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Usefulness of liquid biopsy biomarkers from aqueous humor in predicting anti-VEGF response in diabetic macular edema : results of a pilot study
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Udaondo, Patricia (Department of Ophthalmology, Hospital Universitari i Politècnic La Fe) ;
Hernández Pascual, Cristina (Vall d'Hebron Insitut de Recerca) ;
Briansó Llort, Laura (Universitat Autònoma de Barcelona) ;
García-Delpech, Salvador (Department of Ophthalmology, Hospital Universitari i Politècnic La Fe) ;
Simó-Servat, Olga (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Simó, Rafael (Universitat Autònoma de Barcelona. Departament de Medicina)
The objective was to investigate the usefulness of the "liquid biopsy" of aqueous humor (AH) to predict the clinical response after intravitreal injections (IVT) of anti-VEGF agents for treating diabetic macular edema (DME). [...]
2019 -  10.3390/jcm8111841
Journal of Clinical Medicine, Vol. 8 (2019), p. 1-9
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Compartmentalized immune response in leishmaniasis : Changing patterns throughout the disease
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Rodríguez-Cortés, Alhelí. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Carrillo, Eugenia. (Centro Nacional de Microbiología. Leishmaniasis and Chagas Disease Unit) ;
Martorell, Susanna (Zoetis Inc.) ;
Todolí, Felicitat (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Ojeda, Ana (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martínez-Flórez, Alba (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Urniza, Alicia (Zoetis Inc.) ;
Moreno, Javier (Centro Nacional de Microbiología. Leishmaniasis and Chagas Disease Unit) ;
Alberola, Jordi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Visceral leishmaniasis (VL) is characterized by loss of T-cell responsiveness and absence of Leishmania-specific IFN-γ production by peripheral blood mononuclear cells. However, the expressions of IFN-γ and TNF-α are up-regulated in the tissues and plasma of VL patients. [...]
2016 - 10.1371/journal.pone.0155224
PLoS ONE, Vol. 11 Núm. 5 (january 2016) , p. e0155224
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8 p, 201.2 KB |
Simple, low-cost and timely optical biosensors for the detection of epigenetics biomarkers : the future of cancer diagnosis
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Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ;
Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
The cancer burden continues to grow with enormous physical, emotional, and financial pressure on individuals, families, communities, and health systems. Early detection and effective treatment are crucial. [...]
2017
European Medical Journal Oncology, Vol. 5, Núm. 1 (October 2017) , p. 54-61
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27 p, 1.1 MB |
Early sepsis diagnosis via protein and miRNA biomarkers using a novel point-of-care photonic biosensor
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Fabri Faja, Nuria (Institut Català de Nanociència i Nanotecnologia) ;
Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ;
Dey, Priyanka (Institut Català de Nanociència i Nanotecnologia) ;
Terborg, Roland A. (ICFO—Institut de Ciències Fotòniques) ;
Estévez Alberola, Maria Carmen (Institut Català de Nanociència i Nanotecnologia) ;
Belushkin, Alexander (École Polytechnique Fédérale de Lausanne) ;
Yesilköy, Filiz (École Polytechnique Fédérale de Lausanne) ;
Duempelmann, Luc (ICFO—Institut de Ciències Fotòniques) ;
Altug, Hatice (École Polytechnique Fédérale de Lausanne) ;
Pruneri, Valerio (Institució Catalana de Recerca i Estudis Avançats) ;
Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Sepsis is a condition characterized by a severe stage of blood-infection often leading to tissue damage, organ failure and finally death. Fast diagnosis and identification of the sepsis stage (sepsis, severe sepsis or septic shock) is critical for the patient's evolution and could help in defining the most adequate treatment in order to reduce its mortality. [...]
2019 - 10.1016/j.aca.2019.05.038
Analytica chimica acta, Vol. 1077 (October 2019) , p. 232-242
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12 p, 1.3 MB |
Early measurement of interleukin-10 predicts the absence of CT scan lesions in mild traumatic brain injury
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Lagerstedt,Linnéa (University of Geneva. Department of Human Protein Sciences) ;
Egea Guerrero, Juan José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Rodríguez Rodríguez, Ana (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Bustamante Rangel, Alejandro (Vall d'Hebron Institut de Recerca) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
El Rahal, Amir (Geneva University Hospitals. Department of Clinical Neurosciences.) ;
Andereggen, Elisabeth (Geneva University Hospitals. Emergency Center) ;
Rinaldi, Lara (Geneva University Hospitals. Department of Surgery) ;
Sarrafzadeh, Asita (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Schaller, Karl (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Sanchez, Jean-Charles (University of Geneva. Department of Human Protein Sciences)
Traumatic brain injury is a common event where 70%–90% will be classified as mild TBI (mTBI). Among these, only 10% will have a brain lesion visible via CT scan. A triage biomarker would help clinicians to identify patients with mTBI who are at risk of developing a brain lesion and require a CT scan. [...]
2019 - 10.1371/journal.pone.0193278
PloS one, Vol. 13 Núm. 2 (2019) , p. e0193278
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13 p, 3.4 MB |
Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
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Lagerstedt, Linnéa (University of Geneva. Department of Specialities of Internal Medicine) ;
Egea Guerrero, Juan José (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Bustamante rangel, Alejandro (Vall d'Hebron Institut de Recerca) ;
Rodríguez Rodríguez, Ana (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Quintana, Manuel (Hospital Universitario La Paz (Madrid)) ;
García Armengol, Roser (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prica, Carmen Melinda (Hospital de Tortosa Verge de la Cinta) ;
Andereggen, Elisabeth (Geneva University Hospitals. Emergency Center) ;
Rinaldi, Lara (Geneva University Hospitals. Department of Surgery) ;
Sarrafzadeh, Asita (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Schaller, Karl (Geneva University Hospitals. Department of Clinical Neurosciences) ;
Montaner, Joan (Vall d'Hebron Institut de Recerca) ;
Sanchez, Jean-Charles (University of Geneva. Department of Specialities of Internal Medicine)
Mild traumatic brain injury (mTBI) patients may have trauma-induced brain lesions detectable using CT scans. However, most patients will be CT-negative. There is thus a need for an additional tool to detect patients at risk. [...]
