical Oncology, General Hospital of Alicante, 11, Baeza, 03010 Alicante, Spain) ; Favaretto, Adolfo (Medical Oncology 2 Unit, Istituto Oncologico Veneto I.R.C.C.S, Via Gattamelata 64, 35128 Padova, Italy) ; Rugge, Massimo (Cytology and Pathology, Università degli Studi di Padova, Via Gabelli 61, Padova, Italy) ; Pallares, Cinta (Institut d'Investigació Biomèdica Sant Pau) ; Taron, Miquel (Universitat Autònoma de Barcelona. Institut Universitari Dexeus) ; Rosell, Rafael (Universitat Autònoma de Barcelona. Institut Universitari Dexeus) ; Universitat Autònoma de Barcelona
BRCA1 is a main component of homologous recombination and induces resistance to platinum in preclinical models. It has been studied as a potential predictive marker in lung cancer. Several proteins modulate the function of BRCA1. [...]
2016 - 10.1186/s12885-016-2339-5
BMC Cancer, Vol. 16 (may 2016)  
6.
13 p, 3.9 MB Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome / Menendez, Javier A. (Institut d'Investigació Biomèdica (Girona)) ; Folguera-Blasco, Núria (Centre de Recerca Matemàtica) ; Cuyàs Navarro, Elisabet (Institut d'Investigació Biomèdica (Girona)) ; Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ; Joven, Jorge (Hospital Universitari de Sant Joan) ; Alarcón Cor, Tomás (Universitat Autònoma de Barcelona. Departament de Matemàtiques)
The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. [...]
2016 - 10.18632/oncotarget.7867
Oncotarget, Vol. 7, issue 11 (March 2016) , p. 11959-11971  

Documentos de investigación Encontrados 1 registros  
1.
1 p, 1.5 MB Chromatin plasticity in the DNA damage response: a key player in double-strand break repair pathway choice / García Moro, Eva ; Universitat Autònoma de Barcelona. Facultat de Biociències
2018
Grau en Ciències Biomèdiques [832]  

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