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19 p, 8.1 MB |
Formation of an invasion-permissive matrix requires TGFβ/SNAIL1-regulated alternative splicing of fibronectin
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Franco Valls, Héctor (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Tusquets Uxó, Elsa (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Sala, Laura (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Val, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Peña, Raúl (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Iaconcig, Alessandra (International Centre for Genetic Engineering and Biotechnology (ICGEB)) ;
Villarino, Álvaro (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Jiménez Arriola, Martín (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Massó, Pere (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Trincado Alonso, Juan Luis, 1987- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Eyras, Eduardo (John Curtin School of Medical Research. Australian National University) ;
Muro, Andrés F. (International Centre for Genetic Engineering and Biotechnology (ICGEB)) ;
Otero, Jorge (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Garcia de Herreros, Antonio (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM)) ;
Baulida, Josep (Programa de Recerca en Càncer. Hospital del Mar Research Institute (IMIM))
Background: As in most solid cancers, the emergence of cells with oncogenic mutations in the mammary epithelium alters the tissue homeostasis. Some soluble factors, such as TGFβ, potently modify the behavior of healthy stromal cells. [...]
2023 -  10.1186/s13058-023-01736-y
Breast cancer research, Vol. 25 Núm. 1 (december 2023) , p. 143
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11 p, 5.0 MB |
Fibroblast activation and abnormal extracellular matrix remodelling as common hallmarks in three cancer-prone genodermatoses
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Chacón-Solano, Esteban (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
León Canseco, Carlos (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Díaz, F. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
García-García, Francisco (Bioinformatics and Biostatistics Unit. Centro de Investigación Príncipe Felipe (CIPF)) ;
García, M. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Escámez Toledano, María José (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Guerrero-Aspizua, Sara (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Conti, C.J. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Mencía, None (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Martínez-Santamaría, L. (Regenerative Medicine and Tissue Engineering Group. Fundación Jiménez Díaz (IIS-FJD)) ;
Llames, S. (Tissue Engineering Unit. Centro Comunitario Sangre y Tejidos (CCST)) ;
Pévida, M. (Tissue Engineering Unit. Centro Comunitario Sangre y Tejidos (CCST)) ;
Carbonell-Caballero, J. (Department of Computational Genomics. Centro de Investigación Príncipe Felipe (CIPF)) ;
Puig-Butille, Joan Anton (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Maseda, R. (Department of Pediatric Dermatology. La Paz Hospital) ;
Puig, Susana (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
de Lucas, R. (Department of Pediatric Dermatology. La Paz Hospital) ;
Baselga Torres, Eulàlia (Institut d'Investigació Biomèdica Sant Pau) ;
Larcher, F. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714)) ;
Dopazo, J. (Bioinformatics in Rare Diseases (BiER-U715). CIBERER. FPS. Hospital Virgen del Rocío) ;
del Río, M. (Epithelial Biomedicine Division. CIEMAT-CIBERER (U714))
Background: Recessive dystrophic epidermolysis bullosa (RDEB), Kindler syndrome (KS) and xeroderma pigmentosum complementation group C (XPC) are three cancer-prone genodermatoses whose causal genetic mutations cannot fully explain, on their own, the array of associated phenotypic manifestations. [...]
2019 - 10.1111/bjd.17698
British journal of dermatology, Vol. 181 Núm. 3 (january 2019) , p. 512-522
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11 p, 4.4 MB |
Lung Extracellular Matrix Hydrogels Enhance Preservation of Type II Phenotype in Primary Alveolar Epithelial Cells
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Marhuenda, Esther (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Villarino, Alvaro (Universitat de Barcelona) ;
Narciso, Maria Leonor (Universitat de Barcelona) ;
Camprubí-Rimblas, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Gavara, Núria (Universitat de Barcelona) ;
Artigas Raventós, Antoni (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Almendros, Isaac (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Otero, Jorge (Universitat de Barcelona) ;
Universitat Autònoma de Barcelona
One of the main limitations of in vitro studies on lung diseases is the difficulty of maintaining the type II phenotype of alveolar epithelial cells in culture. This fact has previously been related to the translocation of the mechanosensing Yes-associated protein (YAP) to the nuclei and Rho signaling pathway. [...]
