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24 p, 6.3 MB |
CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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Evans, Frances (Instituto Pasteur de Montevideo) ;
Alí-Ruiz, Daniela (Instituto Pasteur de Montevideo) ;
Rego, Natalia (Instituto Pasteur de Montevideo) ;
Negro-Demontel, Maria Luciana (Instituto Pasteur de Montevideo) ;
Lago, Natalia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Cawen, Fabio Andrés (Instituto Pasteur de Montevideo) ;
Pannunzio, Bruno (Instituto Pasteur de Montevideo) ;
Sanchez-Molina, Paula (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Reyes, Laura (Centro Uruguayo de Imagenología Molecular) ;
Paolino, Andrea (Centro Uruguayo de Imagenología Molecular) ;
Rodríguez-Duarte, Jorge (Instituto Pasteur de Montevideo) ;
Pérez-Torrado, Valentina (Instituto Pasteur de Montevideo) ;
Chicote-González, Almudena (Universitat de Barcelona. Departament de Biomedicina) ;
Quijano, Celia (Universidad de la República. Departamento de Bioquímica (Montevideo, Uruguay)) ;
Marmisolle, Inés (Universidad de la República. Departamento de Bioquímica (Montevideo, Uruguay)) ;
Mulet, Ana Paula (Instituto Pasteur de Montevideo) ;
Schlapp, Geraldine (Instituto Pasteur de Montevideo) ;
Meikle, Maria Noel (Instituto Pasteur de Montevideo) ;
Bresque, Mariana (Instituto Pasteur de Montevideo) ;
Crispo, Martina (Instituto Pasteur de Montevideo) ;
Savio, Eduardo (Centro Uruguayo de Imagenología Molecular) ;
Malagelada, Cristina (Universitat de Barcelona. Departament de Biomedicina) ;
Escande, Carlos (Instituto Pasteur de Montevideo) ;
Peluffo, Hugo (Instituto Pasteur de Montevideo) ;
Universitat Autònoma de Barcelona.
Institut de Neurociències
Emerging evidence suggests that immune receptors may participate in many aging-related processes such as energy metabolism, inflammation, and cognitive decline. CD300f, a TREM2-like lipid-sensing immune receptor, is an exceptional receptor as it integrates activating and inhibitory cell-signaling pathways that modulate inflammation, efferocytosis, and microglial metabolic fitness. [...]
2023 -  10.1016/j.celrep.2023.113269
Cell reports, Vol. 42 Núm. 10 (2023) , p. 113269
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4 p, 649.0 KB |
Early gray matter volume loss in MAPT H1H1 de Novo PD patients : A possible association with cognitive decline
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Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau) ;
Marín-Lahoz, Juan (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Martinez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau) ;
Pagonabarraga Mora, Javier (Institut d'Investigació Biomèdica Sant Pau) ;
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The MAPT H1 haplotype has been identified as a predictor of cognitive decline in Parkinson's disease (PD). However, its underlying pathological mechanisms have not been fully established. In this work, using a cohort of 120 de novo PD patients with preserved cognition from the Parkinson's Progression Markers Initiative (PPMI) database, we found that patients who were homozygous for MAPT H1 had less gray matter volume (GMV) and greater 1-year GMV loss than patients without this genetic profile. [...]
2018 - 10.3389/fneur.2018.00394
Frontiers in neurology, Vol. 9 Núm. MAY (30 2018) , p. 394
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19 p, 12.6 MB |
Disruption of cortical cell type composition and function underlies diabetes-associated cognitive decline
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Little, Karis (Queen's University Belfast) ;
Singh, Aditi (Queen's University Belfast) ;
Del Marco, Angel (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz) ;
Llorián-Salvador, María (Hospital Universitari Vall d'Hebron) ;
Vargas-Soria, Maria (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz) ;
Turch-Anguera, Mireia (Hospital Universitari Vall d'Hebron) ;
Solé Piñol, Montserrat (Hospital Universitari Vall d'Hebron) ;
Bakker, Noëlle (Amsterdam UMC location University) ;
Scullion, Sarah (Queen's University Belfast) ;
Comella i Carnicé, Joan Xavier 1963- (Hospital Universitari Vall d'Hebron) ;
Klaassen, Ingeborg (Amsterdam UMC location University of Amsterdam) ;
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron) ;
Garcia-Alloza, Monica (Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz) ;
Tiwari, Vijay K. (Odense University Hospital (Dinamarca)) ;
Stitt, Alan W. (Queen's University Belfast) ;
Universitat Autònoma de Barcelona
Type 2 diabetes is associated with increased risk of cognitive decline although the pathogenic basis for this remains obscure. Deciphering diabetes-linked molecular mechanisms in cells of the cerebral cortex could uncover novel therapeutic targets. [...]
