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Articles, 29 registres trobats
Documents de recerca, 5 registres trobats
Articles 29 registres trobats  1 - 10següentfinal  anar al registre:
14 p, 1.4 MB Survival Time after Surgical Debulking and Temozolomide Adjuvant Chemotherapy in Canine Intracranial Gliomas / Hidalgo Crespo, E. (AÚNA Especialidades Veterinarias) ; Farré Mariné, A. (AÚNA Especialidades Veterinarias) ; Pumarola i Batlle, Martí (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Borrego Massó, J.F. (AÚNA Especialidades Veterinarias) ; Luján Feliu-Pascual, A. (AÚNA Especialidades Veterinarias)
Intracranial gliomas are associated with a poor prognosis, and the most appropriate treatment is yet to be defined. The objectives of this retrospective study are to report the time to progression and survival times of a group of dogs with histologically confirmed intracranial gliomas treated with surgical debulking and adjuvant temozolomide chemotherapy. [...]
2022 - 10.3390/vetsci9080427
Veterinary Sciences, Vol. 9 Núm. 8 (august 2022) , p. 427  
16 p, 1.8 MB Photoactivable Ruthenium-Based Coordination Polymer Nanoparticles for Light-Induced Chemotherapy / Zhang, Junda (Institut Català de Nanociència i Nanotecnologia) ; Ramu, Vadde (Universiteit Leiden. Leiden Institute of Chemistry) ; Zhou, Xue-Quan (Universiteit Leiden. Leiden Institute of Chemistry) ; Frias, Carolina (Institut Català de Nanociència i Nanotecnologia) ; Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia) ; Bonnet, Sylvestre (Universiteit Leiden. Leiden Institute of Chemistry) ; Roscini, Claudio (Institut Català de Nanociència i Nanotecnologia) ; Novio Vázquez, Fernando (Institut Català de Nanociència i Nanotecnologia)
Green light photoactive Ru-based coordination polymer nanoparticles (CPNs), with chemical formula [[Ru(biqbpy)](bis)](PF) (biqbpy = 6,6'-bis[N-(isoquinolyl)-1-amino]-2,2'-bipyridine; bis = bis(imidazol-1-yl)-hexane), were obtained through polymerization of the trans-[Ru(biqbpy)(dmso)Cl]Cl complex (Complex 1) and bis bridging ligands. [...]
2021 - 10.3390/nano11113089
Nanomaterials, Vol. 11, Issue 11 (November 2021) , art. 3089  
15 p, 664.9 KB Ibrutinib plus Venetoclax for First-Line Treatment of Chronic Lymphocytic Leukemia : Primary Analysis Results from the Minimal Residual Disease Cohort of the Randomized Phase II CAPTIVATE Study / Wierda, W. G. (University of Texas.) ; Allan, J. N. (Weill Cornell Medicine) ; Siddiqi, T. (City of Hope National Medical Center) ; Kipps, T. J. (UCSD. Moores Cancer Center) ; Opat, S. (Monash University) ; Tedeschi, Alessandra (ASST Grande Ospedale Metropolitano Niguarda) ; Badoux, X. C. (Ministry of Health) ; Kuss, B. J. (Flinders University. Medical Centre) ; Jackson, S. (Middlemore Hospital) ; Moreno, Carol (Institut d'Investigació Biomèdica Sant Pau) ; Jacobs, R. M. D. (Levine Cancer Institute) ; Pagel, J. M. (Swedish Cancer Institute. Center for Blood Disorders and Stem Cell Transplantation) ; Flinn, I. (Sarah Cannon Research Institute. Tennessee Oncology) ; Pak, Y. (Pharmacyclics LLC. AbbVie Company) ; Zhou, C. (Pharmacyclics LLC. AbbVie Company) ; Szafer-Glusman, E. (Pharmacyclics LLC. AbbVie Company) ; Ninomoto, J. (Pharmacyclics LLC. AbbVie Company) ; Dean, James P (Pharmacyclics LLC. AbbVie Company) ; James, D. F. (Pharmacyclics LLC. AbbVie Company) ; Ghia, Paolo (Università Vita-Salute San Raffaele. IRCCS Ospedale San Raffaele) ; Tam, C. S. (Peter MacCallum Cancer Center. St Vincent's Hospital. University of Melbourne) ; Universitat Autònoma de Barcelona
PURPOSE CAPTIVATE (NCT02910583), a randomized phase II study, evaluates minimal residual disease (MRD)-guided treatment discontinuation following completion of first-line ibrutinib plus venetoclax treatment in patients with chronic lymphocytic leukemia (CLL). [...]
