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11 p, 1.2 MB |
Alzheimer's disease in Down syndrome : An overlooked population for prevention trials
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Strydom, André (South London and Maudsley NHS Foundation Trust) ;
Coppus, Antonia (Department of Primary and Community Care, Radboud University Medical Center, Nijmegen) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Danek, Adrian (Department of Neurology, Ludwig-Maximilians-Universität München) ;
Fortea, Juan (Barcelona Down Medical Center, Fundació Catalana de Síndrome de Down) ;
Hardy, John (Reta Lila Weston Institute, Institute of Neurology, University College London) ;
Levin, Johannes (German Center for Neurodegenerative Diseases (DZNE) site Munich) ;
Nuebling, Georg (Department of Neurology, Ludwig-Maximilians-Universität München) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Ritchie, Craig (Centre for Clinical Brain Sciences. University of Edinburgh) ;
van Duijn, Cornelia (Department of Epidemiology, Erasmus Medical Centre, Rotterdam) ;
Zaman, Shahid (Cambridgeshire & Peterborough NHS Foundation Trust (CBFT), Fulbourn Hospital) ;
Zetterberg, Henrik (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital) ;
Universitat Autònoma de Barcelona
The discovery that adults with Down syndrome (DS) have neuropathological features identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the identification of the amyloid precursor protein gene on chromosome 21 and resulted in the amyloid cascade hypothesis. [...]
2018 -  10.1016/j.trci.2018.10.006
Alzheimer's & Dementia : Translational Research & Clinical Interventions, Vol. 4 (december 2018) , p. 703-713
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13 p, 787.1 KB |
Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease
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Dekker, Alain D. (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Vermeiren, Yannick (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Carmona-Iragui, Maria (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
Benejam, Bessy (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
Videla, Laura (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
Gelpi, Ellen (Neurological Tissue Bank-Biobanc, Hospital Clinic Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain) ;
Aerts, Tony (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Van Dam, Debby (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Fernández, Susana (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
Lleó Bisa, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Videla, Sebastian (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut) ;
Sieben, Anne (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Martin, Jean-Jacques (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Wilrijk, Antwerp, Belgium) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
Fortea, Juan (Down Medical Center, Catalan Down Syndrome Foundation, Barcelona, Spain) ;
De Deyn, Peter P. (Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium) ;
Universitat Autònoma de Barcelona
People with Down syndrome (DS) are at high risk for Alzheimer's disease (AD). Defects in monoamine neurotransmitter systems are implicated in DS and AD but have not been comprehensively studied in DS. [...]
2017 - 10.1016/j.dadm.2017.11.001
Alzheimer's & dementia, Vol. 10 (november 2017) , p. 99-111
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23 p, 1.3 MB |
The behavioral and psychological symptoms of dementia in Down syndrome (BPSD-DS) scale : comprehensive assessment of psychopathology in Down syndrome
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Dekker, Alain D. (Universitair Medisch Centrum Groningen) ;
Sacco, Silvia (Institut Jérôme Lejeune) ;
Carfi, Angelo (Universitá Cattolica del Sacro Cuore) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Vermeiren, Yannick (Universitair Medisch Centrum Groningen) ;
Beugelsdijk, Gonny (Ipse de Bruggen) ;
Schippers, Mieke (Ipse de Bruggen) ;
Hassefras, Lyanne (Ipse de Bruggen) ;
Eleveld, José (Cosis (Groningen)) ;
Grefelman, Sharina (Cosis (Groningen)) ;
Fopma, Roelie (Talant (Heerenveen)) ;
Bomer-Veenboer, Monique (Pameijer (Rotterdam)) ;
Boti, Mariángeles (Fundació Catalana Síndrome de Down) ;
Oosterling, G. Danielle E. (Aveleijn (Borne)) ;
Scholten, Esther (Elver (Nieuw-Wehl)) ;
Tollenaere, Marleen (Institute Born-Bunge) ;
Checkley, Laura (University College London. Division of Psychiatry) ;
Strydom, André (University College London. Division of Psychiatry) ;
Van Goethem, Gert (Het GielsBos (Gierle)) ;
Onder, Graziano (Universitá Cattolica del Sacro Cuore) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
zu Eulenburg, Christine (Universitair Medisch Centrum Groningen) ;
Coppus, Antonia M.W. (Dichterbij (Gennep)) ;
Rebillat, Anne-Sophie (Institut Jérôme Lejeune) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
De Deyn, Peter P. (Universitair Medisch Centrum Groningen) ;
Universitat Autònoma de Barcelona
People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. [...]
2018 - 10.3233/JAD-170920
Journal of Alzheimer's disease, Vol. 63, issue 2 (2018) , p. 797-819
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10 p, 566.6 KB |
Cerebrospinal fluid biomarkers for Alzheimer's disease in Down syndrome
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Dekker, Alain D. (University of Antwerp) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Blesa, Rafael (Institut d'Investigació Biomèdica Sant Pau) ;
De Deyn, Peter P. (Laboratory of Neurochemistry and Behaviour, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium) ;
Universitat Autònoma de Barcelona
Down syndrome (DS), present in nearly six million people, is associated with an extremely high risk to develop Alzheimer's disease (AD). Amyloid-β and tau pathology are omnipresent from age 40 years onward, but clinical symptoms do not appear in all DS individuals. [...]
