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21 p, 1.2 MB |
PAR2 Pepducin-Based Suppression of Inflammation and Itch in Atopic Dermatitis Models
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Barr, T.P. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ;
Garzia, C. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ;
Guha, S. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ;
Fletcher, E.K. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ;
Nguyen, N. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ;
Wieschhaus, A.J. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ;
Ferrer i Caubet, Lluís (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Covic, L. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research) ;
Kuliopulos, A. (Tufts University School of Medicine. Center of Hemostasis and Thrombosis Research)
PAR2 has been proposed to contribute to lesion formation and intense itch in atopic dermatitis. Here, we tested the ability of a cell-penetrating pepducin, PZ-235, to mitigate the potentially deleterious effects of PAR2 in models of atopic dermatitis. [...]
2019 -  10.1016/j.jid.2018.08.019
The Journal of investigative dermatology, Vol. 139 Núm. 2 (february 2019) , p. 412-421
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34 p, 4.2 MB |
Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals
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Taglialegna, Agustina (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología) ;
Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Garnett, James A. (Queen Mary University of London. School of Biological and Chemical Sciences) ;
Matthews, Steve (Imperial College London. Department of Life Sciences) ;
Penades, José R. (University of Glasgow. College of Medical, Veterinary and Life Sciences) ;
Lasa, Iñigo (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología) ;
Valle, Jaione (Consejo Superior de Investigaciones Científicas (Espanya). Instituto de Agrobiotecnología)
Biofilms are communities of bacteria that grow encased in an extracellular matrix that often contains proteins. The spatial organization and the molecular interactions between matrix scaffold proteins remain in most cases largely unknown. [...]
2016 - 10.1371/journal.ppat.1005711
PLOS pathogens, Vol. 12, issue 6 (June 2016) , p. e1005711
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31 p, 4.4 MB |
The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility
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Gomez Hernández, Laura (Centro de Investigación del Cáncer) ;
Felipe Medina, Natalia (Centro de Investigación del Cáncer) ;
Bejarano Condezo, Yazmine (Centro de Investigación del Cáncer) ;
Garcia Valiente, Rodrigo (Centro de Investigación del Cáncer) ;
Ramos, Isabel (Centro de Investigación del Cáncer) ;
Suja, José Ángel (Universidad Autónoma de Madrid. Unidad de Biologia Celular) ;
Barbero, José Luis (Centro de Investigaciones Biológicas (Madrid)) ;
Roig, Ignasi (Ignasi) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sanchez Martin, Manuel. (Universidad de Salamanca. Departamento de Medicina) ;
De Rooij, Dirk G.. (Utrecht University. Departent of Biology) ;
Llano, Elena (Universidad de Salamanca. Departamento de Fisiología y Farmacología) ;
Martín Pendas, Alberto (Centro de Investigación del Cáncer)
The ubiquitin proteasome system regulates meiotic recombination in yeast through its association with the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. [...]
2019 - 10.1371/journal.pgen.1008316
PLoS Genetics, Vol. 15, issue 8 (August 2019) , e1008316
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11 p, 4.2 MB |
Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis
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Penas Pérez, Clara (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Maloof, M. E. (University of Miami Miller School of Medicine. Center for Therapeutic Innovation. Department of Psychiatry and Behavioral Sciences) ;
Stathias, V. (University of Miami Miller School of Medicine. Center for Therapeutic Innovation. Department of Psychiatry and Behavioral Sciences) ;
Long, J. (University of Miami Miller School of Medicine. Department of Surgery) ;
Tan, S. K. (University of Miami Miller School of Medicine. Department of Psychiatry and Behavioral Sciences) ;
Mier, J. (University of Miami Miller School of Medicine. Department of Neurosurgery. Miami Project to Cure Paralysis) ;
Fang, Y. (The Rockefeller University. Laboratory of Development Neurobiology) ;
Valdes, C. (Florida International University. Computing and Information Sciences) ;
Rodriguez-Blanco, J. (University of Miami Miller School of Medicine. Department of Surgery) ;
Chiang, C. M. (University of Texas Southwestern Medical Center. Simmons Comprehensive Cancer Center. Department of Biochemistry and Department of Pharmacology) ;
Robbins, D. J. (University of Miami Miller School of Medicine. Department of Surgery) ;
Liebl, D. J. (University of Miami Miller School of Medicine. Department of Surgery) ;
Lee, J. K. (University of Miami Miller School of Medicine. Department of Neurosurgery. Miami Project to Cure Paralysis) ;
Hatten, M. E. (The Rockefeller University. Laboratory of Development Neurobiology) ;
Clarke, J. (University of Nebraska. Department of Statistics) ;
Ayad, N. G. (University of Miami Miller School of Medicine. Department of Psychiatry and Behavioral Sciences. Center for Therapeutic Innovation. Sylvester Comprehensive Cancer Center. Miami Project to Cure Paralysis)
Cerebellar neuronal progenitors undergo a series of divisions before irreversibly exiting the cell cycle and differentiating into neurons. Dysfunction of this process underlies many neurological diseases including ataxia and the most common pediatric brain tumor, medulloblastoma. [...]
