Resultados globales: 7 registros encontrados en 0.02 segundos.
Artículos, Encontrados 7 registros
Artículos Encontrados 7 registros  
1.
14 p, 6.4 MB ATR is required to complete meiotic recombination in mice / Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Maldonado Linares, Andros (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Rojas, Cristina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Fuentes-Lazaro, Judit (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Fernández-Capetillo, Oscar (Centro Nacional de Investigaciones Oncológicas.) ; Garcia-Caldés, Montserrat (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Precise execution of recombination during meiosis is essential for forming chromosomally-balanced gametes. Meiotic recombination initiates with the formation and resection of DNA double-strand breaks (DSBs). [...]
2018 - 10.1038/s41467-018-04851-z
Nature communications, Vol. 9 (2018) , art. 2622  
2.
24 p, 25.7 MB p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes / Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castillo, Helena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex-ATM-CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845  
3.
13 p, 6.6 MB Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination / Abreu, Carla M. (Memorial Sloan Kettering Cancer Center) ; Prakash, Rohit (Memorial Sloan Kettering Cancer Center) ; Romanienko, Peter J. (Rutgers-Cancer Institute of New Jersey) ; Roig, I. (Ignasi) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA-damage repair pathway homologous recombination (HR) requires factors that promote the activity of strand-exchange protein RAD51 and its meiosis-specific homolog DMC1. Here we show that the Shu complex SWS1-SWSAP1, a candidate for one such HR regulator, is dispensable for mouse viability but essential for male and female fertility, promoting the assembly of RAD51 and DMC1 on early meiotic HR intermediates. [...]
2018 - 10.1038/s41467-018-06384-x
Nature communications, Vol. 9 (2018) , art. 3961  
4.
27 p, 21.8 MB The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes / Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017  
5.
6 p, 700.6 KB IMKT : the integrative McDonald and Kreitman test / Murga-Moreno, Jesus (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Coronado-Zamora, Marta (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Hervás Fernández, Sergi (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Casillas Viladerrams, Sònia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Barbadilla Prados, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The McDonald and Kreitman test (MKT) is one of the most powerful and widely used methods to detect and quantify recurrent natural selection using DNA sequence data. Here we present iMKT (acronym for integrative McDonald and Kreitman test), a novel web-based service performing four distinct MKT types. [...]
2019 - 10.1093/nar/gkz372
Nucleic acids research, Vol. 47, issue W1 (Jan. 2019) , p. W283-W288  
6.
10 p, 3.0 MB CENP-A binding domains and recombination patterns in horse spermatocytes / Cappelletti, Eleonora (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ; Piras, Francesca M. (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ; Badiale, Claudia (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ; Bambi, Marina (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ; Santagostino, Marco (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ; Vara, Covadonga (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Masterson, Teri A. (National University of Ireland. Centre for Chromosome Biology) ; Sullivan, Kevin F. (National University of Ireland. Centre for Chromosome Biology) ; Nergadze, Solomon G. (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani") ; Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Giulotto, Elena (Università degli Studi di Pavia. Dipartimento di Biologia e Biotecnologie "L. Spallanzani")
Centromeres exert an inhibitory effect on meiotic recombination, but the possible contribution of satellite DNA to this "centromere effect" is under debate. In the horse, satellite DNA is present at all centromeres with the exception of the one from chromosome 11. [...]
2019 - 10.1038/s41598-019-52153-1
Scientific reports (Nature Publishing Group), Vol. 9, issue 1 (Jan. 2019) , art. 15800  
7.
14 p, 4.7 MB A novel sigma factor reveals a unique regulon controlling cell-specific recombination in Mycoplasma genitalium / Torres-Puig, Sergi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Broto, Alicia (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Piñol, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pich, Oscar Q. (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
The Mycoplasma genitalium MG428 protein shows homology to members of the sigma-70 family of sigma factors. Herein, we found that MG428 activates transcription of recA, ruvA and ruvB as well as several genes with unknown function. [...]
2015 - 10.1093/nar/gkv422
Nucleic acids research, Vol. 43 (april 2015) , p. 4923-4936  

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