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1.
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12 p, 1.3 MB |
Dual targeted therapy in patients with psoriatic arthritis and spondyloarthritis : a real-world multicenter experience from Spain
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Valero-Martínez, Cristina (Hospital Universitario de La Princesa) ;
Urgelles, Judit Font (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sallés, Meritxell (Althaia Xarxa Assistencial Universitària) ;
Joven-Ibáñez, Beatriz E. (Hospital 12 de Octubre (Madrid)) ;
de Juanes, Alexia (Hospital 12 de Octubre (Madrid)) ;
Ramírez, Julio (Hospital Clínic i Provincial de Barcelona) ;
Juanola, Xavier (Hospital Universitari de Bellvitge) ;
Almodóvar, Raquel (Hospital Universitario Fundación Alcorcón) ;
Laiz, Ana (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Moreno Martínez-Losa, Mireia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Pujol, Manel (Hospital Universitari MútuaTerrassa) ;
Beltran Catalan, Emma (Hospital del Mar (Barcelona, Catalunya)) ;
Pinto-Tasende, José Antonio (Hospital Universitario de A Coruña) ;
Crespí, Laura (Hospital de Manacor) ;
Sala-Icardo, Luis (Hospital de Torrejón de Ardoz) ;
Castañeda, Santos (Universidad Autónoma de Madrid) ;
García-Vicuña, Rosario (Universidad Autónoma de Madrid) ;
Universitat Autònoma de Barcelona
Dual targeted therapy (DTT) has emerged as a promising approach in patients with refractory spondyloarthritis (SpA) or psoriatic arthritis (PsA) and extra-musculoskeletal manifestations of both diseases, but its effectiveness/safety ratio still remains unclear. [...]
2023 -  10.3389/fimmu.2023.1283251
Frontiers in immunology, Vol. 14 (october 2023)
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2.
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11 p, 474.2 KB |
Phase 1/2 Study of the CD56-Targeting Antibody-Drug Conjugate Lorvotuzumab Mertansine (IMGN901) in Combination With Carboplatin/Etoposide in Small-Cell Lung Cancer Patients With Extensive-Stage Disease
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Socinski, Mark A. (Univeristy of Pittsburgh Cancer Institute) ;
Kaye, Frederic J. (University of Florida College of Medicine) ;
Spigel, David R. (Sarah Cannon Research Institute) ;
Kudrik, Fred J. (South Carolina Oncology Associates) ;
Ponce, Santiago (Hospital 12 de Octubre (Madrid)) ;
Ellis, Peter M. (Juravinski Cancer Centre) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Lorigan, Paul (University of Manchester/Christie NHS Foundation Trust) ;
Gandhi, Leena (Dana-Farber Cancer Institute (Boston, Estats Units d'Amèrica)) ;
Gutierrez, Martin E. (Holy Cross Hospital) ;
Nepert, Dale (Clinical Development. ImmunoGen Inc) ;
Corral, Jesus (Hospital 12 de Octubre (Madrid)) ;
Ares, Luis Paz (Hospital 12 de Octubre (Madrid)) ;
Universitat Autònoma de Barcelona
Lorvotuzumab mertansine (LM, IMGN901) is a CD56-targeting antibody-drug conjugate developed for tumor-selective delivery of the cytotoxic maytansinoid DM1. This phase 1/2 study evaluated the combination of LM with first-line carboplatin/etoposide chemotherapy in patients with extensive-disease small-cell lung cancer. [...]
2017 - 10.1016/j.cllc.2016.09.002
Clinical Lung Cancer, Vol. 18 Núm. 1 (january 2017) , p. 68-76.e2
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3.
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19 p, 633.5 KB |
Systematic review on long-term adverse effects of inhaled corticosteroids in the treatment of COPD
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Miravitlles, M. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Auladell-Rispau, Ariadna (Institut d'Investigació Biomèdica Sant Pau) ;
Monteagudo, M. (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Vázquez-Niebla, Juan Carlos (Institut d'Investigació Biomèdica Sant Pau) ;
Mohammed, J. (Dept of Physiotherapy. Bayero University) ;
Núñez, Alexa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Urrútia, Gerard (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Inhaled corticosteroids (ICSs) are indicated for the prevention of exacerbations in COPD; however, a significant proportion of patients at low risk of exacerbations are treated with ICSs. We conducted a systematic review including a diversity of types of study designs and safety outcomes with the objective of describing the risk of adverse effects associated with the long-term use of ICSs in patients with COPD. [...]
