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Artículos, Encontrados 6 registros
Artículos Encontrados 6 registros  
1.
8 p, 1.6 MB T1/T2-weighted ratio in multiple sclerosis : A longitudinal study with clinical associations / Boaventura de Oliveira, Mateus (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Garcia-Vidal, Aran (Hospital Universitari Vall d'Hebron) ; Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Quartana, Davide (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Carvajal-Junco, René (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Auger, Cristina (Hospital Universitari Vall d'Hebron) ; Alberich, Manel (Hospital Universitari Vall d'Hebron) ; Tintoré, Mar (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Rovira, Alex (Hospital Universitari Vall d'Hebron) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Pareto, Deborah (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
Background: T1w/T2-w ratio has been proposed as a clinically feasible MRI biomarker to assess tissue integrity in multiple sclerosis. However, no data is available in the earliest stages of the disease and longitudinal studies analysing clinical associations are scarce. [...]
2022 - 10.1016/j.nicl.2022.102967
NeuroImage, Vol. 34 (2022) , p. 102967  
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2.
8 p, 871.8 KB Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis / Otero-Romero, Susana (Hospital Universitari Vall d'Hebron) ; Carbonell-Mirabent, Pere (Hospital Universitari Vall d'Hebron) ; Midaglia, Luciana (Hospital Universitari Vall d'Hebron) ; Zuluaga Rodas, María Isabel (Hospital Universitari Vall d'Hebron) ; Galan, Ingrid (Hospital Universitari Vall d'Hebron) ; Cobo-Calvo, Álvaro (Hospital Universitari Vall d'Hebron) ; Río, Jordi (Hospital Universitari Vall d'Hebron) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron) ; Castilló, Joaquín (Hospital Universitari Vall d'Hebron) ; Rodríguez Acevedo, Breogán (Hospital Universitari Vall d'Hebron) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron) ; Rodríguez, Marta (Hospital Universitari Vall d'Hebron) ; Tur, Carmen (Hospital Universitari Vall d'Hebron) ; Auger, Cristina (Hospital Universitari Vall d'Hebron) ; Rovira, Alex (Hospital Universitari Vall d'Hebron) ; Sastre-Garriga, Jaume (Hospital Universitari Vall d'Hebron) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron) ; Tintoré, Mar (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
To evaluate whether oral contraceptive (OC) use is associated with the risk of a second attack and disability accrual in women with a clinically isolated syndrome (CIS) and early multiple sclerosis (MS). [...]
2021 - 10.1177/13524585211053001
Multiple sclerosis, Vol. 28 (november 2021) , p. 950-957  
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3.
13 p, 1.9 MB Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A systematic review and meta-analysis / Hegen, Harald (Medical University of Innsbruck) ; Walde, Janette (University of Innsbruck) ; Berek, Klaus (University of Innsbruck) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Gnanapavan, Sharmilee (Queen Mary University of London) ; Kaplan, Batia (Sheba Medical Center (Israel)) ; Khalil, Michael (Medical University of Graz) ; Saadeh, Ruba (Clínica Mayo) ; Teunissen, Charlotte E (Vrije Universiteit) ; Tumani, Hayrettin (University of Ulm) ; Villar, Luisa M (Hospital Universitario Ramón y Cajal (Madrid)) ; Willrich, Maria Alice V (Clínica Mayo) ; Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ; Deisenhammer, Florian ; Universitat Autònoma de Barcelona
Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid. To perform a systematic review and meta-analysis to evaluate whether κ-FLC index has similar diagnostic value to identify patients with clinically isolated syndrome (CIS) or MS compared to OCB, and to determine κ-FLC index cut-off. [...]
2022 - 10.1177/13524585221134213
Multiple sclerosis, Vol. 29 (december 2022) , p. 169-181  
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4.
