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19 p, 792.0 KB |
“Drug Research” : una secuencia contextualizada de indagación sobre mitosis, cáncer y creación del conocimiento científico
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Domenech Casal, Jordi (Universitat Autònoma de Barcelona. Departament de Didàctica de la Matemàtica i de les Ciències Experimentals)
La adquisición de habilidades y perspectivas científicas es clave en la educación científica de los futuros ciudadanos. A pesar de los esfuerzos que se realizan en este sentido, el alumnado conserva una visión estereotipada y rígida del método y el conocimiento científico. [...]
Acquiring scientific skills and perspectives is a key point in science education. In spite of the efforts on this field, students keep a rigid and stereotyped image of the creation of the scientific knowledge. [...]
L'acquisition d'habiletés et perspectives scientifiques est un point clé chez l'éducation scientifique. Malgré les efforts mis en œuvre, les élèves maintiennent une image rigide et stéréotypée de la méthode et le savoir scientifique. [...]
2016
Investigación en la escuela, Núm. 88 (2016) , p. 93-111
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9 p, 1.9 MB |
Intravesical Mycobacterium brumae triggers both local and systemic immunotherapeutic responses against bladder cancer in mice
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Noguera Ortega, Estela (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Rabanal Prados, Rosa Mª (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Gómez-Mora, Elisabet (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Cabrera Navarro, Cecilia (Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol) ;
Luquín Fernández, Marina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Julián, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The standard treatment for high-risk non-muscle invasive bladder cancer (BC) is the intravesical administration of live Mycobacterium bovis BCG. Previous studies suggest improving this therapy by implementing non-pathogenic mycobacteria, such as Mycobacterium brumae, and/or different vehicles for mycobacteria delivery, such as an olive oil (OO)-in-water emulsion. [...]
2018 -  10.1038/s41598-018-33253-w
Scientific Reports, Núm. 8 (2018)
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12 p, 1.7 MB |
Mycobacteria emulsified in olive oil-in-water trigger a robust immune response in bladder cancer treatment
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Noguera Ortega, Estela (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Blanco-Cabra, Núria (The Barcelona Institute of Science and Technology. Bacterial Infections and Antimicrobial Therapies) ;
Rabanal Prados, Rosa Mª (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Sánchez-Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Roldán, Mónica (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Guallar Garrido, Sandra (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Torrents Serra, Eduard (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Luquín Fernández, Marina (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Julián Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i Microbiologia)
The hydrophobic composition of mycobacterial cell walls leads to the formation of clumps when attempting to resuspend mycobacteria in aqueous solutions. Such aggregation may interfere in the mycobacteria-host cells interaction and, consequently, influence their antitumor effect. [...]
2016 - 10.1038/srep27232
Scientific Reports, 6 Juny 2016
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5 p, 273.4 KB |
¿Facilita el optimismo la eficacia de una terapia basada en emociones positivas en pacientes de cáncer?
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Louro, Andre (Instituto Português de Oncologia Francisco Gentil) ;
Blasco, Tomás (Universitat Autònoma de Barcelona. Grup d'Investigació en Estrès i Salut) ;
Fernández-Castro, Jordi (Universitat Autònoma de Barcelona. Grup d'Investigació en Estrès i Salut)
No está claro si el optimismo modera el efecto de las intervenciones psicológicas en pacientes de cáncer. El presente trabajo analiza si el optimismo se relacionaba con la eficacia de una intervención basada en la potenciación de emociones positivas en una muestra de 24 pacientes de cáncer colorrectal que la recibieron mientras se les administraba quimioterapia. [...]
It is not clear whether optimism moderates the effect of psychological interventions on cancer patients. The present paper analyzes whether optimism was related to the effectiveness of an intervention based on the potentiation of positive emotions in a sample of 24 colorectal cancer patients who received over chemotherapy. [...]
2018 - 10.5565/rev/qpsicologia.1467
Quaderns de psicologia, Vol. 20 Núm. 3 (2018) , p. 287-291 (Notas de Investigación)
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7 p, 176.2 KB |
Incorporating BEAMing technology as a liquid biopsy into clinical practice for the management of colorectal cancer patients : an expert taskforce review
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García-Foncillas, J (Hospital Universitario Fundación Jiménez Díaz) ;
Alba, E (Hospital Universitario Regional Virgen de la Victoria, IBIMA, Málaga) ;
Aranda, E (Hospital Reina Sofía, Cordoba) ;
Díaz Rubio, E (Universidad Complutense de Madrid. Hospital Clínico San Carlos) ;
López López, R (Hospital Clínico Universitario (Santiago de Compostela)) ;
Tabernero, J (Universitat Autònoma de Barcelona) ;
Vivancos, A (Vall d'Hebron Institut d'Oncologia)
The importance of mutation identification for advanced colorectal cancer treatment with anti-epidermal growth factor receptor agents is well established. However, due to delays in turnaround time, low-quality tissue samples, and/or lack of standardization of testing methods a significant proportion of patients are being treated without the information that Kirsten rat sarcoma and neuroblastoma rat sarcoma (RAS) testing can provide. [...]
