Resultados globales: 14 registros encontrados en 0.02 segundos.
Artículos, Encontrados 12 registros
Documentos de investigación, Encontrados 2 registros
Artículos Encontrados 12 registros  1 - 10siguiente  ir al registro:
1.
24 p, 25.7 MB p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes / Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez Marchal, Ana (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castillo, Helena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Flores, Elsa (The University of Texas M. D. Anderson Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
To protect germ cells from genomic instability, surveillance mechanisms ensure meiosis occurs properly. In mammals, spermatocytes that display recombination defects experience a so-called recombination-dependent arrest at the pachytene stage, which relies on the MRE11 complex—ATM—CHK2 pathway responding to unrepaired DNA double-strand breaks (DSBs). [...]
2017 - 10.1371/journal.pgen.1006845
PLoS Genetics, Vol. 13, issue 6 (2017) , art. e1006845  
2.
28 p, 2.6 MB Functional impact and evolution of a novel human polymorphic inversion that disrupts a gene and creates a fusion transcript / Puig Font, Marta (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Castellano Esteve, David (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pantano, Lorena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Giner Delgado, Carla (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Izquierdo, David (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Gayà Vidal, Magdalena (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lucas Lledó, Jose Ignacio (Universitat de València. Institut Cavanilles de Biologia Evolutiva i Biodiversitat) ; Esko, Tõnu (Estonian Genome Center) ; Terao, Chikashi (Kyoto University Graduate School of Medicine) ; Matsuda, Fumihiko (Center for Genomic Medicine. Kyoto University Graduate School of Medicine) ; Cáceres Aguilar, Mario (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Despite many years of study into inversions, very little is known about their functional consequences, especially in humans. A common hypothesis is that the selective value of inversions stems in part from their effects on nearby genes, although evidence of this in natural populations is almost nonexistent. [...]
2015 - 10.1371/journal.pgen.1005495
PLoS Genetics, Vol. 11, issue 10 (2015) , art. e1005495  
3.
19 p, 1001.5 KB The ATM signaling network in development and disease / Stracker, Travis H. (Institut de Recerca Biomèdica) ; Roig, I. (Ignasi) (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Knobel, Philip A. (Institut de Recerca Biomèdica) ; Marjanović, Marko (Institut de Recerca Biomèdica) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
The DNA damage response (DDR) rapidly recognizes DNA lesions and initiates the appropriate cellular programs to maintain genome integrity. This includes the coordination of cell cycle checkpoints, transcription, translation, DNA repair, metabolism, and cell fate decisions, such as apoptosis or senescence (Jackson and Bartek, 2009). [...]
2013 - 10.3389/fgene.2013.00037
Frontiers in genetics, Vol. 4 (March 2013) , art. 37  
4.
27 p, 21.8 MB The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes / Pacheco, Sarai (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Marcet-Ortega, Marina (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Lange, Julian (Memorial Sloan Kettering Cancer Center) ; Jasin, Maria (Memorial Sloan Kettering Cancer Center) ; Keeney, Scott (Memorial Sloan Kettering Cancer Center) ; Roig, I. (Ignasi) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Most mutations that compromise meiotic recombination or synapsis in mouse spermatocytes result in arrest and apoptosis at the pachytene stage of the first meiotic prophase. Two main mechanisms are thought to trigger arrest: one independent of the double-strand breaks (DSBs) that initiate meiotic recombination, and another activated by persistent recombination intermediates. [...]
2015 - 10.1371/journal.pgen.1005017
PLoS Genetics, Vol. 11, issue 3 (2015) , art. e1005017  
5.
19 p, 2.5 MB Interactome analysis and docking sites of MutS homologs reveal new physiological roles in arabidopsis thaliana / AbdelGawwad, Mohamed Ragab (International University of Sarajevo. Genetics and Bioengineering) ; Marić, Aida (Centre de Recerca en Agrigenòmica) ; Al-Ghamdi, Abdullah Ahmed (King Saud University. Department of Botany and Microbiology) ; Hatamleh, Ashraf A. (King Saud University. Department of Botany and Microbiology)
Due to their sedentary lifestyle, plants are constantly exposed to different stress stimuli. Stress comes in variety of forms where factors like radiation, free radicals, "replication errors, polymerase slippage", and chemical mutagens result in genotoxic or cytotoxic damage. [...]
2019 - 10.3390/molecules24132493
Molecules, Vol. 24, Issue 13 (2019) , art. 2493  
6.
10 p, 1.2 MB Polymorphisms in MDM2 and TP53 genes and risk of developing therapy-related myeloid neoplasms / Cabezas Somalo, Maria (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; García Quevedo, Lydia (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Alonso, Cintia (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Manubens Oliveras, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Álvarez, Yolanda (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Barquinero, J. F. (Joan Francesc) (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Ramón y Cajal, Santiago (Hospital Vall d'Hebron. Departament de Patologia) ; Ortega, Margarita (Hospital Vall d'Hebron. Departament d'Hematologia) ; Blanco, Adoración (Hospital Vall d'Hebron. Departament de Patologia) ; Caballín, M. R. (María Rosa) (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ; Armengol Rosell, Gemma (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia)
One of the most severe complications after successful cancer therapy is the development of therapy-related myeloid neoplasms (t-MN). Constitutional genetic variation is likely to impact on t-MN risk. [...]
2019 - 10.1038/s41598-018-36931-x
Scientific reports, Vol. 9 (2019) , art. 150  
7.
