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15 p, 3.9 MB |
Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection
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Guillén, Yolanda (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Noguera-Julian, Marc (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rivera Pinto, Javier (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Casadellà, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Zevin, Alexander (University of Washington) ;
Rocafort, M. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Parera, M. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodríguez, C. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Arumí Rovira, Marçal (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Carrillo, Jorge (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Mothe, Beatriz. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Estany Quera, Carla (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Coll, Josep (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Bravo, Isabel (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Herrero, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Saz, J. (BCN Checkpoint) ;
Sirera, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrella Domingo, Adriana (Hospital Universitari Vall d'Hebron) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Crespo Casal, Manuel (Instituto de Investigación Sanitaria Galicia Sur) ;
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Brander, Christian. (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Blanco, Julià (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Calle, M. Luz (Universitat de Vic - Universitat Central de Catalunya) ;
Klatt, N. R. (University of Washington) ;
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Universitat Autònoma de Barcelona
Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. [...]
2019 - 10.1038/s41385-018-0083-7
Mucosal Immunology, Vol. 12 Núm. 1 (january 2019) , p. 232-246
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18 p, 347.2 KB |
Comparing dynamic monitoring strategies based on evolving CD4 cell counts in virologically suppressed HIV-positive individuals on cART : a prospective observational study in high-income countries
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Caniglia, Ellen C (Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.) ;
Cain, Lauren E. ;
Sabin, Caroline A. ;
Robins, James M. ;
Logan, Roger ;
Abgrall, Sophie ;
Mugavero, Michael J. ;
Hernández-Díaz, Sonia ;
Meyer, Laurence ;
Seng, Remonie ;
Drozd, Daniel R. ;
Seage, George R. ;
Dabis, Francois ;
Fabrice, Bonnet ;
Richard, D. Moore ;
Reiss, Peter ;
van Sighem, Ard ;
Mathews, William C. ;
Del Amo, Julia ;
Moreno, Santiago ;
Deeks, Steven G. ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boswell, Stephen L. ;
Ferrer, Elena ;
Eron, Joseph J. ;
Napravnik, Sonia ;
Jose, Sophie ;
Phillips, Andrew ;
Justice, Amy C. ;
Tate, Janet P. ;
Gill, John ;
Pacheco, Antonio ;
Veloso, Valdilea G. ;
Bucher, Heiner ;
Egger, Matthias ;
Furrer, Hansjakob ;
Kholoud, Porter ;
Touloumi, Giota ;
Crane, Heidi ;
Miró, José M ;
Sterne, Jonathan A. ;
Dominique, Costagliola ;
Saag, Michael ;
Hernán, Miguel A.
Clinical guidelines vary with respect to the optimal monitoring frequency of HIV-positive individuals. We compared dynamic monitoring strategies based on evolving CD4 cell counts in virologically suppressed HIV-positive individuals. [...]
2017 - 10.1016/S2352-3018(17)30043-7
The lancet. HIV, Vol. 4 (april 2017) , p. e251-e259
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9 p, 319.8 KB |
Limiting Cumulative HIV Viremia Copy-Years by Early Treatment Reduces Risk of AIDS and Death
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Olson, Ashley D. (Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom) ;
Walker, A. Sarah (Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom) ;
Suthar, Amitabh B. (South African Centre for Epidemiological Modelling and Analysis, University of Stellenbosch, South Africa) ;
Sabin, Caroline A. (Department of Infection and Population Health, University College London (UCL), London, United Kingdom) ;
Bucher, Heiner (University Hospital Basel (Basilea, Suïssa)) ;
Jarrín, Inmaculada (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno, Santiago (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Pérez-Hoyos, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Porter, Kholoud (Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom) ;
Ford, Deborah (Medical Research Council Clinical Trials Unit, University College London, London, United Kingdom) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is Available in the Text. Viremia copy-years (VCY), a time-updated measure of cumulative HIV exposure, predicts AIDS/death; although its utility in deciding when to start combination antiretroviral therapy (cART) remains unclear. [...]
