|
1.
|
|
18 p, 8.2 MB |
SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations
/
Banerjee, Kuheli (Heidelberg University) ;
Lin, Yanzhu (EHeidelberg University) ;
Gahn, Johannes (Heidelberg University) ;
Cordero, Julio (German Centre for Cardiovascular Research) ;
Gupta, Purnima (Heidelberg University) ;
Mohamed, Islam (Heidelberg University) ;
Graupera, Mariona (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Dobreva, Gergana (German Centre for Cardiovascular Research) ;
Schwartz, Martin A. (Yale School of Medicine) ;
Ola, Roxana (Heidelberg University)
Vascular networks form, remodel, and mature under the influence of both fluid shear stress (FSS) and soluble factors. Physiological FSS promotes and maintains vascular stability via synergy with bone morphogenic proteins 9 and 10 (BMP9 and BMP10). [...]
2023 -  10.1172/JCI168352
The journal of clinical investigation, Vol. 133 Núm. 18 (15 2023) , p. e168352
|
|
|
2.
|
|
15 p, 2.7 MB |
Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
/
García Gómez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martín Sánchez, Montserrat (Universidad de Salamanca) ;
San Segundo, Laura (Universidad de Salamanca) ;
Muntión, Sandra (Universidad de Salamanca) ;
Morales, Xabier (Universidad de Navarra) ;
Ortiz de Solórzano, Carlos (Universidad de Navarra) ;
Oyarzabal, Julen (Universidad de Navarra) ;
San José Enériz, Edurne (Universidad de Navarra) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques) ;
Agirre, Xabier (Universidad de Navarra) ;
Prosper, Felipe (Universidad de Navarra) ;
Garayoa, Mercedes (Universidad de Salamanca) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. [...]
2021 - 10.1038/s41467-020-20715-x
Nature communications, Vol. 12 Núm. 1 (december 2021) , p. 421
|
|
|
3.
|
|
15 p, 3.5 MB |
Identification of an Immunosuppressive Cell Population during Classical Swine Fever Virus Infection and Its Role in Viral Persistence in the Host
/
Bohórquez Garzón, José Alejandro (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Muñoz-González, Sara (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Pérez-Simó, Marta (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
Revilla, Concepción (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya)) ;
Domínguez, Javier (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya)) ;
Ganges, Llilianne (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal)
Classical swine fever virus (CSFV) remains a highly important pathogen, causing major losses in the swine industry. Persistent infection is highly relevant for CSFV maintenance in the field; however, this form of infection is not fully understood. [...]
2019 - 10.3390/v11090822
Viruses, Vol. 11 (september 2019)
|
|
|
4.
|
|
|
5.
|
|
7 p, 1.6 MB |
Fibronectin-coating enhances attachment and proliferation of mesenchymal stem cells on a polyurethane meniscal scaffold
/
Arredondo, Raquel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Poggioli, Francesco (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Martínez-Díaz, Santos (Hospital del Mar (Barcelona, Catalunya)) ;
Piera-Trilla, María (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torres-Claramunt, Raúl (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tío Barrera, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Monllau García, Joan Carles (Hospital del Mar (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Partial meniscectomy is one of the most common surgical strategy for a meniscal injury, but sometimes, patients complain of knee pain due to an overload in the ablated compartment. In these cases, implantation of tissue engineering scaffold could be indicated. [...]
2021 - 10.1016/j.reth.2021.11.001
Regenerative Therapy, Vol. 18 (november 2021) , p. 480-486
|
|
|
6.
|
|
|
7.
|
|
9 p, 925.7 KB |
The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction : the BAMI trial
/
Mathur, Anthony (Centre for Cardiovascular Medicine & Devices, Queen Mary University of London) ;
Fernández Avilés, F. (Hospital General Universitario Gregorio Marañón) ;
Bartunek, Jozef (Cardiovascular Center, OLV Hospital Aalst) ;
Belmans, Ann (KU) ;
Crea, Filippo (Fondazione Policlinico Universitario A. Gemelli IRCCS) ;
Dowlut, Sheik (Centre for Cardiovascular Medicine & Devices, Queen Mary University of London) ;
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Good, Marie-Claire (Queen Mary University of London) ;
Hartikainen, Juha (Kuopio University Hospital ( Finlàndia)) ;
Hauskeller, Christine (University of Exeter) ;
Janssens, Stefan (University Hospitals Leuven (Bèlgica)) ;
Kala, Petr (University Hospital Brno (República Txeca)) ;
Kastrup, Jens (University of Copenhagen) ;
Martin, John (University College London) ;
Menasché, Philippe (Department of Cardiovascular Surgery, Hôpital Européen Georges Pompidou and University of Paris) ;
Sanz-Ruiz, Ricardo (Hospital General Universitario Gregorio Marañón) ;
Ylä-Herttuala, Seppo (University of Eastern Finland) ;
Zeiher, Andreas Michael (Department of Medicine III, Goethe University of Frankfurt) ;
Universitat Autònoma de Barcelona
Bone marrow-derived mononuclear cell (BM-MNC) therapy may improve myocardial recovery in patients following acute myocardial infarction (AMI), though existing trial results are inconsistent. Originally an open-label, multicentre Phase III trial, BAMI was designed to demonstrate the safety and efficacy of intracoronary infusion of BM-MNCs in reducing the time to all-cause mortality in patients with reduced left ventricular ejection fraction (LVEF, ≤45%) after primary angioplasty (PPCI) for ST-elevation AMI. [...]
