Resultats globals: 8 registres trobats en 0.02 segons.
Articles, 8 registres trobats
Articles 8 registres trobats  
1.
12 p, 319.2 KB Relative Codon Adaptation : A Generic Codon Bias Index for Prediction of Gene Expression / Fox, Jesse M. (University of Maryland Baltimore County. Department of Biological Sciences) ; Erill, Ivan (University of Maryland Baltimore County. Department of Biological Sciences)
The development of codon bias indices (CBIs) remains an active field of research due to their myriad applications in computational biology. Recently, the relative codon usage bias (RCBS) was introduced as a novel CBI able to estimate codon bias without using a reference set. [...]
2010 - 10.1093/dnares/dsq012
DNA Research, Vol. 17, Issue 3 (June 2010) , p. 185-196  
2.
10 p, 949.6 KB Synonymous Codon Pair Recoding of the HIV-1 env Gene Affects Virus Replication Capacity / Jordan de Paiz, Ana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Franco Cirera, Sandra (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martinez, Miguel Angel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Synonymous codon pair deoptimization is an efficient strategy for virus attenuation; however, the underlying mechanism remains controversial. Here, we optimized and deoptimized the codon pair bias (CPB) of the human immunodeficiency virus type 1 (HIV-1) envelope (env) gene to investigate the influence of env synonymous CPB recoding on virus replication capacity, as well as the potential mechanism. [...]
2021 - 10.3390/cells10071636
Cells, Vol. 10 (june 2021)  
3.
12 p, 5.8 MB Absence of p.R50X Pygm read-through in McArdle disease cellular models / Tarrasó, Guillermo (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Real-Martinez, Alberto (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Parés, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Romero-Cortadellas, Lídia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Puigros, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Moya Borrego, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; de Luna Salva, Noemí (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Brull, Astrid (Sorbonne Université, INSERM UMRS_974, Center of Research in Myology) ; Martín, Miguel Angel (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Arenas, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Lucia, Alejandro (European University) ; Andreu Périz, Antoni Lluís (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Barquinero, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Vissing, John (Copenhagen University Hospital Rigshospitalet) ; Krag, Thomas (Copenhagen University Hospital Rigshospitalet) ; Pinós Figueras, Tomàs (Hospital Universitari Vall d'Hebron. Institut de Recerca) ; Universitat Autònoma de Barcelona
McArdle disease is an autosomal recessive disorder caused by the absence of muscle glycogen phosphorylase, which leads to blocked muscle glycogen breakdown. We used three different cellular models to evaluate the efficiency of different read-through agents (including amlexanox, Ataluren, RTC13 and G418) in McArdle disease. [...]
2020 - 10.1242/dmm.043281
Disease Models & Mechanisms, Vol. 13 (january 2020)  
4.
15 p, 1.6 MB Comprehensive Analysis of Codon Usage Patterns in Chinese Porcine Circoviruses Based on Their Major Protein-Coding Sequences / Feng, Hua (Henan Provincial Key Laboratory of Animal Immunology) ; Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ; Wang, Fangyu (Henan Provincial Key Laboratory of Animal Immunology) ; Jin, Qianyue (Henan Provincial Key Laboratory of Animal Immunology) ; Wang, Aiping (Zhengzhou University. School of Life Sciences) ; Zhang, Gaiping (Zhengzhou University. School of Life Sciences) ; Franzo, Giovanni (University of Padua. Department of Animal Medicine)
Porcine circoviruses (PCVs) are distributed in swine herds worldwide and represent a threat to the health of domestic pigs and the profits of the swine industry. Currently, four PCV species, including PCV-1, PCV-2, PCV-3 and PCV-4, have been identified in China. [...]
2022 - 10.3390/v14010081
Viruses, Vol. 14 (january 2022)  
5.
11 p, 2.4 MB Amino acid substitutions at sugar-recognizing codons confer ABO blood group system-related α1,3 Gal(NAc) transferases with differential enzymatic activity / Cid, Emili (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Yamamoto, Miyako (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Yamamoto, Fumiichiro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
Functional paralogous ABO, GBGT1, A3GALT2, and GGTA1 genes encode blood group A and B transferases (AT and BT), Forssman glycolipid synthase (FS), isoglobotriaosylceramide synthase (iGb3S), and α1,3-galactosyltransferase (GT), respectively. [...]
2019 - 10.1038/s41598-018-37515-5
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 846  
6.
27 p, 835.3 KB Detection of homozygous genotypes for a putatively lethal recessive mutation in the porcine argininosuccinate synthase 1 (ASS1) gene / Mármol-Sánchez, Emilio (Centre de Recerca en Agrigenòmica) ; Luigi Sierra, Maria Gracia (Centre de Recerca en Agrigenòmica) ; Quintanilla, Raquel (Institut de Recerca i Tecnologia Agroalimentàries) ; Amills i Eras, Marcel (Centre de Recerca en Agrigenòmica)
The sequencing of the pig genome revealed the existence of homozygous individuals for a nonsense mutation in the argininosuccinate synthase 1 (ASS1) gene (rs81212146, c. 944T>A, L315X). Paradoxically, an AA homozygous genotype for this polymorphism is expected to abolish the function of the ASS1 enzyme that participates in the urea cycle, leading to citrullinemia, hyperammonemia, coma and death. [...]
2020 - 10.1111/age.12877
Animal Genetics, Vol. 51, Issue 1 (February 2020) , p. 106-110  
7.
12 p, 786.4 KB Changes in codon-pair bias of human immunodeficiency virus type 1 have profound effects on virus replication in cell culture / Martrus, Gloria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Nevot Banús, Maria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Andrés, Cristina (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ; Martinez, Miguel Ángel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Background: Human immunodeficiency virus type 1 (HIV-1) has a biased nucleotide composition different from human genes. This raises the question of how evolution has chosen the nucleotide sequence of HIV-1 that is observed today, or to what extent the actual encoding contributes to virus replication capacity, evolvability and pathogenesis. [...]
2013 - 10.1186/1742-4690-10-78
Retrovirology, Vol. 10, N. 78 (25 July 2013) , p. 1-12
6 documents
8.
6 p, 219.5 KB Hacking the code : una aproximació indagadora a l'ensenyament del codi genètic, o seguint les passes de Nirenberg i Khorana / Domènech Casal, Jordi (INS Marta Mata (Montornès del Vallès)) ; Universitat Autònoma de Barcelona. Grup de Recerca Llenguatge i Ensenyament de les Ciències
Es descriu el disseny i aplicació d'una activitat didàctica sobre el codi genètic, al llarg de tres eixos didàctics: l'aprenentatge per indagació, la naturalesa del coneixement científic i la reflexió sobre els aprenentatges. [...]
The article presents a didactic activity about the Genetic Code, based on three methodo-logic principles: Inquiry-based science education, creation and nature of the scientific knowledge , and reflection on the learning process. [...]

2013 - 10.5565/rev/ciencies.90
Ciències : revista del professorat de ciències de primària i secundària, Núm. 25 (Juny 2013) , p. 20-25  

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