2016 - 10.1097/QAI.0000000000001029
Journal of acquired immune deficiency syndromes (1999), Vol. 73 (august 2016) , p. 100-108
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7 p, 259.3 KB |
Mortality According to CD4 Count at Start of Combination Antiretroviral Therapy Among HIV-infected Patients Followed for up to 15 Years After Start of Treatment : Collaborative Cohort Study
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May, Margaret T. ;
Vehreschild, Jorg-Janne ;
Trickey, Adam ;
Obel, Niels ;
Reiss, Peter ;
Bonnet, Fabrice ;
Mary-Krause, Murielle ;
Samji, Hasina ;
Cavassini, Matthias ;
Gill, Michael John ;
Shepherd, Leah C. ;
Crane, Heidi ;
D'Arminio Monforte, Antonella ;
Burkholder, Greer A. ;
Johnson, Margaret M. ;
Sobrino-Vegas, Paz ;
Domingo, Pere (Domingo Pedrol) ;
Zangerle, Robert (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Justice, Amy C. ;
Sterling, Timothy R. ;
Miró, José M. ;
Sterne, Jonathan A. C.
The strong association of CD4 count at start of combination therapy with subsequent survival in HIV-infected patients diminished during the first 5 years of treatment. After 5 years, lower baseline CD4 counts were not associated with higher mortality. [...]
2016 - 10.1093/cid/ciw183
Clinical Infectious Diseases, Vol. 62 (march 2016) , p. 1571-1577
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8 p, 283.7 KB |
When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries : A Prospective Observational Study
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Caniglia, Ellen C. (Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA) ;
Sabin, Caroline A. (University College London, London, United Kingdom) ;
Robins, James M. (Department of Biostatistics, Harvard T.H. Chan School of Public Health) ;
Logan, Roger (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Cain, Lauren E. (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Abgrall, Sophie (Assistance Publique-Hopitaux de Paris (AP-HP), Hopital Antoine Béclère, Service de Médecine Interne) ;
Mugavero, Michael J. (University of Alabama at Birmingham) ;
Hernandez-Diaz, Sonia (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Meyer, Laurence (Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique) ;
Seng, Remonie (Université Paris Sud, INSERM CESP U1018, and AP-HP, Hopital de Bicêtre, Service de Santé Publique) ;
Drozd, Daniel R. (Division of Allergy and Infectious Diseases, School of Medicine, University of Washington) ;
Seage, George R. (Department of Epidemiology, Harvard T.H. Chan School of Public Health) ;
Bonnet, Fabrice (Bordeaux University, ISPED, INSERM U897 CHU de Bordeaux) ;
Dabis, Francois (INSERM U897, Centre Inserm Epidémiologie et Biostatistique, Université de Bordeaux, and Department of Internal Medicine, Bordeaux University Hospital) ;
Moore, Richard R. (School of Medicine, Johns Hopkins University, Baltimore, MD) ;
Reiss, Peter (Stichting HIV Monitoring, Amsterdam, Netherlands; Academic Medical Center, Department of Global Health and Division of Infectious Diseases, University of Amsterdam, and Amsterdam Institute for Global Health and Development) ;
van Sighem, Ard (Stichting HIV Monitoring, Amsterdam, Netherlands) ;
Mathews, William C. (Internal Medicine, Johns Hopkins University) ;
Del Amo, Julia (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Moreno, Santiago (Instituto Ramón y Cajal de Investigación Sanitaria (Madrid)) ;
Deeks, Steven G. (Positive Health Program, San Francisco General Hospital) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Boswell, Stephen L. (Fenway Health) ;
Ferrer, Elena (Institut d'Investigació Biomèdica de Bellvitge) ;
Eron, Joseph J. (Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill) ;
Napravnik, Sonia (Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill) ;
Jose, Sophie (University College London) ;
Phillips, Andrew (University College London, London, United Kingdom) ;
Olson, Ashley (Medical Research Council Clinical Trials Unit, University College London) ;
Justice, Amy C. (VA Connecticut Healthcare System) ;
Tate, Janet P. (VA Connecticut Healthcare System) ;
Bucher, Heiner (University Hospital Basel (Basilea, Suïssa)) ;
Egger, Matthias (University of Bern, Institute for Social and Preventive Medicine, Bern, Switzerland) ;
Touloumi, Giota (Department of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School) ;
Sterne, Jonathan A. (School of Social and Community Medicine, University of Bristol) ;
Costagliola, Dominique (Institute Pierre Louis d'Épidémiologie et de Santé Publique) ;
Saag, Michael (Department of Medicine, University of Alabama at Birmingham) ;
Hernán, Miguel A. (Department of Medicine, University of Alabama at Birmingham) ;
Universitat Autònoma de Barcelona
Supplemental Digital Content is Available in the Text. To illustrate an approach to compare CD4 cell count and HIV-RNA monitoring strategies in HIV-positive individuals on antiretroviral therapy (ART). [...]
2016 - 10.1097/QAI.0000000000000956
Journal of acquired immune deficiency syndromes (1999), Vol. 72 (may 2016) , p. 214-221
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