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15 p, 2.0 MB |
MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression
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Toll, Agustí (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Salgado, Rocío (Hospital del Mar (Barcelona)) ;
Espinet, Blanca (Hospital del Mar (Barcelona)) ;
Díaz-Lagares, Angel (Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain) ;
Hernández-Ruiz, Eugenia (Hospital Universitari Vall d'Hebron) ;
Andrades, Evelyn (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sandoval, Juan (Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Barcelona, Spain) ;
Esteller, Manel (Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia Spain) ;
Pujol, Ramón M (Hospital del Mar (Barcelona)) ;
Hernández-Muñoz, Inmaculada (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and frequently progresses from an actinic keratosis (AK), a sun-induced keratinocyte intraepithelial neoplasia (KIN). Epigenetic mechanisms involved in the phenomenon of progression from AK to cSCC remain to be elicited. [...]
2016 -  10.1186/s12943-016-0537-z
Molecular Cancer, Vol. 15 (july 2016)
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2.
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14 p, 1.8 MB |
Genomic Adaptations and Evolutionary History of the Extinct Scimitar-Toothed Cat, Homotherium latidens
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Barnett, Ross (University of Copenhagen. Section for Evolutionary Genomics) ;
Westbury, Michael V. (University of Copenhagen. Section for Evolutionary Genomics) ;
Sandoval-Velasco, Marcela (University of Copenhagen. Section for Evolutionary Genomics) ;
Vieira, Filippe Garrett (University of Copenhagen. Section for Evolutionary Genomics) ;
Jeon, Sungwon (Ulsan National Institute of Science and Technology. Department of Biomedical Engineering) ;
Zazula, Grant (Government of Yukon. Yukon Palaeontology Program) ;
Martin, Michael (Norwegian University of Science and Technology. Department of Natural History) ;
Ho, Simon Y.W. (University of Sydney. School of Life and Environmental Sciences) ;
Mather, Niklas (University of Sydney. School of Life and Environmental Sciences) ;
Gopalakrishnan, Shyam (University of Copenhagen. Center for Evolutionary Hologenomics) ;
Ramos-Madrigal, Jazmín (University of Copenhagen. Center for Evolutionary Hologenomics) ;
de Manuel, Marc (Universitat Pompeu Fabara. Institut de Biologia Evolutiva) ;
Zepeda Mendoza, Marie Lisandra (University of Birmingham. Institute of Microbiology and Infection) ;
Antunes, Agostinho (University of Porto. Department of Biology) ;
Baez, Aldo Carmon (University of Copenhagen. Section for Evolutionary Genomics) ;
De Cahsan, Binia (University of Copenhagen. Center for Evolutionary Hologenomics) ;
Larson, Greger (University of Oxford. The Palaeogenomics and Bio-Archaeology Research Network) ;
O'Brien, Stephen J. (Nova Southeastern University. Guy Harvey Oceanographic Center) ;
Eizirik, Eduardo (Instituto Pró-Carnívoros) ;
Johnson, Warren E. (Walter Reed Army Institute of Research) ;
Koepfli, Klaus-Peter (Center for Species Survival. Smithsonian Conservation Biology Institute) ;
Wilting, Andreas (Leibniz Institute for Zoo and Wildlife Research) ;
Fickel, Jöms (University of Potsdam. Institute for Biochemistry and Biology) ;
Dalén, Love (Swedish Museum of Natural History. Department of Bioinformatics and Genetics) ;
Lorenzen, Eline D. (University of Copenhagen. Center for Evolutionary Hologenomics) ;
Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ;
Hansen, Anders J. (University of Copenhagen. Section for GeoGenetics) ;
Zhang, Guojie (Chinese Academy of Sciences. Kunming Institute of Zoology) ;
Bhak, Jong (Personal Genomics Institute. Genome Research Foundation) ;
Yamaguchi, Nobuyuki (Universiti Malaysia Terengganu. Institute of Tropical Biodiversity and Sustainable Development) ;
Gilbert, M. Thomas P. (University of Copenhagen. Center for Evolutionary Hologenomics)
Homotherium was a genus of large-bodied scimitar-toothed cats, morphologically distinct from any extant felid species, that went extinct at the end of the Pleistocene [1-4]. They possessed large, saber-form serrated canine teeth, powerful forelimbs, a sloping back, and an enlarged optic bulb, all of which were key characteristics for predation on Pleistocene megafauna [5]. [...]
2020 - 10.1016/j.cub.2020.09.051
Current Biology, (October 2020)
2 documents
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3.
