Results overview: Found 11 records in 0.03 seconds.
Articles, 9 records found
Research literature, 2 records found
Articles 9 records found  
1.
Label-free DNA-methylation detection by direct ds-DNA fragment screening using poly-purine hairpins / Sánchez Huertas, César (Institut Català de Nanociència i Nanotecnologia) ; Aviñó, Anna (Institut de Química Avançada de Catalunya) ; Kurachi, Cristina (Institut Català de Nanociència i Nanotecnologia) ; Piqué, Albert (Institut Català de Nanociència i Nanotecnologia) ; Sandoval, Juan (Institut de Recerca Biomèdia Bellvitge) ; Eritja, Ramon (Institut de Química Avançada de Catalunya) ; Esteller, Manel (Institucio Catalana de Recerca i Estudis Avançats (ICREA)) ; Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Cancer diagnosis continuously evolves due to the better understanding of tumorigenic processes. DNA-methylation is consolidated as an effective biomarker for cancer prognosis and diagnostic even in tumors of unknown origin. [...]
2018 - 10.1016/j.bios.2018.08.027
Biosensors and bioelectronics, Vol. 120 (November 2018) , p. 47-54  
2.
14 p, 4.9 MB Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs / Nogales, Vanesa (Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain) ; Reinhold, William C. (Genomics and Bioinformatics Group, Developmental Therapeutics Branch, National Cancer Institute, Bethesda, MD, USA) ; Varma, Sudhir (Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA) ; Martinez-Cardus, Anna (Institut de Recerca Biomèdica Bellvitge (IDIBELL)) ; Moutinho, Catia (Institut de Recerca Biomèdica Bellvitge (IDIBELL)) ; Moran, Sebastian (Institut de Recerca Biomèdica Bellvitge (IDIBELL)) ; Heyn, Holger (Institut de Recerca Biomèdica Bellvitge (IDIBELL)) ; Sebio, Ana (Institut d'Investigació Biomèdica Sant Pau) ; Barnadas i Molins, Agustí (Institut d'Investigació Biomèdica Sant Pau) ; Pommier, Yves (Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA) ; Esteller, Manel (Institucio Catalana de Recerca i Estudis Avançats (ICREA)) ; Universitat Autònoma de Barcelona
Platinum-derived drugs such as cisplatin and carboplatin are among the most commonly used cancer chemotherapy drugs, but very few specific molecular and cellular markers predicting differential sensitivity to these agents in a given tumor type have been clearly identified. [...]
2015 - 10.18632/oncotarget.6413
Oncotarget, Vol. 7 (november 2015) , p. 3084-3097  
3.
15 p, 2.3 MB Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylation / Carrió Gaspar, Elvira ((Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Magli, Alessandro (Lillehei Heart Institute (Minneapolis, Estats Units d'Amèrica)) ; Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Perlingeiro, Rita (Lillehei Heart Institute (Minneapolis, Estats Units d'Amèrica)) ; Suelves Esteban, Mònica (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
BACKGROUND: Skeletal muscle stem cells enable the formation, growth, maintenance, and regeneration of skeletal muscle throughout life. The regeneration process is compromised in several pathological conditions, and muscle progenitors derived from pluripotent stem cells have been suggested as a potential therapeutic source for tissue replacement. [...]
2016 - 10.1186/s12915-016-0250-9
BMC Biology, Vol. 14, Núm. 30 (2016)  
4.
13 p, 2.1 MB Epigenetic Alterations in Fanconi Anaemia : Role in Pathophysiology and Therapeutic Potential / Belo, Hélio (Universidade Nova de Lisboa. Faculdade de Ciências Médicas) ; Silva, Gabriela (Universidade Nova de Lisboa. Faculdade de Ciências Médicas) ; Cardoso, Bruno A. (Universidade Nova de Lisboa. Faculdade de Ciências Médicas) ; Porto, Beatriz (Instituto de Ciências Biomédicas de Abel Salazar (Porto, Portugal)) ; Minguillón, Jordi (Universitat Autonoma de Barcelona. Departament de Genètica i de Microbiologia) ; Barbot, José (Centro Hospitalar do Porto (Porto, Portugal)) ; Coutinho, Jorge (Centro Hospitalar do Porto (Porto, Portugal)) ; Casado, José A. (Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)) ; Benedito, Manuela (Centro Hospitalar e Universitário de Coimbra (Coimbra, Portugal)) ; Saturnino, Hema (Centro Hospitalar e Universitário de Coimbra (Coimbra, Portugal)) ; Costa, Emília (Centro Hospitalar do Porto (Porto, Portugal)) ; Bueren, Juan A. (Centro Hospitalar do Porto (Porto, Portugal)) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Almeida, Antonio (Universidade Nova de Lisboa. Faculdade de Ciências Médicas)
Fanconi anaemia (FA) is an inherited disorder characterized by chromosomal instability. The phenotype is variable, which raises the possibility that it may be affected by other factors, such as epigenetic modifications. [...]