2021 - 10.1183/16000617.0075-2021
European Respiratory Review, Vol. 30 Núm. 160 (june 2021) , p. 210075
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4.
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10 p, 1005.5 KB |
Automatic Estimation of the Most Likely Drug Combination in Electronic Health Records Using the Smooth Algorithm : Development and Validation Study
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Ouchi, Dan (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Giner-Soriano, Maria (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Gomez-Lumbreras, Ainhoa (University of Utah) ;
Vedia Urgell, Cristina (Institut Català de la Salut) ;
Torres, Ferran (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Morros, Rosa (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Since the use of electronic health records (EHRs) in an automated way, pharmacovigilance or pharmacoepidemiology studies have been used to characterize the therapy using different algorithms. Although progress has been made in this area for monotherapy, with combinations of 2 or more drugs the challenge to characterize the treatment increases significantly, and more research is needed. [...]
2022 - 10.2196/37976
JMIR Medical Informatics, Vol. 10 (november 2022)
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5.
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25 p, 4.8 MB |
Selectively Targeting Breast Cancer Stem Cells by 8-Quinolinol and Niclosamide
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Cámara-Sánchez, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Díaz Riascos, Zamira Vanessa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García Aranda, Natalia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gener, Petra (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Giani-Alonso, Micaela (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Royo, Miriam (Institut de Química Avançada de Catalunya) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Schwartz, Simon (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Abasolo, Ibane (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona.
Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí"
Cancer maintenance, metastatic dissemination and drug resistance are sustained by cancer stem cells (CSCs). Triple negative breast cancer (TNBC) is the breast cancer subtype with the highest number of CSCs and the poorest prognosis. [...]
2022 - 10.3390/ijms231911760
International journal of molecular sciences, Vol. 23, Issue 19 (October 2022) , art. 11760
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16 p, 3.3 MB |
Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis
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Bernardo-Faura, Martí (Centre de Recerca en Agrigenòmica) ;
Rinas, Melanie (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ;
Wirbel, Jakob (Rwth Aachen University. Joint Research Center for Computational Biomedicine) ;
Pertsovskaya, Inna (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Pliaka, Vicky (School of Mechanical Engineering, National Technical University of Athens) ;
Messinis, Dimitris E. (ProtATonce) ;
Vila, Gemma (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Sakellaropoulos, Theodore (National Technical University of Athens) ;
Faigle, Wolfgang (University of Zurich) ;
Stridh, Pernilla (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Behrens, Janina R. (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ;
Olsson, Tomas (Karolinska Institutet (Estocolm, Suècia). Department of Clinical Neuroscience) ;
Martin, Roland (University Hospital Zurich (Suïssa)) ;
Paul, Friedemann (Charité University Medicine Berlin. NeuroCure Clinical Research Center and Department of Neurology) ;
Alexopoulos, Leonidas G. (ProtATonce) ;
Villoslada, Pablo (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Saez-Rodriguez, Julio (Heidelberg University Hospital (Alemanya))
Multiple sclerosis (MS) is a major health problem, leading to a significant disability and patient suffering. Although chronic activation of the immune system is a hallmark of the disease, its pathogenesis is poorly understood, while current treatments only ameliorate the disease and may produce severe side effects. [...]
2021 - 10.1186/s13073-021-00925-8
Genome Medicine, Vol. 13 (July 2021) , art. 117
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8 p, 1.4 MB |
Antitumoral effect of maintained neutrophilia induced by rhG-CSF in a murine model of pancreatic cancer
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Brú, A. (Universidad Complutense de Madrid. Facultad de Matemáticas) ;
Bosch, R. (Institut d'Investigació Biomèdica Sant Pau) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Carmona, Silvia (Institut d'Investigació Biomèdica Sant Pau) ;
Pascual, E. (Institut d'Investigació Biomèdica Sant Pau) ;
Brú, I. (Centro de Salud La Estación) ;
Souto, J. C. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Although the protumoral functions of polymorphonuclear neutrophils are well known, some now-forgotten studies report antitumoral roles for these cells. The present work examines the antitumoral effect of maintained neutrophilia induced via the injection of recombinant human granulocyte colony stimulating factor (rhG-CSF, 100 μg/kg/day) in a Panc-1 subcutaneous xenograft murine model of pancreatic cancer. [...]
