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15 p, 4.3 MB |
Acellular cardiac scaffolds enriched with MSC-derived extracellular vesicles limit ventricular remodelling and exert local and systemic immunomodulation in a myocardial infarction porcine model
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Monguió-Tortajada, Marta (Institut Germans Trias i Pujol) ;
Prat-Vidal, Cristina (Banc de Sang i Teixits) ;
Martínez-Falguera, Daina (Universitat de Barcelona) ;
Teis, Albert (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Soler-Botija, Carolina (Instituto de Salud Carlos III) ;
Courageux, Yvan (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ;
Munizaga-Larroudé, Micaela (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Borràs i Serres, Francesc Enric (Universitat de Barcelona. Departament de Biologia Cel·lular, Fisiologia i Immunologia) ;
Rudilla, F. (Institut d'Investigació Biomèdica de Bellvitge) ;
Gálvez-Montón, Carolina (Institut d'Investigació Biomèdica de Bellvitge)
Rationale: Extracellular vesicles (EVs) from mesenchymal stromal cell (MSC) are a potential therapy for cardiac healing after myocardial infarction (MI). Nevertheless, neither their efficient administration nor therapeutic mechanisms are fully elucidated. [...]
2022 -  10.7150/thno.72289
Theranostics, Vol. 12, Issue 10 (June 2022) , p. 4656-4670
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23 p, 2.5 MB |
Extracellular vesicles, the emerging mirrors of brain physiopathology
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Cano, Amanda (Ace Alzheimer Center Barcelona) ;
Ettcheto, Miren (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Bernuz, Mireia (Universitat Autònoma de Barcelona. Departament de Química) ;
Puerta, Raquel (Ace Alzheimer Center Barcelona) ;
Esteban de Antonio, Ester (Ace Alzheimer Center Barcelona) ;
Sánchez-López, Elena (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Souto, Eliana B. (Universidade do Porto. Faculdade de Farmácia) ;
Camins, Antoni (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Boada, Mercè (Ace Alzheimer Center Barcelona) ;
Ruiz, Agustín (Ace Alzheimer Center Barcelona)
Extracellular vesicles are secreted by a wide variety of cells, and their primary functions include intercellular communication, immune responses, human reproduction, and synaptic plasticity. Their molecular cargo reflects the physiological processes that their cells of origin are undergoing. [...]
2023 - 10.7150/ijbs.79063
International journal of biological sciences, Vol. 19, issue 3 (2023) , p. 721-743
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19 p, 5.2 MB |
Plasma extracellular vesicles reveal early molecular differences in amyloid positive patients with early-onset mild cognitive impairment
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Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Esteban-De Antonio, Ester (Universitat Internacional de Catalunya) ;
Bernuz, Mireia (Universitat Autònoma de Barcelona. Departament de Química) ;
Puerta, Raquel (Universitat Internacional de Catalunya) ;
García-González, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
De Rojas, Itziar (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Olivé, Claudia (Universitat Internacional de Catalunya. Ace Alzheimer Center Barcelona) ;
Pérez-Cordón, Alba (Universitat Internacional de Catalunya) ;
Montrreal, Laura (Universitat Internacional de Catalunya) ;
Núñez-Llaves, Raúl (Universitat Internacional de Catalunya) ;
Sotolongo Grau, Oscar (Universitat Internacional de Catalunya) ;
Alarcón-Martín, Emilio (Universitat Internacional de Catalunya) ;
Valero, Sergi (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Alegret, Montserrat (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Martín, Elvira (Universitat Internacional de Catalunya) ;
Martino-Adami, Pamela V. (University of Cologne. Department of Psychiatry and Psychotherapy) ;
Ettcheto, Miren (Universitat de Barcelona. Institut de Neurociències) ;
Camins, Antoni (Universitat de Barcelona. Institut de Neurociències) ;
Vivas, Assumpta (Clínica Corachan) ;
Gomez-Chiari, Marta (Clínica Corachan) ;
Tejero, Miguel Ángel (Clínica Corachan) ;
Orellana, Adelina (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Tárraga, Lluís (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Marquié, Marta (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ramirez, Alfredo (Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne) ;
Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Química) ;
Pividori, María Isabel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Boada, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ;
Ruiz, Agustín (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
In the clinical course of Alzheimer's disease (AD) development, the dementia phase is commonly preceded by a prodromal AD phase, which is mainly characterized by reaching the highest levels of Aβ and p-tau-mediated neuronal injury and a mild cognitive impairment (MCI) clinical status. [...]
