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Resultats globals: 4 registres trobats en 0.03 segons.
Articles, 4 registres trobats
Articles 4 registres trobats  
1.
16 p, 3.3 MB The stem region of group A transferase is crucial for its specificity, and its alteration promotes heterologous Forssman synthase activity / Cid, Emili (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Yamamoto, Miyako (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Barrero, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Yamamoto, Fumiichiro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Some stem region mutants of human blood group A transferase (hAT) possess Forssman synthase (FS) activity, but very little is known about the mechanisms responsible for this enzymatic crosstalk. We performed confocal microscopy and image analysis to determine whether different intra-Golgi localization was accountable for this acquired activity. [...]
2023 - 10.1038/s41598-023-40900-4
Scientific reports, Vol. 13 Núm. 1 (december 2023) , p. 13996  
Registre complet - Creative Commons
2.
29 p, 9.5 MB Substrate specificity of human metallocarboxypeptidase D : comparison of the two active carboxypeptidase domains / Garcia-Pardo, Javier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tanco, Sebastián Martín (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Díaz, Lucía (Barcelona Supercomputing Center) ; Dasgupta, Sayani (Albert Einstein College of Medicine. Department of Molecular Pharmacology) ; Fernández-Recio, Juan (Barcelona Supercomputing Center) ; Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Avilés, Francesc X. (Francesc Xavier) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Fricker, Lloyd D. (Albert Einstein College of Medicine. Department of Molecular Pharmacology)
Metallocarboxypeptidase D (CPD) is a membrane-bound component of the trans-Golgi network that cycles to the cell surface through exocytic and endocytic pathways. Unlike other members of the metallocarboxypeptidase family, CPD is a multicatalytic enzyme with three carboxypeptidase-like domains, although only the first two domains are predicted to be enzymatically active. [...]
2017 - 10.1371/journal.pone.0187778
PloS one, Vol. 12 issue 11 (2017) , art. e0187778  
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3.
13 p, 2.3 MB A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25 / Liu, Bing (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sureda-Gómez, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Zhen, Yang (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amador, Virginia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
USP25 deubiquitinating enzyme is a key member of the ubiquitin system, which acts as a positive regulator of the Wnt/β-catenin signaling by promoting the deubiquitination and stabilization of tankyrases. [...]
2018 - 10.1038/s41467-018-07510-5
Nature communications, Vol. 9 (2018) , art. 4973  
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4.
12 p, 1.7 MB Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization / Haq, Tamanna (University of Leicester. Department of Biochemistry) ; Richards, Mark W. (University of Leicester. Department of Biochemistry) ; Burgess, Selena G. (University of Leicester. Department of Biochemistry) ; Gallego Alonso, Pablo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Yeoh, Sharon (University of Leicester. Department of Biochemistry) ; O'Regan, Laura (University of Leicester. Department of Biochemistry) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Roig, Joan (Institut de Recerca Biomèdica de Lleida) ; Fry, Andrew M. (University of Leicester. Department of Biochemistry) ; Bayliss, Richard (Cancer Research UK Leicester Centre)
Mitotic spindle assembly requires the regulated activities of protein kinases such as Nek7 and Nek9. Nek7 is autoinhibited by the protrusion of Tyr97 into the active site and activated by the Nek9 non-catalytic C-terminal domain (CTD). [...]
2015 - 10.1038/ncomms9771
Nature communications, Vol. 6 (2015) , art. 8771  
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