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21 p, 2.4 MB |
Differential DNA methylation of vocal and facial anatomy genes in modern humans
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Gokhman, David (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel)) ;
Nissim-Rafinia, Malka (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel)) ;
Agranat-Tamir, Lily (The Hebrew University of Jerusalem. Department of Statistics (Israel)) ;
Housman, Genevieve (Arizona State University. Center for Evolution and Medicine (USA)) ;
García-Pérez, Raquel (Universitat Pompeu Fabra. Institut de Biologia Evolutiva) ;
Lizano, Esther (Universitat Pompeu Fabra. Institut de Biologia Evolutiva) ;
Cheronet, Olivia (University of Vienna. Department of Evolutionary Anthropology (Austria)) ;
Mallick, Swapan (Howard Hughes Medical Institute. Harvard Medical School (USA)) ;
Nieves-Colón, Maria A. (Arizona State University. Center for Evolution and Medicine (USA)) ;
Li, Heng (Broad Institute (USA)) ;
Alpaslan-Roodenberg, Songül (Harvard Medical School. Department of Genetics (USA)) ;
Novak, Mario (University College Dublin. Earth Institute and School of Archaeology (Ireland)) ;
Gu, Hongcang (Broad Institute (USA)) ;
Osinski, Jason M. (University at Buffalo. Jacobs School of Medicine and Biomedical Sciences. Department of Biochemistry (USA)) ;
Ferrando-Bernal, Manuel (Universitat Pompeu Fabra. Institut de Biologia Evolutiva) ;
Gelabert, Pere (Universitat Pompeu Fabra. Institut de Biologia Evolutiva) ;
Lipende, Iddi (Jane Goodall Institute. Gombe Stream Research Center (Tanzania)) ;
Mjungu, Deus (Jane Goodall Institute. Gombe Stream Research Center (Tanzania)) ;
Kondova, Ivanela (Biomedical Primate Research Centre (Netherlands)) ;
Bontrop, Ronald (Biomedical Primate Research Centre (Netherlands)) ;
Kullmer, Ottmar (Senckenberg Center of Human Evolution and Paleoecology. Department of Palaeoanthropology and Messel Research (Germany)) ;
Weber, Gerhard (University of Vienna. Department of Evolutionary Anthropology (Austria)) ;
Shahar, Tal (Shaare Zedek Medical Center. Department of Neurosurgery (Israel)) ;
Dvir-Ginzberg, Mona (Hebrew University of Jerusalem. Institute of Dental Sciences. Laboratory of Cartilage Biology (Israel)) ;
Faerman, Marina (Hebrew University of Jerusalem. Institute of Dental Sciences. Laboratory of Bioanthropology and Ancient DNA (Israel)) ;
Quillen, Ellen E. (Texas Biomedical Research Institute. Department of Genetics (USA)) ;
Meissner, Alexander (Harvard University. Department of Stem Cell and Regenerative Biology (USA)) ;
Lahav, Yonatan (The Hebrew University Medical School (Israel)) ;
Kandel, Leonid (Hadassah - Hebrew University Medical Center. Orthopaedic Department (Israel)) ;
Liebergall, Meir (Hadassah - Hebrew University Medical Center. Orthopaedic Department (Israel)) ;
Prada, María E. (I.E.S.O. 'Los Salados'. Junta de Castilla y León) ;
Vidal, Julio M. (Junta de Castilla y León. Servicio de Cultura de León) ;
Gronostajski, Richard M. (University at Buffalo. Jacobs School of Medicine and Biomedical Sciences. Department of Biochemistry (USA)) ;
Stone, Anne C. (Arizona State University. Institute of Human Origins (USA)) ;
Yakir, Benjamin (The Hebrew University of Jerusalem. Department of Statistics (Israel)) ;
Lalueza-Fox, Carles (Universitat Pompeu Fabra. Institut de Biologia Evolutiva) ;
Pinhasi, Ron (University of Vienna. Department of Evolutionary Anthropology (Austria)) ;
Reich, David (Howard Hughes Medical Institute. Harvard Medical School (USA)) ;
Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ;
Meshorer, Eran (The Hebrew University of Jerusalem. The Edmond and Lily Safra Center for Brain Sciences (Israel)) ;
Carmel, Liran (The Hebrew University of Jerusalem. The Alexander Silberman Institute of Life Sciences. Department of Genetics (Israel))
Changes in potential regulatory elements are thought to be key drivers of phenotypic divergence. However, identifying changes to regulatory elements that underlie human-specific traits has proven very challenging. [...]