2023 - 10.1007/s00125-023-05935-2
Diabetologia, Vol. 66 (june 2023) , p. 1557-1575
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14 p, 1.6 MB |
Characteristics of subjective cognitive decline associated with amyloid positivity
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Janssen, Olin (Maastricht University. School for Mental Health and Neuroscience) ;
Jansen, W.J. (Maastricht University. School for Mental Health and Neuroscience) ;
Vos, S.J.B. (Maastricht University. School for Mental Health and Neuroscience) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Parnetti, Lucilla (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Gabryelewicz, T. (Department of Neurodegenerative Disorders. Mossakowski Medical Research Centre. Polish Academy of Sciences) ;
Fladby, T. (Department of Neurology. Akershus University Hospital) ;
Molinuevo, José Luis (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Villeneuve, S. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Hort, J. (International Clinical Research Center. St. Anne's University Hospital) ;
Epelbaum, S. (Inserm Sorbonne Université. Inria. Aramis project-team. Paris Brain Institute - Institut du Cerveau (ICM)) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Engelborghs, Sebastiaan (Vrije Universiteit Brussel. (VUB) Brussels. and University of Antwerp) ;
van der Flier, W.M. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Landau, S. (Helen Wills Neuroscience Institute. University of California) ;
Popp, J. (Old Age Psychiatry. University Hospital of Lausanne) ;
Wallin, Anders (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Scheltens, P. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Rikkert, M.O. (Department of Geriatric Medicine. Radboud Alzheimer Center. Radboud University Medical Center) ;
Snyder, P.J. (Kingston. The University of Rhode Island) ;
Rowe, C. (Department of Molecular Imaging & Therapy. Austin Health) ;
Chételat, G.. (Institut National de la Santé et de la Recherche Médicale (Inserm)) ;
Ruíz, A. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Marquié, M. (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Chipi, E. (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Wolfsgruber, S. (Department of Neurodegenerative Diseases and Psychiatry. University Hospital Bonn) ;
Heneka, M. (Department of Neurodegenerative Diseases and Psychiatry. University Hospital Bonn) ;
Boecker, H. (Functional Neuroimaging Group. Department of Radiology. University Hospital Bonn) ;
Peters, O. (Charité - Universitätsmedizin Berlin) ;
Jarholm, J. (Department of Neurology. Akershus University Hospital) ;
Rami, L. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Tort-Merino, A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Binette, A.P. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Poirier, J. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Rosa-Neto, P. (Centre for Studies on Prevention of Alzheimer's Disease (StOP-AD) Centre) ;
Cerman, J. (International Clinical Research Center. St. Anne's University Hospital) ;
Dubois, B. (AP-HP. Hôpital de la Pitié Salpêtrière. Institute of Memory and Alzheimer's Disease (IM2A). Centre of excellence of neurodegenerative disease (CoEN). Department of Neurology) ;
Teichmann, M. (AP-HP. Hôpital de la Pitié Salpêtrière. Institute of Memory and Alzheimer's Disease (IM2A). Centre of excellence of neurodegenerative disease (CoEN). Department of Neurology) ;
Alcolea, Daniel (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez-Saudinós, María Belén (Institut d'Investigació Biomèdica Sant Pau) ;
Ebenau, J. (Alzheimer Center Amsterdam. Department of Neurology. Amsterdam Neuroscience. Amsterdam UMC. Vrije Universiteit Amsterdam) ;
Pocnet, C. (Old Age Psychiatry. University Hospital of Lausanne) ;
Eckerström, M. (Institute of Neuroscience and Physiology. Sahlgrenska Academy at University of Gothenburg) ;
Thompson, L. (Kingston. The University of Rhode Island) ;
Villemagne, V. (Department of Psychiatry. University of Pittsburgh) ;
Buckley, R. (Brigham and Women's Hospital and Department of Neurology Massachusetts General Hospital. Harvard Medical School) ;
Burnham, S. (Section of Neurology. Center for Memory Disturbances - Lab. of Clinical Neurochemistry. Department of Medicine and Surgery. University of Perugia) ;
Delarue, M. (Institut National de la Sant. et de la Recherche M.dicale (Inserm)) ;
Freund-Levi, Yvonne (Department of Neurobiology. Care Sciences and Society. Karolinska Institutet) ;
Wallin, Å.K. (Department of Clinical Sciences Malmö. Clinical Memory Research Unit. Lund University) ;
Ramakers, I. (Maastricht University. School for Mental Health and Neuroscience) ;
Tsolaki, Magda (Memory and Dementia Center. 3rd Department of Neurology. "G Papanicolau. " General Hospital. Aristotle University of Thessaloniki) ;
Soininen, H. (Institute of Clinical Medicine. Neurology. University of Eastern Finland) ;
Hampel, H. (GRC no 21. Alzheimer Precision Medicine (AMP). AP-HP. Pitié-Salpêtrière Hospital. Sorbonne University) ;
Spiru, L. (Geriatrics- Gerontology and Old Age Psychiatry. Alzheimer Unit. Ana Aslan International Foundation - Memory Center and Longevity Medicine) ;
Tijms, B. (Maastricht University. School for Mental Health and Neuroscience) ;
Ossenkoppele, R. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Verhey, F.R.J. (Maastricht University. School for Mental Health and Neuroscience) ;
Jessen, F. (German Center For Neurodegenerative Diseases/Clinical Research. Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE). Zentrum für klinische Forschung/AG) ;
Visser, P.J. (Department of Neurobiology. Care Sciences and Society. Karolinska Institutet)
Introduction: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods: In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity. [...]
