1.
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16 p, 3.4 MB |
Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution
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Tomás-Daza, Laureano (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rovirosa, Llorenç (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
López-Martí, Paula (Barcelona Supercomputing Center) ;
Nieto-Aliseda, Andrea (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Serra, François (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Planas-Riverola, Ainhoa (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Molina, Oscar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
McDonald, Rebecca (Wellcome-MRC Cambridge Stem Cell Institute) ;
Ghevaert, Cedric (NHS Blood and Transplant) ;
Cuatrecasas, Esther (Hospital Sant Joan de Déu) ;
Costa, Dolors (Cancer Network Biomedical Research Center) ;
Camós, Mireia (Instituto Carlos III) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez, Pablo (Institució Catalana de Recerca i Estudis Avançats) ;
Valencia, Alonso (Institució Catalana de Recerca i Estudis Avançats) ;
Javierre, B. M (Institut Germans Trias i Pujol)
Long-range interactions between regulatory elements and promoters are key in gene transcriptional control; however, their study requires large amounts of starting material, which is not compatible with clinical scenarios nor the study of rare cell populations. [...]
2023 - 10.1038/s41467-023-35911-8
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 268
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2.
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9 p, 1.4 MB |
Predictive signature of response to neoadjuvant chemotherapy in muscle-invasive bladder cancer integrating mRNA expression, taxonomic subtypes, and clinicopathological features
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Font, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Domenech, Montserrat (Althaia Xarxa Assistencial Universitària de Manresa) ;
Ramirez, Jose Luis (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marqués, Miriam (Centro Nacional de Investigaciones Oncológicas) ;
Benítez, Raquel (Centro Nacional de Investigaciones Oncológicas) ;
Ruiz de Porras, Vicenç (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gago, José L. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carrato, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Sant, Francesc (Althaia Xarxa Assistencial Universitària de Manresa) ;
Lopez, Hector (Althaia Xarxa Assistencial Universitària de Manresa) ;
Castellano, Daniel (Hospital Universitario 12 de Octubre (Madrid)) ;
Malats, Nuria (Centro Nacional de Investigaciones Oncológicas) ;
Calle, M. Luz (Universitat de Vic - Universitat Central de Catalunya) ;
Real, Francisco X. (Universitat Pompeu Fabra)
Background and objective: Neoadjuvant chemotherapy (NAC) followed by cystectomy is the standard of care in muscle-invasive bladder cancer (MIBC). Pathological response has been associated with longer survival, but no currently available clinicopathological variables can identify patients likely to respond, highlighting the need for predictive biomarkers. [...]
2023 - 10.3389/fonc.2023.1155244
Frontiers in Oncology, Vol. 13 (august 2023)
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3.
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27 p, 8.1 MB |
Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
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Liang, Wen-Wei (Washington University in St. Louis) ;
Lu, Rita Jui-Hsien Lu (Washington University in St. Louis) ;
Jayasinghe, Reyka G. (Washington University in St. Louis) ;
Foltz, Steven M. (Washington University in St. Louis) ;
Porta-Pardo, Eduard (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Geffen, Yifat (Massachusetts General Hospital) ;
Wendl, Michael C. (Department of Mathematics. Washington University in St. Louis) ;
Lazcano, Rossana (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Kolodziejczak, Iga (Medical University of Warsaw) ;
Song, Yizhe (Washington University in St. Louis) ;
Govindan, Akshay (Washington University in St. Louis) ;
Demicco, Elisabeth G. (University of Toronto) ;
Li, Xiang (Washington University in St. Louis) ;
Li, Yize (Washington University in St. Louis) ;
Sethuraman, Sunantha (Washington University in St. Louis) ;
Payne, Samuel H. (Department of Biology. Brigham Young University) ;
Fenyö, David (Department of Biochemistry and Molecular Pharmacology. NYU Grossman School of Medicine) ;
Rodriguez, Henry (Office of Cancer Clinical Proteomics Research. National Cancer Institute) ;
Wiznerowicz, Maciej (Poznań University of Medical Sciences) ;
Shen, Hui (Van Andel Research Institute) ;
Mani, D.R. (Broad Institute of Massachusetts Institute of Technology and Harvard) ;
Rodland, Karin D. (Developmental. and Cancer Biology. Oregon Health & Science University) ;
Lazar, Alexander J. (Departments of Pathology & Genomic Medicine. The University of Texas MD Anderson Cancer Center) ;
Robles, Ana I. (Office of Cancer Clinical Proteomics Research) ;
Ding, L. (Washington University in St. Louis) ;
Universitat Autònoma de Barcelona
DNA methylation plays a critical role in establishing and maintaining cellular identity. However, it is frequently dysregulated during tumor development and is closely intertwined with other genetic alterations. [...]
