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Protein-only Nanoparticles for T Cell Expansion and Activation
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Fornt Suñé, Marc (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lázaro Bermejo, Gonzalo (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Gil Garcia, Marcos (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Aran, Andrea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Garcia Pardo, Javier (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular)
The in vitro expansion and activation of T cells utilizing synthetic nanosized artificial antigen presenting cells (aAPCs) have emerged as a promising technique for cancer treatment. Although diverse nanomaterials have been explored as aAPC scaffolds, protein-only nanoparticles have been largely overlooked, despite their high designability and biocompatibility. [...]
2024 -  10.1021/acsanm.4c00698
ACS applied nano materials, Vol. 7 Núm. 6 (22 2024) , p. 6669-6680
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12 p, 4.0 MB |
Domain generalization in deep learning for contrast-enhanced imaging
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Sendra-Balcells, C. (Universitat de Barcelona) ;
Campello, Victor M (Universitat de Barcelona) ;
Martín-Isla, C. (Universitat de Barcelona) ;
Viladés Medel, David (Institut d'Investigació Biomèdica Sant Pau) ;
Descalzo, Martin (Institut d'Investigació Biomèdica Sant Pau) ;
Guala, Andrea (Hospital Universitari Vall d'Hebron) ;
Rodriguez-Palomares, Jose F (Hospital Universitari Vall d'Hebron) ;
Lekadir, K. (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
The domain generalization problem has been widely investigated in deep learning for non-contrast imaging over the last years, but it received limited attention for contrast-enhanced imaging. However, there are marked differences in contrast imaging protocols across clinical centers, in particular in the time between contrast injection and image acquisition, while access to multi-center contrast-enhanced image data is limited compared to available datasets for non-contrast imaging. [...]
2022 - 10.1016/j.compbiomed.2022.106052
Computers in Biology and Medicine, Vol. 149 (october 2022) , p. 106052
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6 p, 2.3 MB |
Zero-field routing of spin waves in a multiferroic heterostructure
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Zhu, Weijia (Aalto University School of Science. Department of Applied Physics) ;
Qin, Huajun (Aalto University School of Science. Department of Applied Physics) ;
Flajšman, Lukáš (Aalto University School of Science. Department of Applied Physics) ;
Taniyama, Tomoyasu (Nagoya University. Department of Physics) ;
Van Dijken, Sebastiaan (Aalto University School of Science. Department of Applied Physics)
We report zero-field routing of spin waves in a multiferroic heterostructure comprising a ferromagnetic Fe film and a ferroelectric BaTiO3 substrate with fully correlated strain-coupled domains. In the Fe film, a regular alternation of magnetic anisotropy produces a back-and-forth rotation of uniform magnetization in zero magnetic field. [...]
2022 - 10.1063/5.0086430
Applied physics letters, Vol. 120, Issue 11 (March 2022) , art. 112407
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5.
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12 p, 1.7 MB |
Role of POLE and POLD1 in familial cancer
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Mur, Pilar (Centro de Investigación Biomédica en Red de Cáncer) ;
García-Mulero, Sandra (Hospital Universitari de Bellvitge) ;
del Valle, Jesús (Centro de Investigación Biomédica en Red de Cáncer) ;
Magraner-Pardo, Lorena (Spanish National Cancer Research Center (CNIO)) ;
Vidal, August (Hospital Universitari de Bellvitge) ;
Pineda, Marta (Centro de Investigación Biomédica en Red de Cáncer) ;
Cinnirella, Giacomo (Hospital Universitari de Bellvitge) ;
Martín-Ramos, Edgar (Universitat de Barcelona) ;
Pons, Tirso (Consell Superior d'Investigacions Científiques) ;
López-Doriga, Adriana (Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública (CIBERESP)) ;
Belhadj, Sami (Hospital Universitari de Bellvitge) ;
Feliubadaló, Lidia (Centro de Investigación Biomédica en Red de Cáncer) ;
Munoz-Torres, Pau M. (Hospital Universitari de Bellvitge) ;
Navarro, Matilde (Centro de Investigación Biomédica en Red de Cáncer) ;
Grau, Elia (Hospital Universitari de Bellvitge) ;
Darder, Esther (Institut Català d'Oncologia) ;
Llort, Gemma (Consorci Sanitari de Terrassa) ;
Sanz, Judit (Althaia Xarxa Assistencial Universitària de Manresa) ;
Ramon y Cajal, Teresa (Institut d'Investigació Biomèdica Sant Pau) ;
Balmaña Gelpí, Judith (Hospital Universitari Vall d'Hebron) ;
Brunet, Joan (Institut Català d'Oncologia) ;
Moreno, Víctor (Universitat de Barcelona) ;
Piulats, Josep M. (Hospital Universitari de Bellvitge) ;
Matías-Guiu, Xavier (Hospital Universitari de Bellvitge) ;
Sanz-Pamplona, Rebeca (Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública (CIBERESP)) ;
Aligué, Rosa (Universitat de Barcelona) ;
Capellá, G. (Gabriel) (Centro de Investigación Biomédica en Red de Cáncer) ;
Lázaro, Conxi (Centro de Investigación Biomédica en Red de Cáncer) ;
Valle, Laura (Centro de Investigación Biomédica en Red de Cáncer) ;
Universitat Autònoma de Barcelona
Germline pathogenic variants in the exonuclease domain (ED) of polymerases POLE and POLD1 predispose to adenomatous polyps, colorectal cancer (CRC), endometrial tumors, and other malignancies, and exhibit increased mutation rate and highly specific associated mutational signatures. [...]
