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11 p, 5.0 MB |
Fibroblast activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer-prone genodermatoses
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Chacón-Solano, Esteban (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
León Canseco, Carlos (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Díaz, F. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
García-García, Francisco (Bioinformatics and Biostatistics Unit. Centro de Investigación Príncipe Felipe (CIPF)) ;
García, M. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Escámez Toledano, María José (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Guerrero-Aspizua, Sara (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Conti, C.J. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Mencía, None (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Martínez-Santamaría, L. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Llames, S. (Tissue Engineering Unit. Centro Comunitario Sangre y Tejidos (CCST)) ;
Pévida, M. (Tissue Engineering Unit. Centro Comunitario Sangre y Tejidos (CCST)) ;
Carbonell-Caballero, J. (Department of Computational Genomics. Centro de Investigación Príncipe Felipe (CIPF)) ;
Puig-Butille, Joan Anton (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Maseda, R. (Department of Pediatric Dermatology. La Paz Hospital) ;
Puig, Susana (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
de Lucas, R. (Department of Pediatric Dermatology. La Paz Hospital) ;
Baselga Torres, Eulàlia (Institut d'Investigació Biomèdica Sant Pau) ;
Larcher, F. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Dopazo, J. (Bioinformatics in Rare Diseases (BiER-U715). CIBERER. FPS. Hospital Virgen del Rocío) ;
del Río, M. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714))
Background: Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS) and xeroderma pigmentosum complementation group C (XPC) are three cancer-prone genodermatoses whose causal genetic mutations cannot fully explain, on their own, the array of associated phenotypic manifestations. [...]
2019 -  10.1111/bjd.17698
British journal of dermatology, Vol. 181 Núm. 3 (january 2019) , p. 512-522
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19 p, 5.0 MB |
Coordinated glucocorticoid receptor and MAFB action induces tolerogenesis and epigenome remodeling in dendritic cells
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Morante-Palacios, Octavio. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Micheroli, Raphael (University of Zurich) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Barbisan, Gisela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Houtman, Miranda (University of Zurich) ;
Edalat, Sam G. (University of Zurich) ;
Frank-Bertoncelj, Mojca (University of Zurich) ;
Ospelt, Caroline (University of Zurich) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Glucocorticoids (GCs) exert potent anti-inflammatory effects in immune cells through the glucocorticoid receptor (GR). Dendritic cells (DCs), central actors for coordinating immune responses, acquire tolerogenic properties in response to GCs. [...]
2022 - 10.1093/nar/gkab1182
Nucleic acids research, Vol. 50 Núm. 1 (january 2022) , p. 108-126
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3.
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22 p, 4.5 MB |
Transient reprogramming of postnatal cardiomyocytes to a dedifferentiated state
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Kisby, Thomas (University of Manchester. Nanomedicine Lab) ;
de Lázaro, Irene (University of Manchester. Nanomedicine Lab) ;
Stylianou, Maria (University of Manchester. Nanomedicine Lab) ;
Cossu, Giulio (University of Manchester. Division of Cell Matrix Biology and Regenerative Medicine) ;
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
In contrast to mammals, lower vertebrates are capable of extraordinary myocardial regeneration thanks to the ability of their cardiomyocytes to undergo transient dedifferentiation and proliferation. Somatic cells can be temporarily reprogrammed to a proliferative, dedifferentiated state through forced expression of Oct3/4, Sox2, Klf4 and c-Myc (OSKM). [...]
2021 - 10.1371/journal.pone.0251054
PloS one, Vol. 16, Issue 5 (May 2021) , p. e0251054
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4.
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66 p, 14.0 MB |
Single-layer graphene modulates neuronal communication and augments membrane ion currents
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Pampaloni, Niccolò Paolo (International School for Advanced Studies (Trieste, Itàlia)) ;
Lottner, Martin (Technische Universität München. Walter Schottky Institut. Physik-Department) ;
Giugliano, Michele (Universiteit Antwerp. Department of Biomedical Sciences) ;
Matruglio, Alessia (CERIC-ERIC) ;
D'Amico, Francesco (Elettra Sincrotrone Trieste) ;
Prato, Maurizio (CIC biomaGUNE) ;
Garrido, Jose (Institut Català de Nanociència i Nanotecnologia) ;
Ballerini, Laura (International School for Advanced Studies (Trieste, Itàlia)) ;
Scaini, Denis (International School for Advanced Studies (Trieste, Itàlia))
The use of graphene-based materials to engineer sophisticated biosensing interfaces that can adapt to the central nervous system requires a detailed understanding of how such materials behave in a biological context. [...]
2018 - 10.1038/s41565-018-0163-6
Nature Nanotechnology, Vol. 13 Núm. 8 (August 2018) , p. 755-764
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5.