2023 - 10.1016/j.ccell.2023.07.013
Cancer Cell, Vol. 41 Núm. 9 (november 2023) , p. 1567-1585.e7
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4.
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12 p, 2.5 MB |
Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice
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Galindo Campos, Miguel A. (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Lutfi, Nura (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Bonnin, Sarah (Centre de Regulació Genòmica) ;
Martínez, Carlos (Experimental Pathology Unit. Instituto Murciano de Investigación Biosanitaria-Laboratorio de Investigación Biosanitaria-Arrixaca) ;
Velasco-Hernández, Talia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
García-Hernández, Violeta (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Martín Caballero, Juan (Instituto Cajal. Consejo Superior de Investigaciones Científicas (CSIC)) ;
Ampurdanés, Coral (Cancer Research Program. Hospital del Mar Medical Research Institute (IMIM)) ;
Gimeno, Ramón (Laboratory of Immunology. Department of Pathology) ;
Colomo, Lluís (Hospital del Mar (Barcelona, Catalunya)) ;
Roué, Gaël (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guilbaud, Guillaume (Division of Protein and Nucleic Acid Chemistry. Medical Research Council Laboratory of Molecular Biology) ;
Dantzer, Françoise (Biotechnology and Cell Signaling. Unité Mixte de Recherche (UMR) 7242 Centre National de la Recherche Scientifique. Laboratory of Excellence Medalis. École Supérieure de Biotechnologie de Strasbourg. Strasbourg University) ;
Navarro, Pilar (Hospital del Mar Medical Research Institute. Unidad Asociada IIBB-CSIC) ;
Murga, Matilde (Genomic Instability Group. Spanish National Cancer Research Centre) ;
Fernández Capetillo, Oscar (Science for Life Laboratory. Department of Medical Biochemistry and Biophysics. Karolinska Institutet) ;
Bigas Salvans, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sale, Julian E. (Division of Protein and Nucleic Acid Chemistry. Medical Research Council Laboratory of Molecular Biology) ;
Yélamos, José (Laboratory of Immunology. Department of Pathology)
Dysregulation of the c-Myc oncogene occurs in a wide variety of hematologic malignancies, and its overexpression has been linked with aggressive tumor progression. Here, we show that poly (ADP-ribose) polymerase 1 (PARP-1) and PARP-2 exert opposing influences on progression of c-Myc-driven B-cell lymphoma. [...]
2022 - 10.1182/blood.2021012805
Blood, Vol. 139 Núm. 2 (13 2022) , p. 228-239
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5.
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8 p, 664.1 KB |
Cardiac activation-repolarization patterns and ion channel expression mapping in intact isolated normal human hearts
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Opthof, Tobias (University Medical Center Utrecht) ;
Remme, Carol Ann (Heart Center Amsterdam) ;
Jorge, Esther (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Noriega, Francisco (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Wiegerinck, Rob F. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Tasiam, Arlin (Heart Center Amsterdam) ;
Beekman, Leander (Heart Center Amsterdam) ;
Alvarez-Garcia, Jesus (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Munoz-Guijosa, Cristian (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Coronel, Ruben (Fondation Bordeaux Université) ;
Cinca, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Universitat Autònoma de Barcelona
The repolarization pattern of the human heart is unknown. The purpose of this study was to perform a multisite analysis of the activation-repolarization patterns and mRNA expression patterns of ion channel subunits in isolated human hearts. [...]
2017 - 10.1016/j.hrthm.2016.10.010
Heart Rhythm, Vol. 14 Núm. 2 (january 2017) , p. 265-272
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6.
