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4 p, 793.8 KB |
Clinical and imaging features of a feline lumbar myelopathy resembling ossification of the posterior longitudinal ligament in humans
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Reus-Coll, M. (Hospital Veterinari Montjuïc) ;
Añor Torres, Sònia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Montes de Oca, I. (Hospital Veterinari Montjuïc) ;
de la Fuente, Cristian (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
A 9-year-old, male, neutered Russian blue cat was presented for a 2-week history of pelvic limb weakness and reluctance to jump and climb stairs. Neurological examination was consistent with an L4-L6 myelopathy. [...]
2023 -  10.1002/vrc2.741
Veterinary Record Case Reports, Vol. 11 Núm. 4 (december 2023) , p. e741
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2.
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11 p, 1.0 MB |
Prevalence of vertebral fractures and their prognostic significance in the survival in patients with chronic kidney disease stages 3-5 not on dialysis
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Castro-Alonso, Cristina (Universitat de València) ;
D'Marco, Luis (Universitat de València) ;
Pomes Tallo, Jaume (Hospital Clínic i Provincial de Barcelona) ;
Conill, Montserrat Del Amo (Hospital Clínic i Provincial de Barcelona) ;
García-Diez, Ana Isabel (Hospital Clínic i Provincial de Barcelona) ;
Molina, Pablo (Universitat de València) ;
Puchades, Mª Jesús (Universitat de València) ;
Valdivielso, José Manuel (Instituto de Salud Carlos III) ;
Escudero Quesada, Verónica (Universitat de València) ;
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Navarro-González, Juan F. (Universidad de La Laguna) ;
Ribas, Begoña (Hospital Universitario La Paz (Madrid)) ;
Pallardo, Luis M. (Universitat de València) ;
Gorriz, Jose Luis (Universitat de València) ;
Universitat Autònoma de Barcelona
The prevalence of vertebral fractures (VF) and their association with clinical risk factors and outcomes are poorly documented in chronic kidney disease (CKD) cohorts. The aim of the study was to evaluate the prevalence of VF in patients with non-dialysis dependent CKD (NDD-CKD), their value in predicting mortality and its correlation with parameters of bone mineral metabolism and vascular calcification. [...]
2020 - 10.3390/JCM9051604
Journal of clinical medicine, Vol. 9 Núm. 5 (may 2020) , p. 1-11
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3.
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11 p, 1.8 MB |
Anthropogenic acidification of surface waters drives decreased biogenic calcification in the Mediterranean Sea
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Pallacks, Sven (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Ziveri, Patrizia (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Schiebel, Ralf (Max Planck Institute for Chemistry. Department of Climate Geochemistry) ;
Vonhof, Hubert (Max Planck Institute for Chemistry. Department of Climate Geochemistry) ;
Rae, James (University of St Andrews. School of Earth and Environmental Sciences) ;
Littley, Eloise (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Garcia-Orellana, Jordi (Universitat Autònoma de Barcelona. Departament de Física) ;
Langer, Gerald (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Grelaud, Michael (Universitat Autònoma de Barcelona. Institut de Ciència i Tecnologia Ambientals) ;
Martrat, Belen (Institut d'Avaluació Ambiental i Recerca de l'Aigua)
Anthropogenic carbon dioxide emissions directly or indirectly drive ocean acidification, warming and enhanced stratification. The combined effects of these processes on marine planktic calcifiers at decadal to centennial timescales are poorly understood. [...]
2023 - 10.1038/s43247-023-00947-7
Communications earth & environment, Vol. 4 (August 2023) , art. 301
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4.
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15 p, 1.0 MB |
Insights into Insulin Resistance and Calcification in the Myocardium in Type 2 Diabetes : A Coronary Artery Analysis
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Martín-Saladich, Queralt (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aguadé-Bruix, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Simó-Servat, Olga (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Aparicio-Gómez, Carolina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Hernández, Cristina (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ramirez-Serra, Clara (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Pizzi, María Nazarena (Universitat de Barcelona. Departament de Medicina) ;
Roque, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González Ballester, Miguel A. (Universitat Pompeu Fabra) ;
Herance, José Raul (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Type 2 diabetes (T2D) is responsible for high incidence of cardiovascular (CV) complications leading to heart failure. Coronary artery region-specific metabolic and structural assessment could provide deeper insight into the extent of the disease and help prevent adverse cardiac events. [...]