2021 - 10.1200/JCO.21.00807
Journal of Clinical Oncology, Vol. 39 Núm. 34 (january 2021) , p. 3853-3865  
41 p, 1.2 MB Therapeutic potential of emerging NAD+-increasing strategies for cardiovascular diseases / Rotllan, Noemi (Institut d'Investigació Biomèdica Sant Pau) ; Camacho, Mercedes (Institut d'Investigació Biomèdica Sant Pau) ; Tondo, Mireia (Institut d'Investigació Biomèdica Sant Pau) ; Diarte-Añazco, E. M. G. (Institut d'Investigació Biomèdica Sant Pau) ; Canyelles, Marina (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Méndez Lara, Karen Alejandra (Institut d'Investigació Biomèdica Sant Pau) ; Benitez, S. (Institut d'Investigació Biomèdica Sant Pau) ; Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ; Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau) ; Escola-Gil, Joan Carles (Institut d'Investigació Biomèdica Sant Pau) ; Blanco Vaca, Francisco (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Julve i Gil, Josep (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Cardiovascular diseases are the leading cause of death worldwide. Aging and/or metabolic stress directly impact the cardiovascular system. Over the last few years, the contributions of altered nicotinamide adenine dinucleotide (NAD+) metabolism to aging and other pathological conditions closely related to cardiovascular diseases have been intensively investigated. [...]
2021 - 10.3390/antiox10121939
Antioxidants, Vol. 10 Núm. 12 (december 2021) , p. 1939  
28 p, 10.5 MB Treatment with anti-TNF alpha protects against the neuropathy induced by the proteasome inhibitor bortezomib in a mouse model / Alé, Albert (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Bruna, Jordi (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Morell, Marta (Universitat Autònoma de Barcelona. Institut de Neurociències) ; van de Velde, Helgi (Janssen Research and Development) ; Monbaliu, Johan (Janssen Research and Development) ; Navarro, X. (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Udina i Bonet, Esther (Universitat Autònoma de Barcelona. Institut de Neurociències)
Bortezomib (BTZ), a proteasome inhibitor, is an effective anti-neoplastic drug used in the treatment of multiple myeloma and mantle cell lymphoma. However, it can induce a reversible peripheral neuropathy that may lead to treatment discontinuation. [...]
2014 - 10.1016/j.expneurol.2013.12.020
Experimental Neurology, Vol. 253 (march 2014) , p. 165-173  
12 p, 1.2 MB Evolution of Angiogenic Factors in Pregnant Patients with Breast Cancer Treated with Chemotherapy / Saura, Cristina (Vall d'Hebron Institut d'Oncologia) ; Sánchez Martínez, M. Olga (Vall d'Hebron Institut d'Oncologia) ; Martínez, Sandra (Vall d'Hebron Institut d'Oncologia) ; Domínguez, Carmen (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Dienstmann, Rodrigo (Vall d'Hebron Institut d'Oncologia) ; Ruíz-Pace, Fiorella (Vall d'Hebron Institut d'Oncologia) ; Céspedes, Maria Concepció (Hematologic Molecular Genetics Unit. Hematology Department. Hospital Universitari Vall d'Hebron. ERN-EuroBloodNet Member) ; Peñuelas, Ángeles (Vall d'Hebron Institut d'Oncologia) ; Cortés, Javier (Vall d'Hebron Institut d'Oncologia) ; Llurba, E. (Institut d'Investigació Biomèdica Sant Pau) ; Córdoba, Octavi (Institut d’Investigació Sanitària Illes Balears) ; Universitat Autònoma de Barcelona
Anthracyclines and taxanes are being used as a standard treatment for breast cancer diagnosed during pregnancy. These chemotherapy regimens allow the continuation of pregnancy without delaying cancer treatment with relatively good maternal and neonatal outcomes. [...]
2021 - 10.3390/cancers13040923
Cancers, Vol. 13 (february 2021)  
15 p, 2.1 MB Tetraploidy-associated genetic heterogeneity confers chemo-radiotherapy resistance to colorectal cancer cells / Galofré, Claudia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Gönül Geyik, Öykü (Dokuz Eylul University. Department of Medical Biology) ; Asensio, Elena (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Wangsa, Darawalee (National Institute of Health (Bethesda, EUA)) ; Hirsch, Daniela (National Institute of Health (Bethesda, EUA)) ; Parra, Carolina (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Saez, Jordi (Hospital Clínic i Provincial de Barcelona) ; Mollà, Meritxell (Hospital Clínic i Provincial de Barcelona) ; Yüce, Zeynep (Dokuz Eylul University. Department of Medical Biology) ; Castells, Antoni (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Ried, Thomas (National Institute of Health (Bethesda, EUA)) ; Camps, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Tetraploidy, or whole-genome duplication, is a common phenomenon in cancer and preludes chromosome instability, which strongly correlates with disease progression, metastasis, and treatment failure. Therefore, it is reasonable to hypothesize that tetraploidization confers multidrug resistance. [...]
