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17 p, 3.0 MB |
Intravenous Statin Administration During Myocardial Infarction Compared With Oral Post-Infarct Administration
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Mendieta, G. (Clinic Hospital) ;
Ben-Aicha Gonzalez, Soumaya (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Gutiérrez, M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Casaní, Laura (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Aržanauskaitė, M. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Carreras, F. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Sabate, M. (Clinic Hospital) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Beyond lipid-lowering, statins exert cardioprotective effects. High-dose statin treatment seems to reduce cardiovascular complications in high-risk patients. The ideal timing and administration regime remain unknown. [...]
2020 -  10.1016/j.jacc.2020.01.042
Journal of the American College of Cardiology, Vol. 75 Núm. 12 (31 2020) , p. 1386-1402
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13 p, 2.0 MB |
Supplementation With Spirulina Reduces Infarct Size and Ameliorates Cardiac Function in a Pig Model of STEMI
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Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Sutelman, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Ben-Aicha Gonzalez, Soumaya (Institut d'Investigació Biomèdica Sant Pau) ;
Mendieta, Guiomar (Institut d'Investigació Biomèdica Sant Pau) ;
Radiké Aržanauskaitė, Monika (Institut d'Investigació Biomèdica Sant Pau) ;
Schoch, Leonie (Institut d'Investigació Biomèdica Sant Pau) ;
Casaní, Laura (Institut d'Investigació Biomèdica Sant Pau) ;
Borrell-Pages, Maria (Institut d'Investigació Biomèdica Sant Pau) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Myocardial infarction (MI) is the clinical manifestation of atherosclerotic coronary artery disease. Spirulina is an algae known to ameliorate cardiometabolic disorders and with proven anti-inflammatory and anti-oxidant effects. [...]
2022 - 10.3389/fphar.2022.891801
Frontiers in Pharmacology, Vol. 13 (may 2022)
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12 p, 2.4 MB |
DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction
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Gallinat, Alex (Universitat Autònoma de Barcelona) ;
Mendieta, Guiomar (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Cardiovascular diseases, and particularly acute myocardial infarction (MI), are the most common causes of death worldwide. Infarct size is the major predictor of clinical outcomes in MI. The Parkinson's disease associated protein, DJ-1 (also known as PARK7), is a multifunctional protein with chaperone, redox sensing and mitochondrial homeostasis activities. [...]
2022 - 10.3389/fphar.2022.1002755
Frontiers in Pharmacology, Vol. 13 (September 2022) , p. 1002755
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24 p, 1.4 MB |
Ischaemic conditioning and targeting reperfusion injury : a 30 year voyage of discovery
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Hausenloy, Derek J. (National Heart Research Institute Singapore) ;
Barrabés, José A.. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bøtker, Hans Erik (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Davidson, Sean M. (University College London) ;
Di Lisa, Fabio (University of Padova, Italy) ;
Downey, James (University of South Alabama, Mobile) ;
Engstrom, Thomas (Copenhagen University Hospital) ;
Ferdinandy, Péter (Pharmahungary Group, Szeged, Hungary) ;
Carbrera-Fuentes, Hector A. (Kazan Federal University, Russian Federation) ;
Heusch, Gerd (University of Essen Medical School, Germany) ;
Ibanez, Borja (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Iliodromitis, Efstathios K. (National and Kapodistrian University of Athens, Greece) ;
Inserte, Javier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jennings, Robert (Duke University, Durham, NC USA) ;
Kalia, Neena (University of Birmingham, UK) ;
Kharbanda, Rajesh (Oxford University Hospitals, UK) ;
Lecour, Sandrine (University of Cape Town, South Africa) ;
Marber, Michael (St. Thomas' Hospital, London, UK) ;
Miura, Tetsuji (Sapporo Medical University School of Medicine, Japan) ;
Ovize, Michel (Université Claude Bernard, Lyon 1, France) ;
Perez-Pinzon, Miguel A. (University of Miami Miller School of Medicine, USA) ;
Piper, Hans Michael (Carl von Ossietzky Universität Oldenburg) ;
Przyklenk, Karin (Wayne State University, Detroit, USA) ;
Schmidt, Michael Rahbek (Duke-National University of Singapore) ;
Redington, Andrew (Cincinnati Children's Hospital Medical Center) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau) ;
Vinten-Johansen, Jakob (Emory University, Atlanta, USA) ;
Yellon, Derek M. (The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotection. [...]
2016 - 10.1007/s00395-016-0588-8
Basic Research in Cardiology, Vol. 111 (october 2016)
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14 p, 2.3 MB |
Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion
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Penela, Petronila (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Inserte, Javier (Universitat Autònoma de Barcelona) ;
Ramos, Paula (Centro de Biología Molecular Severo Ochoa) ;
Rodriguez-Sinovas, Antonio (Universitat Autònoma de Barcelona) ;
García-Dorado, David (Universitat Autònoma de Barcelona) ;
Mayor, F. (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Background: Identification of signaling pathways altered at early stages after cardiac ischemia/reperfusion (I/R) is crucial to develop timely therapies aimed at reducing I/R injury. The expression of G protein-coupled receptor kinase 2 (GRK2), a key signaling hub, is up-regulated in the long-term in patients and in experimental models of heart failure. [...]