2023 - 10.3390/ijms24043250
International journal of molecular sciences, Vol. 24 (february 2023)
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5.
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11 p, 1.1 MB |
Clinical Approach to Vascular Calcification in Patients With Non-dialysis Dependent Chronic Kidney Disease : Mineral-Bone Disorder-Related Aspects
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Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Aguilar, Armando (Instituto Mexicano del Seguro Social) ;
Arana Aliaga, Carolt (Institut d'Investigació Biomèdica Sant Pau) ;
Molina, Pablo (Hospital Universitari Doctor Peset (València)) ;
Lloret, María Jesús (Institut d'Investigació Biomèdica Sant Pau) ;
Ochoa, Jackson (Institut d'Investigació Biomèdica Sant Pau) ;
Berná, Gerson (Institut d'Investigació Biomèdica Sant Pau) ;
Gutiérrez-Maza, Yessica G. (Instituto Mexicano del Seguro Social) ;
Rodrigues, Natacha (Universitário Lisboa Norte) ;
D'Marco, Luis (Hospital Clínic Universitari (València)) ;
Górriz, José L. (Hospital Clínic Universitari (València)) ;
Universitat Autònoma de Barcelona
Chronic kidney disease (CKD) is associated with a very high morbimortality, mainly from cardiovascular origin, and CKD is currently considered in the high- or very high risk- cardiovascular risk category. [...]
2021 - 10.3389/fmed.2021.642718
Frontiers in Medicine, Vol. 8 (may 2021)
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21 p, 3.1 MB |
Emerging Roles of Lysyl Oxidases in the Cardiovascular System : New Concepts and Therapeutic Challenges
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Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Varona, Saray (Institut d'Investigació Biomèdica Sant Pau) ;
Cañes Esteve, Laia (Institut d'Investigació Biomèdica Sant Pau) ;
Galán, María (Institut d'Investigació Biomèdica Sant Pau) ;
Briones, Ana M.. (Hospital Universitario La Paz (Madrid)) ;
Cachofeiro, Victoria (Universidad Complutense de Madrid) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of connective tissues. [...]
2019 - 10.3390/biom9100610
Biomolecules, Vol. 9 (october 2019)
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7.
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19 p, 1.2 MB |
Role of the Scavenger Receptor CD36 in Accelerated Diabetic Atherosclerosis
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Navas Madroñal, Miquel (Institut d'Investigació Biomèdica Sant Pau) ;
Castelblanco, Esmeralda (Institut d'Investigació Biomèdica Sant Pau) ;
Camacho, Mercedes (Institut d'Investigació Biomèdica Sant Pau) ;
Consegal, Marta (Institut d'Investigació Biomèdica Sant Pau) ;
Ramírez-Morros, Anna (Institut Germans Trias i Pujol) ;
Sarrias, Maria-Rosa (Institut Germans Trias i Pujol) ;
Perez, Paulina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Alonso Pedrol, Núria (Institut Germans Trias i Pujol) ;
Galán, María (Institut d'Investigació Biomèdica Sant Pau) ;
Mauricio Puente, Dídac (Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas) ;
Universitat Autònoma de Barcelona
Diabetes mellitus entails increased atherosclerotic burden and medial arterial calcification, but the precise mechanisms are not fully elucidated. We aimed to investigate the implication of CD36 in inflammation and calcification processes orchestrated by vascular smooth muscle cells (VSMCs) under hyperglycemic and atherogenic conditions. [...]
2020 - 10.3390/ijms21197360
International journal of molecular sciences, Vol. 21 (october 2020)
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8.
