1.
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25 p, 1.7 MB |
Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma
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O'Brien, Susan (University of California) ;
Hillmen, Peter (St. James University Hospital) ;
Coutre, Steven E (Stanford University School of Medicine) ;
Barr, Paul M (University of Rochester Cancer Center) ;
Fraser, Graeme (McMaster University (Canadà)) ;
Tedeschi, Alessandra (ASST Grande Ospedale Metropolitano Niguarda) ;
Burger, Jan A. (University of Texas MD Anderson Cancer Center) ;
Dilhuydy, Marie-Sarah (Centre Hospitalier Universitaire Hopitaux de Bordeaux) ;
Hess, Georg (Universitats Medizin Mainz) ;
Moreno Atanasio, Carol (Institut d'Investigació Biomèdica Sant Pau) ;
Cramer, Paula (University of Cologne) ;
Liu, Emily (Pharmacyclics LLC. an AbbVie Company) ;
Chang, Stephen (Pharmacyclics LLC. an AbbVie Company) ;
Vermeulen, Jessica (Janssen Research & Development) ;
Styles, Lori (Pharmacyclics LLC. an AbbVie Company) ;
Howes, Angela (Janssen Research & Development) ;
James, Danelle F. (Pharmacyclics LLC. an AbbVie Company) ;
Patel, Kalpesh (Janssen Pharmaceuticals. Inc) ;
Graef, Thorsten (Pharmacyclics LLC. an AbbVie Company) ;
Valentino, Rudolph (Pharmacyclics LLC. an AbbVie Company) ;
Universitat Autònoma de Barcelona
Ibrutinib, a Bruton's tyrosine kinase inhibitor, has become a standard treatment for patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The present pooled safety analysis of 4 randomized controlled studies demonstrated a favorable benefit/risk profile for ibrutinib in patients with CLL/SLL and mantle cell lymphoma. [...]
2018 - 10.1016/j.clml.2018.06.016
Clinical Lymphoma, Myeloma & Leukemia, Vol. 18 Núm. 10 (october 2018) , p. 648-657.e15
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2.
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3 p, 288.8 KB |
Vehicle Windshield Wiper Fluid as Potential Source of Sporadic Legionnaires' Disease in Commercial Truck Drivers
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Politi, Julieta (Parc de Salut MAR de Barcelona) ;
Queralt, Andreu (Agència de Salut Pública de Barcelona) ;
Valero, Natalia (Agència de Salut Pública de Barcelona) ;
Martín-Gómez, Maria T. (Hospital Universitari Vall d'Hebron) ;
Durán, Raquel González (Agència de Salut Pública de Barcelona) ;
Parra, Elena (Agència de Salut Pública de Barcelona) ;
Sabaté Camps, Sara (Institut d'Investigació Biomèdica Sant Pau) ;
Avellanés, Ingrid (Institut d'Investigació Biomèdica Sant Pau) ;
Hernández-Pineda, Anna (Institut d'Investigació Biomèdica Sant Pau) ;
Masdeu, Eva (Institut d'Investigació Biomèdica Sant Pau) ;
Rius i Gibert, Maria Cristina (Agència de Salut Pública de Barcelona) ;
Álamo-Junquera, Dolores (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
Sporadic Legionnaires' disease is frequently detected in commercial truck drivers. We report 2 sporadic cases of this disease in Barcelona, Spain, that occurred during December 2019 and September 2020. [...]
2022 - 10.3201/eid2804.210814
Emerging Infectious Diseases, Vol. 28 Núm. 4 (april 2022) , p. 841-843
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3.
