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8 p, 798.4 KB |
Circulating markers of bone turnover
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Vervloet, Marc G. (Amsterdam UMC. University Medical Center) ;
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Brandenburg, Vincent M. (RWTH University Hospital Aachen (Alemanya)) ;
Covic, Adrian ;
Cozzolino, Mario ;
Evenepoel, Pieter ;
Goldsmith, David ;
Massy, Ziad ;
Mazzaferro, Sandro ;
Ureña-Torres, Pablo ;
Universitat Autònoma de Barcelona
Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. [...]
2017 -  10.1007/s40620-017-0408-8
Journal of Nephrology, Vol. 30 Núm. 5 (january 2017) , p. 663-670
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16 p, 956.0 KB |
Vitamin D, a modulator of musculoskeletal health in chronic kidney disease
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Molina, Pablo (Universitat de València) ;
Carrero, Juan J. (Karolinska Institutet (Estocolm, Suècia)) ;
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Chauveau, Philippe (Centre Hospitalier Universitaire de Bordeaux et Aurad-Aquitaine) ;
Mazzaferro, Sandro (Sapienza University of Rome) ;
Ureña-Torres, Pablo (University of Paris Descartes) ;
Universitat Autònoma de Barcelona
The spectrum of activity of vitamin D goes beyond calcium and bone homeostasis, and growing evidence suggests that vitamin D contributes to maintain musculoskeletal health in healthy subjects as well as in patients with chronic kidney disease (CKD), who display the combination of bone metabolism disorder, muscle wasting, and weakness. [...]
2017 - 10.1002/jcsm.12218
Journal of Cachexia, Sarcopenia and Muscle, Vol. 8 Núm. 5 (october 2017) , p. 686-701
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3.
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8 p, 316.8 KB |
Solid organ transplantation after hematopoietic stem cell transplantation in childhood : A multicentric retrospective survey
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Faraci, Maura (Istituto G Gaslini) ;
Bertaina, Alice (Stanford University) ;
Dalissier, Arnaud (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Ifversen, Marianne (Copenhagen University Hospital) ;
Schulz, Ansgar (University Medical Center) ;
Gennery, Andrew (Great North Children's Hospital) ;
Burkhardt, Birgit (University Hospital of Münster (Alemanya)) ;
Badell Serra, Isabel (Institut d'Investigació Biomèdica Sant Pau) ;
Díaz de Heredia, Cristina (Vall d'Hebron Institut d'Oncologia) ;
Lanino, Edoardo (Istituto G Gaslini) ;
Lankester, Arjan C. (Leiden University Medical Center) ;
Gruhn, Bernd (Jena University Hospital (Alemania)) ;
Matthes-Martin, Susanne Medical University of Vienna ;
Kühl, Joern S. (Universitätsklinikum Leipzig) ;
Varotto, Stefania (University Hospital of Padova (Pàdua, Itàlia)) ;
Paillard, Catherine (Hôpital Hautepierre) ;
Guilmatre, Audrey (Hôpital Armand Trousseau (París, França)) ;
Sastre, Ana (Hospital Universitario La Paz (Madrid)) ;
Abecasis, Manuel (Instute Portugues Oncologia Lisboa) ;
Garwer, Birgit (University Hospital Eppendorf) ;
Sedlacek, Petr (University Hospital Motol) ;
Boelens, Jaap Jan (Memorial Sloan Kettering Cancer Center) ;
Beohou, Eric (European Society for Blood and Marrow Transplantation Pediatric Disease Working Party) ;
Bader, Peter (University Hospital of Frankfurt (Alemanya)) ;
Universitat Autònoma de Barcelona
We report data obtained from a retrospective multicenter pediatric survey on behalf of the European Society for Blood and Marrow Transplantation (EBMT). Information on solid organ transplantation (SOT) performed in pediatric recipients of either autologous or allogeneic hematopoietic stem cell transplantation (HSCT) between 1984 and 2016 was collected in 20 pediatric EBMT Centers (25. [...]