2022 - 10.1002/alz.12512
Alzheimer's & Dementia, Vol. 18 Núm. 10 (october 2022) , p. 1832-1845
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10 p, 344.1 KB |
Markers of early changes in cognition across cohorts of adults with down syndrome at risk of alzheimer's disease
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Aschenbrenner, A.J. (Washington University in St. Louis. Department of Neurology) ;
Asaad Baksh, R. (The London Down Syndrome (LonDownS) Consortium) ;
Benejam, Bessy (Barcelona Down Medical Center. Fundació Catalana Síndrome de Down) ;
Beresford-Webb, J.A. (Cambridge Intellectual and Developmental Disabilities Research Group. Department of Psychiatry. University of Cambridge) ;
Coppus, Antonia (Department of Primary and Community Care. Radboud University Medical Center) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin L (Department of Psychiatry. University of Pittsburgh) ;
Hartley, S. (Department of Human Development & Family Studies. University of Wisconsin-Madison) ;
Head, E. (Department of Pathology & Laboratory Medicine. University of California) ;
Jaeger, J. (Deptment of Psychiatry and Behavioral Sciences. Albert Einstein College of Medicine) ;
Levin, J. (Munich Cluster for Systems Neurology (SyNergy)) ;
Loosli, S.V. (Department of Neurology. Ludwig-Maximilians-UniversitätMünchen) ;
Rebillat, A.S. (Jerome Lejeune Institute) ;
Sacco, S. (Jerome Lejeune Institute) ;
Schmitt, F.A. (Departments of Neurology. Neurosurgery. Behavioral Science. Psychology. Psychiatry. University of Kentucky) ;
Thurlow, K.E. (King's College London. Institute of Psychiatry, Psychology & Neuroscience) ;
Zaman, S. (Cambridgeshire & Peterborough NHS Foundation Trust) ;
Hassenstab, J. (Washington University in St. Louis. Department of Neurology) ;
Strydom, A. (South London and the Maudsley NHS Foundation Trust)
Introduction: Down syndrome (DS), a genetic variant of early onset Alzheimer's disease (AD), lacks a suitable outcome measure for prevention trials targeting predementia stages. Methods: We used cognitive test data collected in several longitudinal aging studies internationally from 312 participants with DS without dementia to identify composites that were sensitive to change over time. [...]
2021 - 10.1002/dad2.12184
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, Vol. 13 Núm. 1 (2021) , p. e12184
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10 p, 640.7 KB |
Functional and Cognitive Decline Is Associated With Increased Endothelial Cell Inflammation and Platelet Activation : Liquid Biopsy of Microvesicles in Community- Dwelling Octogenarians
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Chiva-Blanch, Gemma (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición) ;
Vilella-Figuerola, Alba (Institut d'Investigació Biomèdica Sant Pau) ;
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Formiga, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Ferrer, A. (Primary Healthcare Centre "El Plà" CAP-I. Sant Feliu de Llobregat) ;
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Increased life expectancy is usually associated with comorbidities, such as cardio and cerebrovascular disease causing impaired functionality. A common underlying cause of these comorbidities is vascular inflammation and injury. [...]