2017 - 10.1371/journal.pone.0200394
PloS one, Vol. 12 Núm. 9 (2017) , p. e0185072
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11 p, 1.2 MB |
Alzheimer's disease in Down syndrome : An overlooked population for prevention trials
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Strydom, André (South London and Maudsley NHS Foundation Trust) ;
Coppus, Antonia (Department of Primary and Community Care, Radboud University Medical Center, Nijmegen) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Danek, Adrian (Department of Neurology, Ludwig-Maximilians-Universität München) ;
Fortea, Juan (Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down) ;
Hardy, John (Reta Lila Weston Institute, Institute of Neurology, University College London) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) site Munich) ;
Nuebling, Georg (Department of Neurology, Ludwig-Maximilians-Universität München) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Ritchie, Craig (Centre for Clinical Brain Sciences. University of Edinburgh) ;
van Duijn, Cornelia (Department of Epidemiology, Erasmus Medical Centre, Rotterdam) ;
Zaman, Shahid (Cambridgeshire & Peterborough NHS Foundation Trust (CBFT), Fulbourn Hospital) ;
Zetterberg, Henrik (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital) ;
Universitat Autònoma de Barcelona
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. [...]
2018 - 10.1016/j.trci.2018.10.006
Alzheimer's & Dementia : Translational Research & Clinical Interventions, Vol. 4 (december 2018) , p. 703-713
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8 p, 500.4 KB |
Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer
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Siena, S (Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy) ;
Sartore-Bianchi, A (Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, Milan, Italy) ;
Garcia-Carbonero, R (Department of Medical Oncology, Hospital Universitario 12 de Octubre, CNIO, CIBERONC, Universidad Complutense, Madrid, Spain) ;
Karthaus, M (Department for Hematology and Oncology, Staedt Klinikum Neuperlach and Harlaching, Munich, Germany) ;
Smith, D (Department of Gastroenterology, University Hospital of Bordeaux, Hopital Haut Levaeque, Bordeaux, France) ;
Tabernero, J (Universitat Autònoma de Barcelona) ;
Van Cutsem, E (KU Leuven, Leuven, Belgium) ;
Guan, X (Amgen Inc., Thousand Oaks, CA, USA) ;
Boedigheimer, M (Amgen Inc., Thousand Oaks, CA, USA) ;
Ang, A (Amgen Inc., Thousand Oaks, CA, USA) ;
Twomey, B (Amgen Inc., Thousand Oaks, CA, USA) ;
Bach, B A (Amgen Inc., Thousand Oaks, CA, USA) ;
Jung, A S (Amgen Inc., Thousand Oaks, CA, USA) ;
Bardelli, A (Department of Oncology, University of Torino, Candiolo, Italy)
Mutations in rat sarcoma (RAS) genes may be a mechanism of secondary resistance in epidermal growth factor receptor inhibitor-treated patients. Tumor-tissue biopsy testing has been the standard for evaluating mutational status; however, plasma testing of cell-free DNA has been shown to be a more sensitive method for detecting clonal evolution. [...]
2017 - 10.1093/annonc/mdx504
Annals of oncology, Vol. 29 (september 2017) , p. 119-126
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9 p, 590.6 KB |
A baseline metabolomic signature is associated with immunological CD4 + T-cell recovery after 36 months of antiretroviral therapy in HIV-infected patients
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Rodríguez-Gallego, Esther (Hospital Universitari Joan XXIII) ;
Gómez, Josep (Hospital Universitari Joan XXIII) ;
Pacheco, Yolanda M. (Instituto de Biomedicina de Sevilla) ;
Peraire, Joaquim (Hospital Universitari Joan XXIII) ;
Viladés, Consuelo (Hospital Universitari Joan XXIII) ;
Beltrán Debón, Raúl (Hospital Universitari Joan XXIII) ;
Mallol, Roger (Universitat Rovira i Virgili. Departament d'Enginyeria Electrònica) ;
López Dupla, Miguel (Hospital Universitari Joan XXIII) ;
Veloso, Sergi (Hospital Universitari Joan XXIII) ;
Alba, Verónica (Hospital Universitari Joan XXIII) ;
Blanco, Julià (Institut Germans Trias i Pujol. Fundació IrsiCaixa) ;
Cañellas, Nicolau (Universitat Rovira i Virgili. Departament d'Enginyeria Electrònica) ;
Rull, Anna (Hospital Universitari Joan XXIII) ;
Leal, Manuel (Instituto de Biomedicina de Sevilla) ;
Correig, Xavier (Universitat Rovira i Virgili. Departament d'Enginyeria Electrònica) ;
Domingo, Pere (Domingo Pedrol) (Institut d'Investigació Biomèdica Sant Pau) ;
Vidal, Francesc (Hospital Universitari Joan XXIII)
Poor immunological recovery in treated HIV-infected patients is associated with greater morbidity and mortality. To date, predictive biomarkers of this incomplete immune reconstitution have not been established. [...]
2018 - 10.1097/QAD.0000000000001730
AIDS (London, England), Vol. 32 (march 2018) , p. 565-573
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