2015 - 10.1371/journal.pone.0139740
PLoS one, Vol. 10, Num. 10 (October 2015) , p. 1-13  
5.
12 p, 1.5 MB DNA methylation dynamics in muscle development and disease / Carrió Gaspar, Elvira (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Suelves Esteban, Mònica (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
DNA methylation is an essential epigenetic modification for mammalian development and is crucial for the establishment and maintenance of cellular identity. Traditionally, DNA methylation has been considered as a permanent repressive epigenetic mark. [...]
2015 - 10.3389/fnagi.2015.00019
Frontiers in aging neuroscience, Vol. 7 Núm. 19 (2015)  
6.
22 p, 1.4 MB Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression / Forn Bernaus, Marta (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Díez-Villanueva, Anna (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Merlos-Suárez, Anna (Institute for Research in Biomedicine (IRB Barcelona)) ; Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Lois, Sergi (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Carrió Gaspar, Elvira (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Jordà Ramos, Mireia (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Bigas Salvans, Anna (Institut Hospital del Mar d'Investigacions Mèdiques) ; Batlle, Eduard (Institute for Research in Biomedicine (IRB Barcelona)) ; Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Mouse models of intestinal crypt cell differentiation and tumorigenesis have been used to characterize the molecular mechanisms underlying both processes. DNA methylation is a key epigenetic mark and plays an important role in cell identity and differentiation programs and cancer. [...]
2015 - 10.1371/journal.pone.0123263
PLoS One, Vol. 10, No. 5 (May 2015) , p. e0123263  
7.
11 p, 2.6 MB Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer / Cebola, Inês (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Custodio Rojo, Joaquín (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Muñoz, Mar (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Díez-Villanueva, Anna (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Paré, Laia (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Prieto, Patricia (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Aussó, Susanna (Institut Català d'Oncologia) ; Coll-Mulet, Llorenç (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer) ; Boscá, Lisardo (Universidad Autónoma de Madrid. Instituto de Investigaciones Biomédicas "Alberto Sols") ; Moreno Aguado, Víctor (Institut Català d'Oncologia) ; Peinado Morales, Miguel Á. (Miguel Ángel) (Institut Germans Trias i Pujol. Institut de Medicina Predictiva i Personalitzada del Càncer)
Background: Misregulation of the PTGS (prostaglandin endoperoxide synthase, also known as cyclooxygenase or COX) pathway may lead to the accumulation of pro-inflammatory signals, which constitutes a hallmark of cancer. [...]
2015 - 10.1186/s13148-015-0110-4
Clinical epigenetics, Vol. 7 Núm. 7 (July 2015)  
8.
16 p, 3.8 MB The Role of Dietary Extra Virgin Olive Oil and Corn Oil on the Alteration of Epigenetic Patterns in the Rat DMBA-Induced Breast Cancer Model / Rodríguez Miguel, Cristina (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Moral Cabrera, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Escrich Navarro, Raquel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Vela Sarrión, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Solanas i Garcia, Montserrat (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Escrich Escriche, Eduardo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Disruption of epigenetic patterns is a major change occurring in all types of cancers. Such alterations are characterized by global DNA hypomethylation, gene-promoter hypermethylation and aberrant histone modifications, and may be modified by environment. [...]
2015 - 10.1371/journal.pone.0138980
PLoS one, Vol. 10 Issue 9 (September 2015) , p. e0138980  
9.
21 p, 1.5 MB Improved Development of Somatic Cell Cloned Mouse Embryos by Vitamin C and Latrunculin A / Mallol, Anna (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Santaló, Josep (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Ibáñez, Elena (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Impaired development of embryos produced by somatic cell nuclear transfer (SCNT) is mostly associated with faulty reprogramming of the somatic nucleus to a totipotent state and can be improved by treatment with epigenetic modifiers. [...]
2015 - 10.1371/journal.pone.0120033
PLoS one, Vol. 10, Issue 3 (March 2015) , p. e0120033  

Research literature 2 records found  
1.
1 p, 738.6 KB Epigenetics as biomarker for Alzheimer's disease : a new approach to prevention, diagnosis and treatment / Martínez Ruiz, Elena ; Barquinero, J. F., (Joan Francesc), dir. (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2015
Graduat o Graduada en Ciències Biomèdiques [832]  
2.
1 p, 570.5 KB Role of the epigenetic regulation of chromatin in breast cancer / Giralt Buch, Irina ; Roque Córdova, Alicia, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2013
Graduat o Graduada en Bioquímica [814]  

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