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9 p, 666.9 KB |
Does Jacobson's relaxation technique reduce consumption of psychotropic and analgesic drugs in cancer patients? A multicenter pre–post intervention study
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Parás-Bravo, Paula (Universidad de Cantabria. Departamento de Enfermería) ;
Alonso-Blanco, Cristina (Universidad Rey Juan Carlos. Departamento de Fisioterapia) ;
Paz-Zulueta, María (Universidad de Cantabria. Departamento de Enfermería) ;
Palacios-Ceña, Domingo (Universidad Rey Juan Carlos. Departamento de Fisioterapia) ;
Sarabia-Cobo, Carmen María (Universidad de Cantabria. Departamento de Enfermería) ;
Herrero-Montes, Manuel (Universidad de Cantabria. Departamento de Enfermería) ;
Boixadera Planas, Ester (Universitat Autònoma de Barcelona. Servei d'Estadística Aplicada) ;
Fernández-de-las-Peñas, César (Universidad Rey Juan Carlos. Departamento de Fisioterapia)
Cancer patients often suffer from emotional distress as a result of the oncological process. The purpose of our study was to determine whether practice of Jacobson's relaxation technique reduced consumption of psychotropic and analgesic drugs in a sample of cancer patients. [...]
2018 -  10.1186/s12906-018-2200-2
BMC complementary and alternative medicine, Vol. 18, issue 1 (May 2018) , art. 139
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16 p, 347.6 KB |
Patient-centered care in breast cancer genetic clinics
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Brédart, Anne (Univesité Paris Descartes) ;
Anota, Amélie (Centre Hospitalier Régional Universitaire de Besançon) ;
Dick, Julia (Cancer Center Cologne) ;
Kuboth, Violetta (Cancer Center Cologne) ;
Lareyre, Olivier (Institut Curie) ;
De Pauw, Antoine (Institut Curie) ;
Cano, Alejandra (Universitat Autònoma de Barcelona. Departament de Psicologia Bàsica, Evolutiva i de l'Educació) ;
Stoppa-Lyonnet, Dominique (Institut Curie) ;
Schmutzler, Rita (Cancer Center Cologne) ;
Dolbeault, Sylvie (Centre de Recherche en Épidémiologie et Santé des Populations (CESP)) ;
Kop, Jean-Luc (Université de Lorraine)
With advances in breast cancer (BC) gene panel testing, risk counseling has become increasingly complex, potentially leading to unmet psychosocial needs. We assessed psychosocial needs and correlates in women initiating testing for high genetic BC risk in clinics in France and Germany, and compared these results with data from a literature review. [...]
2018 - 10.3390/ijerph15020319
International Journal of Environmental Research and Public Health, Vol. 15 (february 2018)
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11 p, 1.8 MB |
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
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Hernández Viedma, Gonzalo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Ramírez de Haro, Ma. José (María José) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Minguillón, Jordi (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Quiles, Paco (Catalan Institute of Oncology) ;
Ruiz de Garibay G. (Institut Català d'Oncologia)ge) ;
Aza-Carmona, Miriam (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Bogliolo, Massimo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Pujol i Calvet, M. Roser (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prados-Carvajal, Rosario (Universidad de Sevilla. Departamento de Genética) ;
Fernández-Rodríguez, Juana (Institut d'Investigació Biomèdica de Bellvitge) ;
García, Nadis (Institut Català d'Oncologia) ;
López, Adrià (Institut Català d'Oncologia) ;
Gutiérrez-Enríquez, Sara (Vall d'Hebron Institut d'Oncologia) ;
Diez, Orland (Vall d'Hebron Institut d'Oncologia) ;
Benítez, Javier (Centro de Investigación biomédica en red de enfermedades raras) ;
Salinas, Mónica (Institut Català d'Oncologia) ;
Teulé, Àlex (Institut Català d'Oncologia) ;
Brunet, Joan (Institut Català d'Oncologia) ;
Radice, Paolo (Istituto Nazionale dei Tumori (Milà)) ;
Peterlongo, Paolo (Istituto Nazionale dei Tumori (Milà)) ;
Schindler, Detlev (Universität Würzburg. Department of Human Genetics) ;
Huertas, Pablo (Universidad de Sevilla. Departamento de Genética) ;
Puente, Xose P. (Universidad de Oviedo. Department de Bioquímica y Biología Molecular) ;
Lázaro, Coxi (Institut Català d'Oncologia) ;
Pujana. Miguel Ángel (Institut Català d'Oncologia) ;
Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors are exquisitely sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. [...]