2017 - 10.1016/j.dadm.2017.02.006
Alzheimer's & dementia, Vol. 8 (march 2017) , p. 1-10
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9 p, 894.2 KB |
VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome
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del Hoyo, Laura (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Xicota, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Langohr, Klaus (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Sánchez-Benavides, Gonzalo (Institut Hospital del Mar d'Investigacions Mèdiques) ;
de Sola, Susana (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Cuenca-Royo, Aida (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodriguez, Joan (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Rodríguez-Morató, Jose (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Farré Albaladejo, Magí (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Dierssen, Mara (CIBER de Enfermedades Raras, Instituto Salud Carlos III) ;
de la Torre, Rafael (CInstitut Hospital del Mar d'Investigacions Mèdiques)
Down syndrome (DS) is an aneuploidy syndrome that is caused by trisomy for human chromosome 21 resulting in a characteristic cognitive and behavioral phenotype, which includes executive functioning and adaptive behavior difficulties possibly due to prefrontal cortex (PFC) deficits. [...]
2016 - 10.3389/fnbeh.2016.00193
Frontiers in Behavioral Neuroscience, Vol. 10 (october 2016)
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9 p, 783.3 KB |
Periodontal disease's contribution to Alzheimer's disease progression in Down syndrome
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Kamer, Angela R. (Department of Psychiatry, Center for Brain Health, School of Medicine, New York, NY, USA) ;
Fortea, Juan O. (Institut d'Investigació Biomèdica Sant Pau) ;
Videla, Sebastià (Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain) ;
Mayoral, Angela (Dentistry School Universitat Internacional de Catalunya, Sant Cugat del Vallés, Barcelona, Spain) ;
Janal, Malvin (Department of Epidemiology, College of Dentistry, New York University, New York, NY, USA) ;
Carmona-Iragui, Maria (Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain) ;
Benejam, Bessy (Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain) ;
Craig, Ronald G. (Department of Basic Sciences and Craniofacial Biology, College of Dentistry, New York University, New York, NY, USA) ;
Saxena, Deepak (Department of Basic Sciences and Craniofacial Biology, College of Dentistry, New York University, New York, NY, USA) ;
Corby, Patricia (Department of Psychiatry, Center for Brain Health, School of Medicine, New York, NY, USA) ;
Glodzik, Lidia (Department of Psychiatry, Center for Brain Health, School of Medicine, New York, NY, USA) ;
Annam, Kumar Raghava Chowdary (Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY, USA) ;
Robbins, Miriam (Department of Dental Medicine, Winthrop University Hospital, Mineola, NY, USA) ;
de Leon, Mony J. (Department of Psychiatry, Center for Brain Health, School of Medicine, New York, NY, USA) ;
Universitat Autònoma de Barcelona
People with Down syndrome (DS) are at an increased risk for Alzheimer's disease (AD). After 60 years of age, >50% of DS subjects acquire dementia. Nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. [...]
2016 - 10.1016/j.dadm.2016.01.001
Alzheimer's & dementia, Vol. 2 (february 2016) , p. 49-57
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10 p, 1.3 MB |
El síndrome de Down como protagonista de la publicidad
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Hontanilla Pizarro, Beatriz
La presente investigación cuantitativa de tipo correlacional tiene como principal objetivo ampliar el conocimiento que se tiene de las personas con síndrome de Down dentro del ámbito publicitario, por lo que se pretende analizar el nivel de agrado de personas con y sin síndrome de Down frente a spots publicitarios de las mismas características, con el fin de conocer mejor las preferencias y los gustos de las personas con esta discapacidad en relación a la publicidad. [...]
This quantitative and correlational research has as a main objective of this research is to expand the knowledge we have of people with Down syndrome in the advertising field, therefore we intend to analyse the level of pleasure that people with and without Down syndrome versus advertising spots of the same features, in order to learn more about the preferences and likes of people with this disability in relation to advertising. [...]
2017 - 10.5565/rev/grafica.83
Grafica, Vol. 5 Núm. 10 (2017) , p. 85-93 (Investigación)
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2 p, 240.5 KB |
The magic stone : a video game to improve communication skills of people with intellectual disabilities
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Corrales Astorgano, Mario (Universidad de Valladolid. Departamento de Informática) ;
Escudero Mancebo, David (Universidad de Valladolid. Departamento de Informática) ;
González Ferreras, César (Universidad de Valladolid. Departamento de Informática) ;
Gutiérrez González, Yurena María (Universitat Autònoma de Barcelona. Departament de Filologia Espanyola) ;
Flores Lucas, Valle (Universidad de Valladolid. Departamento de Psicología) ;
Cardeñoso Payo, Valentín (Universidad de Valladolid. Departamento de Informática) ;
Aguilar, Lourdes (Universitat Autònoma de Barcelona. Departament de Filologia Espanyola)
'The Magic Stone' is a video game whose main aim is to help people with Down syndrome to improve communication skills that have been affected due to their disability, especially those related with prosody. [...]
2016
Interspeech, 2016, p. 1565-1566
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