2019 - 10.1111/ajt.15240
American Journal of Transplantation, Vol. 19 Núm. 6 (june 2019) , p. 1798-1805
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13 p, 587.1 KB |
Post-authorisation safety study of burosumab use in paediatric, adolescent and adult patients with X-linked hypophosphataemia : rationale and description
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Brandi, Maria Luisa (FIRMO Foundation (Itàlia)) ;
Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron) ;
Beck-Nielsen, Signe (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Boot, Annemieke (University of Groningen) ;
Briot, Karine (Université de Paris) ;
de Lucas-Collantes, Carmen (Universidad Autónoma de Madrid) ;
Emma, Francesco (Bambino Gesù Children's Hospital IRCCS (Itàlia)) ;
Giannini, Sandro (University of Padua) ;
Haffner, Dieter (Children's Hospital (Alemanya)) ;
Keen, Richard (Royal National Orthopaedic Hospital NHS Trust (Regne Unit)) ;
Levtchenko, Elena (University Hospitals Leuven) ;
Mӓkitie, Outi (Helsinki University Hospital) ;
Nilsson, Ola (Karolinska Institutet and University Hospital) ;
Schnabel, Dirk (Charitè, University Medicine) ;
Tripto-Shkolnik, Liana (Tel-Aviv University) ;
Zillikens, Maria Carola (Department of Internal Medicine, Erasmus MC Bone Center - Erasmus University Medical Center, Rotterdam (Holanda)) ;
Liu, Jonathan (Kyowa Kirin International (Regne Unit)) ;
Tudor, Alina (Kyowa Kirin International (Regne Unit)) ;
Mughal, M. Zulf (Royal Manchester Children's Hospital) ;
Universitat Autònoma de Barcelona
X-linked hypophosphataemia (XLH) is a rare, inherited, phosphate-wasting disorder that elevates fibroblast growth factor 23 (FGF23), causing renal phosphate-wasting and impaired active vitamin D (1,25(OH)D) synthesis. [...]
2022 - 10.1177/20406223221117471
Therapeutic Advances in Chronic Disease, Vol. 13 (september 2022)
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5.
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17 p, 1.5 MB |
Pathophysiology of bone disease in chronic kidney disease : from basics to renal osteodystrophy and osteoporosis
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Aguilar, Armando (IMSS General Hospital of Zone No 2. Mexican Social Security) ;
Gifre, Laia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ureña-Torres, Pablo (University of Paris Descartes) ;
Carrillo-López, Natalia (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Rodriguez-García, Minerva (Hospital Universitario Central Asturias) ;
Massó, Elisabeth (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
da Silva, Iara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
López-Báez, Víctor Alfonso (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sánchez-Baya, Maya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Prior-Español, Águeda (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Urrutia, Marina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Paul, Javier (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bustos, Misael C. (Pontificia Catholic University of Chile) ;
Vila Santandreu, Anna (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Garnica-León, Isa (IMSS General Hospital of Zone No 2. Mexican Social Security) ;
Navarro-González, Juan F. (Universidad de La Laguna) ;
Mateo, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bover, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Chronic kidney disease (CKD) is a highly prevalent disease that has become a public health problem. Progression of CKD is associated with serious complications, including the systemic CKD-mineral and bone disorder (CKD-MBD). [...]