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9 p, 1.9 MB |
Effect of Sirolimus Exposure on the Need for Preemptive Antiviral Therapy for Cytomeglovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation
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Guglieri-Lopez, Beatriz (Hospital Universitari Doctor Peset (València)) ;
Perez-Pitarch, Alejandro (Hospital Clínico Universitario de València) ;
Garcia Cadenas, Irene (Institut d'Investigació Biomèdica Sant Pau) ;
Gimenez, Estela (Hospital Clínico Universitario de València) ;
Barba, Pere (Hospital Universitari Vall d'Hebron) ;
Rabella, Núria (Institut d'Investigació Biomèdica Sant Pau) ;
Hernandez-Boluda, Juan Carlos (Hospital Clínico Universitario de València) ;
Fox, Maria Laura (Hospital Universitari Vall d'Hebron) ;
Valcárcel, David (Hospital Universitari Vall d'Hebron) ;
Esquirol, Albert (Institut d'Investigació Biomèdica Sant Pau) ;
Ferriols-Lisart, Rafael (Hospital Clínico Universitario de València) ;
Sierra, Jorge (Institut d'Investigació Biomèdica Sant Pau) ;
Solano, Carlos (Universitat de València) ;
Navarro, David (Universitat de València) ;
Martino Bofarull, Rodrigo (Institut d'Investigació Biomèdica Sant Pau) ;
Piñana, José Luis (Instituto de Salud Carlos III) ;
Universitat Autònoma de Barcelona
The current study evaluates the clinical effect of sirolimus exposure on the occurrence of cytomegalovirus (CMV)DNAemia necessitating preemptive antiviral therapy. A total of 167 consecutive recipients of reduced-intensity conditioning (RIC)allogeneic hematopoietic stem cell transplantation (allo-HSCT)who received sirolimus- and tacrolimus-based graft-versus-host disease (GVHD)prophylaxis and whose CMV serostatus was positive for donors and/or recipients were included in this multicenter retrospective study. [...]
2019 - 10.1016/j.bbmt.2019.01.012
Biology of blood and marrow transplantation, Vol. 25 Núm. 5 (may 2019) , p. 1022-1030
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4.
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3 p, 158.6 KB |
Tobacco heated products : a new challenge in tobacco control Los productos de tabaco calentado: nuevo reto en el control del tabaco
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Peruga, Armando (Universidad del Desarrollo (Santiago de Chile)) ;
Rodríguez Lozano, Francisco (European Network for Smoking and Tobacco Prevention (Bèlgica)) ;
López Medina, María José (Institut d'Investigació Biomèdica Sant Pau) ;
Córdoba García, Rodrigo (Universidad de Zaragoza. Facultad de Medicina) ;
Nerín, Isabel (Universidad de Zaragoza. Facultad de Medicina) ;
Sureda, Xisca (Institut d'Investigació Biomèdica de Bellvitge) ;
Fernández, Esteve (Institut d'Investigació Biomèdica de Bellvitge)
As cigarette sales decline, the tobacco industry has turned to the sale of heated tobacco products (HTP), which are on the rise. We are concerned with reports erroneously indicating that heated tobacco is associated with a lower risk of cancer and other diseases than conventional cigarettes, citing as a source the Food and Drug Administration (FDA) of the United States. [...]
2022 - 10.1016/j.gaceta.2020.12.033
Gaceta sanitaria, Vol. 36 Núm. 1 (enero 2022) , p. 57-59
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5.
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17 p, 834.1 KB |
Serum cotinine cut-points for secondhand smoke exposure assessment in children under 5 years : A systemic review
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Mourino, Nerea (Universidad de Santiago de Compostela. Departamento de Medicina Preventiva y Salud Pública) ;
Ruano-Raviña, Alberto (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Varela Lema, Leonor (Universidad de Santiago de Compostela. Departamento de Medicina Preventiva y Salud Pública) ;
Fernández, Esteve (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
López Medina, María José (Institut d'Investigació Biomèdica Sant Pau) ;
Santiago-Pérez, María Isolina (Dirección General de Salud Pública de Galicia. Unidad de Epidemiología) ;
Rey-Brandariz, Julia (Universidad de Santiago de Compostela. Departamento de Medicina Preventiva y Salud Pública) ;
Giraldo-Osorio, Alexandra (Fundación Carolina) ;
Pérez-Ríos, Mónica (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Background Serum cotinine has become the most widely used biomarker of secondhand smoke exposure (SHS) over time in all ages. The aim of this study was to review the serum cotinine cut-points used to classify children under 5 years as exposed to SHS. [...]
2022 - 10.1371/journal.pone.0267319
PloS one, Vol. 17 Núm. 5 May (may 2022) , p. e0267319
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6.
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13 p, 4.5 MB |
Bees exposed to climate change are more sensitive to pesticides
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Albacete, Sergio (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Sancho Blanco, Gonzalo (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Azpiazu, Celeste (Universitat Autònoma de Barcelona) ;
Rodrigo Domínguez, Anselm (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Molowny-Horas, Roberto (Centre de Recerca Ecològica i d'Aplicacions Forestals) ;
Sgolastra, Fabio (Alma Mater Studiorum Università di Bologna. Dipartimento di Scienze e Tecnologie Agro-Alimentari) ;
Bosch, Jordi 1961- (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Bee populations are exposed to multiple stressors, including land-use change, biological invasions, climate change, and pesticide exposure, that may interact synergistically. We analyze the combined effects of climate warming and sublethal insecticide exposure in the solitary bee Osmia cornuta. [...]