2020 - 10.1038/s41467-020-15020-6
Nature communications, Vol. 11 (March 2020) , art. 1189
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13 p, 23.3 MB |
Increased PARP Activity and DNA Damage in NSCLC Patients : influence of COPD
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Tang, Jun (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Curull Serrano, Víctor (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Wang, Xuejie (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Ampurdanés, Coral (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Duran, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pijuan, Lara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez-Fuster, Alberto (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Aguiló, Rafael (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Yélamos, Jose (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Barreiro, Esther (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
(1) Background: Lung cancer (LC) is a major leading cause of death worldwide. Poly (ADP-ribose) polymerase (PARP)-1 and PARP-2 are key players in cancer. We aimed to assess PARP-1 and PARP-2 expression and activity and DNA damage in tumors and non-tumor lungs from patients with/without chronic obstructive pulmonary disease (COPD). [...]
2020 - 10.3390/cancers12113333
Cancers, Vol. 12 Núm. 11 (2020) , p. 3333
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5.
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18 p, 3.3 MB |
Fast and accurate pneumocystis pneumonia diagnosis in human samples using a label-free plasmonic biosensor
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Calvo Lozano, Olalla (Institut Català de Nanociència i Nanotecnologia) ;
Aviñó, Ana (Institut de Química Avançada de Catalunya) ;
Friaza, Vicente (Instituto de Biomedicina de Sevilla) ;
Medina Escuela, Alfonso (Universidad de Las Palmas de Gran Canaria. Instituto Universitario de Microelectrónica Aplicada) ;
Huertas, César S. (Institut Català de Nanociència i Nanotecnologia) ;
Calderón, Enrique J. (Universidad de Sevilla. Departamento de Medicina) ;
Eritja, Ramon (Institut de Química Avançada de Catalunya) ;
Lechuga, Laura M. (Institut Català de Nanociència i Nanotecnologia)
Pneumocystis jirovecii is a fungus responsible for human Pneumocystis pneumonia, one of the most severe infections encountered in immunodepressed individuals. The diagnosis of Pneumocystis pneumonia continues to be challenging due to the absence of specific symptoms in infected patients. [...]
2020 - 10.3390/NANO10061246
Nanomaterials, Vol. 10, issue 6 (June 2020) , art. 1246
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6.
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15 p, 1.2 MB |
Proteomic Analysis in Seminal Plasma of Fertile Donors and Infertile Patients with Sperm DNA Fragmentation
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Fernandez-Encinas, Alba (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
García-Peiró, Agustín (Centro de Infertilidad Masculina y Análisis de Barcelona (CIMAB)) ;
Del Rey Azpiri, Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Ribas-Maynou, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Abad, Carlos (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Amengual, Maria José (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Prada, Elena (Hospital Universitari Mutua de Terrassa. Servei de Ginecologia) ;
Navarro i Ferreté, Joaquima (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Benet i Català, Jordi (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia)
Seminal plasma proteomics studies could represent a new approach for the determination of molecular elements driving male infertility, resulting in a better male infertility characterization. The aim of this study is to investigate proteomic differences in seminal plasma samples from fertile and infertile individuals. [...]
2020 - 10.3390/ijms21145046
International journal of molecular sciences, Vol. 21, Núm. 14 (July 2020) , art. 5046
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15 p, 726.6 KB |
Inference of natural selection from ancient DNA
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Dehasque, Marianne (Stockholm University) ;
Ávila-Arcos, Maria C. (UNAM Juriquilla) ;
Díez, David (Stockholm University) ;
Fumagalli, Matteo (Imperial College London) ;
Guschanski, Katerina (Uppsala University) ;
Lorenzen, Eline (University of Copenhagen) ;
Malaspinas, Anna-Sapfo (University of Lausanne. SIB Swiss Institute of Bioinformatics) ;
Marques-Bonet, Tomas (Institut Català de Paleontologia Miquel Crusafont) ;
Martin, Michael D. (Norwegian University of Science and Technology) ;
Murray, Gemma G. R. (University of Cambridge) ;
Papadopulos, Alexander S. T. (Bangor University) ;
Therkildsen, Nina Overgaard (Cornell University) ;
Wegmann, Daniel (Swiss Institute of Bioinformatics) ;
Dalén, Love (Swedish Museum of Natural History) ;
Foote, Andrew D. (Bangor University)
Evolutionary processes, including selection, can be indirectly inferred based on patterns of genomic variation among contemporary populations or species. However, this often requires unrealistic assumptions of ancestral demography and selective regimes. [...]