2019 - 10.1016/j.ebiom.2019.09.019
EBioMedicine, Vol. 48 (october 2019) , p. 605-618
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13 p, 508.4 KB |
Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia : between bench and bedside
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Cabrera-Fuentes, H. A (Escuela de Ingeniería y Ciencias, Centro de Biotecnología-FEMSA, Tecnológico de Monterrey) ;
Alba-Alba, Corina (Institute of Genetics, Univeristy of the Sea. Puerto Escondido Campus, Oaxaca Oaxacan System of State Universities (SUNEO)) ;
Aragones, Julian (Instituto de Investigación Hospital Universitario de la Princesa) ;
Bernhagen, Jürgen (Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University) ;
Boisvert, William A. (Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii) ;
Bøtker, Hans Erik (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Cesarman-Maus, Gabriela (Department of Hematology, Instituto Nacional de Cancerología, Mexico City, Mexico) ;
Fleming, Ingrid (Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe-University, Frankfurt, Germany) ;
García-Dorado, David (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lecour, Sandrine (Hatter Institute and MRC Inter-University Cape Heart Unit, Faculty of Health Sciences, University of Cape Town) ;
Liehn, Elisa (Institute for Molecular Cardiovascular Research, RWTH University Hospital Aachen) ;
Marber, Michael S. (King's College London) ;
Marina, Nephtali (Department of Clinical Pharmacology, University College London) ;
Mayr, Manuel (King's College London. The James Black Centre) ;
Perez-Mendez, Oscar (Department of Molecular Biology, National Institute of Cardiology, Mexico City) ;
Miura, Tetsuji (Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine) ;
Ruiz-Meana, Marisol (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Salinas-Estefanon, Eduardo M. (Laboratorio de Biofísica Cardiaca, Instituto de Fisiología, Universidad Autónoma de Puebla, Puebla, Mexico) ;
Ong, Sang-Bing (National Heart Research Institute Singapore, National Heart Centre Singapore) ;
Schnittler, Hans J. (Institute of Anatomy and Vascular Biology, Westfalian-Wilhelms-University, Münster) ;
Sanchez-Vega, Jose T. (Universidad Nacional Autónoma de México. Departamento de Microbiología y Parasitología) ;
Sumoza-Toledo, Adriana (Laboratorio Multidisciplinario de Ciencias Biomédicas, Instituto de Investigaciones Medico-Biológicas, Universidad Veracruzana campus Veracruz) ;
Vogel, Carl-Wilhelm (Department of Pathology, John A. Burns School of Medicine, University of Hawaii) ;
Yarullina, Dina (Department of Microbiology, Kazan Federal University, Kazan, Russian Federation) ;
Yellon, Derek M. (The National Institute of Health Research University College London Hospitals Biomedical Research Centre) ;
Preissner, Klaus T. (Institute of Biochemistry, Medical School, Justus-Liebig University, Giessen, Germany) ;
Hausenloy, Derek J. (The National Institute of Health Research University College London Hospitals Biomedical Research Centre) ;
Universitat Autònoma de Barcelona
Recent advances in basic cardiovascular research as well as their translation into the clinical situation were the focus at the last "New Frontiers in Cardiovascular Research meeting". Major topics included the characterization of new targets and procedures in cardioprotection, deciphering new players and inflammatory mechanisms in ischemic heart disease as well as uncovering microRNAs and other biomarkers as versatile and possibly causal factors in cardiovascular pathogenesis. [...]
2015 - 10.1007/s00395-015-0527-0
Basic Research in Cardiology, Vol. 111 (december 2015)
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13 p, 340.4 KB |
ESC working group cellular biology of the heart : position paper: improving the preclinical assessment of novel cardioprotective therapies
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Lecour, Sandrine (Hatter Institute for Cardiovascular Research (Àfrica)) ;
Bøtker, Hans Erik (Aarhus University Hospital (Aarhus, Dinamarca)) ;
Condorelli, Gianluigi (Instituto Clinico Humanitas (Milano, Itàlia)) ;
Davidson, Sean M. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit)) ;
García-Dorado, David (Universitat Autònoma de Barcelona) ;
Engel, Felix B. (Friedrich-Alexander-Universität Erlangen-Nürnberg) ;
Ferdinandy, Péter (Semmelweis Egyetem. Department of Pharmacology and Pharmacotherapy) ;
Heusch, Gerd (Universitätsklinikum Essen) ;
Madonna, Rosalinda (Università degli Studi "G. d'Annunzio" Chieti) ;
Ovize, Michel (Université Claude Bernard Lyon 1) ;
Ruiz Meana, Marisol (Hospital Universitari Vall d'Hebron) ;
Schulz, Rainer (Justus Liebig-Universität Gießen) ;
Sluijter, Joost P. G. (Universitair Medisch Centrum Utrecht) ;
Van Laake, Linda W. (Universitair Medisch Centrum Utrecht) ;
Yellon, Derek M. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit)) ;
Hausenloy, Derek J. (Hatter Institute for Cardiovascular Research (Londres, Regne Unit))
Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia-reperfusion injury, in order to improve clinical outcomes in IHD patients. [...]
2014 - 10.1093/cvr/cvu225
Cardiovascular research, Vol. 104, issue 3 (Dec. 2014) , p. 399-411
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