2023 - 10.1186/s12951-023-01793-7
Journal of nanobiotechnology, Vol. 21 (February 2023) , art. 54
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19 p, 6.0 MB |
Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in down syndrome
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D'Acunzo, Pasquale (New York University. School of Medicine. Department of Psychiatry) ;
Pérez-González, Rocío (Institut d'Investigació Biomèdica Sant Pau) ;
Kim, Yohan (New York University. School of Medicine. Department of Psychiatry) ;
Hargash, Tal (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Miller, Chelsea (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Alldred, Melissa J. (Department of Psychiatry. New York University. School of Medicine) ;
Erdjument-Bromage, Hediye (New York University. School of Medicine. Kimmel Center for Biology and Medicine. The Skirball Institute) ;
Penikalapati, Sai Charan (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Pawlik, Monika (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Saito, Mitsuo (Division of Neurochemistry. Nathan S. Kline Institute for Psychiatric Research) ;
Saito, Mariko (New York University School of Medicine. Department of Psychiatry) ;
Ginsberg, Stephen D. (New York University. School of Medicine. Department of Neuroscience and Physiology) ;
Neubert, Thomas A. (Kimmel Center for Biology and Medicine. The Skirball Institute. New York University. School of Medicine) ;
Goulbourne, Chris N. (Center for Dementia Research. Nathan S. Kline Institute for Psychiatric Research) ;
Levy, Efrat (Department of Biochemistry and Molecular Pharmacology. New York University. School of Medicine)
Mitochondrial dysfunction is an established hallmark of aging and neurodegenerative disorders such as Down syndrome (DS) and Alzheimer's disease (AD). Using a high-resolution density gradient separation of extracellular vesicles (EVs) isolated from murine and human DS and diploid control brains, we identify and characterize a previously unknown population of double-membraned EVs containing multiple mitochondrial proteins distinct from previously described EV subtypes, including microvesicles and exosomes. [...]
2021 - 10.1126/sciadv.abe5085
Science advances, Vol. 7 Núm. 7 (december 2021) , p. eabe5085
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16 p, 2.8 MB |
N-Glycans in Immortalized Mesenchymal Stromal Cell-Derived Extracellular Vesicles Are Critical for EV-Cell Interaction and Functional Activation of Endothelial Cells
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Clos Sansalvador, Marta (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Garcia, Sergio G. (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Morón-Font, Miriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Williams, Charles (Basque Research and Technology Alliance. Center for Cooperative Research in Biosciences) ;
Reichardt, Niels-Christian (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina) ;
Falcón-Pérez, Juan M.. (Basque Foundation for Science) ;
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Roura, Santiago (Universitat de Vic - Universitat Central de Catalunya) ;
Franquesa, Marcella (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EV) are widely considered as a cell-free therapeutic alternative to MSC cell administration, due to their immunomodulatory and regenerative properties. [...]
2022 - 10.3390/ijms23179539
International journal of molecular sciences, Vol. 23, Issue 17 (August 2022) , art. 9539
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13 p, 3.8 MB |
Immunogenicity of Mycobacterial Extracellular Vesicles Isolated From Host-Related Conditions Informs About Tuberculosis Disease Status
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Schirmer, Sebastian (University of Applied Sciences. Department of Medical Engineering and Biotechnology) ;
Rauh, Lucas (University of Applied Sciences. Department of Medical Engineering and Biotechnology) ;
Alebouyeh, Sogol (Universidad Autónoma de Madrid. Departamento de Medicina Preventiva y Salud Pública) ;
Delgado-Velandia, Mario (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública) ;
Salgueiro, Vivian C. (Universidad Autónoma de Madrid. Departamento de Medicina Preventiva y Salud Pública) ;
Lerma, Laura (Universidad Autónoma de Madrid. Departamento de Medicina Preventiva y Salud Pública) ;
Serrano-Mestre, José L. (Universidad Autónoma de Madrid. Departamento de Medicina Preventiva y Salud Pública) ;
Azkargorta, Mikel (Basque Research and Technology Alliance) ;
Elortza, Félix (Basque Research and Technology Alliance) ;
Lavín, José L. (Basque Research and Technology Alliance) ;
García, Maria Jesus (Universidad Autónoma de Madrid. Departamento de Medicina Preventiva y Salud Pública) ;
Tórtola Fernández, María Teresa (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gola, Susanne (University of Applied Sciences. Department of Medical Engineering and Biotechnology) ;
Prados-Rosales, Rafael (Universidad Autónoma de Madrid. Departamento de Medicina Preventiva y Salud Pública)
Tuberculosis (TB) still represents a major global health problem affecting over 10 million people worldwide. The gold-standard procedures for TB diagnosis are culture and nucleic acid amplification techniques. [...]
2022 - 10.3389/fmicb.2022.907296
Frontiers in microbiology, Vol. 13 (June 2022) , art. 907296
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