2022 - 10.3390/ijms23094888
International journal of molecular sciences, Vol. 23 (april 2022)
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16 p, 1.4 MB |
Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells
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Lehmann, Guillermo L. (Regeneron Pharmaceuticals. Inc.) ;
Ginsberg, Michael (Angiocrine Bioscience. Inc.) ;
Nolan, Daniel J. (Angiocrine Bioscience. Inc.) ;
Rodríguez, Cristina (Institut d'Investigació Biomèdica Sant Pau) ;
Martínez-González, José (Institut d'Investigació Biomèdica Sant Pau) ;
Zeng, Shemin (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Voigt, Andrew P. (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Mullins, Robert F. (Institute for Vision Research. Department of Ophthalmology and Visual Sciences. The University of Iowa) ;
Rafii, Shahin (Ansary Stem Cell Institute. Department of Medicine. Division of Regenerative Medicine. Weill Cornell Medicine) ;
Rodriguez-Boulan, Enrique (Margaret Dyson Vision Research Institute. Department of Ophthalmology. Weill Cornell Medicine) ;
Benedicto, Ignacio (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Alpha-2-macroglobulin (A2M) is a protease inhibitor that regulates extracellular matrix (ECM) stability and turnover. Here, we show that A2M is expressed by endothelial cells (ECs) from human eye choroid. [...]
2022 - 10.3390/cells11192975
Cells, Vol. 11 Núm. 19 (october 2022) , p. 2975
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19 p, 6.7 MB |
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
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Sanegre, Sabina (Department of Pathology, School of Medical, University of Valencia-INCLIVA) ;
Eritja, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
de Andrea, Carlos (Clínica Universidad de Navarra) ;
Diaz-Martin, Juan (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Diaz-Lagares, Angel (Hospital Clínico Universitario (Santiago de Compostela, Galícia)) ;
Jácome, María Amalia (Universidade da Coruña) ;
Salguero-Aranda, Carmen (Hopital Universitario Virgen del Rocío) ;
García Ros, David (Clínica Universidad de Navarra) ;
Davidson, Ben (Norwegian Radium Hospital) ;
Lopez, Rafel (Instituto de Investigación Sanitaria de Santiago (IDIS)) ;
Melero, Ignacio (Clínica Universidad de Navarra) ;
Navarro, Samuel (Universitat de València) ;
Ramon y Cajal, Santiago (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
De Álava, Enrique (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia)) ;
Matias-Guiu, Xavier (Institut d'Investigació Biomèdica de Bellvitge) ;
Noguera, Rosa (Universitat de València) ;
Universitat Autònoma de Barcelona
The invasive tumor front (the tumor-host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. [...]
2021 - 10.3389/fcell.2021.670185
Frontiers in Cell and Developmental Biology, Vol. 9 (june 2021)
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7 p, 1.6 MB |
Fibronectin-coating enhances attachment and proliferation of mesenchymal stem cells on a polyurethane meniscal scaffold
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Arredondo, Raquel (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Poggioli, Francesco (Hospital Universitari Dexeus (Barcelona, Catalunya)) ;
Martínez-Díaz, Santos (Hospital del Mar (Barcelona, Catalunya)) ;
Piera-Trilla, María (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Torres-Claramunt, Raúl (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Tío Barrera, Laura (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Monllau García, Joan Carles (Hospital del Mar (Barcelona, Catalunya)) ;
Universitat Autònoma de Barcelona
Partial meniscectomy is one of the most common surgical strategy for a meniscal injury, but sometimes, patients complain of knee pain due to an overload in the ablated compartment. In these cases, implantation of tissue engineering scaffold could be indicated. [...]
