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22 p, 1.4 MB |
Effect of Local Administration of Meglumine Antimoniate and Polyhexamethylene Biguanide Alone or in Combination with a Toll-like Receptor 4 Agonist for the Treatment of Papular Dermatitis due to Leishmania infantum in Dogs
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Martínez-Flórez, Icíar (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Guerrero, Maria Jose (Hospital Veterinario Alhaurín el Grande, 29120 Alhaurín el Grande, Spain) ;
Dalmau, A (AniCura Mediterrani Hospital Veterinari, 43204 Reus, Spain) ;
Cabré, Maria (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Alcover, M. Magdalena (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient) ;
Berenguer, Diana (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient) ;
Good, Liam (University of London. Department of Pathobiology and Population Sciences) ;
Fisa, Roser (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient) ;
Riera, Cristina (Universitat de Barcelona. Departament de Biologia, Sanitat i Medi Ambient) ;
Ordeix, Laura (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Solano Gallego, Laia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Papular dermatitis is a cutaneous manifestation of canine Leishmania infantum infection associated with mild disease. Although it is a typical presentation, nowadays, there is still no established treatment. [...]
2023 -  10.3390/pathogens12060821
Pathogens, Vol. 12 (june 2023)
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11 p, 3.4 MB |
PIVOT-12 : a phase III study of adjuvant bempegaldesleukin plus nivolumab in resected stage III/IV melanoma at high risk for recurrence
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Eggermont, Alexander M. (Princess Máxima Center for Pediatric Oncology & University Medical Center Utrecht) ;
Ascierto, Paolo A. (Istituto Nazionale Tumori IRCCS Fondazione G Pascale) ;
Khushalani, Nikhil I. (H Lee Moffitt Cancer Center & Research Institute) ;
Schadendorf, Dirk (West German Cancer Center at the University Hospital Essen) ;
Boland, Genevieve (Massachusetts General Hospital (Boston)) ;
Weber, Jeffrey (Perlmutter Cancer Center at NYU Langone Health) ;
Lewis, Karl D. (University of Colorado Cancer Center) ;
Johnson, Daniel (Ochsner Medical Center) ;
Rivalland, Gareth (University of Auckland & Auckland City Hospital) ;
Khattak, Adnan (Hollywood Private Hospital. Edith Cowan University) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Gogas, Helen (National & Kapodistrian University of Athens) ;
Long, Georgina V. (Melanoma Institute Australia. University of Sydney. Royal North Shore & Mater Hospitals) ;
Currie, Sue L. (Nektar Therapeutics, San Francisco, CA 94158, USA) ;
Chien, David (Nektar Therapeutics, San Francisco, CA 94158, USA) ;
Tagliaferri, Mary A. (Nektar Therapeutics, San Francisco, CA 94158, USA) ;
Carlino, Matteo S. (Westmead & Blacktown Hospitals & Melanoma Institute Australia. University of Sydney) ;
Diab, Adi (University of Texas MD Anderson Cancer Center)
Bempegaldesleukin (BEMPEG: NKTR-214) is an immunostimulatory IL-2 cytokine prodrug engineered to deliver a controlled, sustained and preferential IL-2 pathway signal. Nivolumab (NIVO), a PD-1 inhibitor, has been shown to prolong survival in patients with advanced melanoma and recurrence-free survival in the adjuvant setting. [...]
2022 - 10.2217/fon-2021-1286
Future oncology (London, England), Vol. 18 Núm. 8 (january 2022) , p. 903-913
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19 p, 1.6 MB |
Update on Management Recommendations for Advanced Cutaneous Squamous Cell Carcinoma
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García-Foncillas, Jesús (Universidad Autónoma de Madrid. Departamento de Medicina) ;
Tejera-Vaquerizo, Antonio (Hospital San Juan de Dios (Còrdova, Espanya)) ;
Sanmartín, Onofre (Fundació Institut Valencià d'Oncologia) ;
Rojo, Federico (Hospital Universitario Fundación Jiménez Díaz) ;
Mestre, Javier (Hospital Universitario Miguel Servet (Saragossa)) ;
Martín, Salvador (Clínica Universidad de Navarra) ;
Azinovic, Ignacio (Hospital Universitario Fundación Jiménez Díaz) ;
Mesía, Ricard (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer, which predominantly occurs on the head and neck. Early detection and treatment of primary tumours is crucial to limit progression and local invasion of deep tissues. [...]
2022 - 10.3390/cancers14030629
Cancers, Vol. 14 Núm. 3 (january 2022)
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10 p, 552.4 KB |
Cutaneous Allodynia in Migraine : A Narrative Review
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Mínguez-Olaondo, Ane (Clínica Universidad de Navarra) ;
Quintas, Sonia (Hospital Universitario de la Princesa (Madrid)) ;
Morollón Sánchez-Mateos, Noemí (Institut d'Investigació Biomèdica Sant Pau) ;
López-Bravo, Alba (Instituto de Investigación Sanitaria de Aragón) ;
Vila-Pueyo, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grozeva, Vesselina (Private Neurology Practice, Sofia) ;
Belvís, Roberto (Institut d'Investigació Biomèdica Sant Pau) ;
Santos-Lasaosa, Sonia (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Irimia, Pablo (Clínica Universidad de Navarra) ;
Universitat Autònoma de Barcelona
In the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. CA is regarded as the perception of pain in response to non-noxious skin stimulation. [...]
