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1.
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34 p, 1.3 MB |
Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells
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Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Amor Minguez, Adrián (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Metwally, Kamel (Zagazig University. Department of Medicinal Chemistry) ;
Avilés, Francesc X (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. [...]
2019 -  10.1016/j.cbi.2019.04.004
Chemico-Biological Interactions, Vol. 306 (2019) , p. 123-130
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2.
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37 p, 16.6 MB |
Marine Invertebrates : A Promissory Still Unexplored Source of Inhibitors of Biomedically Relevant Metallo Aminopeptidases Belonging to the M1 and M17 Families
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Pascual Alonso, Isel (University of Havana. Center for Protein Studies) ;
Almeida García, Fabiola (University of Havana. Center for Protein Studies) ;
Valdés Tresanco, Mario Ernesto (University of Calgary. Department of Biological Sciences) ;
Arrebola Sánchez, Yarini (University of Havana. Center for Protein Studies) ;
Ojeda del Sol, Daniel (University of Havana. Center for Protein Studies) ;
Sánchez Ramírez, Belinda (Centro de Inmunología Molecular) ;
Florent, Isabelle (Muséum National d'Histoire Naturelle) ;
Schmitt, Marjorie (Université de Strasbourg) ;
Avilés, Francesc X. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Proteolytic enzymes, also known as peptidases, are critical in all living organisms. Peptidases control the cleavage, activation, turnover, and synthesis of proteins and regulate many biochemical and physiological processes. [...]
2023 - 10.3390/md21050279
Marine drugs, Vol. 21, Issue 5 (April 2023) , art. 279
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3.
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15 p, 2.7 MB |
Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease
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García Gómez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
de la Calle-Fabregat, Carlos (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Català-Moll, Francesc (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Godoy-Tena, Gerard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martín Sánchez, Montserrat (Universidad de Salamanca) ;
San Segundo, Laura (Universidad de Salamanca) ;
Muntión, Sandra (Universidad de Salamanca) ;
Morales, Xabier (Universidad de Navarra) ;
Ortiz de Solórzano, Carlos (Universidad de Navarra) ;
Oyarzabal, Julen (Universidad de Navarra) ;
San José Enériz, Edurne (Universidad de Navarra) ;
Esteller, M (Universitat de Barcelona. Departament de Ciències Fisiològiques) ;
Agirre, Xabier (Universidad de Navarra) ;
Prosper, Felipe (Universidad de Navarra) ;
Garayoa, Mercedes (Universidad de Salamanca) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Multiple myeloma (MM) progression and myeloma-associated bone disease (MBD) are highly dependent on bone marrow mesenchymal stromal cells (MSCs). MM-MSCs exhibit abnormal transcriptomes, suggesting the involvement of epigenetic mechanisms governing their tumor-promoting functions and prolonged osteoblast suppression. [...]
2021 - 10.1038/s41467-020-20715-x
Nature communications, Vol. 12 Núm. 1 (december 2021) , p. 421
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4.
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14 p, 2.4 MB |
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects
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Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ;
Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia)) ;
Rajagopal, Varshni (Karolinska Institutet (Estocolm, Suècia)) ;
Zhenjun, Zhao (Karolinska Institutet (Estocolm, Suècia)) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Müller, Sarah (Karolinska Institutet (Estocolm, Suècia)) ;
Hanna, Bishoy M. F. (Karolinska Institutet (Estocolm, Suècia)) ;
Loseva, Olga (Karolinska Institutet (Estocolm, Suècia)) ;
Wallner, Olov (Karolinska Institutet (Estocolm, Suècia)) ;
Michel, Maurice (Karolinska Institutet (Estocolm, Suècia)) ;
Rodriguez-Perales, Sandra (Grupo de Citogenética Molecular. Programa de Genética del Cáncer Humano. Centro Nacional de Investigaciones Oncológicas de España (Madrid)) ;
Gad, Helge (The University of Sheffield) ;
Visnes, Torkild (SINTEF Industry (Noruega)) ;
Helleday, Thomas (The University of Sheffield) ;
Benitez, Javier (Centro Nacional de Investigaciones Oncológicas) ;
Osorio, Ana (Centro Nacional de Investigaciones Oncológicas) ;
Universitat Autònoma de Barcelona
The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive to oxidative stress (OS) which disrupts telomere homeostasis triggering genome instability. [...]
2021 - 10.1038/s41598-021-82917-7
Scientific reports, Vol. 11 Núm. 1 (december 2021) , p. 3490
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5.