2023 - 10.3389/fphys.2023.1177829
Frontiers in physiology, Vol. 14 (june 2023)
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12 p, 944.6 KB |
Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B-5) chronic kidney disease : an open cohort multivariable and propensity score analysis from Funen, Denmark
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Ali, M. Sanni (London School of Hygiene and Tropical Medicine. Department of Non-communicable Disease Epidemiology) ;
Ernst, Martin (University of Southern Denmark. Department of Public Health, Clinical Pharmacology and Pharmacy) ;
Robinson, Danielle E. (University of Oxford. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences) ;
Caskey, Fergus (University of Bristol. Population Health Sciences) ;
Arden, N. K (MRC Lifecourse Epidemiology Unit) ;
Ben-Shlomo, Yoav (University of Bristol. Population Health Sciences) ;
Nybo, Mads (Odense University Hospital (Dinamarca)) ;
Rubin, Katrine H. (University of Southern Denmark. Department of Health) ;
Judge, Andrew (MRC Lifecourse Epidemiology Unit) ;
Cooper, Cyrus (MRC Lifecourse Epidemiology Unit) ;
Javaid, M. K. (MRC Lifecourse Epidemiology Unit) ;
Hermann, Anne P. (Odense University Hospital (Dinamarca)) ;
Prieto-Alhambra, Daniel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Universitat Autònoma de Barcelona
Bisphosphonates are contraindicated in moderate-to-severe chronic kidney disease patients. However, they are used to prevent fragility fractures in patients with impaired kidney function, despite a lack of evidence on their effects on bone density in these patients. [...]
2020 - 10.1007/s11657-020-00746-z
Archives of Osteoporosis, Vol. 15 (june 2020)
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7.
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13 p, 4.7 MB |
Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis
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Agraz-Doblás, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rogers, R. B. (Department of Medicine. University of Cambridge. Cambridge Biomedical Campus) ;
Roy, A. (Department of Paediatrics. University of Oxford) ;
Schneider, P. (Princess Maxima Center for Pediatric Oncology) ;
Bardini, Michela (Università degli Studi di Milano-Bicocca) ;
Ballerini, Paola (Pediatric Hematology. A. Trousseau Hospital) ;
Cazzaniga, Giovanni (Centro Ricerca Tettamanti. Department of Pediatrics. University of Milano Bicocca. Fondazione MBBM) ;
Moreno, T. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Revilla, C. (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Gut, Marta (Universitat Pompeu Fabra) ;
Valsecchi, M. G. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Roberts, I. (MRC Molecular Haematology Unit. MRC Weatherall Institute of Molecular Medicine. University of Oxford) ;
Pieters, R. (Princess Maxima Center for Pediatric Oncology) ;
De Lorenzo, P. (Interfant Trial Data Center. University of Milano-Bicocca) ;
Varela, Ignacio (Instituto de Biomedicina y Biotecnología de Cantabria. Universidad de Cantabria-CSIC) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Stam, R. W. (Princess Maxima Center for Pediatric Oncology) ;
Universitat Autònoma de Barcelona
Bcell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1 (MLL-AF4) infant B-cell acute lymphoblastic leukemia remains difficult to model, and the pathogenic contribution in cancer of the reciprocal fusions resulting from derivative translocated-chromosomes remains obscure. [...]
2019 - 10.3324/haematol.2018.206375
Haematologica, Vol. 104 Núm. 6 (2019) , p. 1176-1188
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11 p, 4.3 MB |
Combined intramuscular and intraspinal transplant of bone marrow cells improves neuromuscular function in the SOD1 G93A mice
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Martínez Muriana, Anna (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pastor, Diego (UMH-CSIC. Instituto de Neurociencias) ;
Mancuso, Renzo (KU Leuven. VIB Center for Brain and Disease Research) ;
Rando, Amaya (Universidad de Zaragoza. Laboratorio de Genética Bioquímica) ;
Osta, Rosario (Universidad de Zaragoza. Laboratorio de Genética Bioquímica) ;
Martínez, Salvador (UMH-CSIC. Instituto de Neurociencias) ;
López Vales, Rubèn (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Facultat de Medicina)
The simultaneous contribution of several etiopathogenic disturbances makes amyotrophic lateral sclerosis (ALS) a fatal and challenging disease. Here, we studied two different cell therapy protocols to protect both central and peripheral nervous system in a murine model of ALS. [...]
2020 - 10.1186/s13287-020-1573-6
Stem cell research & therapy, Vol. 11 (february 2020)
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9.
