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Resultados globales: 6 registros encontrados en 0.02 segundos.
Artículos, Encontrados 6 registros
Artículos Encontrados 6 registros  
1.
34 p, 1.3 MB Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents : Kinetic characterization and effect on human cancer cells / Jiménez, Rafael (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pequerul, Raquel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Amor Minguez, Adrián (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Metwally, Kamel (Zagazig University. Department of Medicinal Chemistry) ; Avilés, Francesc X (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Aldehyde dehydrogenases (ALDHs) are enzymes catalyzing the NAD(P)+-dependent oxidation of aldehydes to their corresponding carboxylic acids. High ALDH activity has been related to some important features of cancer stem cells. [...]
2019 - 10.1016/j.cbi.2019.04.004
Chemico-Biological Interactions, Vol. 306 (2019) , p. 123-130  
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2.
18 p, 2.9 MB Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection / Fuentes-Prior, Pablo (Institut d'Investigació Biomèdica Sant Pau)
The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and this death toll will be much higher before effective treatments and vaccines are available. The causative agent of the disease, the coronavirus SARS-CoV-2, shows important similarities with the previously emerged SARS-CoV-1, but also striking differences. [...]
2021 - 10.1074/jbc.REV120.015980
Journal of biological chemistry, Vol. 296 (january 2021) , p. 100135  
Registro completo - Creative Commons
3.
17 p, 4.4 MB Perspective on the structural basis for human aldo-keto reductase 1b10 inhibition / Ruiz, Francesc Xavier (Rutgers University. Department of Chemistry and Chemical Biology) ; Parés i Casasampera, Xavier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Farrés, Jaume (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Human aldo-keto reductase 1B10 (AKR1B10) is overexpressed in many cancer types and is involved in chemoresistance. This makes AKR1B10 to be an interesting drug target and thus many enzyme inhibitors have been investigated. [...]
2021 - 10.3390/metabo11120865
Metabolites, Vol. 11, Issue 12 (December 2021) , art. 865  
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4.
13 p, 2.3 MB A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25 / Liu, Bing (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sureda-Gómez, Marta (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Zhen, Yang (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Amador, Virginia (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
USP25 deubiquitinating enzyme is a key member of the ubiquitin system, which acts as a positive regulator of the Wnt/β-catenin signaling by promoting the deubiquitination and stabilization of tankyrases. [...]
2018 - 10.1038/s41467-018-07510-5
Nature communications, Vol. 9 (2018) , art. 4973  
Registro completo - Creative Commons
5.
12 p, 764.1 KB Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma penetrans / Gallego Alonso, Pablo (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Planell Cerezo, Raquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Benach, Jordi (ALBA Laboratori de Llum de Sincrotró) ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pérez-Pons, Josep A.. (Josep Antoni) (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Reverter i Cendrós, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The metabolism of arginine towards ATP synthesis has been considered a major source of energy for microorganisms such as Mycoplasma penetrans in anaerobic conditions. Additionally, this pathway has also been implicated in pathogenic and virulence mechanism of certain microorganisms, i. [...]
2012 - 10.1371/journal.pone.0047886
PloS one, Vol. 7 Issue 10 (October 2012) , p. e47886  
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6.
18 p, 4.1 MB Crystal Structure of Two Anti-Porphyrin Antibodies with Peroxidase Activity / Muñoz Robles, Victor (Universitat Autònoma de Barcelona. Departament de Química) ; Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química) ; Bahloul, Amel (Centre national de la recherche scientifique (França). Laboratoire d'Enzymologie et Biochimie structurales) ; Golinelli-Pimpaneau, Béatrice (Centre national de la recherche scientifique (França). Laboratoire d'Enzymologie et Biochimie structurales) ; Sari, Marie-Agnès (Centre national de la recherche scientifique (França). Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques) ; Mahy, Jean-Pierre (Centre national de la recherche scientifique (França). Institut de Chimie Moléculaire et des Matériaux d'Orsay)
We report the crystal structures at 2. 05 and 2. 45 Å resolution of two antibodies, 13G10 and 14H7, directed against an iron(III)-αααβ-carboxyphenylporphyrin, which display some peroxidase activity. [...]
2012 - 10.1371/journal.pone.0051128
PloS one, Vol. 7 Issue 12 (December 2012) , p. e51128  
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