2020 - 10.3390/cancers12051118
Cancers, Vol. 12, issue 5 (May 2020) , art. 1118  
11 p, 2.5 MB Impact of Adjuvant Chemotherapy on Survival of Patients with Advanced Residual Disease at Radical Cystectomy following Neoadjuvant Chemotherapy : Systematic Review and Meta-Analysis / Krajewski, Wojciech (Wrocław Medical University, Wroclaw, Poland) ; Nowak, Łukasz (Wrocław Medical University, Wroclaw, Poland) ; Moschini, Marco (Luzerner Kantonsspital, Lucerne, Switzerland) ; Poletajew, Sławomir (Centre of Postgraduate Medical Education, Warsaw, Poland) ; Chorbińska, Joanna (Wrocław Medical University, Wroclaw, Poland) ; Necchi, Andrea (Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy) ; Montorsi, Francesco (IRCCS Ospedale San Raffaele, Milan, Italy) ; Briganti, Alberto (IRCCS Ospedale San Raffaele, Milan, Italy) ; Sanchez-Salas, Rafael (Université Paris-Descartes, Paris, France) ; Shariat, Shahrokh F. (Charles University, Prague, Czech Republic) ; Palou, Juan ; Babjuk, Marek (Institut d'Investigació Biomèdica Sant Pau) ; Teoh, Jeremy Y. C. (The Chinese University of Hong Kong, Hong Kong) ; Soria, Francesco (San Giovanni Battista Hospital) ; Pradere, Benjamin (University Hospital of Tours, Tours) ; Ornaghi, Paola Irene (Luzerner Kantonsspital, Lucerne, Switzerland) ; Pawlak, Aleksandra (Wroclaw University of Environmental and Life Sciences, Wrocław, Poland) ; Dembowski, Janusz (Wrocław Medical University, Wroclaw, Poland) ; Zdrojowy, Romuald (Wrocław Medical University, Wroclaw, Poland) ; Universitat Autònoma de Barcelona
Background: Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with pelvic lymph-node dissection is the standard treatment for cT2-4a cN0 cM0 muscle-invasive bladder cancer (MIBC). [...]
2021 - 10.3390/jcm10040651
Journal of clinical medicine, Vol. 10 (february 2021)  
19 p, 2.8 MB The Beneficial Effects of Heme Oxygenase 1 and Hydrogen Sulfide Activation in the Management of Neuropathic Pain, Anxiety- and Depressive-like Effects of Paclitaxel in Mice / Roch, Gerard (Institut d'Investigació Biomèdica Sant Pau) ; Batallé Melgarejo, Gerard (Institut d'Investigació Biomèdica Sant Pau) ; Bai, Xue (Institut d'Investigació Biomèdica Sant Pau) ; Pouso-Vázquez, Enric (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rodríguez, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pol, Olga (Universitat Autònoma de Barcelona. Institut de Neurociències)
Chemotherapy-induced peripheral neuropathy constitutes an unresolved clinical problem that severely decreases the quality of the patient's life. It is characterized by somatosensory alterations, including chronic pain, and a high risk of suffering mental disorders such as depression and anxiety. [...]
2022 - 10.3390/antiox11010122
Antioxidants, Vol. 11 (january 2022)  
11 p, 726.2 KB Health-related quality of life in advanced gastric/gastroesophageal junction cancer with second-line pembrolizumab in KEYNOTE-061 / Van Cutsem, Eric (University Hospitals Gasthuisberg (Leuven, Bélgica)) ; Amonkar, Mayur (Merck & Co., Inc.. Center for Observational and Real World Evidence) ; Fuchs, Charles S. (Yale School of Medicine. Yale Cancer Center) ; Alsina, Maria (Vall d'Hebron Institut d'Oncologia) ; Özgüroğlu, Mustafa (Istanbul University-Cerrahpaşa. Department of Internal Medicine, Medical Oncology, and Clinical Trial Unit) ; Bang, Yung-Jue (Seoul National University College of Medicine. Department of Internal Medicine) ; Chung, Hyun Cheol (Yonsei University College of Medicine. Department of Medical Oncology) ; Muro, Kei (Aichi Cancer Center Hospital) ; Goekkurt, Eray (University Cancer Center Hamburg. North-German Trial Center for Innovative Oncology) ; Benson, Al B. (Northwestern University. Robert H. Lurie Comprehensive Cancer Center) ; Sun, Weijing (University of Kansas. Department of Internal Medicine and Medical Oncology) ; Wainberg, Zev A. (David Geffen School of Medicine at UCLA. Department of Medicine and Hematology and Oncology) ; Norquist, Josephine M. (Merck & Co., Inc.. Center for Observational and Real World Evidence) ; Chen, Xinqun (Merck & Co., Inc.. Department of Medical Oncology) ; Shih, Chie-Schin (Merck & Co., Inc.. Department of Medical Oncology) ; Shitara, Kohei (National Cancer Center Hospital. Department of Gastrointestinal Oncology) ; Universitat Autònoma de Barcelona
In the primary analysis population (i. e. , PD-L1 combined positive score [CPS] ≥ 1) of the phase 3 KEYNOTE-061 study (NCT02370498), pembrolizumab did not significantly prolong overall survival or progression-free survival. [...]