14 p, 1.1 MB Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis : A consensus statement / Hegen, Harald (Medical University of Innsbruck) ; Arrambide, Georgina (Hospital Universitari Vall d'Hebron) ; Gnanapavan, Sharmilee (Queen Mary University of London) ; Kaplan, Batia (Sheba Medical Center) ; Khalil, Michael (Medical University of Graz) ; Saadeh, Ruba (Mayo Clinic (Rochester)) ; Teunissen, Charlotte E (Amsterdam UMC) ; Tumani, Hayrettin (University of Ulm) ; Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ; Willrich, Maria Alice V (Mayo Clinic) ; Zetterberg, Henrik (Sahlgrenska University Hospital (Suècia)) ; Deisenhammer, Florian (Medical University of Innsbruck) ; Universitat Autònoma de Barcelona
Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria. [...]
2022 - 10.1177/13524585221134217
Multiple sclerosis, Vol. 29 (december 2022) , p. 182-195  
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5.
9 p, 349.5 KB Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome : A MAGNIMS multicentre study / Hagens, M. H. J. (Department of Neurology. MS Center Amsterdam. VU University Medical Center) ; Burggraaff, Jessica (Department of Neurology. MS Center Amsterdam. VU University Medical Center) ; Kilsdonk, I. D. (Department of Radiology and Nuclear Medicine. Onze Lieve Vrouwen Gasthuis) ; Ruggieri, Serena (San Camillo Forlanini Hospital) ; Collorone, S. (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology) ; Cortese, R. (Department of Basic Medical Sciences. Neurosciences and Sense Organs. University of Bari) ; Cawley, Niamh (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology) ; Sbardella, E. (Department of Neurology and Psychiatry. Sapienza University of Rome) ; Andelova, M. (University Hospital Basel (Basilea, Suïssa)) ; Amann, Michael (University Hospital Basel (Basilea, Suïssa)) ; Lieb, J. M. (University Hospital Basel (Basilea, Suïssa)) ; Pantano, P. (Istituto Neurologico Mediterraneo. Neuromed) ; Lissenberg-Witte, B. I. (Department of Epidemiology and Biostatistics. VU University Medical Centre) ; Killestein, Joep (Department of Neurology. MS Center Amsterdam. VU University Medical Center) ; Oreja-Guevara, Celia (Hospital Clínico San Carlos (Madrid)) ; Wuerfel, J. (University Hospital Basel (Basilea, Suïssa)) ; Ciccarelli, Olga (NMR Research Unit. Queen Square Multiple Sclerosis Centre. UCL Institute of Neurology) ; Gasperini, C. (San Camillo Forlanini Hospital) ; Lukas, Cédric (Department of Diagnostic and Interventional Radiology and Nuclear Medicine. St. Josef Hospital. Ruhr University) ; Rovira, A. (Hospital Universitari Vall d'Hebron) ; Barkhof, Frederik (UCL Institute of Neurology (Regne Unit)) ; Wattjes, M. P. (Department of Radiology and Nuclear Medicine. MS Center Amsterdam. VU University Medical Center) ; Universitat Autònoma de Barcelona
Background: Compared to 1. 5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. [...]
2019 - 10.1177/1352458517751647
Multiple sclerosis, Vol. 25 Núm. 3 (january 2019) , p. 352-360  
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6.
9 p, 542.1 KB Validation of semaphorin 7A and ala-β-his-dipeptidase as biomarkers associated with the conversion from clinically isolated syndrome to multiple sclerosis / Cantó Puig, Ester (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Tintoré, Mar ; Villar, Luisa Maria (Hospital Universitario Ramón y Cajal (Madrid)) ; Borràs, Eva (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Alvarez-Cermeño, José C (Hospital Universitario Ramón y Cajal (Madrid)) ; Chiva, Cristina (Universitat Pompeu Fabra) ; Sabidó, Eduard (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ; Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Comabella, Manuel (Hospital Universitari Vall d'Hebron) ; Universitat Autònoma de Barcelona
In a previous proteomics study using pooled cerebrospinal fluid (CSF) samples, we proposed apolipoprotein AI, apolipoprotein AIV, vitronectin, plasminogen, semaphorin 7A, and ala-β-his-dipeptidase as candidate biomarkers associated with the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndromes (CIS). [...]
2014 - 10.1186/s12974-014-0181-8
Journal of neuroinflammation, Vol. 11 (november 2014)  
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