2023 - 10.1111/gcb.16928
Global change biology, Vol. 29, Issue 22 (November 2023) , p. 6157-6433
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7.
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8 p, 664.2 KB |
Exposure-response modeling of cabozantinib in patients with renal cell carcinoma : Implications for patient care
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Castellano, Daniel (Hospital Universitario 12 de Octubre (Madrid)) ;
Maroto Rey, Pablo (Institut d'Investigació Biomèdica Sant Pau) ;
Benzaghou, Fawzi (Ipsen Pharma) ;
Taguieva, Naila (Ipsen Pharma) ;
Nguyen, Linh (Exelixis. Inc.) ;
Clary, Douglas O. (Exelixis. Inc.) ;
Jonasch, Eric W. (The University of Texas MD Anderson Cancer Center) ;
Universitat Autònoma de Barcelona
Cabozantinib is an oral tyrosine kinase inhibitor (TKI) approved for the treatment of patients with advanced renal cell carcinoma (RCC) at a dose of 60 mg/day. As with other TKIs, cabozantinib is associated with high interpatient variability in drug clearance and exposure that can significantly impact safety and tolerability across a patient population. [...]
2020 - 10.1016/j.ctrv.2020.102062
Cancer Treatment Reviews, Vol. 89 (september 2020) , p. 102062
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8.
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10 p, 875.5 KB |
Occurrence and dietary intake of food processing contaminants (FPCs) in Catalonia, Spain
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González, Neus (Universitat Rovira i Virgili) ;
Marquès, Montse (Universitat Rovira i Virgili) ;
Calderón, Josep (Institut d'Investigació Biomèdica Sant Pau) ;
Collantes, Roger (Agència de Salut Pública de Barcelona) ;
Corraliza, Lidia (Agència de Salut Pública de Barcelona) ;
Timoner, Isabel (Agència Catalana de Seguretat Alimentària) ;
Bosch, Jaume (Agència Catalana de Seguretat Alimentària) ;
Castell, Victòria (Agència Catalana de Seguretat Alimentària) ;
Domingo, José L. (Universitat Rovira i Virgili) ;
Nadal, Martí (Universitat Rovira i Virgili)
Food processing contaminants (FPCs) form a wide group of chemicals that are generated during different cooking practices. This study was aimed at determining the levels of a number of FPCs (i. e. , acrylamide, furans, monochloropropanediols (MCPDs) and glycidyl esters (GEs)) in foodstuffs purchased in Catalonia (Spain), and assessing the human exposure for different population groups. [...]
2022 - 10.1016/j.jfca.2021.104272
Journal of Food Composition and Analysis, Vol. 106 (march 2022) , p. 104272
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9.
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26 p, 3.6 MB |
In vitro approaches to determine the potential carcinogenic risk of environmental pollutants
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Barguilla, Irene (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Maguer-Satta, Veronique (Centre de Recherche en Cancérologie de Lyon) ;
Guyot, Boris (Centre de Recherche en Cancérologie de Lyon) ;
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
One important environmental/health challenge is to determine, in a feasible way, the potential carcinogenic risk associated with environmental agents/exposures. Since a significant proportion of tumors have an environmental origin, detecting the potential carcinogenic risk of environmental agents is mandatory, as regulated by national and international agencies. [...]
2023 - 10.3390/ijms24097851
International journal of molecular sciences, Vol. 24, Issue 9 (April 2023) , art. 7851
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10.
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10 p, 586.7 KB |
US racial-ethnic mortality gap adjusted for population structure
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Pifarré i Arolas, Héctor (University of Wisconsin) ;
Acosta, Enrique (Max Planck Institute for Demographic Research) ;
Dudel, Christian (Max Planck Institute for Demographic Research) ;
Mhairi Hale, Jo (Max Planck Institute for Demographic Research) ;
Myrskylä, Mikko (Max Planck Institute for Demographic Research)
Standard measures, such as life expectancy or years of life lost, are based on synthetic populations and do not account for the real underlying populations experiencing the inequalities. Methods: We analyze US mortality disparities comparing Asian Americans, Blacks, Hispanics, and Native Americans/Alaska Natives to Whites using 2019 CDC and NCHS data, using a novel approach that estimates the mortality gap, adjusted for population structure by accounting for real-population exposures. [...]
2023 - 10.1097/EDE.0000000000001595
Epidemiology, Vol. 34 Núm. 3 (May 2023) , p. 402-410
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