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20 p, 2.3 MB |
Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA
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Quintana-Bustamante, Oscar (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Fañanas-Baquero, S. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Orman, I. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Duchateau, P. (CELLECTIS) ;
Poirot, L. (CELLECTIS) ;
Gouble, A. (CELLECTIS) ;
Bueren, Juan (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Segovia, J. C. (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Universitat Autònoma de Barcelona
Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme. Erythrocytes from PKD patients show an energetic imbalance and are susceptible to hemolysis. [...]
2019 - 10.1371/journal.pone.0223775
PloS one, Vol. 14 Núm. 10 (january 2019) , p. e0223775
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6.
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22 p, 5.2 MB |
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment
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Urdinguio, Rocío G. (Instituto de Oncología de Asturias-IUOPA) ;
López, Virginia (Centro de Investigación en Nanociencia y Nanotecnología (Oviedo, Astúries)) ;
Fernández Bayón, Gustavo (Instituto de Oncología de Asturias-IUOPA) ;
Díaz de la Guardia, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sierra, Marta I. (Instituto de Oncología de Asturias-IUOPA) ;
García-Toraño, Estela (Instituto de Oncología de Asturias-IUOPA) ;
Pérez, Raúl F. (Instituto de Oncología de Asturias-IUOPA) ;
García, María G. (Instituto de Oncología de Asturias-IUOPA) ;
Carella, Antonella (Instituto de Oncología de Asturias-IUOPA) ;
Pruneda, Patricia C. (Instituto de Oncología de Asturias-IUOPA) ;
Prieto, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Dmitrijeva, Marija (Instituto de Oncología de Asturias-IUOPA) ;
Santamarina-Ojeda, Pablo (Instituto de Oncología de Asturias-IUOPA) ;
Belmonte, Thalia (Instituto de Oncología de Asturias-IUOPA) ;
Mangas, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Diaconu, Elena (Instituto de Oncología de Asturias-IUOPA) ;
Ferrero, Cecilia (Instituto de Oncología de Asturias-IUOPA) ;
Tejedor, Juan Ramón (Instituto de Oncología de Asturias-IUOPA) ;
Fernandez-Morera, Juan Luis (Instituto de Oncología de Asturias-IUOPA) ;
Bravo, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sanjuan-Pla, Alejandra (Instituto de Investigación Sanitaria La Fe) ;
Rodríguez López, Ramón María (Hospital Universitario Central de Asturias) ;
Suárez-Álvarez, Beatriz (Hospital Universitario Central de Asturias) ;
López-Larrea, Carlos (Hospital Universitario Central de Asturias) ;
Bernal, Teresa (Hospital Universitario Central de Asturias) ;
Colado, Enrique (Hospital Universitario Central de Asturias) ;
Balbín, Milagros (Hospital Universitario Central de Asturias) ;
García-Suarez, Olivia (Universidad de Oviedo. Departamento de Morfología y Biología Celular) ;
Chiara, María Dolores (Hospital Universitario Central de Asturias) ;
Sáenz De Santa María, Inés (Hospital Universitario Central de Asturias) ;
Rodríguez, Francisco (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular) ;
Pando-Sandoval, Ana (Hospital Universitario Central de Asturias) ;
Rodrigo-Sáez, Luis (Hospital Universitario Central de Asturias) ;
Santos, Laura. (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Salas, Ana (Universidad de Oviedo. Servicio de Citometría) ;
Vallejo-Díaz, Jesús (Centro Nacional de Biotecnología (CNB-CSIC)) ;
Carrera, Ana C. (Centro Nacional de Biotecnología (CNB-CSIC)) ;
Rico, Daniel (Newcastle University. Institute of Cellular Medicine) ;
Hernández-López, Inmaculada (Newcastle University. Institute of Cellular Medicine) ;
Vayá, Amparo (Hospital Universitari i Politècnic La Fe (València)) ;
Ricart, José María (Quirón Clinic. Dermatology Service) ;
Seto, Edward (George Washington University Cancer Center) ;
Sima, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
Vaquero, Alejandro (Institut d'Investigació Biomèdica de Bellvitge) ;
Valledor, Luís (Universidad de Oviedo. Facultad de Biología) ;
Cañal Villanueva, María Jesús Fátima (Universidad de Oviedo. Facultad de Biología) ;
Pisano, David (Centro Nacional de Investigaciones Oncológicas) ;
Graña-Castro, Osvaldo (Centro Nacional de Investigaciones Oncológicas) ;
Thomas, Tim (University of Melbourne. Department of Medical Biology (Austràlia)) ;
Voss, Anne Kathrin (University of Melbourne. Department of Medical Biology (Austràlia)) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villar-Garea, Ana (University of Regensburg) ;
Deutzmann, Rainer (University of Regensburg) ;
Fernández, Agustín F (Instituto de Oncología de Asturias-IUOPA) ;
Fraga, Mario F. (Centro de Investigación en Nanociencia y Nanotecnología (Oviedo, Astúries)) ;
Universitat Autònoma de Barcelona
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. [...]
