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16 p, 3.1 MB |
Escherichia coli as a New Platform for the Fast Production of Vault-like Nanoparticles : An Optimized Protocol
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Fernández, Roger (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Carreño, Aida (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mendoza, Rosa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Benito, Antoni (Institut d'Investigació Biomèdica de Girona) ;
Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Vaults are protein nanoparticles that are found in almost all eukaryotic cells but are absent in prokaryotic ones. Due to their properties (nanometric size, biodegradability, biocompatibility, and lack of immunogenicity), vaults show enormous potential as a bio-inspired, self-assembled drug-delivery system (DDS). [...]
2022 -  10.3390/ijms232415543
International journal of molecular sciences, Vol. 23, Issue 24 (December 2022) , art. 15543
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17 p, 2.2 MB |
All-in-one biofabrication and loading of recombinant vaults in human cells
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Martín, Fernando (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Carreño, Aida (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mendoza, Rosa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Caruana, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Rodríguez, Francisco (Institut d'Investigació Biomèdica Sant Pau) ;
Bravo, Marlon (Institut d'Investigació Biomèdica de Girona) ;
Benito, Antoni (Institut d'Investigació Biomèdica de Girona) ;
Ferrer-Miralles, Neus (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Corchero Nieto, José Luis (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
One of the most promising approaches in the drug delivery field is the use of naturally occurring self-assembling protein nanoparticles, such as virus-like particles, bacterial microcompartments or vault ribonucleoprotein particles as drug delivery systems (DDSs). [...]
2022 - 10.1088/1758-5090/ac584d
Biofabrication, Vol. 14, Issue 2 (April 2022) , art. 025018
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4.
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20 p, 6.0 MB |
Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug
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Pérez-Hernández, Marta (Institut d'Investigació Biomèdica de Bellvitge) ;
Cuscó, Cristina (Nanobiotechnological Polymers Division) ;
Benítez-García, Cristina (Institut d'Investigació Biomèdica de Bellvitge) ;
Bonelli, Joaquin (Nanobiotechnological Polymers DivisionBusiness Park) ;
Nuevo-Fonoll, Marina (Universitat de Barcelona. Departament de Patologia i Terapèutica Experimental) ;
Soriano, Aroa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martínez-García, David (Institut d'Investigació Biomèdica de Bellvitge) ;
Arias-Betancur, Alain (Universidad de La Frontera) ;
García-Valverde, María (Universidad de Burgos) ;
Segura, Miguel F. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Quesada, Roberto (Universidad de Burgos) ;
Rocas, Josep (Nanobiotechnological Polymers Division) ;
Soto-Cerrato, Vanessa (Institut d'Investigació Biomèdica de Bellvitge) ;
Pérez-Tomás, Ricardo (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
Cancer is one of the leading causes of mortality worldwide due, in part, to limited success of some current therapeutic approaches. The clinical potential of many promising drugs is restricted by their systemic toxicity and lack of selectivity towards cancer cells, leading to insufficient drug concentration at the tumor site. [...]
2021 - 10.3390/biomedicines9050508
Biomedicines, Vol. 9 (may 2021)
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20 p, 1.8 MB |
Extracellular Vesicles as Drug Delivery Systems in Cancer
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Hernandez-Oller, Laia (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Seras-Franzoso, Joaquin (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Andrade, Fernanda (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Rafael, Diana (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Abasolo, Ibane (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Gener, Petra (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Schwartz, Simon (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Universitat Autònoma de Barcelona
Within tumors, Cancer Stem Cell (CSC) subpopulation has an important role in maintaining growth and dissemination while preserving high resistance against current treatments. It has been shown that, when CSCs are eliminated, the surrounding Differentiated Cancer Cells (DCCs) may reverse their phenotype and gain CSC-like features to preserve tumor progression and ensure tumor survival. [...]
2020 - 10.3390/pharmaceutics12121146
Pharmaceutics, Vol. 12 (november 2020)
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7.
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32 p, 1.2 MB |
Release of targeted protein nanoparticles from functional bacterial amyloids : A death star-like approach
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Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Céspedes, María Virtudes (Institut d'Investigació Biomèdica Sant Pau) ;
Sala, Rita (Institut d'Investigació Biomèdica Sant Pau) ;
Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez Chardi, Alejandro (Universitat Autònoma de Barcelona. Servei de Microscòpia) ;
Pesarrodona Roches, Mireia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez-García, Laura (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Cano-Garrido, Olivia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Seras-Franzoso, Joaquin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Sustained release of drug delivery systems (DDS) has the capacity to increase cancer treatment efficiency in terms of drug dosage reduction and subsequent decrease of deleterious side effects. In this regard, many biomaterials are being investigated but none offers morphometric and functional plasticity and versatility comparable to protein-based nanoparticles (pNPs). [...]