14 p, 745.8 KB Functional comparison of XPF missense mutations associated to multiple DNA repair disorders / Marín, Maria (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Ramírez de Haro, Ma. José (María José) (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Aza-Carmona, Miriam (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Jia, Nan (Nagoya University. Research Institute of Environmental Medicine) ; Ogi, Tomoo (Nagoya University. Research Institute of Environmental Medicine) ; Bogliolo, Massimo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Surrallés i Calonge, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
XPF endonuclease is one of the most important DNA repair proteins. Encoded by XPF/ERCC4, XPF provides the enzymatic activity of XPF-ERCC1 heterodimer, an endonuclease that incises at the 5' side of various DNA lesions. [...]
2019 - 10.3390/genes10010060
Genes, Vol. 10, Núm. 1 (January 2019) , art. 60  
8.
13 p, 5.2 MB The Verrucomicrobia LexA-Binding Motif : Insights into the Evolutionary Dynamics of the SOS Response / Erill, Ivan (University of Maryland Baltimore County. Erill Lab, Department of Biological Sciences) ; Campoy Sánchez, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Kiliç, Sefa (University of Maryland Baltimore County. Erill Lab, Department of Biological Sciences) ; Barbé García, Jordi (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The SOS response is the primary bacterial mechanism to address DNA damage, coordinating multiple cellular processes that include DNA repair, cell division, and translesion synthesis. In contrast to other regulatory systems, the composition of the SOS genetic network and the binding motif of its transcriptional repressor, LexA, have been shown to vary greatly across bacterial clades, making it an ideal system to study the co-evolution of transcription factors and their regulons. [...]
2016 - 10.3389/fmolb.2016.00033
Frontiers in Molecular Biosciences, Vol. 3 (july 2016) , art. 33  
9.
13 p, 2.3 MB The NER-related gene GTF2H5 predicts survival in high-grade serous ovarian cancer patients / Gayarre, Javier (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ; Kamieniak, Marta M. (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ; Cazorla-Jiménez, Alicia (Department of Pathology, Fundación Jiménez Díaz-IDC Salud,) ; Muñoz-Repeto, Ivan (Human Genetics Group, Spanish National Cancer Research Center (CNIO)) ; Borrego, Salud (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ; García-Donas, Jesús (Medical Oncology Service, Oncologic Center Clara Campal) ; Hernando, Susana (Department of Oncology, Fundación Hospital Alcorcón) ; Robles-Díaz, Luis (Familial Cancer Unit and Medical Oncology Department, Hospital 12 de Octubre) ; García-Bueno, José M. (Department of Oncology, Hospital General de Albacete) ; Ramón y Cajal, Teresa (Hospital Santa Creu i Sant Pau. Servei d'Oncologia Mèdica) ; Hernández-Agudo, Elena (Breast Cancer Clinical Research Unit, Spanish National Cancer Research Center (CNIO)) ; Heredia Soto, Victoria (Pathology and Translational Oncology Research Laboratories, Hospital La Paz Institute for Health Research (IdiPAZ)) ; Márquez-Rodas, Ivan (Medical Oncology Service, Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense) ; Echarri, María José (Medical Oncology Service, Hospital Severo Ochoa) ; Lacambra-Calvet, Carmen (Department of Internal Medicine, Hospital Severo Ochoa) ; Sáez, Raquel (Laboratory of Genetics, Hospital Donostia) ; Cusidó, Maite (Department of Obstetrics and Gynecology, Hospital Universitario Quirón-Dexeus) ; Redondo, Andrés (Department of Medical Oncology, Hospital La Paz IdiPAZ, Madrid) ; Paz-Ares, Luis (Medical Oncology Service, Hospital 12 de Octubre) ; Hardisson, David (Pathology Research Laboratory, Department of Pathology, Hospital La Paz IdiPAZ, and Facultad de Medicina, Universidad Autónoma de Madrid) ; Mendiola, Marta (Pathology and Translational Oncology Research Laboratories, Hospital La Paz Institute for Health Research (IdiPAZ)) ; Palacios, José (Department of Pathology, Hospital Universitario Ramón y Cajal) ; Benítez, Javier (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ; García, María José (Biomedical Network Research Centre on Rare Diseases (CIBERER)) ; Universitat Autònoma de Barcelona. Departament de Medicina
We aimed to evaluate the prognostic and predictive value of the nucleotide excision repair-related gene GTF2H5, which is localized at the 6q24. 2-26 deletion previously reported by our group to predict longer survival of high-grade serous ovarian cancer patients. [...]
2015 - 10.3802/jgo.2016.27.e7
Journal of Gynecologic Oncology, Vol. 27 (november 2015)  
10.
9 p, 774.4 KB Aging and radiation : bad companions / Hernández Garcia, Laia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Terradas Ill, Mariona (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Camps, Jordi (Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)) ; Martín Flix, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Tusell Padrós, Laura (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Genescà, A. (Anna) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Aging involves a deterioration of cell functions and changes that may predispose the cell to undergo an oncogenic transformation. The carcinogenic risks following radiation exposure rise with age among adults. [...]
2015 - 10.1111/acel.12306
Aging Cell, Vol. 14, Issue 2 (April 2015) , p. 153-161  

Artículos : Encontrados 12 registros   1 - 10siguiente  ir al registro:
Documentos de investigación Encontrados 2 registros  
1.
1 p, 1.5 MB Chromatin plasticity in the DNA damage response: a key player in double-strand break repair pathway choice / García Moro, Eva ; Universitat Autònoma de Barcelona. Facultat de Biociències
2018
Grau en Ciències Biomèdiques [832]  
2.
1 p, 1.1 MB Genomic instability as a link between cancer and aging / Sebastián Pérez, Rubén ; Pallarès i Goitiz, Irantzu, dir. (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ; Universitat Autònoma de Barcelona. Facultat de Biociències
2016
Grau en Bioquímica [814]  

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