2020 - 10.1038/s41436-020-0922-2
Genetics in medicine, Vol. 22 Núm. 12 (december 2020) , p. 2089-2100
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9 p, 6.1 MB |
Engineering Heat Transport Across Epitaxial Lattice-Mismatched van der Waals Heterointerfaces
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Chávez Ángel, Emigdio (Institut Català de Nanociència i Nanotecnologia) ;
Tsipas, Polychronis (National Center for Scientific Research "Demokritos") ;
Xiao, Peng (Institut Català de Nanociència i Nanotecnologia) ;
Ahmadi, Mohammad Taghi (University of Warwick) ;
Daaoub, Abdalghani H. S. (University of Warwick) ;
Sadeghi, Hatef (University of Warwick) ;
Sotomayor Torres, Clivia M. (Institut Català de Nanociència i Nanotecnologia) ;
Dimoulas, Athanasios (National Center for Scientific Research "Demokritos") ;
Sachat, Alexandros el (Institut Català de Nanociència i Nanotecnologia)
Artificially engineered 2D materials offer unique physical properties for thermal management, surpassing naturally occurring materials. Here, using van der Waals epitaxy, we demonstrate the ability to engineer extremely insulating thermal metamaterials based on atomically thin lattice-mismatched BiSe/MoSe superlattices and graphene/PdSe heterostructures with exceptional thermal resistances (70-202 m 2 K/GW) and ultralow cross-plane thermal conductivities (0. [...]
2023 - 10.1021/acs.nanolett.3c01280
Nano letters, Vol. 23, Issue 15 (August 2023) , p. 6883-6891
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29 p, 1.5 MB |
Deconvolution of Phonon Scattering by Ferroelectric Domain Walls and Point Defects in a PbTiO3Thin Film Deposited in a Composition-Spread Geometry
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Bugallo, David (Universidade de Santiago de Compostela. Departamento de Química Física) ;
Langenberg, Eric (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia) ;
Ferreiro-Vila, Elias (Centro Singular de Investigacion en Quimica Bioloxica e Materiais Moleculares (CiQUS)) ;
Smith, Eva H. (Cornell University. Department of Materials Science and Engineering) ;
Stefani, Christina (Institut Català de Nanociència i Nanotecnologia) ;
Batlle, Xavier (Universitat de Barcelona. Departament de Física de la Matèria Condensada) ;
Catalan, Gustau (Institut Català de Nanociència i Nanotecnologia) ;
Domingo Marimon, Neus (Institut Català de Nanociència i Nanotecnologia) ;
Schlom, Darrell G. (Kavli Institute at Cornell for Nanoscale Science) ;
Rivadulla, Francisco (Universidade de Santiago de Compostela. Departamento de Química Física)
We present a detailed analysis of the temperature dependence of the thermal conductivity of a ferroelectric PbTiO3 thin film deposited in a composition-spread geometry enabling a continuous range of compositions from ∼25% titanium deficient to ∼20% titanium rich to be studied. [...]
2021 - 10.1021/acsami.1c08758
ACS applied materials & interfaces, Vol. 13, Num. 38 (September 2021) , p. 45679-45685
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16 p, 5.6 MB |
Co-Training for On-Board Deep Object Detection
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Villalonga, Gabriel (Centre de Visió per Computador (Bellaterra, Catalunya)) ;
López Peña, Antonio M. (Universitat Autònoma de Barcelona. Departament de Ciències de la Computació)
Providing ground truth supervision to train visual models has been a bottleneck over the years, exacerbated by domain shifts which degenerate the performance of such models. This was the case when visual tasks relied on handcrafted features and shallow machine learning and, despite its unprecedented performance gains, the problem remains open within the deep learning paradigm due to its data-hungry nature. [...]
2020 - 10.1109/ACCESS.2020.3032024
IEEE Access, Vol. 8 (October 2020) p. 194441-194456
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