2021 - 10.3389/fcell.2021.716435
Frontiers in Cell and Developmental Biology, Vol. 9 (july 2021) , p. 716435
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13 p, 792.5 KB |
"Guttmann Cognitest" ®, preliminary validation of a digital solution to test cognitive performance
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Cattaneo, Gabriele (Institut Germans Trias i Pujol) ;
Pachón-García, Catherine (Institut Germans Trias i Pujol) ;
Roca, Alba (Universitat de Barcelona. Departament de Medicina) ;
Alviarez-Schulze, Vanessa (Universidad Metropolitana (Veneçuela)) ;
Opisso, Eloy (Institut Germans Trias i Pujol) ;
García-Molina, Alberto (Institut Germans Trias i Pujol) ;
Bartrés-Faz, David (Universitat de Barcelona. Departament de Medicina) ;
Pascual Leone, Álvaro (Harvard Medical School) ;
Tormos, Jose M (Institut Germans Trias i Pujol) ;
Solana-Sánchez, Javier (Institut Germans Trias i Pujol)
Thanks to technological advances, the administration of cognitive assessments via digital solutions continues to increase, both in research and clinical practice. "Guttmann Cognitest" °ledR is a digital solution for cognitive assessment which includes seven computerized tasks designed to assess main cognitive functions requiring approximately 20 min to be completed. [...]
2022 - 10.3389/fnagi.2022.987891
Frontiers in aging neuroscience, Vol. 14 (november 2022)
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10 p, 743.4 KB |
Neuropsychiatric Profile as a Predictor of Cognitive Decline in Mild Cognitive Impairment
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Roberto Herrero, Natalia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Portella, Maria J.. (Institut d'Investigació Biomèdica Sant Pau) ;
Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Hernández, Isabel (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Mauleón, Ana (Universitat Internacional de Catalunya) ;
Rosende-Roca, Maitee (Universitat Internacional de Catalunya) ;
Abdelnour, Carla (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Esteban de Antonio, Ester (Universitat Internacional de Catalunya) ;
Tartari, Juan P. (Universitat Internacional de Catalunya) ;
Vargas, Liliana (Universitat Internacional de Catalunya) ;
López-Cuevas, Rogelio (Universitat Internacional de Catalunya) ;
Bojaryn, Urszula (Universitat Internacional de Catalunya) ;
Espinosa, Ana (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ortega, Gemma (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Sanabria, Ángela (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Orellana, Adelina (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
De Rojas, Itziar (Universitat Internacional de Catalunya) ;
Moreno-Grau, Sonia (Universitat Internacional de Catalunya) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Introduction: Mild cognitive impairment is often associated with affective and other neuropsychiatric symptoms (NPS). This co-occurrence might have a relevant impact on disease progression, from MCI to dementia. [...]
2021 - 10.3389/fnagi.2021.718949
Frontiers in aging neuroscience, Vol. 13 (august 2021) , p. 718949
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14 p, 632.5 KB |
Diabetes, Albuminuria and the Kidney-Brain Axis
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Ariton, Diana María (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Jiménez-Balado, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Maisterra Santos, Olga (Hospital Universitari Vall d'Hebron) ;
Pujadas, Francesc (Hospital Universitari Vall d'Hebron) ;
Soler, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Delgado Martínez, María Pilar (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Cognitive decline and kidney disease are significant public health problems that share similar characteristics and risk factors. The pathophysiology of the kidney-brain axis is not completely understood, and studies analysing the relationship between the biomarkers of kidney damage and cognitive impairment show different results. [...]
2021 - 10.3390/jcm10112364
Journal of clinical medicine, Vol. 10 (may 2021)
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10 p, 571.3 KB |
Risk of Atrial Fibrillation, Ischemic Stroke and Cognitive Impairment : Study of a Population Cohort ≥65 Years of Age
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Clua Espuny, Jose Luis (Universitat Rovira i Virgili) ;
Muria-Subirats, Eulalia (Institut Català de la Salut) ;
Ballesta-Ors, Juan (Universitat Rovira i Virgili) ;
Lorman-Carbo, Blanca (Institut Català de la Salut) ;
Clua-Queralt, Josep (Universitat de Lleida) ;
Palà, Elena (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Lechuga-Duran, Iñigo (Hospital de Tortosa Verge de la Cinta) ;
Gentille-Lorente, Delicia (Hospital de Tortosa Verge de la Cinta) ;
Bustamante, Alejandro (Hospital Universitari Vall d'Hebron) ;
Muñoz, Miguel-Angel (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
To evaluate a model for calculating the risk of AF and its relationship with the incidence of ischemic stroke and prevalence of cognitive decline. It was a multicenter, observational, retrospective, community-based study of a cohort of general population ≥6ct 35 years, between 01/01/2016 and 31/12/2018. [...]
2020 - 10.2147/VHRM.S276477
Vascular Health and Risk Management, Vol. 16 (october 2020) , p. 445-454
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