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5 p, 1.6 MB |
Effects of SNF472, a Novel Inhibitor of Hydroxyapatite Crystallization in Patients Receiving Hemodialysis - Subgroup Analyses of the CALIPSO Trial
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Raggi, Paolo (Division of Cardiology and Department of Medicine, University of Alberta, Edmonton, Alberta, Canada) ;
Bellasi, Antonio (Research, Innovation and Brand Reputation Unit, ASST Papa Giovanni XXIII, Bergamo, Italy) ;
Sinha, Smeeta (Department of Renal Medicine, Salford Royal NHS Foundation Trust, Salford, United Kingdom) ;
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Rodriguez, Mariano (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Ketteler, Markus (Department of General Internal Medicine and Nephrology, Robert-Bosch-Krankenhaus, Stuttgart, Germany) ;
Bushinsky, David A. (Department of Medicine, University of Rochester School of Medicine, Rochester, New York, USA) ;
Garg, Rekha (PharmaDRS, LLC, San Diego, California, USA) ;
Perelló, Joan (University of the Balearic Islands, Palma, Spain) ;
Gold, Alex (Department of Medicine, Stanford University, Palo Alto, California, USA) ;
Chertow, Glenn M. (Department of Medicine, Stanford University, Palo Alto, California, USA) ;
Universitat Autònoma de Barcelona
Coronary artery calcium (CAC) is highly prevalent and linked with poor outcomes in patients receiving maintenance hemodialysis, and its reduction may improve patient prognosis. SNF472, a selective inhibitor of hydroxyapatite crystallization, slows CAC progression in patients receiving maintenance hemodialysis. [...]
2020 - 10.1016/j.ekir.2020.09.032
Kidney International Reports, Vol. 5 (november 2020) , p. 2178-2182
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9.
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9 p, 506.6 KB |
Trial design and baseline characteristics of CaLIPSO : a randomized, double-blind placebo-controlled trial of SNF472 in patients receiving haemodialysis with cardiovascular calcification
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Bellasi, Antonio (Research, Innovation and Brand Reputation Unit, ASST Papa Giovanni XXIII) ;
Raggi, Paolo (Department of Medicine, Mazankowski Alberta Heart Institute and University of Alberta) ;
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau) ;
Bushinsky, David A. (Department of Medicine, University of Rochester Medical Center) ;
Chertow, Glenn M. (Department of Medicine, Stanford University) ;
Ketteler, Markus (Department of General Internal Medicine and Nephrology, Robert-Bosch-Krankenhaus) ;
Rodriguez, Mariano (Hospital Universitario Reina Sofía (Còrdova, Espanya)) ;
Sinha, Smeeta (Department of Renal Medicine, Salford Royal NHS Foundation Trust) ;
Salcedo, Carolina (Research and Development, Sanifit Therapeutics) ;
Garg, Rekha (Research and Development, Sanifit Therapeutics) ;
Gold, Alex (Research and Development, Sanifit Therapeutics) ;
Perelló, Joan (Research and Development, Sanifit Therapeutics) ;
Universitat Autònoma de Barcelona
The objective of CaLIPSO, a Phase 2b, randomized, double-blind, placebo-controlled clinical trial, is to test the hypothesis that myo-inositol hexaphosphate (SNF472) attenuates the progression of cardiovascular calcification in patients receiving maintenance haemodialysis. [...]
2019 - 10.1093/ckj/sfz144
Clinical Kidney Journal, Vol. 14 (october 2019) , p. 366-374
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10.
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25 p, 3.0 MB |
FGF23 and its role in X-linked hypophosphatemia-related morbidity
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Beck-Nielsen, Signe (Aarhus University Hospital. Centre for Rare Diseases) ;
Mughal, Zulf (Royal Manchester Children's Hospital) ;
Haffner, Dieter (Hannover Medical School) ;
Nilsson, Ola (Karolinska Institutet, Stockholm, Sweden and Örebro University) ;
Levtchenko, Elena (Katholieke Universiteit Leuven) ;
Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
de Lucas-Collantes, Carmen (Hospital Infantil Universitario Niño Jesús (Madrid)) ;
Schnabel, Dirk (University Children's Hospital of Berlin, Berlin) ;
Jandhyala, Ravi (Medialis Ltd, Banbury) ;
Mäkitie, Outi (Helsinki University Hospital (Finlàndia)) ;
Universitat Autònoma de Barcelona
X-linked hypophosphatemia (XLH) is an inherited disease of phosphate metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase Homolog, X-Linked (PHEX) gene lead to local and systemic effects including impaired growth, rickets, osteomalacia, bone abnormalities, bone pain, spontaneous dental abscesses, hearing difficulties, enthesopathy, osteoarthritis, and muscular dysfunction. [...]
2019 - 10.1186/s13023-019-1014-8
Orphanet Journal of Rare Diseases, Vol. 14 (february 2019)
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