2019 - 10.1093/nar/gkz195
Nucleic acids research, Vol. 47 Núm. 10 (april 2019) , p. 5016-5037
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7.
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17 p, 5.7 MB |
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells
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Colli, M. L. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Ramos-Rodríguez, M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Nakayasu, E. S. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Alvelos, M. I. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Lopes, M. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Hill, J. L. E. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Turatsinze, J. V. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Coomans de Brachène, A. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Russell, M. A. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Raurell Vila, Helena (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Castela, A. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Juan-Mateu, J. (ULB Center for Diabetes Research. Medical Faculty. Université Libre de Bruxelles) ;
Webb-Robertson, B. J. M. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Krogvold, L. (Oslo University Hospital (Oslo, Noruega)) ;
Dahl-Jorgensen, K. (Oslo University Hospital (Oslo, Noruega)) ;
Marselli, L. (Department of Clinical and Experimental Medicine. Islet Cell Laboratory. University of Pisa) ;
Marchetti, P. (Department of Clinical and Experimental Medicine. Islet Cell Laboratory. University of Pisa) ;
Richardson, S. J. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Morgan, N. G. (Institute of Biomedical & Clinical Science. University of Exeter Medical School) ;
Metz, T. O. (Biological Sciences Division. Pacific Northwest National Laboratory) ;
Pasquali, Lorenzo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Eizirik, D. L. (Indiana Biosciences Research Institute) ;
Universitat Autònoma de Barcelona
Interferon-α (IFNα), a type I interferon, is expressed in the islets of type 1 diabetic individuals, and its expression and signaling are regulated by T1D genetic risk variants and viral infections associated with T1D. [...]
2020 - 10.1038/s41467-020-16327-0
Nature communications, Vol. 11 Núm. 1 (january 2020) , p. 2584
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8.
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12 p, 1.6 MB |
Immuno-metabolic profile of human macrophages after Leishmania and Trypanosoma cruzi infection
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Ty, M. C. (New York University School of Medicine. Department of Microbiology) ;
Loke, P. (New York University School of Medicine. Department of Microbiology) ;
Alberola, Jordi (Alberola i Domingo) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Rodriguez-Cortes, Alheli (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Macrophages can reprogram their metabolism in response to the surrounding stimuli, which affects their capacity to kill intracellular pathogens. We have investigated the metabolic and immune status of human macrophages after infection with the intracellular trypanosomatid parasites Leishmania donovani, L. [...]
2019 - 10.1371/journal.pone.0225588
PloS one, Vol. 14 Núm. 12 (december 2019) , p. e0225588
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9.
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26 p, 9.8 MB |
Presenilin/γ-secretase-dependent epha3 processing mediates axon elongation through non-muscle myosin IIA
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Javier, Miriam (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Marco, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Rocandio, Daniel (Institut de Recerca Biomèdica de Lleida) ;
Pons Vizcarra, Maria (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Janes, Peter W. (Tumour Targeting Program. Olivia Newton-John Cancer Research Institute) ;
Lackmann, Martin (Department of Biochemistry and Molecular Biology. Monash University) ;
Egea, Joaquim (Institut de Recerca Biomèdica de Lleida) ;
Saura Antolín, Carlos (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain. [...]
2019 - 10.7554/eLife.43646
eLife, Vol. 8 (october 2019) , p. e43646
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10.
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9 p, 2.4 MB |
Two-photon neuronal and astrocytic stimulation with azobenzene-based photoswitches
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Izquierdo Serra, Mercè (Institut de Bioenginyeria de Catalunya) ;
Gascón Moya, Marta (Universitat Autònoma de Barcelona. Departament de Química) ;
Hirtz, Jan J. (Columbia University. Department of Biological Sciences) ;
Pittolo, Silvia (Institut de Bioenginyeria de Catalunya) ;
Poskanzer, Kira E. (Columbia University. Department of Biological Sciences) ;
Ferrer Mallofré, Èric (Universitat Autònoma de Barcelona. Departament de Química) ;
Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química) ;
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química) ;
Yuste, Rafael (Columbia University. Department of Biological Sciences) ;
Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química) ;
Gorostiza, Pau (Institut de Bioenginyeria de Catalunya)
Synthetic photochromic compounds can be designed to control a variety of proteins and their biochemical functions in living cells, but the high spatiotemporal precision and tissue penetration of two-photon stimulation have never been investigated in these molecules. [...]
2014 - 10.1021/ja5026326
Journal of the American Chemical Society, Vol. 136, Issue 24 (June 2014) , p. 8693-8701
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