2018 - 10.1016/j.jconrel.2018.04.004
Journal of Controlled Release, Vol. 279 (June 2018) , p. 29-39
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8.
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30 p, 1.5 MB |
Nanostructure empowers active tumor targeting in ligand-based molecular delivery
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López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sala, Rita (Institut d'Investigació Biomèdica Sant Pau) ;
Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Álamo, Patricia (Institut d'Investigació Biomèdica Sant Pau) ;
Unzueta Elorza, Ugutz (Institut d'Investigació Biomèdica Sant Pau) ;
Sánchez Chardi, Alejandro (Universitat de Barcelona. Departament de Biologia Evolutiva, Ecologia i Ciències Ambientals) ;
Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Sánchez García, Laura 1992- (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Mangues, Ramon 1957- (Institut d'Investigació Biomèdica Sant Pau) ;
Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Genètica i de Microbiologia
Cell-selective targeting is expected to enhance effectiveness and minimize side effects of cytotoxic agents. Functionalization of drugs or drug nanoconjugates with specific cell ligands allows receptor-mediated selective cell delivery. [...]
2019 - 10.1002/ppsc.201900304
Particle & particle systems characterization, Vol. 36, Issue 11 (November 2019) , art. 1900304
5 documentos
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14 p, 1.2 MB |
Advances in Parkinson's Disease : 200 Years Later
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Del Rey, Natalia López-González (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Quiroga-Varela, Ana (Department of Neuroscience, Centro de Investigación Médica Aplicada (CIMA), University of Navarra) ;
Garbayo, Elisa (Instituto de Investigación Sanitaria de Navarra) ;
Carballo-Carbajal, Iria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández-Santiago, Rubén (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Monje, Mariana H. G. (Universidad Autónoma de Madrid. Departamento de Anatomía, Histología y Neurociencia) ;
Trigo-Damas, Inés (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Blanco-Prieto, María J. (Instituto de Investigación Sanitaria de Navarra) ;
Blesa, Javier (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Universitat Autònoma de Barcelona
When James Parkinson described the classical symptoms of the disease he could hardly foresee the evolution of our understanding over the next two hundred years. Nowadays, Parkinson's disease is considered a complex multifactorial disease in which genetic factors, either causative or susceptibility variants, unknown environmental cues, and the potential interaction of both could ultimately trigger the pathology. [...]
2018 - 10.3389/fnana.2018.00113
Frontiers in Neuroanatomy, Vol. 12 (december 2018)
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69 p, 6.0 MB |
Diverse applications of nanomedicine
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Pelaz, Beatriz (Philipps Universitaẗ Marburg) ;
Alexiou, Christoph (University Hospital Erlangen (Alemanya)) ;
Álvarez Puebla, Ramon A. (Institució Catalana de Recerca i Estudis Avançats) ;
Alves, Frauke (Max-Planck-Institute for Experimental Medicine) ;
Andrews, Anne M. (University of California. Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior) ;
Ashraf, Sumaira (Philipps Universitaẗ Marburg) ;
Balogh, Lajos P. (AA Nanomedicine & Nanotechnology Consultants) ;
Ballerini, Laura (International School for Advanced Studies) ;
Bestetti, Alessandra (University of Melbourne) ;
Brendel, Cornelia (Philipps Universitaẗ Marburg) ;
Bosi, Susanna (University of Trieste. Department of Chemical and Pharmaceutical Sciences) ;
Carril, Monica (Ikerbasque) ;
Chan, Warren C. W. (University of Toronto) ;
Chen, Chunying (National Center for Nanoscience and Technology of China) ;
Chen, Xiaodong (National Institute of Biomedical Imaging and Bioengineering) ;
Chen, Xiaoyuan (National Institute of Biomedical Imaging and Bioengineering) ;
Cheng, Zhen (Stanford University) ;
