Results overview: Found 8 records in 0.03 seconds.
Articles, 6 records found
Research literature, 2 records found
Articles 6 records found  
1.
34 p, 1.3 MB Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells / Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Amor Minguez, Adrián (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Metwally, Kamel (Zagazig University. Department of Medicinal Chemistry) ; Avilés, Francesc X (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. [...]
2019 - 10.1016/j.cbi.2019.04.004
Chemico-Biological Interactions, Vol. 306 (2019) , p. 123-130  
2.
25 p, 4.4 MB Current trends in spr biosensing of sars-cov-2 entry inhibitors / Mauriz, Elba (Universidad de León) ; Lechuga, Laura M (Institut Català de Nanociència i Nanotecnologia)
The emerging risk of viral diseases has triggered the search for preventive and therapeutic agents. Since the beginning of the COVID-19 pandemic, greater efforts have been devoted to investigating virus entry mechanisms into host cells. [...]
2021 - 10.3390/chemosensors9120330
Chemosensors, Vol. 9, issue 12 (Dec. 2021) , art. 330  
3.
9 p, 1.5 MB High content drug screening for Fanconi anemia therapeutics / Montanuy, Helena (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Camps-Fajol, Cristina (Institut d'Investigació Biomèdica Sant Pau) ; Carreras-Puigvert, Jordi (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Häggblad, Maria (Karolinska Institutet (Estocolm, Suècia)) ; Lundgren, Bo (Stockholm University) ; Aza-Carmona, Miriam (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Helleday, Thomas (Karolinska Institutet (Estocolm, Suècia). Department of Molecular Biochemistry and Biophysics) ; Minguillón Pedreño, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Surrallés i Calonge, Jordi (Institut d'Investigació Biomèdica Sant Pau) ; Universitat Autònoma de Barcelona
Fanconi anemia is a rare disease clinically characterized by malformations, bone marrow failure and an increased risk of solid tumors and hematologic malignancies. The only therapies available are hematopoietic stem cell transplantation for bone marrow failure or leukemia, and surgical resection for solid tumors. [...]
2020 - 10.1186/s13023-020-01437-1
Orphanet Journal of Rare Diseases, Vol. 15 (june 2020)  
4.
69 p, 6.0 MB Diverse applications of nanomedicine / Pelaz, Beatriz (Philipps Universitaẗ Marburg) ; Alexiou, Christoph (University Hospital Erlangen (Alemanya)) ; Álvarez Puebla, Ramon A. (Institució Catalana de Recerca i Estudis Avançats) ; Alves, Frauke (Max-Planck-Institute for Experimental Medicine) ; Andrews, Anne M. (University of California. Department of Psychiatry and Semel Institute for Neuroscience and Human Behavior) ; Ashraf, Sumaira (Philipps Universitaẗ Marburg) ; Balogh, Lajos P. (AA Nanomedicine & Nanotechnology Consultants) ; Ballerini, Laura (International School for Advanced Studies) ; Bestetti, Alessandra (University of Melbourne) ; Brendel, Cornelia (Philipps Universitaẗ Marburg) ; Bosi, Susanna (University of Trieste. Department of Chemical and Pharmaceutical Sciences) ; Carril, Monica (Ikerbasque) ; Chan, Warren C. W. (University of Toronto) ; Chen, Chunying (National Center for Nanoscience and Technology of China) ; Chen, Xiaodong (National Institute of Biomedical Imaging and Bioengineering) ; Chen, Xiaoyuan (National Institute of Biomedical Imaging and Bioengineering) ; Cheng, Zhen (Stanford University) ; Cui, Daxiang (Shanghai Jiao Tong University) ; Du, Jianzhong (Tongji University) ; Dullin, Christian (University Medical Center Göttingen. Department of Diagnostic and Interventional Radiology) ; Escudero, Alberto (Instituto de Ciencia de Materiales de Sevilla) ; Feliu, Neus (Karolinska Institutet (Estocolm, Suècia)) ; Gao, Mingyuan (Chinese Academy of Sciences) ; George, Michael (Nanion) ; Gogotsi, Yury (Drexel University) ; Grünweller, Arnold (Philipps Universitaẗ Marburg) ; Gu, Zhongwei (Sichuan University) ; Halas, Naomi J. (Rice University. Departments of Physics and Astronomy) ; Hampp, Norbert (Philipps Universitaẗ Marburg. Department of Chemistry) ; Hartmann, Roland K. (Philipps Universitaẗ Marburg) ; Hersam, Mark C. (Northwestern University. Departments of Materials Science and Engineering) ; Hunziker, Patrick (European Foundation for Clinical Nanomedicine) ; Jian, Ji (Zhejiang University. Department of Polymer Science and Engineering) ; Jiang, Xingyu (National Center for Nanoscience and Technology of China) ; Jungebluth, Philipp (Universitaẗsklinikum Heidelberg) ; Kadhiresan, Pranav (University of Toronto) ; Kataoka, Kazunori (The University of Tokyo) ; Khademhosseini, Ali (Harvard University) ; Kopeček, Jindrich (University of Utah) ; Kotov, Nicholas A. (University of Michigan) ; Krug, Harald F. (Federal Institute for Materials Science and Technology) ; Lee, Dong Soo (Seoul National University. Department of Molecular Medicine and Biopharmaceutical Sciences) ; Lehr, Claus-Michael (Helmholtz-Center for Infection Research) ; Leong, Kam W. (Columbia University. Department of Biomedical Engineering) ; Liang, Xing-Jie (Chinese Academy of Sciences) ; Lim, Mei Ling (Karolinska Institutet (Estocolm, Suècia)) ; Liz-Marzán, Luis M. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ; Ma, Xiaowei (Chinese Academy of Sciences) ; Macchiarini, Paolo (Kazan Federal University) ; Meng, Huan (University of California) ; Möhwald, Helmuth (Max-Planck Institute of Colloids and Interfaces) ; Mulvaney, Paul (University of Melbourne) ; Nel, Andre E. (University of California) ; Nie, Shuming (Emory University) ; Nordlander, Peter (Rice University. Departments of Physics and Astronomy) ; Okano, Teruo (Tokyo Women's Medical University) ; Oliveira, Jose (SMALL. Wiley-VCH) ; Park, Tai Hyun (Advanced Institutes of Convergence Technology) ; Penner, Reginald M. (University of California. Department of Chemistry) ; Prato, Maurizio (Ikerbasque) ; Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia) ; Rotello, Vincent M. (University of Massachusetts. Department of Chemistry) ; Samarakoon, Amila (University of Toronto) ; Schaak, Raymond E. (The Pennsylvania State University. Department of Chemistry) ; Shen, Youqing (Zhejiang University) ; Sjöqvist, Sebastian (Karolinska Institutet (Estocolm, Suècia)) ; Skirtach, Andre G. (University of Ghent. Department of Molecular Biotechnology) ; Soliman, Mahmoud G. (Philipps Universitaẗ Marburg) ; Stevens, Molly M. (Imperial College London) ; Sung, Hsing-Wen (National Tsing Hua University. Department of Chemical Engineering and Institute of Biomedical Engineering) ; Tang, Ben Zhong (Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction) ; Tietze, Rainer (University Hospital Erlangen (Alemanya)) ; Udugama, Buddhisha N. (University of Toronto) ; Scott VanEpps, J. (University of Michigan) ; Weil, Tanja (Max-Planck-Institute for Polymer Research) ; Weiss, Paul S. (University of California. Department of Materials Science and Engineering) ; Willner, Itamar (The Hebrew University of Jerusalem) ; Wu, Yuzhou (Huazhong University of Science and Technology) ; Yang, Lily (SMALL. Wiley-VCH) ; Yue, Zhao (Philipps Universitaẗ Marburg) ; Zhang, Qian (Peking University) ; Zhang, Xian-En (Chinese Academy of Sciences) ; Zhao, Yuliang (National Center for Nanoscience and Technology of China) ; Zhou, Xin (Chinese Academy of Sciences) ; Parak, Wolfgang J. (CIC biomaGUNE)
The design and use of materials in the nanoscale size range for addressing medical and health-related issues continues to receive increasing interest. Research in nanomedicine spans a multitude of areas, including drug delivery, vaccine development, antibacterial, diagnosis and imaging tools, wearable devices, implants, high-throughput screening platforms, etc. [...]