2019 - 10.1038/s41598-019-39805-y
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 2879
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20 p, 6.8 MB |
IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
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Colomer, Carlota (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Margalef, Pol (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Villanueva, Alberto (Institut d'Investigació Biomèdica de Bellvitge) ;
Vert, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pecharroman, Irene (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Solé Font, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gonzàlez-Farré, Mònica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Alonso, Josune (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Montagut, Clara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martinez-Iniesta, Maria (Institut d'Investigació Biomèdica de Bellvitge) ;
Bertran, Joan (Universitat de Vic - Universitat Central de Catalunya) ;
Borràs, Eva (Centre de Regulació Genòmica) ;
Iglesias, Mar (Universitat Autònoma de Barcelona. Departament de Ciències Morfològiques) ;
Sabidó, Eduard (Centre de Regulació Genòmica) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Boulton, Simon J. (The Francis Crick Institute) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques)
Phosphorylated IKKα(p45) is a nuclear active form of the IKKα kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-κB signaling. Insights into the sources of IKKα(p45) activation and its downstream substrates in the nucleus remain to be defined. [...]
2019 - 10.1016/j.molcel.2019.05.036
Molecular Cell, Vol. 75 (august 2019) , p. 669-682.e5
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41 p, 2.4 MB |
Autophagy modulators : mechanistic aspects and drug delivery systems
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Tavakol, Shima (Iran University of Medical Sciences. Cellular and Molecular Research Center) ;
Ashrafizadeh, Milad (University of Tabriz. Department of basic science) ;
Deng, Shuo (National University of Singapore. Department of Physiology) ;
Azarian, Maryam (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Abdoli, Asghar (Pasteur Institute of Iran. Department of Hepatitis and AIDS) ;
Motavaf, Mahsa (Tarbiat Modares University. Department of Molecular Genetics) ;
Poormoghadam, Delaram (Islamic Azad University. Department of Medical Nanotechnology) ;
Khanbabaei, Hashem (Ahvaz Jundishapur University of Medical Sciences. Medical Physics Departmen) ;
Ghasemipour Afshar, Elham (Kerman University of Medical Sciences. Neuroscience Research Center) ;
Mandegary, Ali (Kerman University of Medical Sciences. Neuroscience Research Center) ;
Pardakhty, Abbas (Kerman University of Medical Sciences. Neuroscience Research Center) ;
Yap, Celestial T. (National University of Singapore. Department of Physiology) ;
Mohammadinejad, Reza (Kerman University of Medical Sciences. Pharmaceutics Research Center) ;
Prem Kumar, Alan (Cancer Science Institute of Singapore) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Autophagy modulation is considered to be a promising programmed cell death mechanism to prevent and cure a great number of disorders and diseases. The crucial step in designing an effective therapeutic approach is to understand the correct and accurate causes of diseases and to understand whether autophagy plays a cytoprotective or cytotoxic/cytostatic role in the progression and prevention of disease. [...]
2019 - 10.3390/biom9100530
Biomolecules, Vol. 9, issue 10 (Sep. 2019) , art. 530
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24 p, 2.0 MB |
Recent advances in the targeting of epigenetic regulators in b-cell non-hodgkin lymphoma
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Ribeiro, Marcelo L. (Vall d'Hebron Institut d'Oncologia) ;
Reyes Garau, Diana (Vall d'Hebron Institut d'Oncologia) ;
Armengol, Marc Antoni (Vall d'Hebron Institut d'Oncologia) ;
Roué, Gaël (Vall d'Hebron Institut d'Oncologia) ;
Universitat Autònoma de Barcelona
In the last 10 years, major advances have been made in the diagnosis and development of selective therapies for several blood cancers, including B-cell non-Hodgkin lymphoma (B-NHL), a heterogeneous group of malignancies arising from the mature B lymphocyte compartment. [...]
2019 - 10.3389/fgene.2019.00986
Frontiers in genetics, Vol. 10 Núm. OCT (2019) , p. 986
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