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18 p, 4.0 MB |
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress
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Visnes, T. (Sintef Industry. Department of Biotechnology and Nanomedicine) ;
Benítez-Buelga, Carlos (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Cázares-Körner, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Sanjiv, K. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Hanna, Bishoy (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Mortusewicz, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Rajagopal, Veera M (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Albers, J. J. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Hagey, D. W. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ;
Bekkhus, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Eshtad, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Baquero, Juan Miguel (Centro Nacional de Investigaciones Oncológicas) ;
Masuyer, G. (University of Bath. Department of Pharmacy and Pharmacology) ;
Wallner, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Müller, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Pham, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Göktürk, C. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Rasti, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Suman, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Torres, Raul (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sarno, A. (Sintef Ocean. Department of Environment and New Resources) ;
Wiita, E. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Homan, E. J. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Karsten, S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Marimuthu, K. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Michel, M. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Koolmeister, T. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Scobie, M. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Loseva, O. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Almlöf, I. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Unterlass, J. E. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Pettke, A. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Boström, J. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ;
Pandey, M. (University of Sheffield. Weston Park Cancer Centre) ;
Gad, H. (University of Sheffield. Weston Park Cancer Centre) ;
Herr, P. (University of Sheffield. Weston Park Cancer Centre) ;
Jemth, A. S. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
El Andaloussi, S. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ;
Kalderén, C. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Rodriguez-Perales, Sandra (Centro Nacional de Investigaciones Oncológicas) ;
Benítez, J. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Krokan, H. E. (Research and Innovation in Central Norway) ;
Altun, M. (Karolinska Institutet (Estocolm, Suècia). Department of Laboratory Medicine) ;
Stenmark, P. (Lund University. Department of Experimental Medical Science.) ;
Berglund, U. W. (Karolinska Institutet (Estocolm, Suècia). Department of Oncology and Pathology) ;
Helleday, Thomas (University of Sheffield.Weston Park Cancer Centre) ;
Universitat Autònoma de Barcelona
Altered oncogene expression in cancer cells causes loss of redox homeostasis resulting in oxidative DNA damage, e. g. 8-oxoguanine (8-oxoG), repaired by base excision repair (BER). PARP1 coordinates BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG. [...]
2021 - 10.1093/nar/gkaa1048
Nucleic acids research, Vol. 48 Núm. 21 (february 2021) , p. 12234-12251
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6.
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8 p, 401.5 KB |
Impact of Medication Adherence on Mortality and Cardiovascular Morbidity : Protocol for a Population-Based Cohort Study
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Giner-Soriano, Maria (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Sotorra Figuerola, Gerard (Universitat Autònoma de Barcelona) ;
Cortés, Jordi (Universitat Autònoma de Barcelona) ;
Pera Pujadas, Helena (Institut Universitari d'Investigació en Atenció Primària Jordi Gol) ;
Garcia-Sangenis, Ana (Universitat Autònoma de Barcelona) ;
Morros, Rosa (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Cardiovascular disease (CVD) is a group of disorders of the heart and blood vessels, such as coronary heart disease (CHD), cerebrovascular disease, and peripheral artery disease. CVD is the leading threat to global health, whether measured by mortality, morbidity, or economic cost. [...]
2018 - 10.2196/resprot.8121
JMIR Research Protocols, Vol. 7, Issue 3 (March 2018) , art. e73
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7.
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19 p, 2.5 MB |
Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15 : a Novel Human Retinaldehyde Reductase
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Giménez Dejoz, Joan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Kolář, Michal H. (Academy of Sciences of the Czech Republic. Institute of Organic Chemistry and Biochemistry) ;
Ruiz, Francesc X. (Centre de Biologie Intégrative (Illkirch-Graffenstaden, França)) ;
Crespo, Isidro (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Cousido-Siah, Alexandra (Centre de Biologie Intégrative (Illkirch-Graffenstaden, França)) ;
Podjarny, Alberto (Centre de Biologie Intégrative (Illkirch-Graffenstaden, França)) ;
Barski, Oleg A. (University of Louisville. School of Medicine) ;
Fanfrlík, Jindřich (Academy of Sciences of the Czech Republic. Institute of Organic Chemistry and Biochemistry) ;
Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Porté Orduna, Sergio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Human aldo-keto reductase 1B15 (AKR1B15) is a newly discovered enzyme which shares 92% amino acid sequence identity with AKR1B10. While AKR1B10 is a well characterized enzyme with high retinaldehyde reductase activity, involved in the development of several cancer types, the enzymatic activity and physiological role of AKR1B15 are still poorly known. [...]
2015 - 10.1371/journal.pone.0134506
PloS one, Vol. 10 Núm. 7 (July 2015) , p. e0134506
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