2019 - 10.1038/s41467-019-10799-5
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3028
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15 p, 4.1 MB |
Prenatal Betamethasone interferes with immune system development and alters target cells in autoimmune diabetes
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Perna-Barrull, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Rodríguez-Fernández, Silvia (Institut Germans Trias i Pujol) ;
Pujol-Autonell, Irma (Institut Germans Trias i Pujol) ;
Gieras, A. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ;
Ampudia Carrasco, Rosa María (Institut Germans Trias i Pujol) ;
Villalba Felipe, Adrián (Institut Germans Trias i Pujol) ;
Glau, L. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ;
Tolosa, E. (Department of Immunology. University Medical Center Hamburg-Eppendorf) ;
Vives Pi, Marta (Institut Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
Non-genetic factors are crucial in the pathogenesis of type 1 diabetes (T1D), a disease caused by autoimmunity against insulin-producing β-cells. Exposure to medications in the prenatal period may influence the immune system maturation, thus altering self-tolerance. [...]
2019 - 10.1038/s41598-018-37878-9
Scientific reports, Vol. 9 Núm. 1 (january 2019) , p. 1235
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20 p, 2.2 MB |
Fluid supplementation accelerates epithelial repair during chemical colitis
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Burgueño, Juan F. (University of Miami-Leonard. Division of Gastroenterology.) ;
Lang, Jessica K. (Harvard T.H. Chan School of Public Health (Boston, Estats Units d'Amèrica)) ;
Santander, Ana M. (University of Miami-Leonard. Division of Gastroenterology) ;
Fernández, Irina (University of Miami-Leonard. Division of Gastroenterology) ;
Fernandez, Ester (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Zaias, Julia (University of Miami-Leonard. Department of Pathology and Laboratory Medicine) ;
Abreu, Maria T. (University of Miami-Leonard. Division of Gastroenterology)
The dextran sulfate sodium (DSS) model of colitis is a common animal model of inflammatory bowel disease that causes pain and distress. In this study, we aimed to determine whether fluid supplementation can be used as a welfare-based intervention to minimize animal suffering. [...]
2019 - 10.1371/journal.pone.0215387
PloS one, Vol. 14, Issue 4 (April 2019) , art. e0215387
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33 p, 2.7 MB |
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
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Eraña, Hasier (ATLAS Molecular Pharma S. L.) ;
Charco, Jorge M. (CIC bioGUNE) ;
Di Bari, Michele Angelo (CIC bioGUNE) ;
Díaz-Domínguez, Carlos M. (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
López-Moreno, R. (CIC bioGUNE) ;
Vidal Barba, Enric (Institut de Recerca i Tecnologia Agroalimentàries. Centre de Recerca en Sanitat Animal) ;
González-Miranda, E. (CIC bioGUNE) ;
Pérez-Castro, Miguel A. (CIC bioGUNE) ;
García-Martínez, Sandra (ATLAS Molecular Pharma S. L.) ;
Bravo Lopez, Susana Belén (Proteomics Lab. IDIS) ;
Fernández-Borges, Natalia (CIC bioGUNE) ;
Geijo, Maria V. (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
D'Agostino, C. (Department of Veterinary Public Health and Food Safety. Istituto Superiore di Sanità) ;
Garrido, Joseba M (NEIKER-Instituto Vasco de Investigación y Desarrollo Agrario) ;
Bian, J. (Colorado State University. Prion Research Center (PRC).) ;
König, A. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Uluca-Yazgi, B. (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Sabate, R. (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ;
Khaychuk, V. (Colorado State University. Prion Research Center (PRC).) ;
Vanni, Ilaria (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
Telling, G. C. (Colorado State University. Prion Research Center (PRC).) ;
Heise, Henrike (Heinrich-Heine-Universität Düsseldorf. Physikalische Biologie.) ;
Nonno, Romolo (Istituto Superiore di Sanità. Department of Veterinary Public Health and Food Safety.) ;
Requena, Jesús R (Universidade de Santiago de Compostela) ;
Castilla, Joaquín (IKERBasque. Basque Foundation for Science)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due to certain particularities of these proteinaceous pathogens. [...]
2019 - 10.1371/journal.ppat.1008117
PLOS pathogens, Vol. 15 Núm. 10 (2019) , p. e1008117
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9.
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19 p, 6.1 MB |
Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis
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Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Laguna, Ariadna (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Romero-Giménez, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Cuadros, Thais (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Bové, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martinez-Vicente, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Parent, Annabelle (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
González Sepúlveda, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peñuelas, Núria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torra, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Rodríguez-Galván, Beatriz (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ballabio, Andrea (Telethon Institute of Genetics and Medicine (TIGEM)) ;
Hasegawa, Takafumi (Department of Neurology. Tohoku University School of Medicin) ;
Bortolozzi, Analía (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gelpi, Ellen (Institute of Neurology. Medical University of Vienna) ;
Vila Bover, Miquel (Institució Catalana de Recerca i Estudis Avançats) ;
Universitat Autònoma de Barcelona
2019 - 10.1038/s41467-019-08858-y
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 973
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17 p, 2.6 MB |
Succination is increased on select proteins in the brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome
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Piroli, G. G. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ;
Manuel, A. M. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ;
Clapper, A. C. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ;
Walla, M. D. (Mass Spectrometry Center. Department of Chemistry and Biochemistry. University of South Carolina) ;
Baatz, J. E. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina) ;
Palmiter, Richard D (Howard Hughes Medical Institute and Department of Biochemistry. University of Washington) ;
Quintana Puebla, Alberto (Seattle Children's Research Institute) ;
Frizzell, N. (Department of Pharmacology. Physiology and Neuroscience. University of South Carolina)
Elevated fumarate concentrations as a result of Krebs cycle inhibition lead to increases in protein succination, an irreversible post-Translational modification that occurs when fumarate reacts with cysteine residues to generate S-(2-succino)cysteine (2SC). [...]
2016 - 10.1074/mcp.M115.051516
Molecular and Cellular Proteomics, Vol. 15 Núm. 2 (february 2016) , p. 445-461
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