2017 - 10.1093/annonc/mdx501
Annals of Oncology, Vol. 28 (september 2017) , p. 2943-2949
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8 p, 196.5 KB |
Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer
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Sclafani, Francesco (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Brown, Gina (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Cunningham, David (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Wotherspoon, Andrew (Department of Histopathology, The Royal Marsden NHS Foundation Trust) ;
Mendes, Larissa Sena Teixeira (Department of Histopathology, The Royal Marsden NHS Foundation Trust) ;
Balyasnikova, Svetlana (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Evans, Jessica (Department of Radiology, The Royal Marsden NHS Foundation Trust) ;
Peckitt, Clare (Clinical Research & Development, The Royal Marsden NHS Foundation Trust) ;
Begum, Ruwaida (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Tait, Diana (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Tabernero, Josep (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Glimelius, Bengt (Department of Immunology, Genetics and Pathology, Section of Experimental and Clinical Oncology, University of Uppsala) ;
Roselló, Susana (Department of Haematology and Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia) ;
Thomas, Janet (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Oates, Jacqui (Department of Medicine, The Royal Marsden NHS Foundation Trust) ;
Chau, Ian (Department of Medicine, The Royal Marsden NHS Foundation Trust)
Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). [...]
2017 - 10.1038/bjc.2017.320
British Journal of Cancer, Vol. 117 (09 2017) , p. 1478-1485
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12 p, 1.7 MB |
Ligand-dependent Hedgehog pathway activation in Rhabdomyosarcoma : the oncogenic role of the ligands
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Almazán-Moga, A (Hospital Universitari Vall d'Hebron) ;
Zarzosa, P (Hospital Universitari Vall d'Hebron) ;
Molist, C (Hospital Universitari Vall d'Hebron) ;
Velasco, Pablo (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública) ;
Pyczek, J (Institute of Human Genetics, University of Goettingen) ;
Simon-Keller, K (Institute of Pathology, University Medical Centre Mannheim, University of Heidelberg) ;
Giralt, I (Hospital Universitari Vall d'Hebron) ;
Vidal, I (LHospital Universitari Vall d'Hebron) ;
Navarro, N (Hospital Universitari Vall d'Hebron) ;
Segura, M F (Hospital Universitari Vall d'Hebron) ;
Soriano, A (Hospital Universitari Vall d'Hebron) ;
Navarro, S (Universitat de València. Departament de Patologia) ;
Tirado, O M (Institut d'Investigació Biomèdica de Bellvitge (IDIBELL)) ;
Ferreres, J C (Hospital Universitari Vall d'Hebron) ;
Santamaria, A (Hospital Universitari Vall d'Hebron) ;
Rota, R (Ospedale Pediatrico Bambino Gesù, IRCCS) ;
Hahn, H (Institute of Human Genetics, University of Goettingen) ;
Sánchez de Toledo, J (Hospital Universitari Vall d'Hebron) ;
Roma, J (Hospital Universitari Vall d'Hebron) ;
Gallego, S (Hospital Universitari Vall d'Hebron)
Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children. The Hedgehog (HH) pathway is known to develop an oncogenic role in RMS. However, the molecular mechanism that drives activation of the pathway in RMS is not well understood. [...]
2017 - 10.1038/bjc.2017.305
British Journal of Cancer, Vol. 117 (09 2017) , p. 1314-1325
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10 p, 1.9 MB |
Nuclear IGF-1R predicts chemotherapy and targeted therapy resistance in metastatic colorectal cancer
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Codony Servat, Jordi (Institut Germans Trias i Pujol. Institut Català d'Oncologia) ;
Cuatrecasas Freixas, Miriam (Hospital Clínic) ;
Asensio, Elena (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Montironi, Carla (Hospital Clínic) ;
Martínez Cardús, Anna (Institut Germans Trias i Pujol. Institut Català d'Oncologia) ;
Marín Aguilera, Mercedes (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Horndler, Carlos (Hospital Miguel Servet) ;
Martínez Balibrea, Eva (Institut Germans Trias i Pujol. Institut Català d'Oncologia) ;
Rubini, Michele (Department of Experimental and Diagnostic Medicine, University of Ferrara) ;
Jares, Pedro (Hospital Clínic) ;
Reig, Oscar (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Victoria, Iván (Medical Oncology Department, Hospital Clínic, Translational Genomics and Targeted Therapeutics in Solid Tumors Group, IDIBAPS, Universitat de Barcelona) ;
Gaba, Lydia (Medical Oncology Department, Hospital Clínic, Translational Genomics and Targeted Therapeutics in Solid Tumors Group, IDIBAPS, Universitat de Barcelona) ;
Martín Richard, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Alonso, Vicente (Hospital Miguel Servet) ;
Escudero, Pilar (Hospital Clínico Universitatio Lozano Blesa) ;
Fernández-Martos, Carlos (Instituto Valenciano de Oncología) ;
Feliu, Jaime (Hospital La Paz, CIBERONC) ;
Méndez, Jose Carlos (Centro Oncológico de Galicia) ;
Méndez, Miguel (Hospital de Móstoles) ;
Gallego, Javier (Hospital de Elche) ;
Salud, Antonieta (Hospital Arnau de Vilanova) ;
Rojo, Federico (Pathology Department, Fundación Jiménez Diaz University) ;
Castells, Antoni (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Prat, Aleix (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ;
Rosell, Rafael (Institut Germans Trias i Pujol. Institut Català d'Oncologia) ;
García-Albéniz, Xabier (Harvard T.H. Chan School of Public Health) ;
Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Maurel, Joan (Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS))
Although chemotherapy is the cornerstone treatment for patients with metastatic colorectal cancer (mCRC), acquired chemoresistance is common and constitutes the main reason for treatment failure. Monoclonal antibodies against insulin-like growth factor-1 receptor (IGF-1R) have been tested in pre-treated mCRC patients, but results have been largely deceiving. [...]
2017 - 10.1038/bjc.2017.279
British Journal of Cancer, Vol. 117 (november 2017) , p. 1777-1786
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