2021 - 10.1007/s10120-021-01200-w
Gastric Cancer, Vol. 24 (august 2021) , p. 1330-1340  

Articles : 29 registres trobats   1 - 10següentfinal  anar al registre:
Documents de recerca 5 registres trobats  
332 p, 9.5 MB Evaluación de nuevas técnicas ecocardiográficas basades en la deformación miocárdica para la detección precoç de cardiotoxicidad en la teràpia del càncer en la edad pediátrica / Sabidó Sánchez, Laura ; Rodrigo Gonzalo de Liria, Carlos, dir. ; Sabaté-Rotés, Anna, dir. ; Gallego, Soledad, dir.
La cardiotoxicidad por agentes antitumorales durante la terapia o años después de la suspensión ha sido principalmente atribuida a las antraciclinas y a la radioterapia. Las técnicas clásicas de evaluación cardiológica en pacientes pediátricos que reciben quimioterapia no detectan la disfunción cardiaca en sus fases más precoces, cuando la terapia sería la mayor ayuda. [...]
Cardiotoxicity from antitumor agents during therapy or years after discontinuation has been primarily attributed to anthracyclines and radiation therapy. Classic cardiac evaluation techniques in pediatric patients receiving chemotherapy don't detect cardiac dysfunction in its earliest stages, when therapy would be the most helpful. [...]

107 p, 1.8 MB Cáncer colorrectal : resultados del tratamiento con quimioterapia con o sin terapias dirigidas y rescate quirúrgico de la metástasis / Sun, Chen ; Balañá, Carmen, dir. ; Romeo, Margarita, dir. ; Ribera Santasusana, J. M. (José María), dir.
Encara que s'ha establert l'eficàcia de tractament combinat de quimioteràpia amb anti EGFR o anti VEGF en pacients amb càncer colorectal metastàtic (CCRM), es necessiten estudis poblacionals per conèixer millor la implementació real de tractament combinat d'anti EGFR o anti VEGF en la pràctica diària . [...]
Aunque se ha establecido la eficacia de tratamiento combinado de quimioterapia con anti EGFR o anti VEGF en pacientes con cáncer colorrectal metastásico (CCRm), se necesitan estudios poblacionales para conocer mejor la implementación real de tratamiento combinado de anti EGFR o anti VEGF en la práctica diaria. [...]
Although the efficacy of combined chemotherapy treatment with anti EGFR or anti VEGF in patients with metastatic colorectal cancer (mCRC) has been established, population studies are needed to better understand the real implementation of combined anti EGFR or anti VEGF treatment in daily practice. [...]

320 p, 9.8 MB Metabolomic analysis of oxidative stress and inflammation biomarkers during chemotherapy treatment in pregnant women with breast cancer and their offspring / Martínez González, Sandra ; LLurba Olivé, Elisa, dir. ; Tornador Antolin, Cristian, 1979-, dir. ; Schwartz Navarro, Simó, dir.
El càncer de mama associat a l'embaràs (PABC) és definit com càncer de mama diagnosticat durant l'embaràs o un any després del part. La quimioteràpia durant l'embaràs pot incrementar la producció d'estrès oxidatiu i inflamació elevant el risc de complicacions obstètriques. [...]
El cáncer de mama asociado al embarazo (PABC en inglés) es definido como cáncer de mama diagnosticado durante el embarazo o un año después del parto. La quimioterapia administrada durante el embarazo puede aumentar la producción de estrés oxidativo e inflamación elevando el riesgo de problemas obstétricos. [...]
Pregnancy-associated breast cancer (PABC) is defined as breast cancer diagnosed during pregnancy or one-year following postpartum. Chemotherapy treatment in pregnancy may aumentate the production of oxidative stress and inflammation increasing risk of obstetrics complications. [...]

1 p, 8.3 MB Nanotechnology to overcome cancer drug resistance / F. Gusta, Muriel ; Farrés, Jaume, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Grau en Ciències Biomèdiques [832]  
1 p, 962.8 KB Leukemias induced by chemotherapy / García Salas, Inés ; Armengol Rosell, Gemma, dir. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
Grau en Ciències Biomèdiques [832]  

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