2020 - 10.1093/eurheartj/ehaa651
European heart journal, Vol. 41 (august 2020) , p. 3702-3710
|
|
|
8.
|
|
11 p, 4.3 MB |
Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1 G93A mice
/
Martínez Muriana, Anna (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pastor, Diego (UMH-CSIC. Instituto de Neurociencias) ;
Mancuso, Renzo (KU Leuven. VIB Center for Brain and Disease Research) ;
Rando, Amaya (Universidad de Zaragoza. Laboratorio de Genética Bioquímica) ;
Osta, Rosario (Universidad de Zaragoza. Laboratorio de Genética Bioquímica) ;
Martínez, Salvador (UMH-CSIC. Instituto de Neurociencias) ;
López Vales, Rubèn (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Facultat de Medicina)
The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect both central and peripheral nervous system in a murine model of ALS. [...]
2020 - 10.1186/s13287-020-1573-6
Stem cell research & therapy, Vol. 11 (february 2020)
|
|
|
9.
|
|
11 p, 7.8 MB |
Osteogenic commitment of Wharton's jelly mesenchymal stromal cells : Mechanisms and implications for bioprocess development and clinical application
/
Cabrera-Pérez, Raquel (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rojas-Márquez, R. (Centre de Regulació Genòmica) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rudilla, F. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: Orthopaedic diseases are one of the major targets for regenerative medicine. In this context, Wharton's jelly (WJ) is an alternative source to bone marrow (BM) for allogeneic transplantation since its isolation does not require an invasive procedure for cell collection and does not raise major ethical concerns. [...]
2019 - 10.1186/s13287-019-1450-3
Stem cell research & therapy, Vol. 10 Núm. 1 (28 2019) , p. 356
|
|
|
10.
|
|
36 p, 10.5 MB |
Defective AMH signaling disrupts GnRH neuron development and function and contributes to hypogonadotropic hypogonadism
/
Malone, Samuel Andrew (Jean-Pierre Aubert Research Center) ;
Papadakis, Georgios E. (Lausanne University Hospital) ;
Messina, Andrea (Lausanne University Hospital) ;
Mimouni, Nour El Houda (Jean-Pierre Aubert Research Center) ;
Trova, Sara (Jean-Pierre Aubert Research Center) ;
Imbernon, Monica (Jean-Pierre Aubert Research Center) ;
Allet, Cecile (Jean-Pierre Aubert Research Center) ;
Cimino, Irene (Jean-Pierre Aubert Research Center) ;
Acierno, James (Lausanne University Hospital) ;
Cassatella, Daniele (Lausanne University Hospital) ;
Xu, Cheng (Lausanne University Hospital) ;
Quinton, Richard (University of Newcastle-upon-Tyne. Institute of Genetic Medicine) ;
Szinnai, Gabor (University Children's Hospital Basel (Basilea, Suïssa)) ;
Pigny, Pascal (Centre de Biologie Pathologie Génétique. Service Hormonologie Métabolisme Nutrition Oncologie) ;
Alonso-Cotchico, Lur (Universitat Autònoma de Barcelona. Departament de Química) ;
Masgrau, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ;
Prevot, V. (Jean-Pierre Aubert Research Center) ;
Pitteloud, Nelly (Lausanne University Hospital) ;
Giacobini, Polo (Jean-Pierre Aubert Research Center)
Congenital hypogonadotropic hypogonadism (CHH) is a condition characterized by absent puberty and infertility due to gonadotropin releasing hormone (GnRH) deficiency, which is often associated with anosmia (Kallmann syndrome, KS). [...]
2019 - 10.7554/eLife.47198
eLife, Vol. 8 (2019) , art. e47198
|
|
visitant ::
identificació
alerta personal via correu electrònic o subscribiu-vos al 
canal RSS.