2022 - 10.3389/fneur.2021.831035
Frontiers in neurology, Vol. 12 (january 2022)
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7 p, 819.8 KB |
The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders
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de Jesús-Gil, Carmen (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Sans-de SanNicolàs, Lídia (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
García-Jiménez, Irene (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Ferran, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Celada, Antonio (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Chiriac, Anca (Department of Dermatophysiology, Apollonia University) ;
Pujol Vallverdú, Ramón M (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Santamaria-Babí, Luis F. (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia)
Circulating memory T cells are heterogeneous in their tissue tropism. The skin-seeking T cell subset expresses the cutaneous lymphocyte-associated antigen (CLA) on their surface. CLA + memory T cells not only migrate from blood to skin but also recirculate between blood and skin. [...]
2021 - 10.3389/fimmu.2021.652613
Frontiers in immunology, Vol. 12 (march 2021)
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12 p, 1.5 MB |
Epigenetic Silencing of Tumor Suppressor miR-124 Directly Supports STAT3 Activation in Cutaneous T-Cell Lymphoma
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García-Colmenero, Lidia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
González, Jéssica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sandoval, Juan (Epigenomics Unit (València)) ;
Guillén, Yolanda (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Diaz-Lagares, Angel (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Andrades, Evelyn (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Iglesias, Arnau (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Nonell, Lara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pujol Vallverdú, Ramón M (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Gallardo, Fernando (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Increasing evidence supports a potential role for STAT3 as a tumor driver in cutaneous T-cell lymphomas (CTCL). The mechanisms leading to STAT3 activation are not fully understood; however, we recently found that miR-124, a known STAT3 regulator, is robustly silenced in MF tumor-stage and CTCL cells. [...]
2020 - 10.3390/cells9122692
Cells, Vol. 9 (december 2020)
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18 p, 1.1 MB |
Design and characterization of high-affinity synthetic peptides as bioreceptors for diagnosis of cutaneous leishmaniasis
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Prada, Y. A. (Universidad Industrial de Santander. Laboratorio de Espectroscopia Atómica y Molecular) ;
Soler Aznar, Maria (Institut Català de Nanociència i Nanotecnologia) ;
Guzmán, Fanny (Pontificia Universidad Católica de Valparaíso. Laboratorio de Síntesis de Péptidos) ;
Castillo, John J. (Universidad Industrial de Santander. Grupo de Investigación en Bioquímica y Microbiología) ;
Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia) ;
Mejía-Ospino, Enrique (Universidad Industrial de Santander. Laboratorio de Espectroscopia Atómica y Molecular)
Cutaneous leishmaniasis (CL) is one of the illnesses caused by Leishmania parasite infection, which can be asymptomatic or severe according to the infecting Leishmania strain. CL is commonly diagnosed by directly detecting the parasites or their DNA in tissue samples. [...]
2021 - 10.1007/s00216-021-03424-2
Analytical and bioanalytical chemistry, Vol. 413, issue 17 (July 2021) , p. 4545-4555
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15 p, 2.0 MB |
MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression
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Toll Abelló, Agustí (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Salgado Sánchez, Rocío Nieves (Hospital del Mar (Barcelona, Catalunya)) ;
Espinet, Blanca (Hospital del Mar (Barcelona, Catalunya)) ;
Diaz-Lagares, Angel (Institut d'Investigació Biomèdica de Bellvitge) ;
Hernández-Ruiz, Eugenia (Hospital Universitari Vall d'Hebron) ;
Andrades, Evelyn (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sandoval, Juan (Institut d'Investigació Biomèdica de Bellvitge) ;
Esteller, M. (Institució Catalana de Recerca i Estudis Avançats) ;
Pujol, Ramón M.. (Hospital del Mar (Barcelona, Catalunya)) ;
Hernández-Muñoz, Inmaculada (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and frequently progresses from an actinic keratosis (AK), a sun-induced keratinocyte intraepithelial neoplasia (KIN). Epigenetic mechanisms involved in the phenomenon of progression from AK to cSCC remain to be elicited. [...]
2016 - 10.1186/s12943-016-0537-z
Molecular cancer, Vol. 15 (july 2016)
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13 p, 3.1 MB |
Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma
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Gallardo, Fernando (Hospital del Mar (Barcelona, Catalunya)) ;
Bertran, Joan (Universitat de Vic - Universitat Central de Catalunya) ;
López-Arribillaga, Erika (Institut Hospital del Mar d'Investigacions Mèdiques) ;
González, Jéssica (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Menéndez, Silvia (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sánchez, Ignacio (Hospital del Mar (Barcelona, Catalunya)) ;
Colomo, Luis (Hospital del Mar (Barcelona, Catalunya)) ;
Iglesias, Mar (Hospital del Mar (Barcelona, Catalunya)) ;
Garrido, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Santamaría-Babí, Luis Francisco (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Torres, Ferran (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública) ;
Pujol Vallverdú, Ramón M (Hospital del Mar (Barcelona, Catalunya)) ;
Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Espinosa, Lluís (Institut Hospital del Mar d'Investigacions Mèdiques)
Cutaneous T-cell lymphomas (CTCLs) represent different subtypes of lymphoproliferative disorders with no curative therapies for the advanced forms of the disease (namely mycosis fungoides and the leukemic variant, Sézary syndrome). [...]
2018 - 10.1038/s41375-018-0066-4
Leukemia, Vol. 32 (february 2018) , p. 2211-2223
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