2021 - 10.1016/j.reth.2021.11.001
Regenerative Therapy, Vol. 18 (november 2021) , p. 480-486
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18 p, 5.7 MB |
Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)
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de Boer, Rudolf A.. (University Medical Center Groningen) ;
Hulot, Jean-Sébastien (Université de Paris) ;
Tocchetti, Carlo Gabriele (Federico II University) ;
Aboumsallem, Joseph Pierre (University Medical Center Groningen) ;
Ameri, Pietro (University of Genova. Department of Internal Medicine) ;
Anker, Stefan D. (Charité - Universitätsmedizin Berlin) ;
Bauersachs, Johann (Hannover Medical School) ;
Bertero, Edoardo (University Clinic Würzburg) ;
Coats, Andrew J. S. (San Raffaele Pisana Scientific Institute) ;
Čelutkienė, Jelena (Vilnius University) ;
Chioncel, O. (University of Medicine Carol Davila) ;
Dodion, Pierre (Innate Pharma) ;
Eschenhagen, Thomas (University Medical Center Hamburg. Institute of Experimental Pharmacology and Toxicology) ;
Farmakis, D. (University of Cyprus Medical School) ;
Bayés-Genís, Antoni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Jäger, Dirk (Heidelberg University Hospital (Alemanya)) ;
Jankowska, Ewa A. (Wroclaw Medical University. Department of Heart Diseases) ;
Kitsis, Richard N. (Albert Einstein College of Medicine) ;
Konety, Suma H. (University of Minnesota Medical School) ;
Larkin, James (Royal Marsden NHS Foundation Trust) ;
Lehmann, Lorenz (University of Heidelberg. Department of Cardiology) ;
Lenihan, Daniel J. (Washington University in St. Louis) ;
Maack, Christoph (University Clinic Würzburg) ;
Moslehi, Javid J. (Vanderbilt University Medical Center) ;
Müller, Oliver J. (University of Kiel. Department of Internal Medicine) ;
Nowak-Sliwinska, Patrycja (University of Geneva. Institute of Pharmaceutical Sciences of Western Switzerland) ;
Piepoli, Massimo Francesco (University of Parma) ;
Ponikowski, Piotr (Wroclaw Medical University. Department of Heart Diseases) ;
Pudil, Radek (University Hospital and Medical Faculty (Czech Republic)) ;
Rainer, Peter P. (7 Medical University of Graz) ;
Ruschitzka, Frank (University Hospital Zurich (Suïssa)) ;
Sawyer, Douglas (Maine Medical Center) ;
Seferovic, Petar M. (University of Belgrade) ;
Suter, Thomas (Bern University) ;
Thum, Thomas (Hannover Medical School) ;
van der Meer, Peter (University Medical Center Groningen) ;
Van Laake, Linda W. (Utrecht University) ;
von Haehling, Stephan (University of Göttingen Medical Center. Department of Cardiology and Pneumology) ;
Heymans, Stephane (Maastricht University. Department of Cardiology) ;
Lyon, Alexander R. (Imperial College London. National Heart and Lung Institute) ;
Backs, Johannes (Heidelberg University Hospital (Alemanya)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. [...]
2020 - 10.1002/ejhf.2029
European Journal of Heart Failure, Vol. 22 (november 2020) , p. 2272-2289
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26 p, 1.2 MB |
Segregation of motor and sensory axons regenerating through bicompartmental tubes by combining extracellular matrix components with neurotrophic factors
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Del Valle, Jaume (Institut Català de Nanociència i Nanotecnologia) ;
Santos, Daniel (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Delgado Martínez, Ignacio (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
de la Oliva, Natalia (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Giudetti, Guido (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ;
Micera, Silvestro (Scuola Superiore Sant׳Anna (Pontedera, Itàlia). BioRobotics Institute) ;
Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Segregation of regenerating motor and sensory axons may be a good strategy to improve selective functionality of regenerative interfaces to provide closed-loop commands. Provided that extracellular matrix components and neurotrophic factors exert guidance effects on different neuronal populations, we assessed in vivo the potential of separating sensory and motor axons regenerating in a bicompartmental Y-type tube, with each branch prefilled with an adequate combination of extracellular matrix and neurotrophic factors. [...]
2018 - 10.1002/term.2629
Journal of tissue engineering and regenerative medicine, Vol. 12, Issue 4 (April 2018) , p. e1991-e2000
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