2017 - 10.1021/acsnano.6b06040
ACS nano, Vol. 11, Issue 3 (March 2017) , p. 2313-2381  
5.
27 p, 1.1 MB Rapid on-chip apoptosis assay on human carcinoma cells based on annexin-V/quantum dot probes / Montón i Domingo, Helena (Institut Català de Nanociència i Nanotecnologia) ; Medina-Sánchez, Mariana (Institut Català de Nanociència i Nanotecnologia) ; Soler, Joan Antoni (Institut Català de Nanociència i Nanotecnologia) ; Chałupniak, Andrzej (Institut Català de Nanociència i Nanotecnologia) ; Nogués, C. (Carme) (Carme) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)
Despite all the efforts made over years to study the cancer expression and the metastasis event, there is not a clear understanding of its origins and effective treatment. Therefore, more specialized and rapid techniques are required for studying cell behaviour under different drug-based treatments. [...]
2017 - 10.1016/j.bios.2017.03.034
Biosensors & bioelectronics, Vol. 94 (August 2017) , p. 408-414  
6.
17 p, 5.8 MB Novel Neuroprotective Multicomponent Therapy for Amyotrophic Lateral Sclerosis Designed by Networked Systems / Herrando-Grabulosa, Mireia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Mulet, Roger (Anaxomics Biotech) ; Pujol, Albert (Institut de Recerca Biomèdica de Lleida) ; Mas, José Manuel (Anaxomics Biotech) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Aloy, Patrick (Institut de Recerca Biomèdica de Lleida) ; Coma, Mireia (Anaxomics Biotech) ; Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
Amyotrophic Lateral Sclerosis is a fatal, progressive neurodegenerative disease characterized by loss of motor neuron function for which there is no effective treatment. One of the main difficulties in developing new therapies lies on the multiple events that contribute to motor neuron death in amyotrophic lateral sclerosis. [...]
2016 - 10.1371/journal.pone.0147626
PloS one, Vol. 11, Num. 1 (January 2016) , p. 1-17  

Research literature 2 records found  
1.
15 p, 1.1 MB Xarxes neuronals basades en grafs per a processos de screening molecular / Oms Font, Guiu ; Lladós, Josep, dir. (Universitat Autònoma de Barcelona. Departament de Ciències de la Computació) ; Universitat Autònoma de Barcelona. Escola d'Enginyeria
El treball es planteja en el context de cerca de molècules candidates mitjançant metodologies de deep learning, per tal de trobar-ne alguna amb certa acció biològica requerida. Per això, s'han explorat xarxes neuronals basades en grafs (GNN) que prediguin les energies lliures d'interacció entre una molècula i una proteïna en impactar sobre la base de l'estructura química d'ambdues. [...]
This work has been developed in the context of the research of candidate molecules using deep learning methodologies, in order to find some with some biologically required action. Therefore, Graph-based Neural Networks (GNN) have been explored in order to predict the free energies of an interaction between a molecule and a protein when they impact on the basis of the chemical structure of both. [...]
El trabajo se plantea en el contexto de búsqueda de moléculas candidatas mediante metodologías de deep learning, para encontrar alguna con cierta acción biológica requerida. Por eso, se han explorado redes neuronales basadas en grafos (GNN) que predigan las energías libres de interacción entre una molécula y una proteína al impactar sobre la base de la estructura química de ambas. [...]

2022
Enginyeria Informàtica [958]  
2.
153 p, 2.7 MB A virtual screening procedure combining pharmacophore filtering and molecular docking with the LIE method / Tunca, Guzin ; Daura i Ribera, Xavier, dir. ; Universitat Autònoma de Barcelona. Departament de Medicina
Actualment, el cribratge virtual juga un paper central en el món del descobriment de fàrmacs. L'anàlisi in silico permet el cribatge de milions de molècules petites i la tria de les més prometedores per a les proves experimentals. [...]
Virtual screening plays a central role in the world of drug discovery today. In silico testing allows to screen millions of small molecules and to choose only the most promising ones for experimental testing. [...]

[Barcelona] : Universitat Autònoma de Barcelona, 2014  

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