2020 - 10.1002/evl3.165
Evolution Letters, Vol. 4, Issue 2 (April 2020) , p. 94-108
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8 p, 1.6 MB |
DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues
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Gallego-Fabrega, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Cullell, Natalia (Institut d'Investigació Biomèdica Sant Pau) ;
Soriano-Tárraga, Carolina (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Carrera, Caty (Institut d'Investigació Biomèdica Sant Pau) ;
Torres-Aguila, Nuria P. (Institut d'Investigació Biomèdica Sant Pau) ;
Muiño, Elena (Institut d'Investigació Biomèdica Sant Pau) ;
Cárcel-Márquez, Jara (Institut d'Investigació Biomèdica Sant Pau) ;
de Moura, Manuel Castro (Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain) ;
Fernández-Sanlés, Alba (Cardiovascular Epidemiology and Genetics Research Group, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Barcelona, Spain) ;
Esteller, Manel (Institucio Catalana de Recerca i Estudis Avançats, Barcelona, Spain) ;
Elosua, Roberto (Cardiovascular Epidemiology and Genetics Research Group, Hospital del Mar Medical Research Institute, Universitat Pompeu Fabra, Barcelona, Spain) ;
Jiménez-Conde, Jordi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Montaner, Joan (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Krupinski, Jerzy (* These authors contributed equally to this work) ;
Fernandez-Cadenas, Israel (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
Background and Purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while no studies of DNA methylation (DNAm) patterns of MMP or TIMP have been performed to that end. [...]
2020 - 10.18632/oncotarget.27469
Oncotarget, Vol. 11 (march 2020) , p. 905-912
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9.
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13 p, 1.5 MB |
Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
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van Dorp, Lucy (University College London. UCL Genetics Institute (UK)) ;
Gelabert Xirinachs, Pere (Universitat Pompeu Fabra. Institut de Biologia Evolutiva) ;
Rieux, Adrien (Coopération Internationale en Recherche Agronomique pour le Développement (France)) ;
de Manuel, Marc (Universitat Pompeu Fabra. Institut de Biologia Evolutiva) ;
de Dios, Toni (Universitat Pompeu Fabra. Institut de Biologia Evolutiva) ;
Gopalakrishnan, Shyam (University of Copenhagen. The GLOBE Institute (Denmark)) ;
Carøe, Christian (University of Copenhagen. The GLOBE Institute (Denmark)) ;
Sandoval Velasco, Marcela (University of Copenhagen. The GLOBE Institute (Denmark)) ;
Fregel, Rosa (Universidad de La Laguna. Departamento de Bioquímica, Microbiología, Biología Celular y Genética) ;
Olalde, Iñigo (Harvard Medical School. Department of Genetics (USA)) ;
Escosa, Raül (Consorci de Polítiques Ambientals de les Terres de l'Ebre) ;
Aranda, Carles (Consell Comarcal del Baix Llobregat. Servei de Control de Mosquits) ;
Huijben, Silvie (Hospital Clínic-Universitat de Barcelona. ISGlobal Institut de Salut Global de Barcelona) ;
Mueller, Ivo (Hospital Clínic-Universitat de Barcelona. ISGlobal Institut de Salut Global de Barcelona) ;
Marques-Bonet, Tomas, 1975- (Institut Català de Paleontologia Miquel Crusafont) ;
Balloux, François (University College London. UCL Genetics Institute (UK)) ;
Gilbert, M Thomas P (University of Copenhagen. The GLOBE Institute (Denmark)) ;
Lalueza-Fox, Carles (Universitat Pompeu Fabra. Institut de Biologia Evolutiva)
The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania, and the Americas. [...]
2020 - 10.1093/molbev/msz264
Molecular biology and evolution, Vol. 37, Issue 3 (March 2020) , p. 773-785
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10.
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14 p, 3.3 MB |
Interaction of camel Lactoferrin derived peptides with DNA : a molecular dynamics study
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Pirkhezranian, Zana (Ferdowsi University of Mashhad. Department of Animal Science) ;
Tahmoorespur, Mojtaba. (Ferdowsi University of Mashhad. Department of Animal Science) ;
Daura i Ribera, Xavier (Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Monhemi, Hassan (University of Neyshabur. Department of Chemistry) ;
Sekhavati, Mohammad Hadi (Ferdowsi University of Mashhad. Department of Animal Science)
Background: lactoferrampin (LFampin), Lactoferricin (LFcin), and LFchimera are three well-known antimicrobial peptides derived from Lactoferrin and proposed as alternatives for antibiotics. Although the intracellular activity of these peptides has been previously demonstrated, their mode of action is not yet fully understood. [...]
2020 - 10.1186/s12864-020-6458-7
BMC genomics, Vol. 21 (2020) , art. 60
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