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7.
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15 p, 1.2 MB |
Programmed death-ligand (PD-L1), epidermal growth factor (EGF), relaxin and metalloproteinase-3 (MMP3), potential biomarkers of malignancy in canine mammary neoplasia
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Galadima, Makchit ;
Teles, Mariana (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Pastor Milán, Josep (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Hernandez-Losa, Javier (Hospital Universitari Vall d'Hebron) ;
Rodríguez Gil, Joan Enric (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Rivera del Álamo, Maria Montserrat (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Gene expression has been suggested as a putative tool for prognosis and diagnosis in canine mammary neoplasia (CMNs). In the present study, 58 formalin-fixed paraffin-embedded (FFPE) paraffined canine mammary neoplasias from 27 different bitches were included. [...]
2024 - 10.3390/ijms25021170
International journal of molecular sciences, Vol. 25 (2024) , p. 1170
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8.
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10 p, 5.0 MB |
Titanium-doped PET nanoplastics, from opaque milk bottle degradation, as a model of environmental true-to-life nanoplastics. Hazardous effects on Drosophila
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Alaraby, Mohamed (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Villacorta, Aliro (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Abass, Doaa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Hernández, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Micro and nanoplastics (MNPLs) are emergent environmental pollutants, resulting from the degradation of plastic waste, requiring urgent information on their potential risks to human health. To determine such risks, reliable true-to-life materials are essential. [...]
2024 - 10.1016/j.envpol.2023.122968
Environmental Pollution, Vol. 341 (January 2024) , art. 122968
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9.
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33 p, 1.2 MB |
Metabotropic Glutamate Receptor 2 and Dopamine Receptor 2 Gene Expression Predict Sensorimotor Gating Response in the Genetically Heterogeneous NIH-HS Rat Strain
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Østerbøg, Tina Becher (Research Laboratory for Stereology and Neuroscience. Bispebjerg and Frederiksberg Hospitals. Copenhagen) ;
On, Doan Minh (Department of Physiology and Biophysics. Virginia Commonwealth University School of Medicine) ;
Oliveras, Ignasi (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Río-Álamos, Cristobal (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Sánchez González, Ana (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Tapias-Espinosa, Carles (Departamento de Psiquiatría y Medicina Legal.) ;
Tobeña, Adolf 1950- (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Gonzalez-Maeso, Javier (Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine) ;
Fernández-Teruel, Alberto (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Aznar, Susana (Bispebjerg and Frederiksberg Hospitals (Copenhagen, Dinamarca))
Disruption of sensorimotor gating causes "flooding" of irrelevant sensory input and is considered a congenital trait in several neurodevelopmental disorders. Prepulse inhibition of acoustic startle response (PPI) is the operational measurement and has a high translational validity. [...]
2020 - 10.1007/s12035-019-01829-w
Molecular neurobiology, Vol. 57 Núm. 3 (March 2020) , p. 1516-1528
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10.
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16 p, 2.1 MB |
A protein-coding gene expression atlas from the brain of pregnant and non-pregnant goats
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Luigi Sierra, Maria Gracia (Centre de Recerca en Agrigenòmica) ;
Guan, Dailu (Centre de Recerca en Agrigenòmica) ;
López Béjar, Manel (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Casas Díaz, Encarna (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Olvera-Maneu, Sergi (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Gardela Santacruz, Jaume (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals) ;
Palomo Peiró, María Jesús (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Osuagwuh, Uchebuchi Ike (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Ohaneje, Uchechi Linda (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ;
Mármol-Sánchez, Emilio (Centre de Recerca en Agrigenòmica) ;
Amills i Eras, Marcel (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Background: The brain is an extraordinarily complex organ with multiple anatomical structures involved in highly specialized functions related with behavior and physiological homeostasis. Our goal was to build an atlas of protein-coding gene expression in the goat brain by sequencing the transcriptomes of 12 brain regions in seven female Murciano-Granadina goats, from which three of them were 1-month pregnant. [...]
2023 - 10.3389/fgene.2023.1114749
Frontiers in genetics, Vol. 14 (july 2023)
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