Cui, Daxiang (Shanghai Jiao Tong University) ;
Du, Jianzhong (Tongji University) ;
Dullin, Christian (University Medical Center Göttingen. Department of Diagnostic and Interventional Radiology) ;
Escudero, Alberto (Instituto de Ciencia de Materiales de Sevilla) ;
Feliu, Neus (Karolinska Institutet (Estocolm, Suècia)) ;
Gao, Mingyuan (Chinese Academy of Sciences) ;
George, Michael (Nanion) ;
Gogotsi, Yury (Drexel University) ;
Grünweller, Arnold (Philipps Universitaẗ Marburg) ;
Gu, Zhongwei (Sichuan University) ;
Halas, Naomi J. (Rice University. Departments of Physics and Astronomy) ;
Hampp, Norbert (Philipps Universitaẗ Marburg. Department of Chemistry) ;
Hartmann, Roland K. (Philipps Universitaẗ Marburg) ;
Hersam, Mark C. (Northwestern University. Departments of Materials Science and Engineering) ;
Hunziker, Patrick (European Foundation for Clinical Nanomedicine) ;
Jian, Ji (Zhejiang University. Department of Polymer Science and Engineering) ;
Jiang, Xingyu (National Center for Nanoscience and Technology of China) ;
Jungebluth, Philipp (Universitaẗsklinikum Heidelberg) ;
Kadhiresan, Pranav (University of Toronto) ;
Kataoka, Kazunori (The University of Tokyo) ;
Khademhosseini, Ali (Harvard University) ;
Kopeček, Jindrich (University of Utah) ;
Kotov, Nicholas A. (University of Michigan) ;
Krug, Harald F. (Federal Institute for Materials Science and Technology) ;
Lee, Dong Soo (Seoul National University. Department of Molecular Medicine and Biopharmaceutical Sciences) ;
Lehr, Claus-Michael (Helmholtz-Center for Infection Research) ;
Leong, Kam W. (Columbia University. Department of Biomedical Engineering) ;
Liang, Xing-Jie (Chinese Academy of Sciences) ;
Lim, Mei Ling (Karolinska Institutet (Estocolm, Suècia)) ;
Liz-Marzán, Luis M. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Ma, Xiaowei (Chinese Academy of Sciences) ;
Macchiarini, Paolo (Kazan Federal University) ;
Meng, Huan (University of California) ;
Möhwald, Helmuth (Max-Planck Institute of Colloids and Interfaces) ;
Mulvaney, Paul (University of Melbourne) ;
Nel, Andre E. (University of California) ;
Nie, Shuming (Emory University) ;
Nordlander, Peter (Rice University. Departments of Physics and Astronomy) ;
Okano, Teruo (Tokyo Women's Medical University) ;
Oliveira, Jose (SMALL. Wiley-VCH) ;
Park, Tai Hyun (Advanced Institutes of Convergence Technology) ;
Penner, Reginald M. (University of California. Department of Chemistry) ;
Prato, Maurizio (Ikerbasque) ;
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ;
Rotello, Vincent M. (University of Massachusetts. Department of Chemistry) ;
Samarakoon, Amila (University of Toronto) ;
Schaak, Raymond E. (The Pennsylvania State University. Department of Chemistry) ;
Shen, Youqing (Zhejiang University) ;
Sjöqvist, Sebastian (Karolinska Institutet (Estocolm, Suècia)) ;
Skirtach, Andre G. (University of Ghent. Department of Molecular Biotechnology) ;
Soliman, Mahmoud G. (Philipps Universitaẗ Marburg) ;
Stevens, Molly M. (Imperial College London) ;
Sung, Hsing-Wen (National Tsing Hua University. Department of Chemical Engineering and Institute of Biomedical Engineering) ;
Tang, Ben Zhong (Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction) ;
Tietze, Rainer (University Hospital Erlangen (Alemanya)) ;
Udugama, Buddhisha N. (University of Toronto) ;
Scott VanEpps, J. (University of Michigan) ;
Weil, Tanja (Max-Planck-Institute for Polymer Research) ;
Weiss, Paul S. (University of California. Department of Materials Science and Engineering) ;
Willner, Itamar (The Hebrew University of Jerusalem) ;
Wu, Yuzhou (Huazhong University of Science and Technology) ;
Yang, Lily (SMALL. Wiley-VCH) ;
Yue, Zhao (Philipps Universitaẗ Marburg) ;
Zhang, Qian (Peking University) ;
Zhang, Xian-En (Chinese Academy of Sciences) ;
Zhao, Yuliang (National Center for Nanoscience and Technology of China) ;
Zhou, Xin (Chinese Academy of Sciences) ;
Parak, Wolfgang J. (CIC biomaGUNE)
The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. [...]
2017 - 10.1021/acsnano.6b06040
ACS nano, Vol. 11, Issue 3 (March 2017) , p. 2313-2381
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