2018 - 10.1038/s41467-018-03433-3
Nature Communications, Vol. 9 (2018) , art. 967
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11 p, 2.4 MB |
Oncometabolic nuclear reprogramming of cancer stemness
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Menendez, Javier A. (Institut Català d'Oncologia) ;
Corominas-Faja, Bruna (Institut d'Investigació Biomèdica de Girona) ;
Cuyàs, Elisabet (Institut d'Investigació Biomèdica de Girona) ;
García, María G. (Instituto Universitario de Oncología del Principado de Asturias) ;
Fernández-Arroyo, Salvador (Hospital Universitari de Sant Joan) ;
Fernández, Agustín F. (Instituto Universitario de Oncología del Principado de Asturias) ;
Joven, Jorge (Hospital Universitari de Sant Joan) ;
Fraga, Mario F. (Instituto Universitario de Oncología del Principado de Asturias) ;
Alarcón Cor, Tomás (Centre de Recerca Matemàtica)
By impairing histone demethylation and locking cells into a reprogramming-prone state, oncometabolites can partially mimic the process of induced pluripotent stem cell generation. Using a systems biology approach, combining mathematical modeling, computation, and proof-of-concept studies with live cells, we found that an oncometabolite-driven pathological version of nuclear reprogramming increases the speed and efficiency of dedifferentiating committed epithelial cells into stem-like states with only a minimal core of stemness transcription factors. [...]
2016 - 10.1016/j.stemcr.2015.12.012
Stem cell reports, Vol. 6, issue 3 (March 2016) , p. 273-283
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10 p, 1.6 MB |
Simultaneous underexpression of let-7a-5p and let-7f-5p microRNAs in plasma and stool samples from early stage colorectal carcinoma
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Ghanbari, Reza (Tehran University of Medical Sciences) ;
Mosakhani, Neda (The University of Helsinki. Department of Pathology) ;
Sarhadi, Virinder K. (The University of Helsinki. Department of Pathology) ;
Armengol Rosell, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Nouraee, Nazila (Tarbiat Moddares University. Department of Molecular Genetics) ;
Mohammadkhani, Ashraf (Tehran University of Medical Sciences) ;
Khorrami, Samaneh (Tehran University of Medical Sciences) ;
Arefian, Ehsan (University of Tehran. Department of Microbiology) ;
Paryan, Mahdi (Pasteur Institute of Iran) ;
Malekzadeh, Reza (Tehran University of Medical Sciences) ;
Knuutila, Sakari (The University of Helsinki. Department of Pathology)
Colorectal cancer (CRC) is the third most common malignancy and the second most common cause of cancer death worldwide. Early detection of CRC can improve patient survival rates; thus, the identification of noninvasive diagnostic markers is urgently needed. [...]
2015 - 10.4137/BIC.S25252
Biomarkers in cancer, Vol. 7, suppl. 1 (2015) , p. 39-48
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16 p, 2.1 MB |
Cationic liposome- multi-walled carbon nanotubes hybrids for dual siPLK1 and doxorubicin delivery in vitro
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Pereira, Sara (University of East Anglia. School of Pharmacy) ;
Lee, Jin (King's College London. Institute of Pharmaceutical Science) ;
Rubio, Noelia (King's College London. Institute of Pharmaceutical Science) ;
Hassan, Hatem A. F. M. (King's College London. Institute of Pharmaceutical Science) ;
Suffian, Izzat Bin Mohamed (King's College London. Institute of Pharmaceutical Science) ;
Wang, Julie T. W. (King's College London. Institute of Pharmaceutical Science) ;
Klippstein, Rebecca (King's College London. Institute of Pharmaceutical Science) ;
Ballesteros Pérez, Belén (Institut de Catala de Nanociència i Nanotecnologia) ;
Al-Jamal, Wafa' T. (University of East Anglia. School of Pharmacy) ;
Al-Jamal, Khuloud T. (King's College London. Institute of Pharmaceutical Science)
To formulate f -MWNTs-cationic liposome hybrids for the simultaneous delivery of siPLK1 and doxorubicin to cancer cells. f -MWNTs-cationic liposome hybrids were prepared by the thin film hydration method where the lipid film was hydrated with 100 μg/ml or 1 mg/ml of ox-MWNTs-NH₃+ or MWNTs-NH₃+ in 5% dextrose. [...]
2015 - 10.1007/s11095-015-1707-1
Pharmaceutical research, Vol. 32, Issue 10 (Oct. 2015) , p. 3293-3308
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