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9 p, 1.2 MB |
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone
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Westhrin, Marita (Norwegian University of Science and Technology) ;
Holien, Toril (St Olav's University Hospital) ;
Zahoor, Muhammad (Norwegian University of Science and Technology) ;
Moen, Siv Helen (Norwegian University of Science and Technology) ;
Buene, Glenn (Norwegian University of Science and Technology) ;
Størdal, Berit (Norwegian University of Science and Technology) ;
Hella, Hanne (Norwegian University of Science and Technology) ;
Yuan, Huipin (Kuros Biosciences) ;
de Bruijn, Joost D. (Queen Mary University of London) ;
Martens, Anton (University Medical Center. Cancer Center Amsterdam) ;
Groen, Richard W. J. (University Medical Center. Cancer Center Amsterdam) ;
Bosch i Tubert, Fàtima (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Smith, Ulf (Sahlgrenska University Hospital (Suècia)) ;
Sponaas, Anne-Marit (Norwegian University of Science and Technology) ;
Sundan, Anders (Norwegian University of Science and Technology) ;
Standal, Therese (St Olav's University Hospital)
Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation. [...]
2019 - 10.1002/jbm4.10247
JBMR Plus, Vol. 4 (november 2019)
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10.
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6 p, 617.5 KB |
The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction : rationale and design of the trial
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Mathur, Anthony (Queen Mary University of London) ;
Arnold, Roman (Hospital Clínico Universitario de Valladolid) ;
Assmus, Birgit (Johann-Wolfgang-Goethe University (Germany)) ;
Bartunek, Jozef (VZW Cardiovascular Research Center Aalst (Belgium)) ;
Belmans, Ann (KU Leuven-University of Leuven & Universiteit Hasselt (Belgium)) ;
Bönig, Halvard (Johann-Wolfgang-Goethe University (Germany)) ;
Crea, Filippo (Catholic University of the Sacred Heart (Italy)) ;
Dimmeler, Stefanie (Johann-Wolfgang-Goethe University (Germany)) ;
Dowlut, Sheik (Queen Mary University of London) ;
Fernández Avilés, F. (Hospital General Universitario Gregorio Marañón) ;
Galiñanes, Manuel (Hospital Universitari Vall d'Hebron) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron) ;
Hartikainen, Juha (Kuopio University Hospital ( Finlàndia)) ;
Hill, Jonathan (King's College Hospital NHS Foundation Trust) ;
Hogardt-Noll, Annette (t2cure (Germany)) ;
Homsy, Christian (Celyad SA (Belgium)) ;
Janssens, Stefan (University Hospitals Leuven (Bèlgica)) ;
Kala, Petr (Faculty Hospital and Masaryk University (Czech Republic)) ;
Kastrup, Jens (University of Copenhagen) ;
Martin, John (University College London (UK)) ;
Menasche, Philippe (University Paris Descartes. Assistance Publique Hopitaux de Paris (France)) ;
Miklik, Roman (Faculty Hospital and Masaryk University (Czech Republic)) ;
Mozid, Abdul (Barts Heart Centre (UK)) ;
San Román, J. Alberto (Hospital Clínico Universitario de Valladolid) ;
Sanz-Ruiz, Ricardo (Hospital General Universitario Gregorio Marañón) ;
Tendera, Michal (Medical University of Silesia (Poland)) ;
Wojakowski, Wojtek (Medical University of Silesia (Poland)) ;
Ylä-Herttuala, Seppo (Kuopio University Hospital ( Finlàndia)) ;
Zeiher, Andreas (Johann-Wolfgang-Goethe University (Germany)) ;
Universitat Autònoma de Barcelona
Over the past 13 years bone marrow-derived mononuclear cells () have been widely investigated for clinical efficacy in patients following acute myocardial infarction (). These early phase trials have used various surrogate markers to judge efficacy and, although promising, the results have been inconsistent. [...]
2017 - 10.1002/ejhf.829
European Journal of Heart Failure, Vol. 19, Issue 11 (November 2017) , p. 1545-1550
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